期刊
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
卷 49, 期 3, 页码 309-315出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03602550903284255
关键词
Composite; PLGA; Preparation; Property
资金
- National Natural Science Foundation of China [50774096, 50604017]
- Central South University, P.R. China [1343-74334000011]
Poly(lactide-co-glycolide)/bone meals composites using poly (lactide-co-glycolide) (PLGA) and bone meals (BM) as the starting materials were successfully prepared via solution dispersion method. Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction and BET were used to characterize the resulting PLGA and bone meals. The mechanical properties of composites were carried out by the three-point-bending test, and the micrographs of cross-section of composites were observed using SEM. The results indicate that both the bending strength and modulus of PLGA/BM composites increased with bone meals increasing up to 10 wt%, then decreased with bone meals content, indicating that the fracture feature of PLGA/BM composites changed from typical brittle to ductile fracture when the bone meals content changed from 0 to 10 wt% and from ductile to brittle facture while bone meals content ranging from 10 to 20 wt%. It was further confirmed by SEM images of composites. The biocompatibility results show that resulted PLGA/BM composites are favorable biomaterials for cell adhesion, differentiation and proliferation. PLGA/BM composite has shown great potential for biomedical applications as biodegradable polymers.
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