Structure-based design, synthesis by click chemistry and in vivo activity of highly selective A3 adenosine receptor agonists

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

(2014) Joshua W. Little et al.   BRAIN

In Vivo Phenotypic Screening for Treating Chronic Neuropathic Pain: Modification of C2-Arylethynyl Group of Conformationally Constrained A3 Adenosine Receptor Agonists

(2014) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Probing of Off-Target G Protein-Coupled Receptor Activities within a Series of Adenosine/Adenine Congeners

(2014) Silvia Paoletta et al.   PLoS One

Rational Design of Sulfonated A3 Adenosine Receptor-Selective Nucleosides as Pharmacological Tools To Study Chronic Neuropathic Pain

(2013) Silvia Paoletta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Controlling murine and rat chronic pain through A3 adenosine receptor activation

(2012) Zhoumou Chen et al.   FASEB JOURNAL

Structure-Guided Design of A3 Adenosine Receptor-Selective Nucleosides: Combination of 2-Arylethynyl and Bicyclo[3.1.0]hexane Substitutions

(2012) Dilip K. Tosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Methanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: synthetic approaches

(2012) Dilip K. Tosh et al.   MedChemComm

Managing the Liabilities Arising from Structural Alerts: A Safe Philosophy for Medicinal Chemists

(2011) P. J. Edwards et al.   CURRENT MEDICINAL CHEMISTRY

The Importance of Alkynyl Chain Presence for the Activity of Adenine Nucleosides/Nucleotides on Purinergic Receptors

(2011) D. Dal Ben et al.   CURRENT MEDICINAL CHEMISTRY

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

2-Dialkynyl derivatives of (N)-methanocarba nucleosides: ‘Clickable’ A3 adenosine receptor-selective agonists

(2009) Dilip K. Tosh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design of (N)-methanocarba adenosine 5′-uronamides as species-independent A3 receptor-selective agonists

(2008) Artem Melman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Ethyl (1S,2R,3S,4S,5S)-2,3-O-(Isopropylidene)-4-Hydroxy-Bicyclo[3.1.0]Hexane-Carboxylate from L-Ribose: A Versatile Chiral Synthon for Preparation of Adenosine and P2 Receptor Ligands

(2008) Bhalchandra V. Joshi et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS