Article
Engineering, Biomedical
Xiao Liu, Yilong Yang, Miaomiao Han, Jianwei Guo, Hui Liu, Yadong Liu, Junjie Xu, Shengxiang Ji, Xuesi Chen
Summary: This study reports that hyperbranched polylysine (HPL) exhibits antifungal and antibacterial activities, particularly against drug-sensitive and multi-drug resistant Candida strains. The high antimicrobial activities of HPL are attributed to its compact globular structure and high charge density. Modification of amine groups further enhances the antifungal activities.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Ming Liu, Xiao Liu, Hui Liu, Miaomiao Han, Shengxiang Ji
Summary: In this study, a novel antimicrobial cotton fabric was developed by covalently bonding hyperbranched polylysine onto the surface of cotton fabric. The resulting fabric exhibited excellent antimicrobial activity, durability, and safety, highlighting the advantages of using HPL in the antimicrobial finishing of fabrics.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medicine, Research & Experimental
Bo Yu, Xiaoxue Lang, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo, Zhengqi Dong
Summary: Drug delivery systems require carrier materials with good biocompatibility, degradability, and constructability. Poly(amino acids) with a distinctive secondary structure have the basic features of carrier materials and reactive functional groups in the side chain, making them suitable as drug carriers for anticancer drugs. The conformation of drug carrier isomers affects the preparation, morphology, and efficacy of nanoparticles. This study used two isomers of polylysine as drug carriers to construct nano-drug delivery systems for methotrexate. The e-PL/MTX nanoparticles showed smaller size (115.0 nm) and higher drug loading content (57.8%), and exhibited stronger anticancer effects in vivo and in vitro compared to alpha-PL/MTX nanoparticles. e-PL is an ideal drug carrier with potential clinical application prospects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Applied
Nagendra Kalva, Saji Uthaman, Eun Hye Jang, Rimesh Augustine, Su Hyeon Jeon, Kang Moo Huh, In-Kyu Park, Il Kim
Summary: A facile one-pot approach was developed to prepare amphiphilic aggregation-induced emission (AIE)-active hyperbranched fluorescent nanoparticles with a core-shell structure, showing strong blue luminescence in aqueous solution. These nanoparticles exhibited high water solubility, good photostability, and biological imaging properties, with low cytotoxicity and excellent biocompatibility indicated by cell viability assay and confocal microscopy imaging. Thus, TPE-HPG FPNs are promising for biomedical applications.
Article
Agriculture, Dairy & Animal Science
Shangen Xu, Lu Yu, Qiaoyang Teng, Xuesong Li, Zheng Jin, Yang Qu, Jiawei Li, Qihong Zhang, Zejun Li, Kai Zhao
Summary: DNA vaccination has the potential to effectively prevent or treat avian influenza pandemics. However, low immunogenicity and gene delivery have been limitations in clinical testing. This study explores the use of recombinant DNA vaccines containing multiple antigens to enhance immune response. Additionally, dendritic polylysine (DGL) nanoparticles as a gene delivery system and adjuvant were found to significantly improve antigen-specific immunity in mice models. This research suggests that multi-antigen gene expression methods using DGL as a delivery system hold promise in gene therapy.
Article
Pharmacology & Pharmacy
Bo Yu, Xiangtao Wang, Lijuan Ding, Meihua Han, Yifei Guo
Summary: The study found that natural polymer PLL is an ideal polypeptide material for preparing drug-loaded nanoparticles, with higher drug-loading content and smaller particle sizes compared to PEG-PLL. Animal experiments also showed that PLL can improve the anti-tumor activity of MTX. The research results suggest that PLL has potential clinical applications in the field of nano drug delivery.
Review
Polymer Science
Matin Suraj Belgaonkar, Balasubramanian Kandasubramanian
Summary: Hyperbranched polymer nanocomposites, based on unique 3D structure and high solvability of hyperbranched polymers, provide new opportunities and challenges in material science. These materials have wide applications in fields such as light-trapping, modification, and stabilization, highlighting the strong interactions between HBP matrices and nanofillers.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Physical
Komal Rao, Nimra Naz Siddiqui, Muhammad Abdullah, Salim Saifullah, Humera Jahan, Muhammad Raza Shah
Summary: Hyperbranched polymers with unique properties were synthesized and characterized in this study. These polymers were then self-assembled into lipid-polymer hybrid nanoparticles and loaded with curcumin. The curcumin-loaded nanoparticles showed enhanced anticancer potential through improved drug delivery.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Li-Han Rong, Xiang Cheng, Jin Ge, Olivia K. Krebs, Jeffrey R. Capadona, Eugene B. Caldona, Rigoberto C. Advincula
Summary: The hypothesis of this study is that hyperbranched polymers have higher functionality and are easier to prepare compared to dendrimers and dendric polymers. Combining electrodeposition and surface-initiated photoinduced electron transfer-reversible addition-fragmentation chain transfer (SI-PET-RAFT) polymerization is proposed as a novel strategy for preparing hyperbranched polymer films on conductive surfaces without degassing. Experimental results confirmed that these hyperbranched polymer films can potentially be useful for fabricating protective polymer coatings on various conductive surfaces.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Engineering, Environmental
Pengfei Sang, Jiahan Song, Wei Guo, Yongzhu Fu
Summary: Organosulfur polymers are a unique class of cathode materials for rechargeable lithium batteries, synthesized through specific condensation reactions with high theoretical specific capacity and excellent cycling performance.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Svetlana A. Sorokina, Nina Kuchkina, Mariam G. Ezernitskaya, Alexey Bykov, Alexander L. Vasiliev, Nikolay N. Efimov, Zinaida B. Shifrina
Summary: Heat-up and hot-injection methods were used to synthesize Ni nanoparticles with narrow size distribution, using hyperbranched pyridylphenylene polymer as a stabilizing agent. The architecture of the polymer support significantly influenced the characteristics and behavior of the Ni nanoparticles. The synthesized Ni nanoparticles exhibited high catalytic activity and remained stable after multiple uses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Yadagiri L. N. K. Mallela, Se Young Jeong, Santosh Kumar, Jae-Suk Lee
Summary: Silica nanoparticles with hyperbranched polyglycidol (hbP) grafts were synthesized and their ionic conductivity was enhanced by end functionalization with a nitrile group. Among the different batches of hbPs, the 6th-batch CN-hbP-SiO2 nanoparticles showed the best ionic conductivity when blended with PEO.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Biochemical Research Methods
Yao Luo, Guoyi Yu, Fei Liu, Yanwen Feng, Pei Zhao, Jun Yue
Summary: The nontraditional intrinsic fluorescence (NTIF) of polymers containing heteroatoms has been studied for label-free bioimaging applications. Hyper-branched polyureas (aBPUs) with different degrees of branching (DBs) or different modifications were synthesized to investigate their NTIF properties. The results showed that aBPUs exhibited obvious NTIF phenomenon and the NTIF enhanced with the increase of DBs. Chemical modifications and the formation of nanoassembly also affected the NTIF performances.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Yuping Liu, Wei Ma, Zhen Dong, Nanting Qiu, Liwei Ma, Zhong-Ren Chen, Hua Wei
Summary: This study developed a facile and robust method for the synthesis of multifunctional hyperbranched polymers with a precisely modulated degree of branch, predetermined polymer compositions, controlled molecular weights, and low dispersity indexes. The resulting polymers can self-assemble into stabilized unimolecular micelles and show accelerated drug release in reducing or acidic pH conditions.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Materials Science, Biomaterials
Qin Zhang, Daochang Li, Jing Zhong, Yanglin Wu, Yucheng Shi, Huilin Yang, Li Zhao, Kai Yang, Jun Lin
Summary: This study developed multifunctional nanocarriers for clinical treatment of RA, successfully delivering MTX to inflamed joints with significant therapeutic effects and reduced adverse systemic toxicities.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Daniel Hofmann, Ralf Thomann, Rolf Muelhaupt
MACROMOLECULAR MATERIALS AND ENGINEERING
(2018)
Article
Chemistry, Multidisciplinary
Sergej Repp, Ersan Harputlu, Seda Gurgen, Mike Castellano, Nora Kremer, Nils Pompe, Jakob Woerner, Anke Hoffmann, Ralf Thomann, Fatih M. Emen, Stefan Weber, Kasim Ocakoglu, Emre Erdem
Article
Polymer Science
Fan Zhong, Jeremia Schwabe, Daniel Hofmann, Julia Meier, Ralf Thomann, Markus Enders, Rolf Muelhaupt
Article
Polymer Science
Fan Zhong, Jeremia Schwabe, Ralf Thomann, Rolf Muelhaupt
MACROMOLECULAR RAPID COMMUNICATIONS
(2019)
Article
Polymer Science
Fan Zhong, Ralf Thomann, Rolf Muelhaupt
Article
Polymer Science
Alexander Kozur, Laura Burk, Ralf Thomann, Pierre J. Lutz, Rolf Muelhaupt
Article
Polymer Science
Fan Zhong, Ralf Thomann, Yi Thomann, Laura Burk, Rolf Muelhaupt
Article
Chemistry, Multidisciplinary
Jasmin-Clara Buerger, Sebastian Gutsch, Yi Thomann, Ralf Thomann, Bjoern Christian, Oliver Ambacher, Margit Zacharias
Summary: This study discusses the experimental tuning of freestanding SnO2 nanowires growth to a laterally aligned nanowire growth mode, with thermodynamic considerations for influencing parameters. The research shows that a continuous gold film inhibits the laterally aligned growth, leading to growth only at the edges while the central region is covered by freestanding wires.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Physical
Maria Isabel Sierra-Trillo, Ralf Thomann, Ingo Krossing, Ralf Hanselmann, Rolf Muelhaupt, Yi Thomann
Summary: By using high peak power nanosecond-pulsed infrared laser, we found that toluene as a liquid medium is an effective method for producing micrometer-sized graphene material, while water is less ideal.
Article
Nanoscience & Nanotechnology
Benedikt Deuringer, Carmen Haerdtner, Katja Krebs, Ralf Thomann, Martin Holzer, Ingo Hilgendorf, Regine Suess
Summary: The conventional techniques for rHDL preparation have limitations, including long process times and harsh preparation conditions. This study presents a novel method to overcome these challenges and proposes a dual mode of action for Eve-rHDL in atherosclerosis and cardiovascular disease.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Artem Egorov, Bianca Riedel, Johannes Vinke, Hagen Schmal, Ralf Thomann, Yi Thomann, Michael Seidenstuecker
Summary: In this study, different calcification methods for collagen and collagen coatings were compared for their suitability for 3D printing and production of collagen-coated scaffolds. HA directly in the collagen solution resulted in increased viscosity and led to clumping on the scaffolds. The incubation and ALP coating methods resulted in increased HA layer thickness, while no coating on the collagen layer was observed with the poly-L-aspartic acid method.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Kun Dai, Mahesh D. Pol, Lenard Saile, Arti Sharma, Bin Liu, Ralf Thomann, Johanna L. Trefs, Danye Qiu, Sandra Moser, Stefan Wiesler, Bizan N. Balzer, Thorsten Hugel, Henning J. Jessen, Charalampos G. Pappas
Summary: The mechanisms of spontaneous and selective peptide elongation in aqueous abiotic systems remain unclear. This study used aminoacyl phosphate esters to uncover these pathways. The phosphate esters acted as solubility tags, allowing hydrophobic amino acids and their oligomers to be soluble in water and enabling selective elongation and different pathways to emerge.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Electrochemistry
Witali Beichel, Julian Skrotzki, Petra Klose, Christian Njel, Burkhard Butschke, Stephan Burger, Lili Liu, Ralf Thomann, Yi Thomann, Daniel Biro, Simon Thiele, Ingo Krossing
Summary: A study found that Li electrodes treated with the phosphoric-acid derivative HBFEP exhibit self-healing ability and an extended cycle lifetime. This treatment method shows promising performance in Li-Li symmetrical cells, potentially enhancing the rechargeability of Li electrodes.
BATTERIES & SUPERCAPS
(2022)
Article
Chemistry, Physical
Szabolcs Pasztor, Balint Becsei, Gyorgyi Szarka, Yi Thomann, Ralf Thomann, Rolf Muehlhaupt, Bela Ivan
Meeting Abstract
Chemistry, Multidisciplinary
Bela Ivan, Szabolcs Pasztor, Csaba Fodor, Marton Haraszti, Gergely Kali, Yi Thomann, Ralf Thomann, Rolf Muelhaupt
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Polymer Science
Yuanzhang Jiang, Xuyi Wang, Yanting Han, Dakai Gong, Yingchun Gu, Lin Tan
Summary: In this study, FeCl3 and poly(acrylic acid) (PAA) were doped into waterborne polyurethanes (WPUs) to create multifunctional materials with self-healing and antimicrobial properties. WPU/Fe/PAA-5.5, containing 5.5 wt % PAA, exhibited excellent mechanical properties, strong self-healing capabilities, and an impressive antimicrobial rate of over 90%. These supramolecular films were also highly recyclable through hot-pressing.
Article
Polymer Science
Longyu Tian, Min Wang, Guangming Liao, Baoliang Liu, Sujuan Zhang, Yucheng Sun, Zhen Meng, Jintao Zhang, Zaijun Lu
Summary: Two kinds of benzoxazine monomers were synthesized and used to prepare polybenzoxazine anion exchange membranes (AEMs) with quaternary ammonium functionalization. The LQPBZ AEM exhibited better ion conductivity and alkaline stability.
Article
Polymer Science
Claire A. Lemarchand
Summary: This study investigates the shock behavior of three different polymers through molecular dynamics simulations. The results reveal specificities in the shock behavior of polymers, including deviations from the linear relation between shock velocity and particle velocity, as well as differences in shear stress relaxation behind the shock front. It is found that the deviation of the Hugoniot locus is related to the change in the relative contribution of bonding and non-bonding potential energies, while polymers with higher glass transition temperatures exhibit slower shear stress relaxation.
Article
Polymer Science
Zengquan Liu, Xiaochun Yin, He Zhang, Shuo Gao, Qinglin Kuang, Yanhong Feng
Summary: A powder solid-state extension (PSSE) technology was proposed to address the high melt viscosity issue of UHMWPE. By uniaxial extension and sintering in the solid state, a highly self-reinforced material was prepared. X-ray diffraction and scattering techniques were used to study the structural evolution during the PSSE process, and a solid-phase induced transformation model was established.
Article
Polymer Science
Zhike Li, Anyu Luo, Rui Zhou, Xin Li, Haiyan Li
Summary: A novel high temperature resistance IL@SiO2 nanocapsules were successfully prepared and their friction and wear properties in PA6 composites were studied. The addition of IL@SiO2 nanocapsules reduced the friction coefficient and wear rate without affecting the mechanical properties of PA6. The synergy between the IL core and SiO2 wall in the nanocapsules improved the self-lubricating performance of the PA6 composites.
Article
Polymer Science
Xin Liu, Xuhong Guo, Qi Liao
Summary: In this study, an algorithm for accurately estimating viscosity is developed using molecular dynamics simulations and the Green-Kubo formula. This algorithm can be applied to complex systems with long correlations, such as macromolecular and biological simulation systems.
Article
Polymer Science
Hao Pu, Yun-Lei Hou, Jing -Zhou Chen, Dong -Lin Zhao
Summary: The use of modified graphene improves the interfacial adherence of carbon fibers to epoxy resin, resulting in enhanced interfacial and bending properties of CF and matrix in CF/EP composites, as well as increased interlaminar shear strength and flexural strength.
Article
Polymer Science
Wei-Chung Ke, Jin-Wei Lin, Manohar Reddy Busireddy, Yueh-Hsing Lee, Jiun-Tai Chen, Chain-Shu Hsu
Summary: This study introduces a crosslinkable monomer, TAIC, to synthesize three crosslinked polyimide films, which exhibit improved thermal, mechanical, and dielectric properties. The introduction of TAIC enhances the tensile strength, reduces the dielectric constant and dielectric loss, and decreases the coefficient of thermal expansion of the polyimide films.
Article
Polymer Science
Alex Kwasi Kumi, Ruiling Fan, Ye Chen, Yumei Zhang
Summary: The difference in leaching of amylopectin from cellulose/amylopectin/1-butyl-3-methylimidazolium chloride ([Bmim][Cl]) blends during regeneration in water and aqueous ethanol has been studied. Molecular dynamics simulations showed that the dissolution and regeneration mechanisms of amylopectin in [Bmim][Cl] are similar to cellulose in ionic liquids. Water regeneration leads to weak electrostatic interactions, resulting in high leaching of amylopectin. In contrast, ethanol-water interactions enhance electrostatic interactions among amylopectin chains, limiting amylopectin leaching in aqueous ethanol.
Article
Polymer Science
Xi Zeng, Junwei Zhou, Junbiao Peng, Chunsheng Zhang, Danling Wang, Yihu Song, Qiang Zheng
Summary: This study utilizes an oligomer deep eutectic solvent (DES) based on polyethylene glycol to regulate the vulcanization kinetics of rubber. The results show that the DES can accelerate vulcanization at low temperatures without affecting the crosslinking density and Mullins effect.
Article
Polymer Science
Qianqian Yue, Yongfei Peng, Xingjian Liu, Aihua He, Huarong Nie
Summary: The addition of metal deactivators can effectively suppress the aging of TBIR, prolong its lifespan, and have no negative effects on its physical and processing properties. These research findings are of great importance for improving the stability and aging resistance of polymers.
Article
Polymer Science
J. Gomez-Caturla, J. Ivorra-Martinez, R. Tejada-Oliveros, V Moreno, D. Garcia-Garcia, R. Balart
Summary: This work focuses on the development of environmentally friendly PLA formulations by using different esters derived from geraniol as plasticizers. The results show that these esters have good compatibility with PLA, and they can effectively enhance the elongation and plasticity of PLA, reduce its glass transition temperature, and slightly improve its water absorption capabilities.
Article
Polymer Science
Dandan Li, Zhaohui Lu, Zhao Ke, Ke Xu, Fengna Dai, Youhai Yu, Guangtao Qian, Chunhai Chen
Summary: In this study, cross-linked PI aerogel membranes with low dielectric constant and high moisture resistance were prepared by co-polymerization and scraping coating technology. The incorporation of fluorinated blocks and benzimidazole ring structures resulted in novel PI aerogel membranes with fascinating dielectric properties and outstanding moisture resistance.
Article
Polymer Science
Zhaoyang Chu, Qing Zhang, Haihua Luo, Han Zhou, Fapei Zhang, Wei Chen, Wenhua Zhang
Summary: Multi-physical fields solution processing strategy is a universal and facile method for preparing various conjugated polymer films and high-performance devices. In this study, we employed a combined microfluidic flow and ultrasonication strategy (FU) for processing CP solutions, and found a pronounced synergetic effect in promoting the pre-ordering of chains in solution. The conformation order and anisotropy of the solution were revealed through various characterizations. A non-classical nucleation model for polymer crystallization in non-equilibrium solution processing was confirmed. The roles of microfluidic flow and ultrasonication in chain aggregation and crystallization were addressed through multi-physical simulations. Compared to pristine solutions, the FU strategy showed improved solution anisotropy and crystallization kinetics, resulting in higher crystallinity in films and increased mobilities in OFET devices. The FU processing strategy provides a universal approach for regulating chain conformation and aggregation in conjugated polymer solutions.