Article
Biochemistry & Molecular Biology
Ankita Dhiman, Amit Kumar Sharma, Dimpy Bhardwaj, Garima Agrawal
Summary: In order to meet the increasing food demand of the growing world population and reduce the environmental impact of agrochemicals, the development of smart nanoformulation is crucial. This study focuses on the development of dual stimuli responsive alginate based microgels for controlled release of agrochemicals and soil remediation. The microgels, prepared using functionalized alginate and a crosslinker, showed sustained release of the herbicide diuron in specific environmental conditions and demonstrated potential for sustainable agriculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Yingxue Xu, Na Liang, Jia Fu, Zhe Zong, Xueling Long, Shaoping Sun
Summary: In this study, a polymer with tumor targeting function and dual redox/pH sensitivity was designed and synthesized. The polymer can self-assemble to form micelles and solubilize paclitaxel, exhibiting excellent tumor growth inhibition efficacy and low systemic toxicity.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Yingxue Xu, Na Liang, Jia Fu, Zhe Zong, Xueling Long, Shaoping Sun
Summary: In this study, a polymer (P407-CS(FA)-SS-CHO) with tumor targeting function and dual redox/pH sensitivity was designed and synthesized. The polymer can self-assemble in water to form micelles and solubilize paclitaxel (PTX). The PTX-loaded micelles showed triggered drug release behavior in response to acid and glutathione (GSH), and demonstrated excellent tumor growth inhibition efficacy and low systemic toxicity in vitro and in vivo. These findings suggest that the P407-CS(FA)-SS-CHO micelles have the potential to be intelligent drug carriers for PTX delivery.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Peng Zhang, Mingqian Li, Chunsheng Xiao, Xuesi Chen
Summary: This article summarizes the development of polypeptide-based drug delivery systems that respond to physiological stimuli such as pH, redox potential, glucose, and hypoxia. Polypeptides have the potential for controlled drug release.
CHEMICAL COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Pichapak Srikamut, Treethip Phakkeeree, Farzad Seidi, Supitchaya Iamsaard, Daniel Crespy
Summary: Active protection coatings have been developed to mitigate the corrosion of metallic substrates by encapsulating and releasing corrosion inhibitors through responsive particles. Coatings prepared with polymer-inhibitor conjugates, featuring acetal and immolative disulfide linkers, show higher anticorrosion performance than single-responsive polymers. Unlike previous conjugates, the release of inhibitors can be activated not only by a change in pH value but also by a change in electrochemical potential.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Physical
Xiaomin Xu, Yani Xu, Yuai Li, Min Li, Leilei Wang, Qiang Zhang, Bingjie Zhou, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: In this study, a glucose-responsive system mimicking erythrocytes was designed by coupling glucose-responsive nanoparticles to red blood cells, allowing for long-term response to hyperglycemia and potential application in diabetes treatment.
Article
Chemistry, Multidisciplinary
Jinqiang Wang, Zejun Wang, Guojun Chen, Yanfang Wang, Tianyuan Ci, Hongjun Li, Xiangsheng Liu, Daojia Zhou, Anna R. Kahkoska, Zhuxian Zhou, Huan Meng, John B. Buse, Zhen Gu
Summary: This study introduces a glucose-responsive cationic polymer for constructing polymer-insulin complexes, which shows potential for glucose-stimulated insulin delivery. The effects of different parameters on the insulin release kinetics were studied to evaluate the blood glucose regulation ability in type 1 diabetic mice.
Article
Pharmacology & Pharmacy
Daijie Fu, Zhe Ni, Kerong Wu, Peng Cheng, Xiaofeng Ji, Guoyuan Li, Xifu Shang
Summary: A redox-sensitive UA polymeric prodrug formulation was synthesized to significantly prolong circulation in blood, favor accumulation in tumor tissue, and achieve potent antitumor efficacy.
Article
Engineering, Chemical
Dan-Na Hu, Xiao-Jie Ju, Xing-Qun Pu, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: The copolymer Alg-g-PNA shows temperature and glucose responsiveness, with the ability to transition between sol and gel states for insulin delivery based on environmental conditions. Additionally, the hydrogels demonstrate good biocompatibility and reversible sol-gel transitions in response to changes in blood glucose levels, making them a promising option for self-regulating insulin delivery in diabetes therapy.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Qian Luan, Hao Zhang, Chaoji Chen, Feng Jiang, Yonggang Yao, Qianchun Deng, Kaizhu Zeng, Hu Tang, Fenghong Huang
Summary: In this study, a nutrient-delivery system based on a pH-responsive wood scroll was designed for targeted delivery of nutrients to the intestine. The wood scroll allows for storage, protection, and controlled release of nutrients, ensuring higher bioactivity and prolonged release in the intestine. The system was successfully demonstrated with probiotics, tea polyphenols, and rapeseed oil, showing its potential for customized nutrient management. This structurally controlled strategy offers a promising approach for enteric nutrient delivery using readily available and biocompatible biomass materials.
Article
Pharmacology & Pharmacy
Ji Luo, Shuguang Zhang, Peiyao Zhu, Wenke Liu, Jiang Du
Summary: In this study, pH/redox dual-responsive mixed polyprodrug micelles (MPPMs) were prepared for enhanced anticancer drug delivery. The MPPMs showed reasonable size and uniform dispersion, and exhibited pH and redox responsiveness. In vitro and in vivo experiments demonstrated that these MPPMs effectively released the drug and inhibited tumor growth, resulting in improved therapeutic efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Applied
Ni Tan, Zui Ding, Can Chen, Yincheng Yang, Leqing He, Sen Liao, Lijie Liu, Duoduo Wang, Qiaorong Ye
Summary: For the first time, a new pH/redox dual stimulus-responsive formononetin imprinting material was successfully prepared by combining N,N'-bisacryloylcystamine containing disulfide bond as the cross-linking agent with molecularly imprinted technology. The material showed excellent drug-loading property and selectivity to formononetin, and had sensitivity to both pH and redox environments. The repeated regeneration experiment demonstrated its stability and reusability.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Lu Zhou, Yajie Zhang, Yong Ma
Summary: In recent years, various redox-responsive drug delivery systems have been developed to prevent premature drug release and reduce toxicity in cancer treatment. This paper proposes the utilization of AS1411 aptamer's spatial structure as a nano-gatekeeper on MCM-41 mesoporous silica, creating a redox-responsive drug delivery system. The results show that this system can achieve controlled drug release and provide new insights for related research.
NANOSCALE ADVANCES
(2022)
Article
Chemistry, Applied
Lijie Liu, Yaxin Tan, Yuqi Bao, Sen Liao, Duoduo Wang, Qiaorong Ye, Chensi Zeng, Ni Tan
Summary: In this study, a magnetic andrographolide imprinted polymer (ADR-MMIP) with pH/redox/light triple stimulus response was successfully prepared. The ADR-MMIP exhibited excellent adsorption and selectivity capacities, and showed sensitivity to the triple stimuli of pH/redox/light, making it a promising candidate for intelligent drug delivery systems.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Polymer Science
Wojciech Raj, Krzysztof Jerczynski, Mahdi Rahimi, Ewa Pavlova, Miroslav Slouf, Agata Przekora, Joanna Pietrasik
Summary: In this study, a series of vitamin E-based TPGS-poly(2-(dimethylamino)ethyl methacrylate)-b-poly(3-vinyl benzaldehyde) block copolymer micelles were synthesized, and the anticancer drug DOX was loaded within the micelles. The micelles demonstrated potential as drug delivery systems for cancer treatment, with pH-responsive characteristics. However, increasing the hydrophobic block polymerization degree reduced the cytotoxicity of the micelles.
Article
Polymer Science
Yeqiang Lu, Hui Zou, Hua Yuan, Shuying Gu, Weizhong Yuan, Maoquan Li
EUROPEAN POLYMER JOURNAL
(2017)
Article
Polymer Science
Lei Xu, Xun-Hui Xu, Na Liu, Hui Zou, Zong-Quan Wu
Article
Polymer Science
Na Liu, Hao-Jun Lu, Zhi-Qiang Jiang, Yu-Bing Lu, Hui Zou, Li Zhou, Zong-Quan Wu
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2019)
Article
Polymer Science
Min Lin, Qi-Liang Wu, Qian-Wei Li, Xiao-Hua Hou, Hui Zou
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2020)
Review
Chemistry, Multidisciplinary
Chao Wang, Hui Zou, Na Liu, Zong-Quan Wu
Summary: This Minireview highlights recent advances in the preparation of polyallenes and summarizes the self-assembly and stimuli-responses of polyallene-based diblock, ABA and ABC triblock copolymers. It aims to inspire more interest in developing polyallenes and encourage further advances in functional materials.
CHEMISTRY-AN ASIAN JOURNAL
(2021)
Article
Polymer Science
Meng-Qing Wang, Hui Zou, Wen-Bin Liu, Na Liu, Zong-Quan Wu
Summary: In this study, a strategy to synthesize well-defined bottlebrush polymers was reported, which showed great potential in drug delivery.
Article
Polymer Science
Bao-Rui Gao, Yong-Jie Wu, Lei Xu, Hui Zou, Li Zhou, Na Liu, Zong-Quan Wu
Summary: Helical polycarbenes with optical activity were designed and synthesized in an environmentally friendly manner. These polymers exhibited stable helical conformations with preferred handedness and showed efficient chiral separation ability.
Article
Polymer Science
Hui Zou, Shan-Shan Han, Guo-Qiang Li, Li Zhou, Na Liu, Zong-Quan Wu
Summary: Conjugated block copolymers consisting of poly(phenyl isocyanide) (PPI) and polyfluorene (PF) segments are synthesized via one-pot sequential polymerization of monomer 1 and monomer 2. These copolymers exhibit distinctive optical properties and fascinating chiral self-assembly behavior due to the helical conformation of PPI segment and pi-conjugated structure of PF segment. Furthermore, the self-assembled helical nanofibers display excellent circularly polarized luminescence performance.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Polymer Science
Hui Zou, Wei Liu, Chao Wang, Li Zhou, Na Liu, Zong-Quan Wu
Summary: In this study, optically active pi-conjugated block copolymers consisting of polyfluorene and poly(phenyl isocyanide) were synthesized in one pot through two sequential polymerizations. The resulting copolymers self-assembled into single-handed helical nanofibers, exhibiting excellent optical activity and circularly polarized luminescence properties.
Article
Chemistry, Multidisciplinary
Hui Zou, Shan Tai, Shu-Yang Zhao, Li Zhou, Na Liu, Zong-Quan Wu
Summary: Optically active helical polycarbenes were synthesized by catalyzing the living and controlled helix-sense-selective polymerization (HSSP) of methyl salicylate modified diazoacetate monomer with pi-allylPdCl using chiral phosphine ligands. The resulting helical polycarbenes could be postpolymerization modified to produce functional polycarbenes efficiently.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Jinxin Nie, Feiyang Ren, Zhen Li, Kun Tian, Hui Zou, Xiaohua Hou
Summary: Several binuclear vanadium complexes were synthesized and investigated as catalysts for ethylene (co)polymerization. The binuclear complexes exhibited higher activities than the mononuclear analogues in ethylene polymerization and showed moderate activity in copolymerization with polar vinyl monomers.
Article
Polymer Science
Xiang Gao, Jinxin Nie, Xiaojian Chen, Li Zhou, Xiaohua Hou, Hui Zou
Summary: The research found that vanadium complexes containing bulky ligands exhibit excellent 2,3-selectivity in allene polymerization, particularly for phenylallene. High molecular weight polymers can be obtained in the presence of (AlBu3)-Bu-i as a co-catalyst, and polymerization of monomers containing methoxy or bromine groups can proceed smoothly using vanadium complexes.
Article
Polymer Science
Hui Zou, Qian-Wei Li, Qi-Liang Wu, Wen-Quan Liang, Xiao-Hua Hou, Li Zhou, Na Liu, Zong-Quan Wu
Summary: Starlike hybrid helical PPIs with well-defined structures were designed and prepared using POSS as the core; chiral and amphiphilic hybrids were obtained by modifying the monomers and conducting polymerization with POSS-Pd(ii) as the initiator, exhibiting thermoresponsive behaviors and excellent enantioselective crystallization abilities.
Article
Polymer Science
Qian-Wei Li, Yi-Xu Su, Hui Zou, Yong-Yuan Chen, Li Zhou, Xiao-Hua Hou, Na Liu, Zong-Quan Wu
Article
Polymer Science
Hui Zou, Qiliang Wu, Qianwei Li, Chunyao Wang, Li Zhou, Xiao-Hua Hou, Weizhong Yuan
Article
Polymer Science
Paige A. Shaw, Maxime Klausen, Mark Bradley
Summary: A light-responsive polymer capable of controlled release of camptothecin and generation of reactive oxygen species (ROS) was developed, which exhibited high cancer cell killing activity through both camptothecin release and ROS generation.
Article
Polymer Science
Donghui Zhang, Shiqi Liu, Zhihao Cai, Weizhe Luo, Guojian Liu, Runhui Liu
Summary: A straightforward and efficient method for synthesizing NPC monomers has been developed in this study, which enhances the availability of NPC monomers and facilitates the synthesis of polypeptides.
