Article
Biotechnology & Applied Microbiology
Jianhua Yang, Xiaoguang Jing, Zimin Wang, Xuejian Liu, Xiaofeng Zhu, Tao Lei, Xu Li, Weimin Guo, Haijun Rao, Mingxue Chen, Kai Luan, Xiang Sui, Yen Wei, Shuyun Liu, Quanyi Guo
Summary: The study comprehensively analyzed the physical properties and cytocompatibility of hydrogels as cell carriers for ADSC transplantation. Rat models of articular cartilage defect were treated with GCS/DF-PEG hydrogel, showing potential for repairing injured cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Saiedeh Salehi, Hamed Ghomi, S. A. Hassanzadeh-Tabrizi, Narjes Koupaei, Mohammad Khodaei
Summary: This study investigated the use of a porous degradable scaffold made from PLA/PEG using the 3D printing method for bone defect repair. The results showed that adding PEG to the PLA scaffolds improved the surface wettability and did not significantly affect the mechanical properties. The addition of PEG also increased the degradation rate of the scaffolds and enhanced cell viability, adhesion, and osteogenic differentiation. Overall, the PLA/PEG scaffold printed by the FDM method is a suitable candidate for bone repair applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Milena S. Malherbi, Luciano C. Dias, Mariana S. Z. Lima, Larissa G. Ribeiro, Valdirlei F. Freitas, Taiana G. M. Bonadio, Ludmilla M. Silva, Gilvan B. Souza, Eduardo A. Volnistem, Jaciele M. Rosso, Daniel M. Silva, Luiz F. Cotica, Wilson R. Weinand, Ivair A. Santos
Summary: This study synthesized hydroxyapatite/beta-tricalcium phosphate/polyvinylidene fluoride biocomposites and used electrical stimuli to improve and accelerate bone regeneration in vitro. The results showed that the growth rate of hydroxyapatite in the biocomposite significantly increased under specific electric field conditions.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Engineering, Biomedical
M. Khandaker, H. Kotturi, H. Progri, S. Tummala, S. Nikfarjam, P. Rao, A. Hosna, D. T. Arasu, W. Williams, A. M. Haleem
Summary: Polyethylene glycol diacrylate (PEGDA) and polycaprolactone (PCL)-coated PEGDA scaffolds were compared for multi-tissue repair applications. PCL-PEGDA showed better mechanical properties and cytocompatibility, making it more suitable for in vivo studies.
BIOMEDICAL MATERIALS
(2021)
Article
Plant Sciences
Vanja Vuksanovic, Branislav Kovacevic, Marko Kebert, Lazar Pavlovic, Lazar Kesic, Jelena Cukanovic, Sasa Orlovic
Summary: This study aimed to evaluate the tolerance of five white poplar clones to the presence of polyethylene glycol (PEG 6000) and found that high concentrations of PEG 6000 resulted in decreased morphological and photosynthetic pigment values, while total phenolic content, proline and glycine betaine levels, and antioxidant activity increased. Clone L-80 showed better performance in most tested parameters.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Polymer Science
Elham Hamedi, Negin Vahedi, Faraz Sigaroodi, Azim Parandakh, Simzar Hosseinzadeh, Faezeh Zeinali, Mohammad-Mehdi Khani
Summary: Three-dimensional bioprinting is a promising method for tissue engineering. Poly(ethylene glycol) (PEGDA) is a potential bioink due to its biocompatibility and adjustability. This review introduces PEGDA-based bioinks and their applications in soft and hard tissue engineering.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Horticulture
Alexandra Hanasz, Judit Dobranszki, Nora Mendler-Drienyovszki, Laszlo Zsombik, Katalin Magyar-Tabori
Summary: In vitro experiments were conducted to study the responses of potato genotypes to osmotic stress. Different osmotic agents were added to the medium to compare the stress index of different genotypes. The study identified several promising breeding lines and determined suitable treatment conditions for selecting osmotic stress-tolerant genotypes.
Article
Materials Science, Biomaterials
Ting Dai, Jiayi Ma, Su Ni, Chun Liu, Yan Wang, Siyu Wu, Jun Liu, Yiping Weng, Dong Zhou, Ana Jimenez-Franco, Hongbin Zhao, Xiubo Zhao
Summary: Electrospun PCL scaffolds, widely used in tissue engineering, have the potential to mimic the natural extracellular matrix structure. However, their small pore size and low bioactivity hinder cell migration and tissue formation. In this study, different materials were used to fabricate porous scaffolds, and the removal of water-soluble fibers increased the porosity. Biocompatibility and osteogenesis were evaluated, and the results showed that washed PCL/PEG/ATP scaffolds promoted better cell infiltration and differentiation into osteoblasts compared to PCL scaffolds. In vivo studies also demonstrated enhanced bone regeneration in rat cranium defects using ATP-doped electrospun PCL scaffolds.
BIOMATERIALS ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Gyoezoe Lehoczky, Raluca Elena Trofin, Queralt Vallmajo-Martin, Shikha Chawla, Karoliina Pelttari, Marcus Mumme, Martin Haug, Christian Egloff, Marcel Jakob, Martin Ehrbar, Ivan Martin, Andrea Barbero
Summary: This study aimed to determine the feasibility of using nasal chondrocytes (NCs) for cartilage regeneration under minimally invasive settings. NCs were found to have a higher and more reproducible chondrogenic capacity than articular chondrocytes. The study also demonstrated the potential of using a novel strategy for cartilage repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Kenichi Nagase, Ruka Shimane
Summary: This study developed cell separation materials using ethylene glycol-based thermoresponsive block copolymer brushes and cell-affinity peptides, which can separate cells through temperature changes. These materials have the potential to play an important role in tissue engineering applications.
MATERIALS & DESIGN
(2023)
Article
Engineering, Biomedical
Nashaita Y. Patrawalla, Nilabh S. Kajave, Vipuil Kishore
Summary: Biomimetic scaffolds composed of bioactive ceramic-based materials incorporated within a polymeric framework have shown great potential for use in bone tissue engineering applications. This study compared the efficacy of three different bioceramics (Bioglass 45S5, Laponite XLG, and beta-Tricalcium Phosphate) on bone bioactivity and osteogenic differentiation and found that beta-Tricalcium Phosphate exhibited superior osteogenic potential, making it a preferred choice for the design of cell-laden hydrogels in biomimetic bone tissue engineering.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Biochemistry & Molecular Biology
Tatsuhide Hayashi, Masaki Asakura, Mayu Kawase, Masakazu Matsubara, Yasuaki Uematsu, Akimichi Mieki, Tatsushi Kawai
Summary: This study demonstrates the induction of bone-like tissue from immature muscular tissue using recombinant human bone morphogenetic proteins in vitro. The induced tissue showed ossification potential and promoted healing of calvarial defects in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Junyao Cheng, Jianheng Liu, Bing Wu, Zhongyang Liu, Ming Li, Xing Wang, Peifu Tang, Zheng Wang
Summary: The article provides an overview of the promising properties of graphene and its derivatives in bone tissue engineering. Analyses of graphene-based materials in bone regenerative medicine are discussed based on bone regeneration processes, highlighting their applications as scaffolds, membranes, and coatings. The advantages, challenges, and future prospects of using these materials in bone regenerative medicine are also addressed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Amir Kahaie Khosrowshahi, Ali Baradar Khoshfetrat, Younes Beygi Khosrowshahi, Hossein Maleki-Ghaleh
Summary: The study found that a cobalt content of 1.25% in the Co-HA scaffold resulted in optimal osteogenic activity, while higher concentrations may lead to cytotoxic effects. Additionally, apatite growth was observed in the LCo-HA scaffold, and alkaline phosphatase activity and calcium deposition of osteoblastic cells cultured on the LCo-HA scaffold were in line with characterization and cytotoxicity results compared to the HA scaffold and control sample.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biophysics
Susmita Bose, Naboneeta Sarkar, Ujjayan Majumdar
Summary: This study presents a localized drug delivery system based on natural medicine and 3D printed scaffolds. The functionalized scaffold improves osteoblast proliferation and differentiation, promotes endothelial cellular network formation, and exhibits significant antibacterial activity against Staphylococcus aureus. This research provides a new approach for bone defect repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Shakir, Reshma Jolly, Mohd Shoeb Khan, Noor E. Iram, Hans M. Khan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2015)
Article
Biochemistry & Molecular Biology
Noor e Iram, Mohd Shoeb Khan, Reshma Jolly, Mohammad Arshad, Mahboob Alam, Parvez Alam, Rizwan Hasan Khan, Farha Firdaus
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Mohammad Shakir, Reshma Jolly, Mohd Shoeb Khan, Ahmar Rauf, Shadab Kazmi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2016)
Article
Chemistry, Multidisciplinary
Mohammad Shakir, Sumbul Mirza, Reshma Jolly, Ahmar Rauf, Mohammad Owais
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Iram Zia, Sumbul Mirza, Reshma Jolly, Abdur Rehman, Rizwan Ullah, Mohammad Shakir
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Materials Science, Biomaterials
Reshma Jolly, Aijaz Ahmed Khan, Syed Sayeed Ahmed, Sharique Alam, Shadab Kazmi, Mohammad Owais, Mohd Ahmadullah Farooqi, Mohammad Shakir
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Sumbul Mirza, Reshma Jolly, Iram Zia, Mohd Saad Umar, Mohammad Owais, Mohammad Shakir
Article
Chemistry, Multidisciplinary
Sumbul Mirza, Reshma Jolly, Iram Zia, Mohd S. Umar, Mohammad Owais, Mohammad Shakir
Summary: In this study, nano-hydroxyapatite (nHA) reinforced guava seed (GS) - aloe vera (AV) gel nanocomposites were synthesized for bone implants with excellent mechanical properties and osteogenic property. The nanocomposites showed high cellular viability, increased osteogenic activity, antibacterial activity, low haemolysis, and high protein adsorption, indicating their potential in dental and orthopaedic applications.
Review
Polymer Science
Ruheen Khan, Reshma Jolly, Tooba Fatima, Mohammad Shakir
Summary: Cellulose is a versatile compound with many advantages, and its extraction from plants and agricultural waste is the focus of this review.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Polymer Science
Tooba Fatima, Reshma Jolly, Fariha Mushahid, Nazoora Khan, Mohd Saad Umar, Mohammad Owais, Mohammad Shakir
Summary: In this study, ternary nanocomposites consisting of nanohydroxyapatite/kappa-carrageenan/silica doped polyvinyl alcohol in different ratios were fabricated for bone tissue engineering. The samples were characterized by various physico-chemical techniques and the results showed that HCP3 nanocomposite exhibited higher thermal stability, smaller crystallite size, and excellent properties in terms of cell viability, swelling ability, biodegradability, and antibacterial activity.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Reshma Jolly, Mohammad Furkan, Aijaz Ahmed Khan, Syed Sayeed Ahmed, Sharique Alam, Mohd Ahmadullah Farooqi, Rizwan Hasan Khan, Mohammad Shakir
Summary: Heterojunctions containing nano-hydroxyapatite/carboxymethyl chitosan/beta-cyclodextrin fused with date seed extract (DSE) were synthesized to generate BCHD1, BCHD2 and BCHD3 nanocomposite scaffolds with tunable size and amendable surface properties. BCHD3 exhibited optimal compressive modulus, mineralization ability, protein adsorption, alkaline phosphatase performance, and bone regeneration potential compared to CH nanocomposite scaffolds. In vivo studies demonstrated better bone regeneration in critical size calvarial defects treated with BCHD3, indicating its potential application in osteogenic tissue engineering.
MATERIALS ADVANCES
(2021)
Article
Nanoscience & Nanotechnology
Iram Zia, Reshma Jolly, Sumbul Mirza, Mohd Saad Umar, Mohammad Owais, Mohammad Shakir
ACS APPLIED BIO MATERIALS
(2020)
Article
Polymer Science
Zhongming Yuan, Hiroko Yamamoto, Shinji Kanehashi, Takeshi Shimomura
Summary: This study reports the synthesis of a flexible light-emitting polymer film using a solution blending method. The selective positioning of MEH-PPV molecules in the PS phase of the film was confirmed. The film exhibited a nanometer-scale luminescent domain with low aggregation quenching and showed good elastomeric characteristics.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2024)