期刊
MEDCHEMCOMM
卷 6, 期 4, 页码 536-546出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4md00417e
关键词
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资金
- Fundacao para a Ciencia e Tecnologia [Pest-OE/SAL/UI4013/2014, SFRH/BPD/64265/2009]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/64265/2009] Funding Source: FCT
Biomarker discovery and validation techniques have been extensively developed together with the omics era. Nevertheless, there is still a reduced number of biomarker candidates that surpass clinical trials every year. One of the drawbacks of biomarker discovery deals with the quantification of disease-related entities and its correlation with disease predisposition, disease stages or treatment response. Thus, activity-based profiling emerges as an exceptional tool for biomarker discovery and validation and this review highlights advances in this field.
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