Article
Polymer Science
Mohamed Naguib, Kate L. Nixon, Daniel J. Keddie
Summary: This study reports the synthesis of two novel trithiocarbonate RAFT agents for bottlebrush synthesis via ROMP grafting-through polymerization. The correlation between the monomer type, degree of polymerization, and RAFT agent structure has been investigated. The results reveal that the properties of the resulting polymers are influenced by the monomer type, degree of polymerization, and RAFT agent structure.
Review
Chemistry, Multidisciplinary
Sylwia Dworakowska, Francesca Lorandi, Adam Gorczynski, Krzysztof Matyjaszewski
Summary: Reversible-deactivation radical polymerizations (RDRPs) have revolutionized synthetic polymer chemistry. Atom transfer radical polymerization (ATRP) has evolved beyond traditional polymer field, enabling the synthesis of organic-inorganic hybrids, bioconjugates, and environmentally relevant polymeric materials.
Article
Chemistry, Multidisciplinary
You-Chi Mason Wu, Gloria Chyr, Hyunchang Park, Anna Makar-Limanov, Yuran Shi, Joseph M. Desimone, Zhenan Bao
Summary: This study reports a modular system for the production of degradable and recyclable thermosets via photopolymerization. The system utilizes a polyurethane backbone to impart strong mechanical properties to the plastic, while the use of hemiacetal ester linkages allows for easy degradation. Functional polyurethane diol can be regenerated through a simple purification process.
Article
Chemistry, Multidisciplinary
Friederike K. Metze, Irene Filipucci, Harm-Anton Klok
Summary: Polymer brushes can be produced by surface-initiated polymerization using initiators or chain transfer agents. This manuscript presents an alternative method using non-covalent host-guest interactions to immobilize initiators for atom transfer radical polymerization. These non-covalent initiators can generate supramolecular polymer brushes with film thicknesses over 100 nm.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Inorganic & Nuclear
Solene Delaporte, Isabel Abanades Lazaro, Javier Lopez-Cabrelles, Eleni C. Mazarakioti, Sarah Chebourou, Inigo J. Vitorica-Yrezabal, Monica Gimenez-Marques, Guillermo Minguez Espallargas
Summary: A family of robust and stable molybdenum-based metal-organic cages have been obtained using the [Mo2O2(& mu;2-O)2]2+ secondary building unit. The cages are decorated with different pyridine derivatives, which enhance the structural stability and allow for the determination of the activated cage's structure through single-crystal diffraction. The chemical robustness of the cage is demonstrated by the post-synthetic modification that enables the exchange of pyridine derivatives without breaking the cage structure.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Organic
Samantha Saxer, Omer Erdogan, Cedric Paniagua, Alain Chavanieu, Xavier Garric, Vincent Darcos
Summary: Protein-polymer bioconjugates show great potential in biomedical and life science applications, and a highly efficient, versatile, and facile chemical ligation reaction for the synthesis of macromolecules has been proposed in this article. Additionally, the aggregation behavior of amphiphilic graft copolymers based on poly(ethylene glycol) in water was investigated, and a new protein-polymer bioconjugate was prepared by copper-free click chemistry reaction using azido-functionalized polystyrene copolymers.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Shuo Zeng, Jinwei Shi, Anchao Feng, Zhao Wang
Summary: This study successfully grafted poly (DMAEMA) chains/brushes onto electrospun regenerated cellulose nanofiber membrane via ATRP, and investigated the effects of different ATRP conditions on enzyme immobilization. The optimal initiation and monomer grafting times were found to be 1 and 2 hours, leading to a significant increase in the immobilization amount.
Article
Polymer Science
Prithwiraj Mandal, Pierre Marcasuzaa, Laurent Billon
Summary: A block copolymer consisting of polystyrene and polypentafluorostyrene was synthesized and its nano-structure was controlled through a click reaction.
Article
Chemistry, Multidisciplinary
Yuanyuan Xu, Yu Chen, Xuguang Liu, Song Xue
Summary: PyBN, synthesized compound, shows varying photoactivity at different wavelengths and can initiate radical photopolymerization. Efficient photoinitiation of (meth)acrylate materials is achieved under 365 and 395 nm LED irradiation by PyBN. Additionally, a good synergistic interaction is observed when PyBN combines with camphorquinone (CQ) under 470 nm LED irradiation.
Article
Chemistry, Multidisciplinary
Yu Wang, Sushant P. Sahu, Alec J. Clay, Amanda J. Gildersleeve
Summary: By combining nitroxide radicals and ATRP active halogens into a functional reagent, simultaneous ATRP-NRC relay polymerization was successfully achieved, allowing for tailored macromolecular architecture and functionality by using different functional reagents.
CHEMICAL COMMUNICATIONS
(2021)
Article
Polymer Science
Edgar Molle, Hatice Mutlu, Patrick Theato
Summary: A straightforward synthesis of a novel class of polymers, poly(N-(4-vinylphenyl)sulfonamide)s, and their monomers is reported. The monomers with varying electron densities, polymerized by free radical polymerization, exhibit low molar masses and low dispersities. Furthermore, post-polymerization modification of the obtained polymers via aza-Michael addition with electron-deficient alkenes is demonstrated, paving the way towards the facile synthesis of novel polymeric protected beta-amino acid derivatives.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Arman Moini Jazani, Jung Kwon Oh
Summary: A new method for synthesizing multi-stimuli-responsive degradable block copolymers is reported in this study. The copolymer can achieve controlled, sustained, or rapid drug release through different stimuli (acid, reduction, light).
Article
Materials Science, Paper & Wood
Muhammad Asif Iqbal, Toheed Akhter, Muhammad Faheem, Asif Mahmood, Waheed Al-Masry, Sohail Nadeem, Sadaf Ul Hassan, Chan Ho Park
Summary: We synthesized a thermoresponsive polymer with a narrow molecular weight distribution using organic photo-redox-catalyzed atom transfer radical polymerization (O-ATRP). The O-ATRP was mediated by a photoredox catalyst 1,2,3,5-tetrakis (carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN) under visible light irradiation. The polymerization of polymethyl methacrylate (PMMA) chains from a hydroxypropyl cellulose (HPC)-based macroinitiator was characterized using various analytical methods. The resulting PMMA-grafted HPC (PMMA-g-HPC) showed a widened lower critical solution temperature (LCST) window and an inverse pH dependency of the LCST, making it promising for various applications including drug delivery systems.
Article
Polymer Science
Mateusz Olszewski, Jaepil Jeong, Grzegorz Szczepaniak, Sipei Li, Alan Enciso, Hironobu Murata, Saadyah Averick, Kriti Kapil, Subha R. Das, Krzysztof Matyjaszewski
Summary: In this study, a new sulfoxide-containing monomer, MSEAM, was synthesized and well-defined polymers were prepared using PICAR ATRP. The results showed that PMSEAM exhibited excellent biocompatibility and relatively low toxicity.
Article
Nanoscience & Nanotechnology
Madson R. E. Santos, Patricia Mendonca, Rita Branco, Ruben Sousa, Carla Dias, Armenio C. Serra, Jose R. Fernandes, Fernao D. Magalhaes, Paula Morais, Jorge F. J. Coelho
Summary: Research has shown that hospital surfaces are a major route for drug-resistant pathogen-caused nosocomial infections. Industrial waterborne polyurethane varnish formulations containing cationic polymeric biocides and photosensitizer curcumin were developed to create antimicrobial surfaces that can reduce bacterial transmission infections in healthcare environments. The coatings displayed both photokilling effect and a combined antimicrobial effect between the cationic biocide and curcumin, showing potential for practical application.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Seong-Min Jo, Jihye Kim, Ji Eun Lee, Frederik R. Wurm, Katharina Landfester, Sanghyuk Wooh
Summary: This study investigates a novel multimodal enzyme- and photocatalyst-carrying superstructure for colorimetric glucose detection. By utilizing surface-templated evaporation driven suprastructure synthesis, superstructures comprising enzyme-carrying nanoparticles were successfully fabricated. The multimodal enzyme-carrying superstructures demonstrate promising potential for highly sensitive glucose detection in confined environments.
Article
Chemistry, Multidisciplinary
Seong-Min Jo, Hyeong Seok Kim, Miae Won, Carole Champanhac, Jong Seung Kim, Frederik R. Wurm, Katharina Landfester
Summary: The combination of nanoreactors and prodrugs presents great potential in anticancer treatment. However, the precise targeting of cancer cells remains a challenge. In this study, a dual-targeting approach using folate receptor-targeted nanoreactors and cyclooxygenase-2 (COX-2) targeted prodrugs is proposed. This strategy can generate synergistic effects and contribute to the development of selective and effective anticancer therapeutics.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Medicinal
Chiara Pelosi, Lorenzo Arrico, Francesco Zinna, Frederik R. Wurm, Lorenzo Di Bari, Maria R. Tine
Summary: Protein-polymer conjugates are a promising hybrid system with high biomedical potential. In this study, the thermal stability of a set of fully-degradable polyphosphoester-protein conjugates was evaluated using variable temperature circular dichroism. A simple and effective protocol was proposed to obtain useful information about these systems in vitro, which can be used for screening new samples in their early stages.
Article
Engineering, Environmental
Stefan Peil, Hubert Gojzewski, Frederik R. Wurm
Summary: Bio-based and biodegradable cellulose acetals, with their reversible modification of cellulose, provide a versatile and sustainable alternative to non-degradable polyolefin plastics. These cellulose acetals are characterized by solubility in common organic solvents, adjustable physical properties, and the ability to undergo full degradation in compost and enzymatic processes. With the increasing urgency of climate change and plastic pollution, these cellulose derivatives offer a promising solution for a more sustainable future.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Polymer Science
Zhong H. W. Easton, Mike A. J. Essink, Laura Rodriguez Comas, Frederik R. R. Wurm, Hubert Gojzewski
Summary: Biobased and biodegradable polymers are used in bioplastics to adjust their physical properties and biodegradation stability. Mixing with faster degrading polymers or fillers is a strategy to control degradation rates. This review focuses on representative examples of bioplastic blends and composites in applications such as tissue engineering, agriculture, or packaging, with a focus on accelerating biodegradation rates and preventing microplastic formation.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Oncology
Yue Yan, Marc-Andre Gauthier, Ahmad Malik, Iosifina Fotiadou, Michael Ostrovski, Dzana Dervovic, Logine Ghadban, Ricky Tsai, Gerald Gish, Sampath Kumar Loganathan, Daniel Schramek
Summary: The aim of this study is to understand the signaling mechanisms of RIPK4 in SCCs. Through gene profiling and targeted CRISPR screening, we identified ELOVL4 as a downstream target of RIPK4. Our data from in vitro and in vivo mouse experiments show that the NOTCH-RIPK4-IRF6-ELOVL4 signaling axis functions as a potent tumor suppressor in SCCs.
Article
Biochemistry & Molecular Biology
Ahlem Meziadi, Andrea A. Greschner, Marc A. Gauthier
Summary: This study demonstrates that the microwave-induced transient heating phenomenon can significantly accelerate protein PEGylation and increase the degree of PEGylation achievable beyond what is possible at room temperature. Under certain conditions, extremely high levels of PEGylation were achieved in a matter of minutes. Moreover, the microwave induced transient heating concept was adapted for continuous flow manufacturing of bioconjugates.
Correction
Biochemistry & Molecular Biology
Fatemeh Zare, Alessandro Potenza, Andrea A. Greschner, Marc A. Gauthier
Article
Polymer Science
Timo Rheinberger, Mareike Deuker, Frederik R. Wurm
Summary: In this study, the degradation rate of polyphosphoesters (PPEs) with different side-chain structures under different pH conditions was investigated. The degradation mechanism was found to be influenced by the type and size of the side-chain and pH. By modifying the structure of the polyphosphonates or introducing additional breaking points, the half-life of the polymer could be tuned. This study highlights the versatile stability and controllability of water-soluble PPEs, making them promising for various applications, such as tissue regrowth.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Natkritta Huppe, Tassilo Gleede, Frederik R. Wurm
Summary: Poly(alkyl cyanoacrylate)s (PACAs) are widely used as adhesives in engineering and medicine. Achieving precise polymer structures is crucial, particularly for medical applications. By using a small amount (1%) of superbases to activate a functional thiophenol (PhSH) initiator, well-defined PACAs with adjustable molecular weights and moderate dispersities can be synthesized.
POLYMER INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Yunbo Chen, Daniil Nozdriukhin, Sandra Michel-Souzy, Clemens Padberg, Frederik R. R. Wurm, Daniel Razansky, Xose Luis Dean-Ben, Olga Koshkina
Summary: Optoacoustic imaging combines optical contrast with ultrasound resolution in biological tissues. Inorganic particles have potential toxic effects, thus bio-based, biodegradable nano- and microcapsules with clinically-approved ICG are introduced. These capsules can enhance OA imaging and enable the localization and tracking of larger microcapsules.
Article
Polymer Science
Maria Brio Perez, Mark A. Hempenius, Sissi de Beer, Frederik R. Wurm
Summary: Polymer brushes are widely used for versatile surface modifications but most of them are nonbiodegradable. In this study, the researchers presented a synthetic strategy for grafting degradable polymer brushes via organocatalytic surface-initiated ring-opening polymerization. The polymer brushes produced were able to hydrolyze with controlled patterns and be regrown on the same substrate after degradation. The research showed that the polyester brush coatings exhibited different levels of hydrolytic stability and degradation mechanism, making them a potential alternative to nondegradable polymer brushes.
Article
Multidisciplinary Sciences
Olga Koshkina, Timo Rheinberger, Vera Flocke, Anton Windfelder, Pascal Bouvain, Naomi M. Hamelmann, Jos M. J. Paulusse, Hubert Gojzewski, Ulrich Floegel, Frederik R. Wurm
Summary: This study demonstrates the modification of biodegradable polyphosphoesters and tailoring the polymers' microstructure to adjust MRI relaxation times, addressing the issues of environmental pollution and organ accumulation caused by MRI agents. In vivo monitoring of polymers is crucial for drug delivery and tissue regeneration.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Tjerk R. Watt, Stefan Peil, Wendy A. Jonkers, Jurjen A. Regenspurg, Frederik R. Wurm, Wiebe M. de Vos
Summary: Polyelectrolyte multilayers (PEMMs) are versatile materials for nanofiltration membranes, but their nonrenewable nature raises sustainability concerns. This study proposes lignin as a renewable and biodegradable alternative for PEMM fabrication. Experimental results demonstrate that lignin can effectively replace fossil-based polyelectrolytes, producing PEMMs with excellent nanofiltration properties and stability.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Diego A. Resendiz-Lara, Suna Azhdari, Hubert Gojzewski, Andre H. Groeschel, Frederik R. Wurm
Summary: In this work, water-soluble and degradable bottlebrush polymers were synthesized via ROMP using polyphosphoesters (PPEs) as the base material. PPE-macromonomers were first synthesized via organocatalytic anionic ring-opening polymerization and then used in ROMP to produce well-defined bottlebrush polymers. The resulting polymers showed good solubility in water and were degradable, making them promising for various biomedical applications.
Article
Polymer Science
Paige A. Shaw, Maxime Klausen, Mark Bradley
Summary: A light-responsive polymer capable of controlled release of camptothecin and generation of reactive oxygen species (ROS) was developed, which exhibited high cancer cell killing activity through both camptothecin release and ROS generation.
Article
Polymer Science
Donghui Zhang, Shiqi Liu, Zhihao Cai, Weizhe Luo, Guojian Liu, Runhui Liu
Summary: A straightforward and efficient method for synthesizing NPC monomers has been developed in this study, which enhances the availability of NPC monomers and facilitates the synthesis of polypeptides.
