Article
Biochemistry & Molecular Biology
Wojciech Fabianowski, Miroslaw Maziejuk, Monika Szyposzynska, Monika Wisnik-Sawka
Summary: The article presents a technique of differential ion mobility spectrometry (DMS) for the detection and identification of volatile organic compounds (VOCs) from various categories. It analyzes the possibility of mixture identification using only the DMS spectrometer and provides several examples. The article also discusses the analysis of different compounds, their mechanisms of fragmentation, influence on effective ion temperature, and high electric field intensity.
Article
Chemistry, Multidisciplinary
Elina Kalenius, Sami Malola, Maria Francisca Matus, Rania Kazan, Thomas Burgi, Hannu Hakkinen
Summary: High-resolution electrospray ionization ion mobility mass spectrometry has identified a gas-phase isomer of the well-studied Au-25(SR)(18) cluster, with relative abundance controlled by in-source activation. The measured properties of the new isomer match theoretical predictions closely, suggesting that structural dynamics play a role in gas-phase reactions of thiolate-protected gold clusters and that isomerization may be manipulated by external stimuli.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Yubin Su, Yao Lin, Tian Ren, Yuanyuan Li, Yurong Deng, Chengbin Zheng
Summary: A simple and environmentally friendly method called solid phase photothermo-induced chemical vapor generation (SP-PT-CVG) is used for the sensitive detection of mercury in water by direct immersion solid phase microextraction (DI-SPME) atomic fluorescence spectrometry (AFS). It combines the advantages of DI-SPME and SP-PT-CVG, eliminating the need for tedious derivatization steps and reducing toxic reagent consumption, while improving extraction throughput and analytical performance. The proposed method provides a low limit of detection for mercury determination and has been evaluated using certified reference materials and river water samples with good spike recoveries.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Christian Ieritano, J. C. Yves Le Blanc, Bradley B. Schneider, Justine R. Bissonnette, Alexander Haack, W. Scott Hopkins
Summary: A workflow was developed to analyze Verapamil and its metabolites, and it was observed that the ionogram of protonated Verapamil had two peaks while the metabolites had only one peak. This was attributed to the protonation at the tertiary amino moiety of Verapamil, which generated a chiral quaternary amine.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemical Research Methods
Dallas P. Freitas, Xi Chen, Erin A. Hirtzel, Madison E. Edwards, Joohan Kim, Hongying Wang, Yuxiang Sun, Klaudia I. Kocurek, David Russell, Xin Yan
Summary: In this study, we developed an in situ droplet-based derivatization method for rapid analysis of tissue lipids at multiple isomer levels. The method involves on-tissue derivatization using the TriVersa NanoMate LESA pipette, followed by extraction and analysis of the derivatized lipids using chip-based LESA mass spectrometry (MS) and tandem MS. This approach enables characterization of lipid isomers at the carbon-carbon double-bond positional and sn-positional levels, as well as relative quantitation based on diagnostic ion intensities. The method allows for multiple derivatizations at different spots in the same functional region of an organ, facilitating orthogonal lipid isomer analysis using a single tissue slide. Lipid isomers in different regions of the mouse brain were profiled, demonstrating the potential of this droplet-based derivatization method in tissue lipid studies requiring fast sample-to-result turnovers.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Xinxin Wang, Ganggang Chang, Chenxi Liu, Ruidong Li, Yucheng Jin, Xu Ding, Xiaolin Liu, Hailong Wang, Tianyu Wang, Jianzhuang Jiang
Summary: Chemical conversion between metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) has been achieved by reacting Ni-3(HITP)(2) with 1,1,3,3-tetramethoxypropane. The resulting P-Ni-3(TAA)(3) exhibits improved chemical stability and enhanced catalytic properties.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Analytical
Dongjie Zhao, Xianqiang Li, Siqing You, Xi Yang, Jun Liu
Summary: A low-cost differential mobility spectrometer was constructed using polytetrafluoroethylene printed circuit boards with gold electrodes, allowing for the detection and distinction of five chemical warfare agents. The sensor exhibited rapid recovery and response times, with detection limits less than 1 ng/L.
INSTRUMENTATION SCIENCE & TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Raquel Gonzalez de Vega, Alex Cameron, David Clases, Tyren M. Dodgen, Philip A. Doble, David P. Bishop
Summary: PFAS, a large group of synthetic organic compounds widely used in consumer and industrial products, have become widespread in the environment. Global regulations requiring monitoring of PFAS have been implemented due to their potential health and eco-toxicological effects. Targeted methods monitor a small fraction of PFAS compounds, while there is growing interest in complementary non-targeted methods to screen and identify unknown PFAS compounds.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Engineering, Environmental
Hongxin Mu, Jiawei Wang, Ling Chen, Haidong Hu, Jinfeng Wang, Cheng Gu, Hongqiang Ren, Bing Wu
Summary: This study identified and characterized 38 branched isomers of 14 typical PFASs in wastewater samples from 148 municipal WWTPs in China. Linear PFASs had higher detection rates than branched isomers, and the proportion of branched isomers increased in the effluents compared to the influents. Conventional biological treatment processes had poor removal efficiency for both linear PFASs and branched isomers. The isomer composition in the WWTPs showed differences among regions, with the usage of short-chain PFASs being a key factor.
Article
Chemistry, Analytical
A. Bianco, I Neefjes, D. Alfaouri, H. Vehkamaki, T. Kurten, L. Ahonen, M. Passananti, J. Kangasluoma
Summary: Mass spectrometry is an effective method for identifying and quantifying environmentally relevant molecules, but it cannot distinguish between isomers. This study combines an experimental set-up using a differential mobility analyser with computational ion mobility calculations to successfully identify isomers. The experimental set-up allows for analysis in both the gas and liquid phase, making it a versatile tool for isomer separation.
Article
Chemistry, Analytical
Xi Chen, Shuli Tang, Dallas Freitas, Erin Hirtzel, Heyong Cheng, Xin Yan
Summary: This study presents a novel method for the characterization of phosphatidylcholine isomers using Mn(II)-catalyzed epoxidation. The method allows for the simultaneous identification of carbon-carbon double bond and stereonumbering positional isomers. The bifunctional derivatization takes place in seconds and produces clear and interpretable diagnostic ions.
Article
Chemistry, Analytical
Jun Young Park, Sarmila Amatya Shrestha, Sangwon Cha
Summary: The study investigated the feasibility of using reversed-phase liquid chromatography to separate ganglioside isomers, successfully achieving the isomer separation of disialogangliosides and trisialogangliosides for the first time. Crucial factors in the mobile-phase composition, such as the organic modifier acetonitrile and the ammonium salt additive ammonium bicarbonate, were identified to influence the differential retention and mass spectral response of the isomers.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Biochemical Research Methods
Tyler S. Larson, Thomas J. Diprospero, Gary L. Glish, Matthew R. Lockett
Summary: In this study, a novel method was used to investigate the lipid profile changes in oxaliplatin-sensitive and resistant cells, revealing significant increases in triglycerides and cholesterol esters caused by oxaliplatin, which were correlated with lipid droplet formation.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Takeshi Furuhashi, Wolfram Weckwerth
Summary: Isomeric compounds play important roles in the human body and drugs with different physiological functions, making their measurement crucial in clinical science. However, measuring isomers is often challenging despite chromatographic separation. Affinity-based sample preparation, such as Immunoprecipitation (IP) and molecularly imprinted polymers (MIP), and the coupling with mass spectrometry have become increasingly important. Additionally, alternative methods including changes in ionization and dissociation energy, ion molecule reactions, and ion mobility mass spectrometry (IMS) have been developed due to the insufficient mass accuracy and resolution to distinguish isomeric compounds. This review discusses recent advancements (mostly 2017-) in mass spectrometry-based isomer analysis methods, highlighting the significance of recent technical advances in IMS, particularly for large molecule isomer analyses.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Daisy Unsihuay, Ruichuan Yin, Daniela Mesa Sanchez, Manxi Yang, Yingju Li, Xiaofei Sun, Sudhansu K. Dey, Julia Laskin
Summary: The study introduces a novel experimental platform that combines nano-DESI and IM spectrometry for high spatial resolution imaging of molecules in mouse uterine tissues, providing unique molecular descriptors and revealing variations in isomeric composition through isomer-specific imaging.
ANALYTICA CHIMICA ACTA
(2021)
