Article
Biochemistry & Molecular Biology
Michal Zabiszak, Justyna Frymark, Martyna Nowak, Jakub Grajewski, Klaudia Stachowiak, Malgorzata T. Kaczmarek, Renata Jastrzab
Summary: In this study, binary complexes of alpha-hydroxy acids with d-electron metal ions were investigated using potentiometric measurements and spectroscopic methods. The results showed that dimers were formed with copper(II) ions, while monomers were formed with cobalt(II) and nickel(II) ions.
Article
Agricultural Engineering
Li Sun, Quanwei Zhang, Xiao Kong, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Rodrigo Ledesma-Amaro, Jian Chen, Long Liu
Summary: A low pH tolerance yeast mutant TAMC was obtained through adaptive laboratory evolution. By overexpressing enzymes and designing a transporter, the production of L-malic acid was significantly increased.
BIORESOURCE TECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Xiaoqing Wang, Chengyuan Li, Mingjia Zhi, Zhanglian Hong
Summary: In our previous work, we used the organic acids assisted sol-gel method to prepare ZrO2 aerogels. We found that organic acids with two carboxyl groups and one side group, or with three carboxyl groups and one hydroxyl group, were necessary to form wet gels. In this work, we used different organic reagents to verify our assumption and successfully synthesized ZrO2 aerogels with high surface area and large pore volume.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Na Wu, Jiahui Zhang, Yaru Chen, Qing Xu, Ping Song, Yingfeng Li, Ke Li, Hao Liu
Summary: This review comprehensively describes the methods, recent progress, and remaining challenges in microbial production of L-malic acid. Various pathways for L-malic acid biosynthesis using different microorganisms are summarized, along with strain engineering strategies and fermentation optimization strategies. The review also discusses alternatives for reducing production costs.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Zhen Wei, Yongxue Xu, Qing Xu, Wei Cao, He Huang, Hao Liu
Summary: Malic acid, a four-carbon dicarboxylic acid, is widely used in various industries and can be produced from renewable sources through microbial fermentation. With advances in genetic engineering, promising strains have been developed for large-scale bio-based production of malic acid. The review highlights recent developments in the fermentative production of malic acid and discusses metabolic engineering strategies to improve production efficiency.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Horticulture
Magdalena Andelini, Nikola Major, Nina Isic, Tvrtko Karlo Kovacevic, Dean Ban, Igor Palcic, Mira Radunic, Smiljana Goreta Ban
Summary: The taste and aroma of fruit and vegetables are influenced by various compounds. The ratio of sugars and organic acids plays a key role in the sweetness and sourness of tomatoes. This study examined the sugar and organic acid content, as well as other parameters, of different tomato landraces from Croatia. The results showed that malic acid, fructooligosaccharide content, citric acid, and dry matter were the most important parameters in distinguishing tomato landraces.
Article
Chemistry, Physical
Zhicheng Gao, Ying Li, Xunqiu Wang
Summary: This study measured the solubility of L-malic acid in three binary solvents and found that the solubility increases with temperature. The dissolution behavior was explained using Hansen solubility parameter, and the data were correlated with different models, with the modified Apelbiat equation showing the best fit. Thermodynamic parameters were calculated using the van't Hoff equation, indicating that the dissolution process is driven by heat absorption and entropy. This study provides important thermodynamic data for the industrial separation of L-malic acid.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Ye Zhong, Hui-ning Li, Lin Zhou, Hua-sheng Su, Mao-sheng Cheng, Yang Liu
Summary: The study synthesized a series of oleanolic acid derivatives with acetyl-substituted L-arabinose moiety and screened them for cytotoxicity against cancer cell lines, showing selective toxicity against A431 cells, with compound 6 exhibiting the best inhibitory activity. Pharmacological experiments demonstrated that compound 6 significantly induced apoptosis and cell cycle arrest in A431 cells, suggesting it as a promising lead candidate for further research.
CARBOHYDRATE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wei Wang, Aijun Hu, Jing Li, Guangxin Liu, Mengting Wang, Jie Zheng
Summary: The effects of microwave alone (MA) and microwave-assisted L-malic acid (MLA) on sweet potato starch were investigated, showing decreased swelling power, lightness, and whiteness index, as well as changes in starch structure and digestibility. MLA treatment led to a new characteristic absorption peak in FT-IR measurement, while MA treatment did not. MLA increased resistant starch content while MA decreased it, and their impact on crystallinity and gelatinization enthalpy varied.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Multidisciplinary
Yumeng Chen, Ao Han, Meng Wang, Dongzhi Wei, Wei Wang
Summary: By using metabolic engineering, the filamentous fungus Trichoderma reesei was successfully transformed into an efficient cell factory for producing L-malic acid. The overexpression of heterologous genes and the manipulation of the reductive tricarboxylic acid pathway resulted in increased production and yield of L-malic acid. The engineered T. reesei strain achieved the highest reported titer of 220.5 g/L in a 5 L fed-batch culture.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Miroslav Horak, Josef Balik, Monika Bieniasz
Summary: The study revealed that leaf area has a significant impact on the quality and taste of wine, especially affecting total soluble solids and titratable acidity. The influence of leaf area varies among different grape varieties, while the ratio of tartaric acid to malic acid shows significant seasonal variation.
Article
Biotechnology & Applied Microbiology
Yongyan Xi, Hongtao Xu, Tao Zhan, Ying Qin, Feiyu Fan, Xueli Zhang
Summary: Currently, the biological production of L-malic acid (L-MA) faces challenges due to the generation of waste salts and environmental hazards. In this study, acid-tolerant yeast Pichia kudriavzevii was engineered to efficiently produce L-MA through low pH fermentation. This was achieved by constructing an L-MA-producing strain and fine-tuning metabolic flux. Overexpression of a pyridine nucleotide transhydrogenase from E. coli helped overcome the insufficient NADH supply and further improved L-MA production. The engineered strain achieved a high L-MA yield and productivity, while reducing the need for neutralizing agents.
METABOLIC ENGINEERING
(2023)
Article
Energy & Fuels
Gheorghita Mitran, Adriana Urda, Octavian-Dumitru Pavel, Stefan Neatu, Mihaela Florea, Florentina Neatu
Summary: A series of cobalt-iron mixed oxides were synthesized and tested as catalysts for the oxidative decarboxylation of malic acid. The Co3Fe sample showed the highest conversion and yield, which could be attributed to the increased number of defects caused by the substitution of Co2+ for Fe3+.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Biochemistry & Molecular Biology
Changsheng Qiao, Guohang Sun, Hongbao Li, Weifeng Cao, Fei Shen, Rong Fan, Yinhua Wan
Summary: Poly(beta-L-malic acid) (PMLA) produced by Aureobasidium spp. was effectively fractionated using 300 and 50 kDa membranes. The results showed that 14.0%, 8.4% and 77.6% of the PMLAs were distributed in the 300 kDa retentate, 50 kDa retentate, and the 50 kDa permeate, respectively. The product was identified as glucoseterminated PMLA based on characteristic spectra of NMR, HPLC and FTIR.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Raluca-Ioana Stefan-van Staden, Ionela Raluca Comnea-Stancu
Summary: Single-walled carbon nanotubes with (7,6) chirality were used to design multimode enantioselective sensors with different carbon matrices, showing enantioselectivity for l- and d-malic acids. The sensitivity and selectivity of the sensors were influenced by the matrix, allowing for analysis of malic acid in wine and juice samples with high recoveries and low RSD values.
Article
Chemistry, Inorganic & Nuclear
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: In this study, a tri-component composite consisting of Fe3O4 nanoparticles, Keggin-type polyoxometalate, and graphene oxide was prepared and investigated as a catalyst for the oxidation of sulfides to sulfoxides. The catalyst showed excellent stability, high yields, and recyclability, making it a promising choice for organic-inorganic hybrid catalytic reactions conducted under mild conditions.
Article
Chemistry, Inorganic & Nuclear
Samuel D. Juarez-Escamilla, Sriloy Dey, Bruno Donnadieu, T. Keith Hollis
Summary: In this study, a bidentate Mo complex was synthesized using metalation and transmetalation methodology. The synthesis was optimized to achieve a high yield. The crystal structure of the bidentate complex was determined. Additionally, alternative forms of ligands were discovered in the reaction.
Article
Chemistry, Inorganic & Nuclear
Mohamed H. Abdel-Rhman, Ghada Samir, Mostafa A. Hussien, Nasser M. Hosny
Summary: This study investigated the dissolution performance of hydrazine carbonate solution on zirconium dibutyl phosphate (Zr-DBP), and found that hydrazine carbonate solution could promote the dissolution of Zr-DBP. The effects of dissolution temperature and hydrogen peroxide concentration on the dissolution efficiency were also explored, and the corrosion effect on stainless steel by hydrazine carbonate solution was studied.
Article
Chemistry, Inorganic & Nuclear
Qiaofang Fu, Fangyu Tan, Wu Ying
Summary: This study successfully prepared vermiculite/g-C3N4/TiO2 composites and found that under specific conditions, the composites exhibited excellent degradation effects, with a high degradation rate for methylene blue. Additionally, the composites were able to enhance surface area, reduce carrier loading rate, improve light energy utilization, and enhance durability.
Article
Chemistry, Inorganic & Nuclear
Annabelle G. W. Hodson, Robert T. Mason
Summary: Functionalised polystyrene resins have been found to be efficient catalysts in the synthesis of specific complexes, with the conversion rate controlled by the polymer structure. The addition of amines or amino acids can further yield substituted 13-butadienyl complexes, which have been analyzed by NMR.
Article
Chemistry, Inorganic & Nuclear
C. Kavitha, S. Anbarasan, P. Subramaniam
Summary: The sulfoxidation of PMAAs by the oxo(salen)chromium(V) complex in aqueous acetonitrile medium was studied. The rate of the reaction is influenced by the polarity of the medium and the substituents on PMAA, with electron donating substituents accelerating the reaction and electron withdrawing substituents retarding the reaction.
Article
Chemistry, Inorganic & Nuclear
Qiang-Qiang Liu, Mithun Kumar Ghosh, Shu-Lan Cai, Xiao-Hong Liu, Lu Lu, Mohd. Muddassir, Tanmay Kumar Ghorai, Jun Wang
Summary: Three newly developed coordination polymers (CPs) with semiconducting properties were synthesized using hydrothermal methods. These CPs exhibit superior photocatalytic activity and can degrade organic pollutants effectively.
Article
Chemistry, Inorganic & Nuclear
Mehrnaz Aliahmadi, Ali Nemati Kharat, Jan Janczak
Summary: This study proposes a method for synthesizing allyl alcohol using cost-effective and renewable bio-resource glycerol. By utilizing catalysts, alcohol as a solvent, and a reducing agent, allyl alcohol with an efficiency of 100% was obtained. The structures of the newly synthesized complexes were determined using X-ray single crystallography.
Article
Chemistry, Inorganic & Nuclear
Ji-Yan Gao, Nan Zhang, Dong-Sheng Huang, Xiang-Rong Liu, Zai-Wen Yang, Shun-Sheng Zhao
Summary: Two new transition metal complexes I and II were synthesized and characterized. The complexes exhibited strong thermal stabilities and showed effective binding to CT-DNA and BSA. Complex II exhibited stronger inhibition activity against P. aeruginosa than gentamicin sulfate. These complexes have potential applications in drug research.
Article
Chemistry, Inorganic & Nuclear
Rishabh Ujjval, Hilal Ahmad Khan, Chinnappan Sivasankar, Natesan Thirupathi
Summary: In this study, a rigid 2-aminobenzimidazole type guanidine and its platinum complexes were synthesized through a series of reactions and characterized by various physical and chemical methods. The reaction mechanism was also explained through DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Marcelo Carpes Nunes, Thais Zaboenco, Vinicius Kemper Melara, Gabriel Barros Baptistella, Andre Luiz Barboza Formiga, Andersson Barison, Fabio Souza Nunes
Summary: A new luminescent molecular thermometer has been developed, which uses the spin-crossover equilibrium of a nickelcyclen derivative to measure temperature. The sensor shows high sensitivity and accuracy.
Article
Chemistry, Inorganic & Nuclear
Yuyu Shan, Zhenqin Zhao, Xia Zhang, Zhan Wu, Xiu-Ling Li
Summary: In this study, a new bridging ligand was synthesized through refluxing, and two mononuclear Cu(I) complexes and two trinuclear Cu(I)-Eu(III) complexes were obtained through self-assembly. The Cu(I) antenna chromophores successfully transferred energy to the Eu(III) centers, achieving sensitized Eu(III) luminescence.
Article
Chemistry, Inorganic & Nuclear
Gabriela Sanchez-Lecuona, Mayra C. Vazquez-Nunez, Bruno Donnadieu, Miguel A. Munoz-Hernandez, Virginia Montiel-Palma
Summary: The reaction of RuHCl(PPh3)3 with GaMe3 has been studied and the obtained complexes were analyzed in detail. The results indicate the formation of a Ru-Ga bond, suggesting the generation of an in situ formed ambiphilic phosphinogallyl ligand. This is of significance for understanding the interaction between metal-halogen bonds and metal-small molecule bonds.
Article
Chemistry, Inorganic & Nuclear
Sevil Sener, Nursel Acar, Fatih Dumludag
Summary: The synthesis, characterization, spectroscopic and bonding features of a new Co (II) phthalocyanine compound containing two thiocarbohydrazone groups were explained. The compound showed semiconductor properties and potential as a temperature sensor.
Article
Chemistry, Inorganic & Nuclear
Ledja B. O. Davi, Aryanna S. P. N. Costa, Mariana S. Silva, Adriana S. Ribeiro, Cintya D. A. E. S. Barbosa, Julio C. S. Da Silva, Dimas J. P. Lima, Daniela S. Anunciacao
Summary: In this study, a dansyl derivative sensor called o-PDDS was prepared and used for the detection of Al3+ ions in water. The o-PDDS sensor exhibited high sensitivity and linear response towards Al3+ ions. Experimental and computational studies confirmed a 1:1 stoichiometry ratio between o-PDDS and Al3+ ions. Real sample analysis demonstrated the selectivity and detection performance of the sensor, indicating its potential for field use.