期刊
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
卷 50, 期 13, 页码 1357-1361出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03602559.2011.584238
关键词
Burst release; Colon targeted; Drug delivery; Hydrogel; SGF; Surface cross-linking
A series of surface cross-linked PVA hydrogels (previously bulk cross-linked with maleic anhydride) were prepared for different cross-linker (glutaraldehyde) concentration. FTIR-ATR study revealed the cross-linking reaction. Surface cross-linking results in contraction of pores and increase in hydrophobicity, pore tortuosity around the surface of the membrane. As a result swelling, drug release decreases with increasing glutaraldehyde concentration. After surface cross-linking swelling of the hydrogels in simulated gastric fluid (SGF) further decreased to attain half of the value as observed for only bulk cross-linked membranes. Surface cross-linking has improved the colon-targeted release characteristics of the drugs from the PVA hydrogels.
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