Article
Cell Biology
Katarzyna D. Kania, Daria Hareza, Jacek R. Wilczynski, Milosz Wilczynski, Dariusz Jarych, Andrzej Malinowski, Edyta Paradowska
Summary: Ovarian cancer is one of the most common cancers affecting women worldwide. The TLR4 Asp299Gly polymorphism may be a genetic risk factor for the development of ovarian cancer.
Article
Immunology
Sara Taha, Aalaa K. Shata, Shereen A. Baioumy, Shaimaa H. Fouad, Sherif G. Anis, Isis M. Mossad, Nouran M. Moustafa, Dina M. Abdou, Mariam K. Youssef
Summary: The study found a significant association between specific genetic polymorphisms of TLR-4 and the severity of COVID-19 and cytokine storm, indicating a higher risk, which is of great importance for guiding prevention and treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Ruifeng Chen, Xuan Wang, Zilin Li, Yumei Dai, Wenya Du, Lixian Wu
Summary: Toll-like receptor 2 (TLR2) is important in tuberculosis development. However, the association between TLR2 polymorphisms and tuberculosis susceptibility has not been explored. This study systematically searched relevant databases and included 37 studies, involving 6 polymorphisms and a total of 9,474 cases and 10,295 controls. The results showed that only the TLR2 rs5743708 polymorphism was significantly associated with a higher tuberculosis risk, while other TLR2 polymorphisms were not associated with tuberculosis susceptibility.
Article
Fisheries
Ayumi Matsuyama-Kato, Nitish Boodhoo, Hiroshi Iseki, Mohamed Faizal Abdul-Careem, Brandon L. Plattner, Shahriar Behboudi, Shayan Sharif
Summary: Gamma delta (γδ) T cells can sense invading pathogens and produce interferon (IFN)-γ as a first line of defense. This study found that polyinosinic-polycytidylic acid (poly(I:C)) and CpG-ODN 2007 can stimulate chicken γδ T cells and induce IFN-γ production.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Review
Immunology
Niloofar Deravi, Mohadeseh Poudineh, Marzieh Pirzadeh, Hanie Yavarpour-Bali, Hoda Mehrabi, Gisou Erabi, Amene Saghazadeh, Nima Rezaei
Summary: Endothelial cells play a critical role in innate immune and inflammatory responses, and Toll-like receptors (TLRs) are key in activating innate mechanisms in ECs. Endothelial dysfunction may lead to tissue damage in various diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Critical Care Medicine
Sahil Gupta, James N. Tsoporis, Song-Hui Jia, Claudia C. dos Santos, Thomas G. Parker, John C. Marshall
Summary: This article discusses how host cells recognize danger signals using pattern recognition receptors, focusing on Toll-like receptors (TLRs) as the most studied class of PRRs. It reviews the expression, regulation, and function of different TLRs, emphasizing TLR-4, and how TLR adaptor protein binding directs intracellular signaling to activate or terminate an innate immune response. The recent progress in research on the involvement of S100 proteins as ligands for TLR-4 in inflammatory disease is also highlighted.
Article
Biochemistry & Molecular Biology
Yu Bai, Xinhua Cui, Xueli Gao, Chaonan Liu, Xiaoping Lv, Shimin Zheng
Summary: The study demonstrated that Poly (I: C) treatment could significantly inhibit REV replication in chicken macrophage-like cell line, HD11, switch HD11 into M1-like polarization, promote interferon-beta secretion, and activate TLR-3 signaling to block REV replication. This provides a theoretical reference for further research on the pathogenic mechanism of REV and Poly (I: C) as a potential therapeutic intervention against REV infection.
MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Fadwa M. AlKhulaifi, Afrah Alkhuriji, Lamjed Mansour, Abdullah Al-jurayyan, Norah M. A. Al-Mulhim, Yusra A. Tashkandy, Ghadeer S. Aldossari, Suliman Alomar
Summary: The study investigated the relationship between single nucleotide polymorphisms (SNPs), Toll-like receptor 4 (TLR4) gene expression, and the risk and prognosis of acute lymphoblastic leukemia (ALL) in the Saudi population. The results showed that specific SNPs of the TLR4 gene were associated with the risk of ALL, and the expression of TLR4 gene was significantly higher in ALL patients.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Infectious Diseases
Meng-Rui Lee, Yen-Lin Chen, Chang-Wei Wu, Lun-Che Chen, Lih-Yu Chang, Jung-Yueh Chen, Yu-Tsung Huang, Jann-Yuan Wang, Jin-Yuan Shih, Chong-Jen Yu
Summary: This study found that single nucleotide polymorphisms (SNPs) in Toll-like receptor 1 (TLR1), Toll-like receptor 2 (TLR2), and matrix metalloproteinase 8 (MMP8) were associated with the risk of tuberculosis (TB) infection and disease. Haplotypes and a polygenic risk score (PRS) could be used to predict TB disease status.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Pharmacology & Pharmacy
Nikoo Bayan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Diabetic retinopathy (DR) is a common complication of diabetes mellitus (DM) and is associated with inflammation, cellular apoptosis, neurodegeneration, oxidative stress, and neovascularization. Toll-like receptor 4 (TLR4) plays a crucial role in the development of DR, and microRNAs are involved in the pathogenesis of DR through their interaction with TLR4. Inhibitors of the TLR4 pathway have shown potential in the treatment of DR.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Malgorzata Sobstyl, Paulina Niedzwiedzka-Rystwej, Rafal Hrynkiewicz, Dominika Bebnowska, Izabela Korona-Glowniak, Marcin Pasiarski, Barbara Sosnowska-Pasiarska, Jolanta Smok-Kalwat, Stanislaw Gozdz, Anna Sobstyl, Wojciech Polkowski, Jacek Rolinski, Ewelina Grywalska
Summary: The study demonstrated the significance of TLR2 as a biomarker in advanced stage ovarian cancer by showing significantly higher expression levels in women with more advanced OC. This research sheds light on the prognostic potential of TLR2 in developing new diagnostic approaches and increasing survival in confirmed ovarian cancer patients.
Article
Agriculture, Dairy & Animal Science
Wootichai Kenchaiwong, Pongphol Pongthaisong, Srinuan Kananit, Monchai Duangjinda, Wuttigrai Boonkum
Summary: This study demonstrates the importance of understanding the genetic diversity of Thai swamp buffalo for conservation and breeding planning. The high genetic diversity found in this population suggests that there is potential for selecting and improving genetic tools to enhance health and production. The variations in the TLR2 gene may be useful for marker-based breeding programs aimed at improving disease resistance.
Review
Biochemistry & Molecular Biology
Saahithh Redddi Patlola, Gary Donohoe, Declan P. McKernan
Summary: Toll-like receptors (TLRs) are pattern recognition receptors that protect the brain from self and foreign antigens/pathogens and can elicit a harmful or beneficial immune response. TLR activation has been associated with neurodegenerative diseases and cytokine imbalance in schizophrenia. This review explores the current literature on TLRs, their potential role in schizophrenia pathogenesis, factors affecting TLR activity and their impact on cognitive performance in schizophrenia.
Review
Immunology
Arash Heidari, Niloufar Yazdanpanah, Nima Rezaei
Summary: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and aggregation of alpha-synuclein. Recent studies suggest that neuroinflammation may contribute to the loss of dopaminergic neurons in PD.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Gastroenterology & Hepatology
Suk Yee Lam, Michiel C. Mommersteeg, Bingting Yu, Linda Broer, Manon C. W. Spaander, Fabian Frost, Stefan Weiss, Henry Voelzke, Markus M. Lerch, Ben Schoettker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C. Wood, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell P. Tracy, Edmond K. Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, Andre Uitterlinden, Ernst J. Kuipers, Gwenny M. Fuhler, Georg Homuth, Maikel P. Peppelenbosch
Summary: The association between anti-H pylori IgG titers and the TLR1/6/10 locus was not replicated across different populations, and the variation at this locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes and neutrophils.
Article
Agriculture, Dairy & Animal Science
Jesper Tessin, Judith Rohde, Arne Jung, Nicole Kemper, Jochen Schulz
Summary: In this study, samples from poultry house environment and culled birds were collected, and E. cecorum was successfully isolated. The principle of isolating the pathogen by streaking on a chromogenic agar may motivate researchers to investigate transmission routes and optimize biosecurity measures.
Article
Agriculture, Dairy & Animal Science
Junqin Zhang, Zimin Xie, Yanlin Pan, Zuoxin Chen, Yunzhen Huang, Linlin Li, Jiawen Dong, Yong Xiang, Qi Zhai, Minhua Sun, Xingying Li, Shujian Huang, Ming Liao
Summary: In recent years, there has been an increase in the occurrence of fowl adenovirus 2 (FAdV-2) in China, posing a significant threat to the poultry industry. This study investigated the epidemiology, phylogenetic relationship, genomic characteristics, and pathogenicity of FAdV-2. The results showed that FAdV-2 was the most commonly detected serotype among various FAdV serotypes. Genetic analysis revealed that these FAdV-2 strains formed a distinct branch within the FAdV-D group and had a high nucleotide similarity with reference strains. Recombination analysis identified recombination events between FAdV-2 and FAdV-11 in some strains. Pathogenicity experiments demonstrated that a recombinant FAdV-2 strain caused a high mortality rate and more severe disease in chickens. These findings contribute to our understanding of FAdV-2 and provide a basis for vaccine development.
Article
Agriculture, Dairy & Animal Science
Ebtsam Iraqi, Ali Abdel Hady, Nadia Elsayed, Hanaa Khalil, Amina El-Saadany, Karim El-Sabrout
Summary: Thermal manipulation during egg incubation, particularly at 12 to 18 days, has positive effects on embryonic development, hatching characteristics, chick quality, as well as posthatch thermotolerance and performance.
Article
Agriculture, Dairy & Animal Science
Yong Liu, Mingxin Song, He Bai, Chunhua Wang, Fei Wang, Qi Yuan
Summary: Dietary curcumin supplementation can significantly improve egg quality of quails in the late laying period, primarily by improving lipid metabolism and selectively regulating the intestinal microbial community.
Article
Agriculture, Dairy & Animal Science
Lei Zhang, Zhixuan Song, Peiyao Li, Xingju Song, Xinming Tang, Dandan Hu
Summary: This study evaluated the vaccine potential of recombinant proteins for avian coccidiosis caused by Eimeria. The results showed that the rEten5-B protein can trigger immune protection against E. tenella and may be a potential and effective subunit vaccine for the control of coccidiosis in poultry.
Article
Agriculture, Dairy & Animal Science
Milan Kumar Sharma, Amit Kumar Singh, Doyun Goo, Venkata Sesha Reddy Choppa, Hanseo Ko, Hanyi Shi, Woo Kyun Kim
Summary: The study investigates the effect of Eimeria infection on gastrointestinal physiology, growth performance, and egg production of Hy-Line W-36 laying hens during peak production. Results show that Eimeria infection negatively affects body weight, feed intake, immune response, and nutrient transporter gene expression. Egg production temporarily ceases in hens infected with high and medium-high dosages of Eimeria.
Article
Agriculture, Dairy & Animal Science
Elwy A. Ashour, Mahmoud Kamal, Hayman A. A. Altaie, Ayman A. Swelum, Gamaleldin M. Suliman, Guillermo Tellez-Isaias, Mohamed E. Abd El-Hack
Summary: This study evaluated the effects of CP and ME on the performance and nutritional value of Japanese quail lay chicken. The results showed that protein and energy levels significantly influenced all productive outcomes except feed conversion ratio. The combination of dietary energy and protein levels had a substantial effect on all egg quality trials evaluated. It is recommended to feed layer Japanese quail between the ages of 8 and 20 weeks during the summer with a dietary energy content of 2,900 kcal ME/kg and 20% CP.
Article
Agriculture, Dairy & Animal Science
J. E. Doornweerd, R. F. Veerkamp, B. de Klerk, M. van der Sluis, A. C. Bouwman, E. D. Ellen, G. Kootstra
Summary: Tracking group-housed individual broilers using video can provide valuable information on their health, welfare, and performance. This study conducted a comprehensive analysis on broiler tracking on video and potential tracking errors, highlighting the potential and challenges of phenotyping broiler locomotion. The results emphasized the importance of addressing tracking errors, potential algorithm improvements, and the need for an external animal identification system for efficient locomotion phenotyping.
Article
Agriculture, Dairy & Animal Science
Jiayu Wu, Yanan Wang, Yu An, Changyu Tian, Lingfeng Wang, Zuhong Liu, Desheng Qi
Summary: This study compared the gene expression differences in liver tissues of laying hens at different ages using RNA sequencing, and found that the transport and metabolism of amino acids changed during the growing period, which influenced the growth and development of the hens.
Article
Agriculture, Dairy & Animal Science
J. Raabe, G. Raveendran, W. Otten, K. Homeyer, T. Bartels
Summary: This study investigated the effects of different flicker frequencies on the behavior, performance, and stress response in male turkeys. The results showed that flicker frequencies of 165 Hz or higher had no detrimental effect on growth performance, injurious pecking, or endocrine stress response in the turkeys.
Article
Agriculture, Dairy & Animal Science
Adamu Mani Isa, Yanyan Sun, Yuanmei Wang, Yunlei Li, Jingwei Yuan, Aixin Ni, Hui Ma, Lei Shi, Hailai Hagos Tesfay, Yunhe Zong, Panlin Wang, Pingzhuang Ge, Jilan Chen
Summary: This study sequenced mRNAs and lncRNAs in the ovary stroma of specific chicken breeds and their reciprocal crossbreds to understand the molecular mechanism of heterosis for egg production. Results showed that genes with nonadditive expression were related to follicle growth and atresia as well as oxidative stress in the crossbred hens.
Article
Agriculture, Dairy & Animal Science
Zhepeng Wang, Qiu Chen, Yiwei Wang, Yulu Wang, Ruifang Liu
Summary: The study investigates the functional variants associated with chicken eggshell color in the SLCO1B3 gene by measuring the eggshell color of Lueyang black-boned chickens and analyzing the genetic data. It identifies 15 variants in SLCO1B3 that are significantly associated with eggshell color. However, the functional analysis shows that one specific variant, 1B3_SNP108, does not have a significant effect on promoter activity. This study highlights the importance of SLCO1B3 and its variants in breeding eggshell color.
Article
Agriculture, Dairy & Animal Science
P. Yin, Q. Tong, B. M. Li, W. C. Zheng, Y. Wang, H. Q. Peng, X. L. Xue, S. Q. Wei
Summary: This study investigated the welfare and health of laying hens in a multitier system. The results showed that the spatial distribution of hens changed with increasing age, and lower-ranking hens preferred to stay in lower tiers to avoid competition but still had access to resources. This improved the welfare and health of the hens near the end of the laying cycle.
Article
Agriculture, Dairy & Animal Science
Wenwen Liang, Siqiong Jie, Yiqin Wang, Xiaowei Wen, Yanling Xiong, Xiaoxi Lin, Zhengrong Lv
Summary: This study examined the effect of risk perceptions on preventive behavior among vendors in the live poultry wholesale market and the live poultry retail market in Guangdong Province using the health belief model and structural equation modeling. The results showed that perceived severity and perceived benefits positively influenced vendors' self-efficacy in the wholesale market, while perceived barriers negatively affected self-efficacy in both the wholesale and retail markets. Moreover, cues to action mediated the relationship between perceived severity, perceived benefits, and self-efficacy, and also mediated the effect of perceived susceptibility among wholesale market vendors.
Article
Agriculture, Dairy & Animal Science
Shreeya Sharma, Raveendra R. Kulkarni, Shayan Sharif, Hosni Hassan, Mohammadali Alizadeh, Scott Pratt, Khaled Abdelaziz
Summary: The study investigates the impact of exposing chick embryos to antigens via in ovo delivery of poultry-specific lactobacilli on the expression of genes associated with early bursal development and maturation. Results indicate that the supplementation of poultry-specific lactobacilli to chick embryos can accelerate the development and immunological maturation of the bursa of Fabricius.