期刊
POLYMER CHEMISTRY
卷 5, 期 1, 页码 126-131出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3py00991b
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资金
- European Regional Development Fund (ERDF)
- Higher Education Funding Council for England (HEFCE)
- University of Warwick
- Engineering and Physical Sciences Research Council [EP/G004897/1] Funding Source: researchfish
- EPSRC [EP/G004897/1] Funding Source: UKRI
The encapsulation and selective delivery of therapeutic compounds within polymeric nanoparticles offers hope for the treatment of a variety of diseases. Traditional approaches to trigger selective cargo release typically rely on polymer degradation which is not always sensitive to the biological location of a material. In this report, we prepare nanoparticles from thermoresponsive polymers with a 'solubility release catch' at the chain-end. This release catch is exclusively activated in the presence of intracellular glutathione, triggering an 'isothermal' response and promoting a change in polymer solubility. This solubility switch leads to specific and rapid nanoparticle disassembly, release of encapsulated cargo and produces completely soluble polymeric side-products.
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