期刊
POLYHEDRON
卷 31, 期 1, 页码 150-158出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2011.09.003
关键词
Chromone derivative; Synthesis; Cytotoxic effect; Antioxidant activity; Copper(II) complexes
资金
- Medical University of Lodz [503/3-066-02/503-01, 503/3-014-02/503-01]
The chromone derivative 5-amino-8-methyl-4H-benzopyran-4-one (ligand) (1) has been used to obtain a series of Cu(II) complexes 2-4 as potential anticancer compounds. The molecular structures of ligand 1 and its Cu(II) complex 3 have been determined by X-ray crystallography. The cytotoxicity of all obtained compounds has been evaluated on melanoma A375 cell line. The ability of compounds 1-4 to take part in redox reactions and their antioxidant activity have been studied. (C) 2011 Elsevier Ltd. All rights reserved.
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