期刊
JOURNAL OF FUNCTIONAL FOODS
卷 13, 期 -, 页码 71-79出版社
ELSEVIER
DOI: 10.1016/j.jff.2014.12.040
关键词
Dendritic cells; Lactobacillus rhamnosus GG; Macrophages; Monocyte
资金
- General Research Fund (GRF) from the Research Grant Council (GRC) of Hong Kong [765810]
Lactobacillus rhamnosus GG (LGG) is clinically documented in relieving and preventing diarrhea, childhood infections, allergies and atopic eczema but knowledge of its immunomodulatory properties on antigen-presenting cells (APCs) is lacking. Here, immunomodulation of LGG on dendritic cells (DCs), macrophages and monocytes was investigated. Toll-like receptor (TLR) mRNA levels and immunophenotype of LGG-treated APCs, and cytokine secretion levels of culture of LGG-treated DCs and peripheral blood mononuclear cells were examined. LGG reduced TLR 8 mRNA level of APCs, implying that the immunomodulation of LGG may be partly due to the reaction of RNA with APCs. LGG reduced CD16 expression on macrophages and CD11b expression on monocytes. The results obtained demonstrated the effect of LGG on type-1 immune response polarization as observed from elevated production of IL-12 and TNFa across different APC stimulation models, suggesting that LGG may have immunotherapeutic potential in ameliorating and preventing the development of Th2-mediated inflammatory diseases and against infections. (C) 2014 Elsevier Ltd. All rights reserved.
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