Article
Neurosciences
Bettina C. Schwab, Peter Koenig, Andreas K. Engel
Summary: This computational study demonstrated that spike-timing-dependent plasticity can explain the connectivity aftereffects of dual-site tACS, but not all combinations of tACS frequency and application sites are expected to effectively modulate connectivity via STDP. It is suggested to use appropriate computational models and/or EEG analysis for planning and interpreting dual-site tACS studies relying on aftereffects.
Article
Neurosciences
Asher Geffen, Nicholas Bland, Martin V. Sale
Summary: The study investigated the effects of slow oscillatory (SO) tACS on motor cortical excitability and found that tACS had a facilitatory effect on motor cortical excitability that outlasted stimulation. However, there was no evidence supporting entrainment of endogenous oscillations as the underlying mechanism.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Review
Neurosciences
Yuchen He, Shuang Liu, Long Chen, Yufeng Ke, Dong Ming
Summary: Neuronal oscillations are crucial for temporal coordination and brain functions, and transcranial alternating current stimulation (tACS) has shown potential in enhancing cognition. However, the variability and translatability of tACS results are challenging, and a thorough understanding of its mechanisms is essential. Animal models provide insights into tACS mechanisms, parameter optimization, and rational design, aiming to improve validity and reproducibility. This review discusses recent electrophysiological advances in tACS using animal models, addressing important issues for result coordination and translation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Ivan Pozdniakov, Alicia Nunez Vorobiova, Giulia Galli, Simone Rossi, Matteo Feurra
Summary: The study investigated the online and offline effects of transcranial alternating current stimulation (tACS) on cortical excitability, finding that tACS may only affect cortical excitability during online application. This contributes to the development of effective stimulation protocols for clinical populations.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Miroslaw Wyczesany, Agnieszka K. K. Adamczyk, Justyna Hobot, Giansalvo Barbalinardo, Przemyslaw Adamczyk, Adam Labaza, Tomasz S. S. Ligeza
Summary: This study confirmed the causal role of the bilateral DLPFC in emotional regulation, showing that inhibitory stimulation of the right DLPFC compromised reappraisal efficacy, affecting attentional deployment and elaboration of affective stimuli.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Maximilian J. Wessel, Laurijn R. Draaisma, Friedhelm C. Hummel
Summary: This narrative review summarizes current studies employing the cerebellar transcranial alternating current stimulation technique (CB-tACS) and discusses open research questions. CB-tACS may contribute to the understanding of cerebellar oscillatory signatures and their role in motor, cognitive, or affective functions. In the long term, CB-tACS could develop into a therapeutic tool for retuning disturbed oscillatory activity in cerebellar networks underlying brain disorders.
Review
Neurosciences
Naoyuki Takeuchi, Shin-Ichi Izumi
Summary: The focus of this review is on the use of tACS to enhance motor learning, targeting motor deficits in patients with stroke or Parkinson's disease. tACS can correct abnormal oscillatory brain activity and promote appropriate oscillatory communication, potentially leading to pro-social effects and enhancing the teaching-learning process during rehabilitation sessions with therapists. Re-establishing oscillatory brain communication through tACS could be effective for motor recovery and pave the way for new neurorehabilitation approaches based on motor learning.
Article
Medicine, General & Internal
Seong Hoon Bae, Seo Jin Moon, Jeong Gum Lee, Yun Kyung Yim, Hee So Oh, Dong Hee Han, In Seok Moon
Summary: The study compared the effects of rTMS and tDCS treatments for chronic tinnitus, showing comparable results in reducing tinnitus symptoms, with tDCS possibly being more cost-effective.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Iris Steinmann, Kathleen A. Williams, Melanie Wilke, Andrea Antal
Summary: This study investigates the influence of subject-specific factors on the effects of tACS on alpha amplitude and DMN functional connectivity. The results suggest that individual EFIELD strength is the most significant factor explaining the modulation of alpha amplitude during tACS.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Neurosciences
Naoyuki Takeuchi
Summary: Developing effective tools and strategies to relieve chronic pain is a high-priority scientific and clinical goal. Non-invasive brain stimulation techniques, such as transcranial alternating current stimulation (tACS), have been explored as potential methods to control pain by manipulating oscillatory brain activity. Several studies have shown that tACS can reduce pain by normalizing abnormal brain activity in patients with chronic pain. Further research should aim to identify pathological oscillatory brain communication in chronic pain as a therapeutic target for tACS. Overall, tACS shows promise for restoring brain activity and facilitating social interaction, potentially leading to novel approaches for pain control.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Jessica Moretti, Welber Marinovic, Alan R. Harvey, Jennifer Rodger, Troy A. W. Visser
Summary: This study investigates the effects of non-invasive brain stimulation techniques on attention. The results indicate that both repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS) do not modulate performance in tasks assessing visuospatial or temporal attention.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychiatry
Jonas Rauh, Anne S. M. Mueller, Guido Nolte, Moritz Haaf, Marius Mussmann, Saskia Steinmann, Christoph Mulert, Gregor Leicht
Summary: This study investigated the effects of non-invasive brain stimulation on working memory performance. The results show that under specific conditions, using transcranial alternating current stimulation at a frequency of 5 Hz on the left dorsolateral prefrontal cortex can significantly improve working memory performance.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Harry Tran, Sina Shirinpour, Alexander Opitz
Summary: Neural oscillations play a key role in information transfer in the brain, with transcranial alternating current stimulation (tACS) directly interacting with brain oscillatory activity. While tACS does not affect the firing rate of neurons in human studies, it can entrain the spiking activity of specific neuron types at lower field strengths. Understanding the impact of oscillating electric fields on single neuron activity highlights the importance of neuron morphology and biophysics in responsiveness to electrical stimulation.
Article
Clinical Neurology
Forouzan Farahani, Greg Kronberg, Mohamad FallahRad, Hysell V. Oviedo, Lucas C. Parra
Summary: This study found that transcranial direct current stimulation (DCS) enhances synaptic plasticity by increasing postsynaptic somatic spiking, but also discovered that an increase in network activity may both boost and limit this enhancement.
Article
Engineering, Biomedical
Lei Zhang, Long Chen, Zhongpeng Wang, Xiuyun Liu, Dong Ming
Summary: This study investigated whether electrically stimulating frontal and parietal regions using dual-site tACS at mu frequency can modulate motor imagery (MI) performance. The results showed that anti-phase stimulation significantly improved event-related desynchronization (ERD) and classification accuracy during complex tasks, while also decreasing event-related functional connectivity within the frontoparietal network. However, no beneficial effects of anti-phase stimulation were found in the simple task.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Psychiatry
Mhairi McDonald, Eleni Christoforidou, Nicola Van Rijsbergen, Ruchika Gajwani, Joachim Gross, Andrew Gumley, Stephen M. Lawrie, Matthias Schwannauer, Frauke Schultze-Lutter, Peter J. Uhlhaas
SCHIZOPHRENIA BULLETIN
(2019)
Article
Neurosciences
Elisabeth S. May, Moritz M. Nickel, Son Ta Dinh, Laura Tiemann, Henrik Heitmann, Isabel Voth, Thomas R. Toelle, Joachim Gross, Markus Ploner
HUMAN BRAIN MAPPING
(2019)
Article
Neurosciences
Christopher S. Y. Benwell, Raquel E. London, Chiara F. Tagliabue, Domenica Veniero, Joachim Gross, Christian Keitel, Gregor Thut
Review
Biochemistry & Molecular Biology
Peter Lakatos, Joachim Gross, Gregor Thut
Article
Neurosciences
Moritz M. Nickel, Son Ta Dinh, Elisabeth S. May, Laura Tiemann, Vanessa D. Hohn, Joachim Gross, Markus Ploner
HUMAN BRAIN MAPPING
(2020)
Article
Neurosciences
D. Momi, F. Neri, G. Coiro, C. Smeralda, D. Veniero, G. Sprugnoli, A. Rossi, A. Pascual-Leone, S. Rossi, E. Santarnecchi
Article
Multidisciplinary Sciences
Gesine Marker, Gemma Learmonth, Gregor Thut, Monika Harvey
Correction
Neurosciences
D. Momi, F. Neri, G. Coiro, C. Smeralda, D. Veniero, G. Sprugnoli, A. Rossi, A. Pascual-Leone, S. Rossi, E. Santarnecchi
Review
Clinical Neurology
Bernhard A. Sabel, Gregor Thut, Jens Haueisen, Petra Henrich-Noack, Christoph S. Herrmann, Alexander Hunold, Thomas Kammer, Barbara Matteo, Elena G. Sergeeva, Wioletta Waleszczyk, Andrea Antal
CLINICAL NEUROPHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Domenica Veniero, Joachim Gross, Stephanie Morand, Felix Duecker, Alexander T. Sack, Gregor Thut
Summary: The activation of the Frontal Eye Fields can shape visual cortex activity and perception through mechanisms of oscillatory realignment at the beta frequency.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Andra Coldea, Stephanie Morand, Domenica Veniero, Monika Harvey, Gregor Thut
Summary: The study attempted to replicate findings of lateralized parietal tACS at alpha frequency to induce a change in attention bias, but unlike previous studies, no effects on attention deployment or visual processing across hemifields were observed. Additional resting EEG did not reveal any notable effects on individual alpha power or frequency, highlighting the need for more replication studies and systematic investigations of factors driving tACS effects.
Article
Neurosciences
Andra Coldea, Domenica Veniero, Stephanie Morand, Jelena Trajkovic, Vincenzo Romei, Monika Harvey, Gregor Thut
Summary: Alpha-band oscillatory activity in occipito-parietal areas is involved in shaping perceptual and cognitive processes. This study used transcranial magnetic stimulation (TMS) to investigate the causal relationship between pre-stimulus alpha-frequency and subjective and objective measures of performance. The results showed that pre-stimulus 10 Hz-TMS did not affect subjective or objective performance, but alpha-frequency was positively correlated with task accuracy.
FRONTIERS IN NEUROSCIENCE
(2022)
Letter
Clinical Neurology
Marta Bortoletto, Domenica Veniero, Petro Julkunen, Julio C. Hernandez-Pavon, Tuomas P. Mutanen, Agnese Zazio, Chiara Bagattini
Review
Clinical Neurology
Julio C. Hernandez-Pavon, Arantzazu San Agustin, Max C. Wang, Domenica Veniero, Jose L. Pons
Summary: The objective of this article is to systematically review the efficacy of ccPAS in inducing plasticity in humans, with a focus on stimulation parameters and hypotheses of underlying neurophysiology. The review found that ccPAS can modulate brain connectivity depending on the interstimulus intervals, and it has the potential for basic research and potential clinical applications. This article highlights the importance of targeting multiple brain areas to study brain connectivity in the field of transcranial magnetic stimulation.
CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Psychiatry
R. Kostova, R. Cecere, G. Thut, Peter J. Uhlhaas
SCHIZOPHRENIA RESEARCH
(2020)