Review
Oncology
Xiaoxiao Wang, Chao Zhang, Huangqin Song, Junlong Yuan, Lei Zhang, Jiefeng He
Summary: Circular RNAs (circRNAs) are a type of endogenous non-coding RNAs (ncRNAs) with a closed-loop structure. The circRNA circCCDC66 has been identified as an oncogenic circRNA that is up-regulated in various types of malignant tumors. It plays a role in cancer progression by regulating epigenetic modifications, variable splicing, transcription, and protein translation. Furthermore, circCCDC66 can be utilized as a biomarker for cancer diagnosis, prognosis assessment, and treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Sung-Hyun Kim, Key-Hwan Lim, Sumin Yang, Jae-Yeol Joo
Summary: Abnormal expression of long non-coding RNAs (lncRNAs) in brain tumors has drawn attention, with current research focusing on their biological functions in cancer. Understanding the molecular mechanisms and signaling pathways related to lncRNAs in brain tumors may guide clinical trials for therapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Cell Biology
Peixin Dong, Ying Xiong, Yosuke Konno, Kei Ihira, Daozhi Xu, Noriko Kobayashi, Junming Yue, Hidemichi Watari
Summary: PIWIL1 is specifically expressed in the testis and frequently overexpressed in tumor tissues compared with normal tissues. Its upregulation leads to tumor cell proliferation, invasion, cancer stem-like properties, tumorigenesis, metastasis, and chemoresistance, possibly through piRNA-independent mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Pengbo Cao, Qian Jin, Lan Feng, Haibei Li, Geng Qin, Gangqiao Zhou
Summary: The article introduces the roles of noncoding RNA (ncRNA) in hepatocellular carcinoma (HCC) and their potential clinical applications in cancer diagnosis and treatment, highlighting ncRNAs as potential novel biomarkers for cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Cell Biology
Zhonghao Mao, Bingyu Wang, Teng Zhang, Baoxia Cui
Summary: This article discusses the biogenesis of m6A, atypical expressions of m6A regulators, and their functions in cervical cancer. The modification of m6A in non-coding RNA is also elucidated. In the context of precision medicine, the application of m6A in clinical diagnosis and treatment of cervical cancer is summarized. Additionally, new perspectives on detection methods, immune regulation, and nano-drug development are presented.
CELL DEATH & DISEASE
(2023)
Review
Neurosciences
Chanon Srihagulang, Jirapong Vongsfak, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, characterized by immediate neuronal destruction and secondary brain injury mechanisms. Vagus nerve stimulation (VNS) shows potential for neuroprotection in TBI through various mechanisms, providing beneficial effects in animal models and patients. Further research is needed to fully understand the therapeutic potential of VNS in treating TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Shuang Zou, Yu-Long Lan, Tong Ren, Xiangyu Li, Lijun Zhang, Hongjin Wang, Xun Wang
Summary: The study identified high expression of AQP4 in CNS tumors, which was closely related to patient prognosis and influenced lymphocyte and cancer-associated fibroblast infiltration. Furthermore, AQP4 functional mechanisms were found to be associated with synaptic vesicle cycle and phosphatidylinositol signaling system.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Jiaqi Sheng, Enjun Lv, Limin Xia, Wenjie Huang
Summary: This article summarizes the mechanisms and biological functions of long non-coding RNA (lncRNA) in hepatocellular carcinoma, and emphasizes its potential as a diagnostic and therapeutic target for liver cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Yuejiao Huang, Yuchan Wang, Jie Tang, Shiyi Qin, Xianjuan Shen, Song He, Shaoqing Ju
Summary: This review focuses on the molecular basis of interactions between cancer cells and their environment, as well as the main signal transduction pathways involved in enhancing cancer cell survival. Therapies targeting these interactions to enhance drug response or prevent drug resistance will also be discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zidan Khan, Nikhil Nath, Abdur Rauf, Talha Bin Emran, Saikat Mitra, Fahadul Islam, Deepak Chandran, Jackie Barua, Mayeen Uddin Khandaker, Abubakr M. Idris, Polrat Wilairatana, Muthu Thiruvengadam
Summary: Currently available therapeutic medications are costly and not entirely effective, leading to interest in natural resources for new alternative therapies. Beta-sitosterol, a plant-derived nutrient, has shown anticancer properties against various cancers. However, further research is needed to fully understand the pharmacology, phytochemistry, and drug delivery of beta-sitosterol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Neurosciences
Jie Wen, Fangkun Liu, Quan Cheng, Nathaniel Weygant, Xisong Liang, Fan Fan, Chuntao Li, Liyang Zhang, Zhixiong Liu
Summary: Lack of appropriate models hinders basic and preclinical research on brain tumors. Organoid technology provides a great recapitulation of the original tumors in brain tumors. In this study, we compared brain tumor organoids (BTOs) with common models, including cell lines, tumor spheroids, and patient-derived xenografts.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
Alvaro M. Martins, Catia C. Ramos, Daniela Freitas, Celso A. Reis
Summary: Glycans and glycoproteins are commonly used in clinical settings as cancer biomarkers, and alterations in glycosylation pathways in cancer cells give rise to specific glycans. EV glycosylation has potential applications in distinguishing tumor EVs from benign EVs and developing novel detection methods.
Review
Oncology
Ladina Greuter, Nicole Frank, Raphael Guzman, Jehuda Soleman
Summary: Liquid biopsy can diagnose and monitor pediatric brain tumors by analyzing circulating DNA in blood, cerebrospinal fluid, or urine. It shows promise in characterizing high-grade gliomas and predicting tumor progression. However, more research is needed to standardize its use for pediatric brain tumors.
Review
Biochemistry & Molecular Biology
Xin-Xin Li, Lu-Xuan Yang, Chuang Wang, Hui Li, De-Shun Shi, Jian Wang
Summary: Exosomal proteins, as one of the major components of extracellular vesicles, have been found to have various roles in the development of diseases including carcinoma, sarcoma, melanoma, neurological disorders, immune responses, cardiovascular diseases, and infection. Understanding the functions and mechanisms of exosomal proteins could potentially aid in clinical diagnosis and targeted therapy. However, current knowledge in this field is still limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Angeliki-Ioanna Giannopoulou, Charalampos Xanthopoulos, Christina Piperi, Efterpi Kostareli
Summary: TRIM proteins play a crucial role in glioma progression and may become potential targets for future treatment. Gliomas are highly heterogeneous and invasive tumors, requiring a better understanding of their molecular mechanisms. TRIM proteins may serve as prognostic biomarkers and therapeutic targets, providing more promising tools for the diagnosis and treatment of gliomas.