期刊
POLYMER INTERNATIONAL
卷 64, 期 2, 页码 293-302出版社
WILEY-BLACKWELL
DOI: 10.1002/pi.4789
关键词
chitosan; silsesquioxane; hybrid membranes; drug delivery; nanocomposites; antibacterial
资金
- National Research Foundation of Korea (NRF) through the Ministry of Science, ICT & Future Planning, Korea (NRF-Russia Foundation for Basic Research (RFBR) Joint Research Program [2013K2A1A7076267]
- Pioneer Research Center Program [2010-0019308/2010-0019482]
- Brain Korea 21 Plus Program [21A2013800002]
We fabricated hybrid (CSSQ) membranes from chitosan and poly(aminopropyl/phenylsilsesquioxane) (PAPSQ) blends via a sol-gel reaction and solution casting followed by crosslinking with glutaraldehyde. The CSSQ membranes were then used for loading of 5-fluorouracil (5-FU) as an anticancer drug as well as templates for the production of silver nanoparticles (AgNPs). The physicochemical properties of the CSSQ membranes were examined using UV-visible spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis and scanning electron microscopy (SEM). SEM results showed the controllable formation of AgNPs around PAPSQ. CSSQ-Ag nanocomposite membranes exhibited good antibacterial activity towards both Escherichia coli and Bacillus subtilis, while the CSSQ membranes worked as good carriers for controlled release of 5-FU as model drug. The results suggest that both CSSQ and CSSQ-Ag nanocomposite membranes can be potentially applied for biomedical applications such as controlled release carriers as well as antibacterial wound dressing materials. (c) 2014 Society of Chemical Industry
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