Article
Health Care Sciences & Services
Yazed AlRuthia, Fahad Alotaibi, Amr Jamal, Ibrahim Sales, Monira Alwhaibi, Nawaf Alqahtani, Sina M. AlNajrany, Khalid Almalki, Abdulaziz Alsaigh, Wael Mansy
Summary: This retrospective chart review study compared the cost effectiveness of ACEI/ARB versus amlodipine in managing essential hypertension, finding that although ACEI/ARB showed slightly more significant reductions in SBP and DBP, the corresponding cost was also higher, making it less cost-effective compared to amlodipine in primary care settings.
Article
Dentistry, Oral Surgery & Medicine
Gulbahar Ustaoglu, Emrah Erdal, Zeynep Karas
Summary: This study aimed to evaluate the occurrence rate of drug-induced gingival overgrowth in patients treated with ACE inhibitors, ARBs, and CCBs, with highest rate found in the amlodipine group. There was a significant relationship between drug dosage and DIGO, while no association was found with the duration of therapy.
Article
Peripheral Vascular Disease
Shin-Yi Lin, Hsin-Yi Huang, Liang-Ting Chiang, Ling-Ya Huang, Chi-Chuan Wang
Summary: This retrospective cohort study aimed to compare the incidence of breast cancer between women aged 55 and older using calcium channel blockers and those using angiotensin converting enzyme inhibitors/angiotensin II receptor blockers. The study found that the risk of breast cancer was similar in both groups.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Wei-Ting Chang, Sudeshna Fisch, Seema Dangwal, Michael Chen, Susan Cheng, Zhih-Cherng Chen, Ronglih Liao
Summary: Coronary flow velocity is decreased in pathologic cardiac hypertrophy, linked to angiotensin II. Angiotensin receptor blockers have been shown to improve CFV and cardiac function. This suggests a molecular and functional link between angiotensin-induced hemodynamic remodeling and coronary vasculature changes.
HYPERTENSION RESEARCH
(2021)
Article
Medicine, General & Internal
Eder H. Cativo, Persio D. Lopez, Diana P. Cativo, Steven A. Atlas, Clive Rosendorff
Summary: This study found that inhibitors of the renin-angiotensin system are more effective than calcium channel blockers in reducing albuminuria in patients with nephropathy due to hypertension and diabetes mellitus. However, there was no significant difference between the two drug classes in terms of markers of renal function.
AMERICAN JOURNAL OF MEDICINE
(2021)
Review
Peripheral Vascular Disease
Ji-Guang Wang, Biff F. Palmer, Katherine Vogel Anderson, Peter Sever
Summary: Hypertension is a major global health issue affecting billions of people. Amlodipine, a calcium channel blocker, has unique characteristics that make it an effective treatment option for hypertension. This review provides an updated overview of the evidence supporting the use of amlodipine and highlights its cardiovascular benefits.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Zhijie Liu, Ning Bian, Shaorong Wu, Yantao Cao, Yiting Su, Wenying Li, Hairui Li, Xianwu Lan, Can Jiang, Yiming Fan, Jun Guo, Dongdong Chen
Summary: This study aimed to investigate the effects of ACEI/ARB and CCB on the risk of NOAF for hypertensive patients with PPI. The results showed that ACEI/ARB were associated with a lower risk of NOAF compared to CCB, and they also had better improvement in left atrial remodelling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Medicine, General & Internal
Julie Rouette, Emily G. McDonald, Tibor Schuster, James M. Brophy, Laurent Azoulay
Summary: This study describes the prescribing trends of antihypertensive drugs in primary care patients and assesses the treatment trajectory of patients with hypertension according to changes in the UK hypertension management guidelines. The findings suggest that most patients are prescribed guideline-recommended first-line agents, but not all patients receive recommended drugs, particularly females, potentially leading to suboptimal cardiovascular outcomes.
Article
Peripheral Vascular Disease
Laura Semenzato, Jeremie Botton, Jerome Drouin, Berangere Baricault, Clementine Vabre, Francois Cuenot, Laetitia Penso, Philippe Herlemont, Emilie Sbidian, Alain Weill, Rosemary Dray-Spira, Mahmoud Zureik
Summary: Recent evidence suggests that hypertensive patients treated with ACE inhibitors or ARBs may have a lower risk of COVID-19 hospitalization and intubation/death compared to those treated with CCBs. This contradicts initial hypotheses regarding the association between renin-angiotensin-aldosterone system inhibitors and COVID-19 risk, raising new questions for further research.
Article
Medicine, General & Internal
Chan Joo Lee, Jung-Hoon Sung, Tae-Soo Kang, Sungha Park, Sang-Hak Lee, Jong-Youn Kim, Byeong-Kuek Kim
Summary: This study compared the effects of telmisartan and amlodipine on glucose metabolism in hypertensive atherosclerotic cardiovascular disease (ASCVD) patients with impaired fasting glucose (IFG) requiring high-intensity rosuvastatin therapy. The results showed that telmisartan did not decrease the insulin resistance, but preserved insulin secretion, leading to a regression from IFG to normal glucose levels and preventing the onset of new-onset diabetes mellitus.
Article
Cardiac & Cardiovascular Systems
Pavel Zhabyeyev, Chandu Sadasivan, Saumya Shah, Faqi Wang, Gavin. Y. Y. Oudit
Summary: This study investigated the rescue action of amlodipine in a murine model of iron overload cardiomyopathy (IOC) and compared it with human cardiac tissue changes due to IOC. The results showed that iron overload resulted in cardiac tissue changes similar to those in humans with IOC. Amlodipine reversed these changes, suggesting its effectiveness as an adjuvant therapy for IOC.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Pharmacology & Pharmacy
Rinada H. Hassan, Heba A. Gad, Sahar Badr El-Din, Dalia S. Shaker, Rania A. H. Ishak
Summary: In this study, chitosan nanoparticles loaded with olmesartan medoxomil were synthesized and delivered via the nasal route. The results showed that these nanoparticles had high bioavailability and low oral side effects, and they were able to efficiently permeate across the nasal mucosa.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Peripheral Vascular Disease
Brent M. Egan, Jianing Yang, Michael K. Rakotz, Susan E. Sutherland, Kenneth A. Jamerson, Jackson T. Wright, Keith C. Ferdinand, Gregory D. Wozniak
Summary: The study found that initial therapy with calcium channel blockers or thiazide-type diuretics had better antihypertensive effects in non-Hispanic Black adults than renin-angiotensin system blockers. Despite the recommendation to use this treatment approach, there is still a gap between the recommended and actual use. Evidence-based monotherapy appears insufficient to improve hypertension control in non-Hispanic Black adults.
