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Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

期刊

FRONTIERS IN CELLULAR NEUROSCIENCE

卷 9, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA

DOI: 10.3389/fncel.2015.00025

关键词

Dopamine; NMDA receptor; AMPA receptors; Addiction; Parkinson disease; Huntington disease

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Neurosciences

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Reagent

摘要

Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms underlying the modulation of the glutamatergic transmission by DA in stnatal circuits.

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