Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Xian-Tao Jiang, Xiao-Hui Wang, Pei-Yuan Li, Wei Su
Summary: Three ruthenium-arene complexes with curcuminoids were synthesized and found to exhibit significant inhibitory effects on human liver cancer cells under light conditions, with their anticancer activity greatly improved by light exposure.
CHINESE JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Srividya Swaminathan, Jebiti Haribabu, Naveen Kumar Kalagatur, Maroli Nikhil, Nithya Balakrishnan, Nattamai S. P. Bhuvanesh, Krishna Kadirvelu, Ponmalai Kolandaivel, Ramasamy Karvembu
Summary: The synthesis of fourteen new Ru-II-arene complexes were characterized and found to exhibit high toxicity towards IMR-32 cancer cells, with two complexes showing the highest activity and the ability to induce apoptosis and cell cycle arrest. These complexes also demonstrated good binding affinity with receptors commonly overexpressed in cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Betty Y. T. Lee, Matthew P. Sullivan, Ena Yano, Kelvin K. H. Tong, Muhammad Hanif, Tomoyo Kawakubo-Yasukochi, Stephen M. F. Jamieson, Tilo Soehnel, David C. Goldstone, Christian G. Hartinger
Summary: N-Heterocyclic carbene (NHC) ligands have been widely studied in medicinal inorganic chemistry. In this study, a series of half-sandwich [M(L)(NHC)Cl-2] complexes with N-flanking anthracenyl moiety were prepared and their anticancer activities were investigated, showing cytotoxicity in low micromolar range. The Ru derivative 1a exhibited stability and specific interactions with biomolecules.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Soren Arlt, Vladana Petkovic, Gerd Ludwig, Thomas Eichhorn, Heinrich Lang, Tobias Rueffer, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Goran N. Kaluderovic
Summary: In this study, various ruthenium complexes were synthesized, characterized, and evaluated for their cytotoxic activity against different cell lines. The complexes showed activity in the lower micromolar range and exhibited higher efficacy than cisplatin, with one complex inducing apoptosis and caspase activation in a cisplatin-resistant cell line.
Article
Biochemistry & Molecular Biology
Marta Orts-Arroyo, Fernanda Gutierrez, Anabel Gil-Tebar, Maider Ibarrola-Villava, Elena Jimenez-Marti, Adriana Silvestre-Llora, Isabel Castro, Gloria Ribas, Jose Martinez-Lillo
Summary: Metal complexes based on purine nucleobases are valuable tools in biomedical applications, including disease diagnosis and treatment. In this study, a novel dinuclear ruthenium(III) complex based on adenine nucleobase was prepared and characterized using various techniques. Cell viability assays showed that the complex exhibited an incipient anticancer effect on a gastric cancer cell line.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Jakob Kljun, Mihaela Rebernik, Lucia M. Balsa, Jerneja Kladnik, Uros Rapus, Tomaz Trobec, Kristina Sepcic, Robert Frangez, Ignacio E. Leon, Iztok Turel
Summary: Organoruthenium pyrithione complexes, such as [(eta(6)-p-cymene)Ru(pyrithionato)(pta)]PF6, show promise as a new class of anticancer drugs. Our study focuses on finding alternatives to the pta ligand and discovering new structural elements to improve the biological properties of ruthenium anticancer drugs. By replacing the pta ligand with different phosphine, phosphite, and arsine ligands, we identified improved inhibitory potency against the enzyme glutathione S-transferase, as well as investigated cytotoxicity in breast, bone, and colon cancers.
Article
Chemistry, Inorganic & Nuclear
Ryo Horikoshi, Ryo Sumitani, Natsuko Shimooka, Tomoyuki Mochida
Summary: This study focuses on the crystal structures, absorption wavelengths, and redox potentials of trinuclear complexes formed by ferrocene-based multidentate ligands and various transition-metal salts.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Yong Wang
Summary: Mononuclear Ru-based compounds with different isomers were synthesized and characterized. The cis-isomer was found to be more thermodynamically stable with lower energy. The luminescence and cell viability of these compounds on HeLa cancer cells were investigated.
JOURNAL OF COORDINATION CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Srividya Swaminathan, Jebiti Haribabu, Mahendiran Dharmasivam, Nikhil Maroli, Jayachandra Prakasan Jayadharini, Nithya Balakrishnan, Nattamai Bhuvanesh, Cesar Echeverria, Ramasamy Karvembu
Summary: We designed and synthesized bipodal ligands with varying substitution on the phenyl group spacer. Ligands and complexes with different arene units were successfully synthesized and characterized. The coordination behavior of the ligands was minimally influenced by substitution change, but differences were observed in the anticancer activity of the complexes. DFT and X-ray diffraction studies revealed structural variations between the different substitutions, and UV-visible spectroscopy determined the correlation between anticancer activity, hydrolysis rate, and lipophilicity index of the complexes. Staining assays, flow cytometry, and Western blot analysis confirmed the apoptotic cell death mechanism of the active complexes.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Stefan Nikolic, Jemma Arakelyan, Vladimir Kushnarev, Samah Mutasim Alfadul, Dalibor Stankovic, Yaroslav I. Kraynik, Sanja Grguric-Sipka, Maria V. Babak
Summary: The astable half-sandwich Ru-dipyridophenazine complex can significantly decrease tumor burden in mouse xenografts without causing kidney and liver toxicity, and its mechanism of action is linked to DNA degradation and ROS induction.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Emanuela Marras, Camilla J. Balacchi, Viviana Orlandi, Enrico Caruso, Maurizio F. Brivio, Fabrizio Bolognese, Maristella Mastore, Miryam C. Malacarne, Miriam Rossi, Francesco Caruso, Veronica Vivona, Nicole Ferrario, Marzia B. Gariboldi
Summary: Photodynamic therapy (PDT) is a promising anticancer/antibacterial strategy that induces cell death through the generation of reactive oxygen species. This study characterized six Ru(II)-arene curcuminoids for their potential application in anticancer and/or antibacterial PDT. The results showed that these derivatives exhibited desirable properties and could be further investigated for their therapeutic potential. The lack of significant toxicity on larvae and promising antimicrobial activity against Gram-positive bacteria are important findings.
Article
Chemistry, Applied
Peiyuan Li, Wei Su, Xiaolin Lei, Qi Xiao, Shan Huang
APPLIED ORGANOMETALLIC CHEMISTRY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaolin Lei, Hong Liu, Yuchi Han, Wei Cheng, Jiayu Sun, Yong Luo, Dan Yang, Yang Dong, Yiochu Chung, Yucheng Chen
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Article
Chemistry, Inorganic & Nuclear
Wei Su, Xiaohui Wang, Xiaolin Lei, Qi Xiao, Shan Huang, Peiyuan Li
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2017)
Article
Energy & Fuels
Cheng Zhang, Yanping Zhang, Xiaolin Lei, Wei Gao
JOURNAL OF SOLAR ENERGY ENGINEERING-TRANSACTIONS OF THE ASME
(2017)
Article
Chemistry, Multidisciplinary
Qiang Li, Yong Wang, Huaxing Rao, Lei Zhang, Jing Ye, Xiaolin Lei, Bingwen Chen
APPLIED SCIENCES-BASEL
(2018)
Article
Physics, Multidisciplinary
Cong Lee, Bing Dong, Xiao-Lin Lei
Article
Biology
Guyu Dai, Xin Xu, Xiaohong Wu, Xiaolin Lei, Xing Wei, Zhibin Li, Qing Xiao, Renming Zhong, Sen Bai
JOURNAL OF RADIATION RESEARCH
(2020)
Meeting Abstract
Oncology
Li Zhang, Wenfeng Fang, Yunpeng Yang, Qitao Yu, Di Wu, Yingcheng Lin, Hua Zhang, Junfei Zhu, Guowu Wu, Bin Lan, Zeqiang Zhou, Zibing Wang, Xiaolin Lei, Haifeng Lin, Xiaohua Hu, Suming Pan
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Mingting Wang, Yifan Gong, Yun Cheng, Lei Yang, Wenhui Wang, Xiaolin Lei
Summary: This study reported on a case of a 29-year-old male non-smoker diagnosed with both pulmonary sarcomatoid carcinoma (PSC) and lung adenocarcinoma, and identified gene fusion and high expression of PD-L1. The combination of Alectinib, Anlotinib and Tirelizumab effectively controlled the disease and alleviated the patient's symptoms. The study demonstrates the efficacy of combining targeted chemotherapy with immunotherapy for patients with PSC, and suggests the potential use of genetic testing and monitoring PD-L1 expression to select suitable candidates for this treatment approach.
Article
Chemistry, Medicinal
Yi-Chang He, Chun Gong, Xiao-Lin Lei, Wei Gao, Jie-Fang Yang, Young-Soo Bae, Jin-Kyu Kim, Chan-Gon Seo, Se-Yeong Park, Sun-Eun Choi, Bao-Tong Li
Summary: A phytochemical study of Camellia oleifera nut shell resulted in the isolation of a new gallotannin, along with three known hydrolyzable tannins and gallic acid. The structure of the new gallotannin was determined based on comprehensive spectroscopic data.
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Article
Gastroenterology & Hepatology
Qiu-Yan Liu, Ling Xie, Xiao-Yun Yang, Lei Yang, Xiao-Lin Lei
Summary: This article aims to explore the clinicopathology presentation, treatments, outcomes, and predictors of small intestine adenocarcinoma patients aged 65 years or older. The study found that surgery and tumor stage are independent prognostic factors for survival in elderly SIA patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Article
Environmental Sciences
Handong Luo, Ting Zhu, Xiaolin Lei, Xiaolan Song, Laicong Luo, Congfei Zhu, Xue Liu, Kunying Wang, Shun Zhang, Yi Liao, Ganping Liu, Ruohong Wu, Jian Bai, Xiaolong Wu, Xiaomin Guo, Dongnan Hu, Dekui Niu
Summary: The study highlights the importance of leaf phenotypic characteristics, chlorophyll fluorescence parameters, and leaf nutrient content in evaluating the drought resistance of different varieties of C. oleifera. The research found that the 12 C. oleifera varieties could be categorized into four types based on their drought resistance, with Gan 62 and Gan 64 showing the strongest resistance.
FRESENIUS ENVIRONMENTAL BULLETIN
(2021)
Proceedings Paper
Energy & Fuels
Fang Jialiang, Zha Weiqliang, Li Zhi, Zhang Xinghai, Li Shichun, Tang Hongyan, Lei Xiaolin
2018 2ND INTERNATIONAL CONFERENCE ON ENVIRONMENTAL AND ENERGY ENGINEERING (IC3E 2018)
(2018)
Article
Agriculture, Multidisciplinary
Yuanyuan Zhou, Song Li, Dalu Wang, Yaguang Zhao, Xiaolin Lei
BIOSCIENCE JOURNAL
(2018)
Article
Materials Science, Multidisciplinary
Bing Dong, G. H. Ding, X. L. Lei
Article
Chemistry, Inorganic & Nuclear
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: In this study, a tri-component composite consisting of Fe3O4 nanoparticles, Keggin-type polyoxometalate, and graphene oxide was prepared and investigated as a catalyst for the oxidation of sulfides to sulfoxides. The catalyst showed excellent stability, high yields, and recyclability, making it a promising choice for organic-inorganic hybrid catalytic reactions conducted under mild conditions.
Article
Chemistry, Inorganic & Nuclear
Samuel D. Juarez-Escamilla, Sriloy Dey, Bruno Donnadieu, T. Keith Hollis
Summary: In this study, a bidentate Mo complex was synthesized using metalation and transmetalation methodology. The synthesis was optimized to achieve a high yield. The crystal structure of the bidentate complex was determined. Additionally, alternative forms of ligands were discovered in the reaction.
Article
Chemistry, Inorganic & Nuclear
Mohamed H. Abdel-Rhman, Ghada Samir, Mostafa A. Hussien, Nasser M. Hosny
Summary: This study investigated the dissolution performance of hydrazine carbonate solution on zirconium dibutyl phosphate (Zr-DBP), and found that hydrazine carbonate solution could promote the dissolution of Zr-DBP. The effects of dissolution temperature and hydrogen peroxide concentration on the dissolution efficiency were also explored, and the corrosion effect on stainless steel by hydrazine carbonate solution was studied.
Article
Chemistry, Inorganic & Nuclear
Qiaofang Fu, Fangyu Tan, Wu Ying
Summary: This study successfully prepared vermiculite/g-C3N4/TiO2 composites and found that under specific conditions, the composites exhibited excellent degradation effects, with a high degradation rate for methylene blue. Additionally, the composites were able to enhance surface area, reduce carrier loading rate, improve light energy utilization, and enhance durability.
Article
Chemistry, Inorganic & Nuclear
Annabelle G. W. Hodson, Robert T. Mason
Summary: Functionalised polystyrene resins have been found to be efficient catalysts in the synthesis of specific complexes, with the conversion rate controlled by the polymer structure. The addition of amines or amino acids can further yield substituted 13-butadienyl complexes, which have been analyzed by NMR.
Article
Chemistry, Inorganic & Nuclear
C. Kavitha, S. Anbarasan, P. Subramaniam
Summary: The sulfoxidation of PMAAs by the oxo(salen)chromium(V) complex in aqueous acetonitrile medium was studied. The rate of the reaction is influenced by the polarity of the medium and the substituents on PMAA, with electron donating substituents accelerating the reaction and electron withdrawing substituents retarding the reaction.
Article
Chemistry, Inorganic & Nuclear
Qiang-Qiang Liu, Mithun Kumar Ghosh, Shu-Lan Cai, Xiao-Hong Liu, Lu Lu, Mohd. Muddassir, Tanmay Kumar Ghorai, Jun Wang
Summary: Three newly developed coordination polymers (CPs) with semiconducting properties were synthesized using hydrothermal methods. These CPs exhibit superior photocatalytic activity and can degrade organic pollutants effectively.
Article
Chemistry, Inorganic & Nuclear
Mehrnaz Aliahmadi, Ali Nemati Kharat, Jan Janczak
Summary: This study proposes a method for synthesizing allyl alcohol using cost-effective and renewable bio-resource glycerol. By utilizing catalysts, alcohol as a solvent, and a reducing agent, allyl alcohol with an efficiency of 100% was obtained. The structures of the newly synthesized complexes were determined using X-ray single crystallography.
Article
Chemistry, Inorganic & Nuclear
Ji-Yan Gao, Nan Zhang, Dong-Sheng Huang, Xiang-Rong Liu, Zai-Wen Yang, Shun-Sheng Zhao
Summary: Two new transition metal complexes I and II were synthesized and characterized. The complexes exhibited strong thermal stabilities and showed effective binding to CT-DNA and BSA. Complex II exhibited stronger inhibition activity against P. aeruginosa than gentamicin sulfate. These complexes have potential applications in drug research.
Article
Chemistry, Inorganic & Nuclear
Rishabh Ujjval, Hilal Ahmad Khan, Chinnappan Sivasankar, Natesan Thirupathi
Summary: In this study, a rigid 2-aminobenzimidazole type guanidine and its platinum complexes were synthesized through a series of reactions and characterized by various physical and chemical methods. The reaction mechanism was also explained through DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Marcelo Carpes Nunes, Thais Zaboenco, Vinicius Kemper Melara, Gabriel Barros Baptistella, Andre Luiz Barboza Formiga, Andersson Barison, Fabio Souza Nunes
Summary: A new luminescent molecular thermometer has been developed, which uses the spin-crossover equilibrium of a nickelcyclen derivative to measure temperature. The sensor shows high sensitivity and accuracy.
Article
Chemistry, Inorganic & Nuclear
Yuyu Shan, Zhenqin Zhao, Xia Zhang, Zhan Wu, Xiu-Ling Li
Summary: In this study, a new bridging ligand was synthesized through refluxing, and two mononuclear Cu(I) complexes and two trinuclear Cu(I)-Eu(III) complexes were obtained through self-assembly. The Cu(I) antenna chromophores successfully transferred energy to the Eu(III) centers, achieving sensitized Eu(III) luminescence.
Article
Chemistry, Inorganic & Nuclear
Gabriela Sanchez-Lecuona, Mayra C. Vazquez-Nunez, Bruno Donnadieu, Miguel A. Munoz-Hernandez, Virginia Montiel-Palma
Summary: The reaction of RuHCl(PPh3)3 with GaMe3 has been studied and the obtained complexes were analyzed in detail. The results indicate the formation of a Ru-Ga bond, suggesting the generation of an in situ formed ambiphilic phosphinogallyl ligand. This is of significance for understanding the interaction between metal-halogen bonds and metal-small molecule bonds.
Article
Chemistry, Inorganic & Nuclear
Sevil Sener, Nursel Acar, Fatih Dumludag
Summary: The synthesis, characterization, spectroscopic and bonding features of a new Co (II) phthalocyanine compound containing two thiocarbohydrazone groups were explained. The compound showed semiconductor properties and potential as a temperature sensor.
Article
Chemistry, Inorganic & Nuclear
Ledja B. O. Davi, Aryanna S. P. N. Costa, Mariana S. Silva, Adriana S. Ribeiro, Cintya D. A. E. S. Barbosa, Julio C. S. Da Silva, Dimas J. P. Lima, Daniela S. Anunciacao
Summary: In this study, a dansyl derivative sensor called o-PDDS was prepared and used for the detection of Al3+ ions in water. The o-PDDS sensor exhibited high sensitivity and linear response towards Al3+ ions. Experimental and computational studies confirmed a 1:1 stoichiometry ratio between o-PDDS and Al3+ ions. Real sample analysis demonstrated the selectivity and detection performance of the sensor, indicating its potential for field use.
