Article
Public, Environmental & Occupational Health
Valentine De Brochowski, G. James Rubin, Rebecca Katie Webster
Summary: Informing patients about side-effects can increase their likelihood of experiencing them (nocebo effect). It is unclear if this can be applied in clinical settings where new medication is prescribed. Additionally, the level of empathy in communicating about the nocebo effect may have an impact.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Article
Medicine, General & Internal
Juergen Barth, Stefanie Muff, Alexandra Kern, Anja Zieger, Stefanie Keiser, Marco Zoller, Thomas Rosemann, Benno Brinkhaus, Leonhard Held, Claudia M. Witt
Summary: A randomized clinical trial conducted in Switzerland among patients with chronic low back pain found that briefing on treatment outcomes and adverse side effects did not significantly affect patients' expectations and reported side effects after minimal acupuncture treatment. Further research is needed to understand the impact of information on adverse side effects.
Article
Psychiatry
Kelly S. Clemens, Kate Faasse, Winston Tan, Ben Colagiuri, Luana Colloca, Rebecca Webster, Lene Vase, Emily Jason, Andrew L. Geers
Summary: This study investigates the influence of social communication on vaccine side-effect experiences, particularly focusing on personal acquaintances and social media. The results show that both sources of social communication can predict pre-vaccination side-effect expectations and post-vaccination side-effect experiences. Moreover, pre-vaccination expectations mediate the relationships between social communication and experienced side-effects. This study provides evidence for the importance of modifying side-effect expectations through personal and online channels.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychiatry
Kate MacKrill, Rebecca Webster, G. James Rubin, Michael Witthoeft, Connor Silvester, Yasaman Emad, Keith J. Petrie
Summary: The Side Effect Attribution Scale (SEAS) has been developed to assess the degree to which individuals believe their symptoms are treatment side effects. The scale demonstrated good internal reliability across three studies and was found to be associated with a greater number of relevant psychological variables.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Rebecca K. Webster, G. James Rubin
Summary: Research on predictors of side-effect expectations found that younger, White individuals with lower optimism and increased anxiety were more likely to expect warned side-effects, while those with lower trust in medicine development were more likely to expect unwarned side-effects. Additionally, individuals with higher somatization, baseline symptoms, modern health worries, and lower trust in pharmaceutical companies were more likely to expect all side-effects. There is a need for further investigation in patient samples where the medication is known to them.
ANNALS OF BEHAVIORAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ingmar Schaefer, Jan Hendrik Oltrogge, Yvonne Nestoriuc, Claire V. Warren, Stefanie Brassen, Maximilian Blattner, Dagmar Luehmann, Alexandra Tinnermann, Martin Scherer, Christian Buechel
Summary: Concerns about adverse effects can affect the uptake of COVID-19 vaccination. Research suggests that positive and negative expectations prior to vaccination are associated with systemic adverse effects. Understanding these associations can improve clinician-patient interactions and public vaccine campaigns.
Article
Psychiatry
Louise E. Smith, Julius Sim, Richard Amlot, Megan Cutts, Hannah Dasch, Nick Sevdalis, G. James Rubin, Susan M. Sherman
Summary: This study investigated the percentage of UK adults who thought side effects from COVID-19 vaccination were likely, and found that side-effect expectations were associated with factors such as age, clinical vulnerability to COVID-19, fear of needles, perceived social norms and safety of vaccination, as well as lack of information.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Carina Schlintl, Anne Schienle
Summary: The study showed that written information can influence the occurrence of reported placebo/nocebo side effects. Additionally, information about the provider's optimistic personality was associated with a lower frequency of reported adverse side effects.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Clinical
Friederike L. Bender, Winfried Rief, Joscha Brueck, Marcel Wilhelm
Summary: This study aimed to develop a comprehensive communication strategy that reduces expectations of negative vaccine effects while respecting informed consent. The results showed that positive information framing has a small but significant impact on vaccination concerns, although vaccination attitudes should be considered.
Article
Public, Environmental & Occupational Health
Clara M. A. de Bruijn, Gabriella A. C. Hamming, Catherijne A. J. Knibbe, Ellen Tromp, Marc A. Benninga, Arine M. Vlieger
Summary: This study investigates teenagers' and parental attitudes towards information on medication side effects, finding that the majority of participants wish to receive extensive information on side effects, even after the explanation of the nocebo effect. Therefore, tailor-made communication strategies for providing medication information to parents and children are crucial.
PATIENT EDUCATION AND COUNSELING
(2023)
Article
Psychology, Multidisciplinary
Giacomo Rossettini, Andrea Colombi, Elisa Carlino, Mattia Manoni, Mattia Mirandola, Andrea Polli, Eleonora Maria Camerone, Marco Testa
Summary: This Perspective applies the validated ViolEx Model to the recovery and maintenance of musculoskeletal pain, exploring the reasons behind the persistence of dysfunctional expectations and the perspective of Bayesian Brain. The importance of tailoring clinical strategies based on the nature and precision of expectations is emphasized.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Stefanie H. Meeuwis, Henriet van Middendorp, Dieuwke S. Veldhuijzen, Andrea W. M. Evers
Summary: Placebo and nocebo effects are mediated by expectation in an open-label context, but not in a closed-label context. Ignorance of bodily signals may moderate the direct effects of nocebo suggestions, and behavioral activation system may modulate the effects of suggestions on itch through expectation. Other interindividual differences showed limited impact on placebo and nocebo responding in itch.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Massimiliano Ruscica, Nicola Ferri, Maciej Banach, Cesare R. Sirtori, Alberto Corsini
Summary: Treatment with statins has proven effective in preventing cardiovascular events, but discontinuation due to intolerance and non-adherence remains a major issue. Muscle side effects, such as myalgia, are the most commonly reported, but whether they are a result of the drug's effect is still debated.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
James P. Howard, Frances A. Wood, Judith A. Finegold, Alexandra N. Nowbar, David M. Thompson, Ahran D. Arnold, Christopher A. Rajkumar, Susan Connolly, Jaimini Cegla, Chris Stride, Peter Sever, Christine Norton, Simon A. M. Thom, Matthew J. Shun-Shin, Darrel P. Francis
Summary: The study found that the majority of symptoms caused by statin tablets were actually due to the placebo effect, suggesting that clinicians should be cautious when attributing symptoms to the medication. The research also indicated that there was no significant difference between abandoning statins and placebos, and the relief of symptoms after stopping medication was similar in both groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Psychiatry
Kate MacKrill
Summary: This study examined the impact of media coverage on side effects of the Pfizer COVID-19 vaccine in New Zealand. The results showed that the reporting rate of mentioned side effects significantly increased after media coverage, while control symptoms were not affected. The findings suggest that a media-induced nocebo response occurred, possibly due to increased expectations and awareness of vaccine side effects, as well as heightened symptom experience from anxiety.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychology, Clinical
Suzanne G. Helfer, Ben Colagiuri, Kate Faasse, Kelly S. Clemens, Fawn Caplandies, Andrew L. Geers
Summary: Attribute framing is a method that can be used ethically to reduce adverse nocebo effects, however, previous studies have shown inconsistent results. This study used a sham tDCS procedure to induce nocebo headaches and explored factors that may contribute to the efficacy of attribute framing. The results showed that attribute framing did not influence headache measures during the sham tDCS task, but did have a modest influence on post-task headache items. It is suggested that attribute framing may have a stronger influence on delayed nocebo effect measures or retrospective symptom reports.
JOURNAL OF BEHAVIORAL MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Andrew L. Geers, Kelly S. Clemens, Ben Colagiuri, Emily Jason, Luana Colloca, Rebecca Webster, Lene Vase, Mette Seig, Kate Faasse
Summary: The aim of this study was to examine whether side effects of the primary COVID-19 vaccine are associated with a decrease in intentions to receive a COVID-19 booster, as well as to identify psychological and demographic factors that predict booster intentions. The results showed that intentions for a booster vaccination were high and not correlated with the side effects of the primary vaccine. Positive vaccination attitudes, trust in vaccine development, worry about the COVID-19 pandemic, low concern over vaccine side effects, and affiliation with the democratic political party were predictors of booster intentions.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Psychiatry
Kate Faasse, Yvette Keevers, Annalise de Groot, Kate Nicholls, Suzanne G. Helfer, Andrew L. Geers
Summary: Lack of treatment choice can increase the occurrence of the nocebo effect, while limited choices may not result in significant effects. However, having more extensive choice options may lead to a similar magnitude of the nocebo effect as lack of choice.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychiatry
Kelly S. Clemens, Kate Faasse, Winston Tan, Ben Colagiuri, Luana Colloca, Rebecca Webster, Lene Vase, Emily Jason, Andrew L. Geers
Summary: This study investigates the influence of social communication on vaccine side-effect experiences, particularly focusing on personal acquaintances and social media. The results show that both sources of social communication can predict pre-vaccination side-effect expectations and post-vaccination side-effect experiences. Moreover, pre-vaccination expectations mediate the relationships between social communication and experienced side-effects. This study provides evidence for the importance of modifying side-effect expectations through personal and online channels.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Psychiatry
Veronica Quinn, Sarah Pearson, Anna Huynh, Kate Nicholls, Kirsten Barnes, Kate Faasse
Summary: This study aimed to investigate the impact of video-based social modelling on negative expectations and nocebo effects. It was found that female participants were more influenced in face-to-face contexts. The results showed that video modelling of side effects increased reporting of symptoms and negative expectations in female participants.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Natalie M. M. Reily, Rebecca T. T. Pinkus, Lenny R. R. Vartanian, Kate Faasse
Summary: In two daily diary studies, we found that exercise and contextual factors influence the healthiness and amount of food eaten after exercise. Contrary to expectations, post-exercise meals were found to be healthier than random meals from non-exercise days, and participants consumed fewer unhealthy meals on exercise days. Additionally, participants ate larger portions after exercise compared to random meals from non-exercise days.
Article
Immunology
K. Barnes, K. Faasse, B. Colagiuri
Summary: The study evaluated the effect of positively attribute-framed side effect information on COVID-19 booster vaccine intention. The results showed that positive framing increased vaccine intention and was not affected by pre-intervention level of intent and vaccine type.
Article
Surgery
Caroline Glicksman, Patricia McGuire, Marshall Kadin, Kirsten Barnes, Roger Wixtrom, Marisa Lawrence, Melinda Haws, Sarah Ferenz, C. James Sung, Robert G. Hamilton, Kate Faasse
Summary: This study aimed to determine if patients with Breast Implant Illness (BII) experienced symptom improvement after explantation, whether the improvement was related to the type of capsulectomy, and which symptoms improved. The results showed that 88% of patients had at least partial symptom improvement after 1 year, including improvement in anxiety, sleep disturbances, and fatigue.
AESTHETIC SURGERY JOURNAL
(2023)
Article
Psychology, Multidisciplinary
Winston Tan, Brydee Pickup, Kate Faasse, Ben Colagiuri, Kirsten Barnes
Summary: This study explores the possibility of symptom transmission through a three-generation social chain in an online setting, and the results demonstrate that symptoms can be readily transmitted online and are influenced by expectancy and anxiety. Social learning plays a significant role in symptom transmission, and observing others' experiences can provide individuals with insights into their own future experiences.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Psychology, Applied
Kirsten Barnes, Emily Babbage, Jessica Barker, Natasha Jain, Kate Faasse
Summary: Open label placebos (OLPs) have generally been found to be effective in clinical samples, but the evidence is mixed regarding their use in non-clinical and sub-clinical samples, as well as when administered without a convincing rationale. This study randomized healthy participants to receive OLP pills with information provision, OLP pills without information provision, or no-treatment control. Results showed that the OLP-plus group had increased well-being compared to the other groups, but only when they reported lower baseline well-being. Expectancies and adherence mediated the effect of OLP on physical symptoms, but only when baseline well-being was below average.
APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
(2023)
Article
Medicine, General & Internal
Jessica M. Barker, Kate Faasse
Summary: Information about medication side effects can influence patients' willingness to take the medication and their memory of the side effects. Informing patients of some, but not several, side effects can optimize medication adherence and accuracy of informed consent.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Psychology, Mathematical
Kristy A. A. Martire, Samuel G. G. Robson, Manisara Drew, Kate Nicholls, Kate Faasse
Summary: Why do people believe implausible claims? A study was conducted to test whether this is due to an unwillingness to effortfully process information. Results show that endorsers of implausible claims performed worse on a cognitive test, took longer to answer, but did not make more intuitive mistakes than non-endorsers. Poor performance on the test does not necessarily indicate a more intuitive cognitive style.
PSYCHONOMIC BULLETIN & REVIEW
(2023)
Article
Psychology, Applied
Kirsten Barnes, Rachelle Wang, Kate Faasse
Summary: This study found that interactions with higher warmth can lead to increased psychological well-being, while interactions with lower warmth can lead to increased side effect reporting. Positive and negative expectations, as well as treatment-related worry, did not vary by interaction style, but individual psychological well-being and side effect reporting were inversely associated.
APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
(2023)
Article
Psychology, Clinical
Kirsten Barnes, Kate Nicholls, Sascha Orlievsky, Christopher Pei, Christopher Elder, Kate Faasse
Summary: The provision of online side effect information can remotely induce the nocebo effect. Negative expectations mediate the nocebo effect, while positive affect does not attenuate it.
Article
Psychology, Applied
Clancy K. Black, Lenny R. Vartanian, Kate Faasse
Summary: This research found that people's perceptions of the harmfulness of excess weight are influenced by its cause. When excess weight was caused by an unhealthy lifestyle, it was perceived as more harmful and individuals were recommended to engage in healthier behaviors. However, obesity itself was viewed as harmful regardless of its cause, and individuals were recommended to go on a diet.
APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
(2023)
