Article
Endocrinology & Metabolism
Qiuxia Min, Yan Wang, TaiCheng Jin, Lei Zhu, XianYan Wu, YiKun Li, YanJiao Wang, Ning Xu
Summary: This study investigates the therapeutic effect of probiotics on type 2 diabetes mellitus and its regulatory effect on short-chain fatty acids, which are metabolites of intestinal microorganisms. The results demonstrate that both probiotics and GLP-1 treatment can improve blood glucose levels, urine glucose, and BMI in patients with type 2 diabetes. The study also reveals changes in intestinal short-chain fatty acids after probiotics or GLP-1 treatment, suggesting potential intervention targets for diabetes treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Knud Josefsen, Lars Krogvold, Ivan C. Gerling, Flemming Pociot, Knut Dahl-Jorgensen, Karsten Buschard
Summary: This study suggests that dormant beta cells in type 1 diabetes (T1D) exhibit secretion defects, fetal dedifferentiation, and desynchronization. Combining with previous evidence, it is proposed to treat individuals with ongoing T1D development prophylactically with type 2 diabetes (T2D) medicine and anti-inflammatory compounds to reactivate dormant beta cells and prevent autoimmune destruction. Further investigation into T2D mechanisms during T1D development is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Francisco J. Pasquel, Maria A. Urrutia, Saumeth Cardona, Karla W. Z. Coronado, Bonnie Albury, Mireya C. Perez-Guzman, Rodolfo J. Galindo, Ajay Chaudhuri, Gianluca Iacobellis, Juan Palacios, Javier M. Farias, Patricia Gomez, Isabel Anzola, Priyathama Vellanki, Maya Fayfman, Georgia M. Davis, Alexandra L. Migdal, Limin Peng, Guillermo E. Umpierrez
Summary: Compared to insulin glargine, treatment with liraglutide at hospital discharge resulted in better glycaemic control, lower frequency of hypoglycaemia, and greater weight loss. However, liraglutide treatment was associated with higher incidence of gastrointestinal adverse events.
DIABETES OBESITY & METABOLISM
(2021)
Article
Genetics & Heredity
Junqi Liu, Bo Zhang, Guanyin Zhu, Chenlu Liu, Shuangcheng Wang, Zhihe Zhao
Summary: This study aimed to reveal the genetic linkage between periodontitis and type 1 diabetes through bioinformatics analysis, and identified 6 hub genes as potential targets in treating these diseases.
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Juergen G. Okun, Patricia M. Rusu, Andrea Y. Chan, Yuqin Wu, Yann W. Yap, Thomas Sharkie, Jonas Schumacher, Kathrin V. Schmidt, Katherine M. Roberts-Thomson, Ryan D. Russell, Annika Zota, Susanne Hille, Andreas Jungmann, Ludovico Maggi, Young Lee, Matthias Bluher, Stephan Herzig, Michelle A. Keske, Mathias Heikenwalder, Oliver J. Mueller, Adam J. Rose
Summary: Elevated hepatic alanine catabolism promotes hyperglycaemia and reduces skeletal muscle protein synthesis, linking sarcopenia with hyperglycaemia in type 2 diabetes. Obesity and sarcopenia are often associated in aging and may together contribute to the progression of conditions such as diabetes and frailty. Liver alanine metabolism driven by chronic glucocorticoid and glucagon signaling promotes hyperglycaemia and skeletal muscle wasting, revealing a metabolic inter-tissue cross-talk in type 2 diabetes.
Article
Endocrinology & Metabolism
Katie M. Sullivan, James Scholey, Rahim Moineddin, Etienne Sochett, Brandy Wicklow, Yesmino Elia, Feng Xiao, Thalia Mederios, Pusha Sadi, Dylan Burger, Farid H. Mahmud, Alison B. Dart
Summary: The study found significant associations between podocyte MPE, blood glucose levels and eGFR in youth with type 1 diabetes, but not in those with type 2 diabetes, despite increased renal pathology in the type 2 diabetes cohort.
Article
Cardiac & Cardiovascular Systems
Ram Prasad, Jason L. Floyd, Mariana Dupont, Angela Harbour, Yvonne Adu-Agyeiwaah, Bright Asare-Bediako, Dibyendu Chakraborty, Kara Kichler, Aayush Rohella, Sergio Li Calzi, Regina Lammendella, Justin Wright, Michael E. Boulton, Gavin Y. Oudit, Mohan K. Raizada, Bruce R. Stevens, Qiuhong Li, Maria B. Grant
Summary: The components of the systemic and intestinal renin-angiotensin system have been found to be associated with gut barrier permeability, glucose homeostasis, systemic inflammation, and the progression of diabetic retinopathy. Changes in gut-regulated components of the immune system, gut leakage markers, and angiotensin II were observed in T1D patients and mice, and were assessed for relevance.
CIRCULATION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Christophe E. M. De Block, Eveline Dirinck, Ann Verhaegen, Luc F. Van Gaal
Summary: Glucagon-like peptide-1 receptor agonists and dual GLP-1/glucose-dependent insulinotropic peptide RA tirzepatide have expanded the population of individuals reaching HbA1c and weight targets, showing potential therapeutic benefits. However, further research is needed to determine whether this will lead to improved cardiovascular outcomes and impact treatment guidelines.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Khary Edwards, Xilong Li, Ildiko Lingvay
Summary: The use of GLP-1RAs and SGLT2is in the management of T1DM in real-world practice has shown clinically relevant benefits, with a reduction in weight and HbA(1c). However, the use of SGLT2is is associated with an increased risk of diabetic ketoacidosis, requiring careful patient selection and monitoring.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Sport Sciences
Varun Vartak, Lynne Chepulis, Matthew Driller, Ryan G. Paul
Summary: In this pilot study, the INS intervention was found to be the most effective approach for maintaining blood glucose levels during aerobic exercise in individuals with T1D. However, further evaluation in other groups, including women, children, and those with suboptimal glycaemic control, is needed.
SPORTS MEDICINE-OPEN
(2021)
Article
Endocrinology & Metabolism
Per G. Hagelqvist, Andreas Andersen, Kaisar Maytham, Christine R. Andreasen, Susanne Engberg, Tommi B. Lindhardt, Julie L. Forman, Ulrik Pedersen-Bjergaard, Filip K. Knop, Tina Vilsboll
Summary: The aim of this study was to investigate the impact of hypoglycaemia, hyperglycaemia and glycaemic variability on arrhythmia susceptibility in people with type 1 diabetes. The results showed that during daytime, hypoglycaemia was associated with a trend of increased risk of arrhythmias, while hyperglycaemia was significantly associated with an increased risk. However, there was no such association during night-time. Increased glycaemic variability was not associated with an increased risk of arrhythmias during daytime, but was associated with a reduced risk during night-time.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Alon Haim, Rotem Shalev Shamy, Dana Ridel, Yisrael Parmet, Neta Loewenthal, Idit Liberty, Shai Tejman-Yarden, Eli Hershkovitz, Avinoam Borowsky
Summary: This study shows that acute hyperglycemia impairs driving performance in young type 1 diabetes patients by reducing hazard perception, decreasing the number of glances, shortening headway distance, and increasing the number of braking events.
DIABETES & METABOLISM
(2021)
Article
Microbiology
Grigorios Nelios, Valentini Santarmaki, Chrysoula Pavlatou, Dimitra Dimitrellou, Yiannis Kourkoutas
Summary: The isolated L. rhamnosus strains from traditional fermented Greek products showed potential probiotic properties, including inhibitory activity against foodborne pathogens and alpha-glucosidase, indicating a possible role in improving T1D symptoms.
Article
Medicine, General & Internal
Teresa Quattrin, Lucy D. Mastrandrea, Lucy S. K. Walker
Summary: Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic beta cells, and individuals with this disease rely on insulin for survival. Despite advancements, the burden of this disease remains high. Research shows that blocking the immune attack on beta cells holds promise in preserving endogenous insulin production.
Article
Endocrinology & Metabolism
Christine R. Andreasen, Andreas Andersen, Per G. Hagelqvist, Kaisar Maytham, Julius V. Lauritsen, Susanne Engberg, Jens Faber, Ulrik Pedersen-Bjergaard, Filip K. Knop, Tina Vilsboll
Summary: The study investigated the effect of insulin-induced hypoglycemia and subsequent recovery to hyperglycemia or euglycemia on cardiac repolarization in people with type 1 diabetes. The results showed that hypoglycemia prolonged the QTc interval, indicating increased risk of serious cardiac arrhythmias and sudden cardiac death. This prolonged repolarization was sustained during the recovery period, regardless of the blood sugar level.
DIABETES OBESITY & METABOLISM
(2023)
Article
Agriculture, Multidisciplinary
Hsiaowen Huang, Kuanyi Li, Yajane Lee, Mingju Chen
Summary: A probiotic screening platform based on gut-derived uremic toxin-reducing probiotics was developed and verified in a CKD mouse model, demonstrating that the probiotic mixture improved kidney function, reversed gut dysbiosis, and enhanced intestinal barrier integrity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Nian-Yao Zheng, Yi-Chen Chen, Yen-Po Chen, Jia-Shian Shiu, Sheng-Yao Wang
Summary: This study aimed to find uses for excess duck egg white by producing translucent egg white jelly through mixing with sodium hydroxide, and controlling storage and heating conditions to maintain its properties and delay liquefaction. Adding ginger juice or turmeric improved the bloom strength and thermal stability of the jelly.
Article
Food Science & Technology
Sheng-Yao Wang, Ren-Feng Huang, Ker-Sin Ng, Yen-Po Chen, Jia-Shian Shiu, Ming-Ju Chen
Summary: Through a co-culture strategy, we have successfully improved the viability of kefir strain HL1 in fermented skimmed milk products and developed a novel milk product with a unique flavor and sufficient probiotics.
Article
Agriculture, Dairy & Animal Science
Ker-Sin Ng, Yu-Chun Chang, Yen-Po Chen, Ya-Hsuan Lo, Sheng-Yao Wang, Ming-Ju Chen
Summary: This study characterized the exopolysaccharides (EPS)-producing lactic acid bacteria from Taiwanese ropy fermented milk (TRFM) and identified Lactococcus (Lc.) lactis subsp. cremoris APL15 as a strain with good fermentation abilities for producing low-fat fermented milk. The findings suggest that EPS-producing lactic acid bacteria have great potential to act as natural food stabilizers for low-fat fermented milk.
Article
Agriculture, Dairy & Animal Science
Shih-Te Chuang, Kuan-Yi Li, Po-Wen Tu, Shang-Tse Ho, Cheng-Chih Hsu, Jui-Chun Hsieh, Ming-Ju Chen
Summary: This study identified ruminal microbial biomarkers and metabolites related to mastitis in dairy cows, revealing differences between healthy and mastitis cows. Potential microbial strains and metabolites were identified, offering novel insights for targeting ruminal microbiota for preventive/therapeutic strategies against mastitis in the future.
Article
Food Science & Technology
Kai-Yi Lee, Ying-Chieh Tsai, Sheng-Yao Wang, Yen-Po Chen, Ming-Ju Chen
Summary: The study explored the effects of fermented milk with L. paracasei PS23 on intestinal cells and colitis, demonstrating a protective effect in vitro and in vivo by enhancing epithelial barrier function and modifying gut microbiota.
Article
Agriculture, Dairy & Animal Science
Shih-Te Chuang, Chien-Ting Chen, Jui-Chun Hsieh, Kuan-Yi Li, Shang-Tse Ho, Ming-Ju Chen
Summary: The study explored the relationship between gastrointestinal microbiota and diarrhea in preruminant calves, identifying potential next-generation probiotics enriched in healthy individuals. Specifically, Bifidobacterium longum subsp. longum showed possible beneficial effects and two strains were found to have antimicrobial and immunoregulatory effects, providing a new probiotic searching approach for preventing gastrointestinal disorders in preruminant calves.
Article
Biology
Yung-Tsan Wu, Yen-Po Chen, King Hei Stanley Lam, Kenneth Dean Reeves, Jui-An Lin, Cheng-Yi Kuo
Summary: High glucose concentrations can alleviate neuroinflammation and cellular metabolic dysfunction.
Article
Nutrition & Dietetics
Mon-Chien Lee, Ming-Ju Chen, Hsiao-Wen Huang, Wei-Kai Wu, Yi-Wei Lee, Hsing-Chun Kuo, Chi-Chang Huang
Summary: Exercise alters the gut microbiota, which in turn affects exercise performance. Supplementation with human-origin probiotics, such as Lactiplantibacillus plantarum Tana, can improve the gut microbiota, enhance exercise performance, and have antifatigue effects without causing any harm.
Article
Microbiology
Sheng-Yao Wang, Yen-Po Chen, Ren-Feng Huang, Yi-Lu Wu, Shang-Tse Ho, Kuan-Yi Li, Koichi Watanabe, Ming-Ju Chen
Summary: HL1 and M1 strains were identified as L. kefiranofaciens subsp. kefirgranum, showing specific genes related to polysaccharide synthesis and other functionalities. The findings provide potential insights for probiotic screening and functionality predictions.
Article
Microbiology
Hsin-Yu Chen, Yung-Tsung Chen, Kuan-Yi Li, Hsiao-Wen Huang, Yu-Chun Lin, Ming-Ju Chen
Summary: Through experiments in a house dust mite (HDM) extraction-induced atopic dermatitis (AD) mouse model, it was found that administration of a mixture of heat-killed Lactococcus lactis subsp. cremoris MP01 and Lactobacillus paracasei subsp. paracasei MP02 relieved AD symptoms, decreased serum IgE concentration, and rebalanced the population of Th1/Th2 cells in the spleen.
Review
Engineering, Chemical
Solomon Abrehame, Valsa Remony Manoj, Merry Hailu, Yu-Yi Chen, Yu-Chun Lin, Yen-Po Chen
Summary: This article provides a detailed review of the structural biochemistry, occurrence, factors contributing to contamination and intoxication, clinical features, as well as suggested preventive and control strategies and detection methods for aflatoxins, the most potent mycotoxins.
Article
Microbiology
Syed Monzur Morshed, Yu-Yi Chen, Chia-Hao Lin, Yen-Po Chen, Tsung-Han Lee
Summary: This study revealed that transfer to freshwater affects the composition and functions of gut microbiota in Asian sea bass, and this is correlated with cytokine gene expression.
FRONTIERS IN MICROBIOLOGY
(2023)
