Article
Chemistry, Inorganic & Nuclear
Sahil Kohli, Garima Rathee, Sunita Hooda, Ramesh Chandra
Summary: This study focuses on the synthesis of an efficient, reusable, and novel Al2O3/CuI/PANI nanocatalyst using a simple self-assembly approach, which was then used for the catalytic one-pot synthesis of 2-substituted benzimidazoles in ethanol. The nanocatalyst showed high % yield, short reaction time, and green metrics values.
DALTON TRANSACTIONS
(2021)
Article
Multidisciplinary Sciences
Shih-Ting Wang, Brian Minevich, Jianfang Liu, Honghu Zhang, Dmytro Nykypanchuk, James Byrnes, Wu Liu, Lev Bershadsky, Qun Liu, Tong Wang, Gang Ren, Oleg Gang
Summary: The study demonstrates the creation of bio-active protein-containing ordered nanomaterials with desired 2D and 3D organizations through the encapsulation of proteins in DNA-based voxels and programmable assembly. This platform approach allows for the retention of protein function in the assembled protein arrays.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Chemistry, Medicinal
Ram W. Sabnis
Summary: This article provides 1,2,4-triazine derivatives used as NLRP3 inhibitors, their pharmaceutical compositions, the use of such compounds in treating diseases, and processes for preparing such compounds.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Medicinal
Camilla Pecoraro, Michele De Franco, Daniela Carbone, Davide Bassani, Matteo Pavan, Stella Cascioferro, Barbara Parrino, Girolamo Cirrincione, Stefano Dall'Acqua, Stefano Moro, Valentina Gandin, Patrizia Diana
Summary: Metabolic deregulation is a key mechanism in promoting cancer resistance and progression. In this study, novel hybrid molecules were synthesized and evaluated for their ability to inhibit PDK, resulting in the suppression of pancreatic cancer cell growth and spread. These compounds also showed promising results in animal models, reducing tumor growth without significant side effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jian Song, Yuan Liu, Xin-Ying Yuan, Wen-Bo Liu, Yin-Ru Li, Guang-Xi Yu, Xin-Yi Tian, Yan-Bing Zhang, Xiang-Jing Fu, Sai-Yang Zhang
Summary: The compound K3, as a NEDDylation agonist, effectively inhibits the growth of gastric cancer cells and induces cell apoptosis by promoting the degradation of c-IAP and YAP/TAZ.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Parinaz Jabbari, Gholam Reza Mahdavinia, Parisa Fathi Rezaei, Bagher Kazemi Heragh, Parisa Labib, Hessam Jafari, Shahrzad Javanshir
Summary: A nanocomposite carrier with double-responsive features was developed by integrating magnetic montmorillonite into a chitosan matrix and crosslinking it with citric acid. The carrier showed high sustained release and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Organic
Jigar Panchal, Sonika Jain, Pankaj Kumar Jain, Dharma Kishore, Jaya Dwivedi
Summary: This review discusses a greener methodology for synthesizing s-triazine derivatives and emphasizes that green methods result in better yields compared to traditional methods, due to rapid reactions, mild reaction conditions, and easy workup procedures.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ahmed A. Elbarbary, El-Refaie Kenawy, Elsayed G. I. Hamada, Tarek B. Edries, Wesam S. Meshrif
Summary: This study focused on synthesizing and testing the insecticidal activity of 1,3,4-oxadiazole derivatives grafted on chitosan and modified polymethyl methacrylate. Four compounds showed good insecticidal activity against the cotton leafworm and low cytotoxicity to human cells, making them promising insecticide candidates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Leer Yuan, Rong Sheng, Mengying Guan, Yuan Wang, Siyuan Chen
Summary: 2-Oxazolidinone is commonly used as a pharmacophore for antibacterial agents, such as Linezolid and Tedizolid. However, recent research has revealed various biological activities of 2-oxazolidinones beyond their antibacterial properties. In this review, we provide an overview of the progress in this unconventional area of 2-oxazolidinones over the past 10 years (2011-2021).
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Lili Chen, Ying Yun, Shimeng Guo, Xiaoyan Wang, Muya Xiong, Tingting Zhao, Tifei Xu, Jianhua Shen, Xin Xie, Kai Wang
Summary: Danuglipron is a representative small-molecule agonist of the glucagon-like peptide-1 receptor (GLP-1R) that has shown positive results in clinical trials for the treatment of type 2 diabetes mellitus (T2DM) and obesity. However, it has limitations such as hERG inhibition, lower activity compared to endogenous GLP-1, and short action time. This study introduces a new class of 5,6-dihydro-1,2,4-triazine derivatives that eliminate hERG inhibition caused by danuglipron, and identifies compound 42 as a highly potent and selective GLP-1R agonist with improved efficacy and acceptable drug-like properties. Compound 42 demonstrates longer-lasting effects in reducing glucose excursion and inhibiting food intake, making it a feasible treatment for T2DM and obesity.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Fatma Ozge Gokmen, Nursel Pekel Bayramgil
Summary: Cellulose and its derivatives, such as 2-HEC and HPMC, are extensively studied biocomponents. The chemical structures of nanocomposite films were analyzed using FT-IR and XRD techniques. Among them, amine modified nano SiO2 doped HPMC film showed the best dispersion of nano-reinforcements but had micron-size agglomerations on the film surface.
CARBOHYDRATE POLYMERS
(2022)
Review
Biochemistry & Molecular Biology
Mariusz Kluska, Joanna Jablonska, Wieslaw Prukala
Summary: This study aimed to summarize information on the qualitative and quantitative analysis of stilbene derivatives, their biological activity, potential applications as preservatives, antiseptics and disinfectants, and stability analysis in various matrices. Optimal conditions for the analysis of the stilbene derivatives in question were developed using the isotachophoresis technique.
Review
Biochemistry & Molecular Biology
Joanna Skopinska-Wisniewska, Silvia De la Flor, Justyna Kozlowska
Summary: Supramolecular hydrogels are water-swelled materials held together by reversible, non-covalent interactions, offering unique properties and potential applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Rohit Pal, Md Jawaid Akhtar, Khadga Raj, Shamsher Singh, Priyanka Sharma, Sourav Kalra, Pooja A. Chawla, Bhupinder Kumar
Summary: A new series of N-(5,6-diphenyl-1,2,4-triazin-3-yl)-2-(4-substituted piperazin-1-yl) acetamide (RP1-5) and 2-((5,6-diphenyl-1,2,4-triazin-3-yl)thio)-1-(4-substituted piperazin1-yl)-ethan-1-one (RP6-10) derivatives were designed and synthesized. Two compounds (RP4 and RP5) exhibited the most potent anticonvulsant activity and significant antidepressant activity in mice models.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Ola R. Shehab, Ahmed M. Mansour
Summary: This study prepared a series of benzimidazole derivatives with different substituents and tested their antimicrobial activity, showing that substituents greatly affect antibacterial activity and spectroscopic data. The relationship between substituents and electron structure can be explained by chemical parameters.
JOURNAL OF MOLECULAR STRUCTURE
(2021)