Article
Sport Sciences
Justin C. Brown, Chao Ma, Qian Shi, Donna Niedzwiecki, Tyler Zemla, Felix Couture, Philip Kuebler, Pankaj Kumar, Judith O. Hopkins, Benjamin Tan, Smitha Krishnamurthi, Eileen M. O'Reilly, Anthony F. Shields, Jeffrey A. Meyerhardt
Summary: This study aimed to determine whether postoperative physical activity can prevent or delay cancer recurrence in patients with stage III colon cancer. Observing a group of 1696 patients who underwent surgery for stage III colon cancer, it was found that postoperative physical activity can lower the recurrence rate and improve survival.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Multidisciplinary Sciences
E. Horwell, F. Sagias
Summary: Colorectal cancer is a major cause of death in the western world, with pathological stage and cancer genetics being crucial for treatment and prognosis. Recent studies have shown potential micro-anatomical differences between the mesenteric and anti-mesenteric borders of the colon. Patients with cancer on the anti-mesenteric border may have higher survival rates based on the research findings.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Oystein Hoydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen, Birger Henning Endreseth
Summary: This study evaluated the relative survival rate of octogenarian patients after major resection of colon cancer. The results showed that the 90-day mortality rate was higher than that of younger patients, but the long-term survival rate was comparable. The incidence of colon cancer increased among octogenarian patients over time. Factors associated with high 90-day mortality were older age, high American Society of Anaesthesiologists (ASA) score, and emergency surgery.
Review
Medicine, General & Internal
Sophie Pilleron, Helen Gower, Maryska Janssen-Heijnen, Virginia Claire Signal, Jason K. Gurney, Eva J. A. Morris, Ruth Cunningham, Diana Sarfati
Summary: This systematic review identified age disparities in cancer survival using colon and lung cancer as examples. The study found that factors such as sex, ethnicity, socioeconomic status, stage at diagnosis, cancer site, morphology, number of nodes examined, and treatment strategy greatly influenced the magnitude of age disparities in survival. Further research is needed to better understand these age disparities in colon and lung cancer survival.
Review
Biochemistry & Molecular Biology
Kyriaki Katsaounou, Elpiniki Nicolaou, Paris Vogazianos, Cameron Brown, Marios Stavrou, Savvas Teloni, Pantelis Hatzis, Agapios Agapiou, Elisavet Fragkou, Georgios Tsiaoussis, George Potamitis, Apostolos Zaravinos, Chrysafis Andreou, Athos Antoniades, Christos Shiammas, Yiorgos Apidianakis
Summary: Colorectal cancer is a common cancer with complex genetic and environmental causes. Unlike other cancers, non-hereditary colorectal cancer is difficult to predict and has no known risk biomarkers. Improving the practice of colonoscopy and assessing individual biomarkers for colorectal cancer risk is crucial. Multi-omics analysis is urgently needed to provide data for risk analysis.
Article
Oncology
Sophie Pilleron, Hadrien Charvat, Marzieh Araghi, Melina Arnold, Miranda M. Fidler-Benaoudia, Aude Bardot, Marianne Gronlie Guren, Hanna Tervonen, Alana Little, Dianne L. O'Connell, Anna Gavin, Prithwish De, Linda Aagard Thomsen, Bjorn Moller, Christopher Jackson, Oliver Bucher, Paul M. Walsh, Sally Vernon, Freddie Bray, Isabelle Soerjomataram
Summary: Age disparities in colon cancer survival were observed in seven high-income countries, with older patients having lower net survival rates. The largest difference in survival was seen in those with distant stage colon cancer. Older patients with localised or regional cancers experienced excess mortality in the first 6 months after diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Jian Yang, Yu-Chen Tang, Ni Yin, Wei Liu, Zhi-Fei Cao, Xi Li, Xiao Zou, Zi-Xiang Zhang, Jian Zhou
Summary: This case report describes a male patient with colorectal cancer who developed pulmonary and pancreatic metastases after surgery and chemotherapy. Next-generation sequencing (NGS) was used to determine the origin of metastases and guide treatment decisions. The study found that genetic profiles of primary tumor, metastases, and ctDNA may have clinical value in auxiliary diagnosis, prognosis, and therapeutic decision-making.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Oncology
Ryosuke Okamura, Yoshiro Itatani, Yusuke Fujita, Nobuaki Hoshino, Shintaro Okumura, Kazuhiro Nishiyama, Koya Hida, Kazutaka Obama
Summary: Regardless of neoadjuvant treatment, detecting distant metastases with intensive surveillance, particularly in the first 2 years after surgery, is important for the treatment and prognosis of patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
M. Schootman, Matthew Mutch, T. Loux, J. M. Eberth, N. O. Davidson
Summary: Patients with locally advanced colon cancer who undergo laparoscopic colectomy experience better overall outcomes, shorter lengths of stay, and reduced postoperative ileus compared to those undergoing open colectomy. Laparoscopic colectomy is equally effective in obese/non-obese patients, T4a/T4b patients, and regardless of the location of the tumor.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Chien-Yi Yang, Min-Hsuan Yen, Kee-Thai Kiu, Yu-Ting Chen, Tung-Cheng Chang
Summary: This study compared the outcomes of right-sided colon cancer (RCC) and left-sided colon cancer (LCC). The results showed no significant difference in overall survival or time to recurrence between patients with RCC and LCC. However, in stage II colon cancer patients, RCC was associated with shorter time to recurrence.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Nadeem Bilani, Marita Yaghi, Olivia Main, Mihir Naik, Iktej Jabbal, Carlos Rivera, Leah Elson, Hong Liang, Diana Saravia, Zeina Nahleh
Summary: In patients with de novo stage IV breast cancer, surgical resection of metastatic sites may be associated with improved overall survival compared to radiation of secondary lesions, particularly in those with only liver or lung involvement. Further randomized controlled trials are needed to confirm these findings in breast cancer patients.
Review
Oncology
Tiuri E. Kroese, Peter S. N. van Rossum, Magnus Nilsson, Florian Lordick, Elizabeth C. Smyth, Riccardo Rosati, Philippe Nafteux, Domenico D'Ugo, M. Asif Chaudry, Wojciech Polkowkski, Franco Roviello, Ines Gockel, Piotr Kolodziejczyk, Karin Haustermans, Matthias Guckenberger, Marianne Nordsmark, Maria A. Hawkins, Andres Cervantes, Tania Fleitas, Eric van Cutsem, Markus Moehler, Anna D. Wagner, Hanneke W. M. van Laarhoven, Richard van Hillegersberg
Summary: Currently, there is a lack of uniform definition and treatment for oligometastatic esophagogastric cancer. The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to develop a multidisciplinary European consensus statement to improve outcomes for these patients.
Article
Oncology
Lauren N. Krumeich, Robert E. Roses, Lindsay E. Kuo, Brenessa M. Lindeman, Matthew A. Nehs, Ali Tavakkoli, Sareh Parangi, Richard A. Hodin, Douglas L. Fraker, Benjamin C. James, Tracy S. Wang, Carmen C. Solorzano, Carrie C. Lubitz, Heather Wachtel
Summary: The aim of this study was to evaluate the clinical benefit of adrenal metastasectomy for all lung cancer subtypes. The results showed that patients undergoing adrenal metastasectomy had longer disease-free survival and overall survival. Adrenal metastasectomy should be considered for isolated adrenal metastases of non-small cell lung cancer, while small cell histology and extra-adrenal metastases are relative contraindications.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Colleen Webber, Michael Brundage, Timothy P. Hanna, Christopher M. Booth, Erin Kennedy, Weidong Kong, Yingwei Peng, Marlo Whitehead, Patti A. Groome
Summary: This study found significant regional variation in colon cancer-specific survival in Ontario, Canada. Case mix explained a considerable portion of the regional survival variation, suggesting that efforts to monitor cancer care quality through survival metrics should take case mix into account. Adjustment for rurality, continuity of primary care, and diagnostic interval length also partially explained the survival variation in certain regions.
Editorial Material
Microbiology
John T. Wren, Juliane Bubeck Wardenburg
Summary: The development of colorectal cancer is linked to the enteric microbiome, and specific microbial signatures can predict the presence of pre-cancerous polyps.
CELL HOST & MICROBE
(2021)
Article
Oncology
Michael A. Liu, Tamra Keeney, Alexa Papaila, Jessica Ogarek, Humera Khurshid, Elizabeth Wulff-Burchfield, Adam Olszewski, Emmanuelle Belanger, Orestis A. Panagiotou
Summary: ADL assessment may stratify mortality outcomes among older nursing home adults with NSCLC, and may be a useful clinical consideration in this population.
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Mengyang Di, Tamra Keeney, Emmanuelle Belanger, Orestis A. Panagiotou, Adam J. Olszewski
Summary: This study examines the impact of global risk on treatment selection and outcomes among older home care recipients with diffuse large B-cell lymphoma. The study finds that high-risk patients are less likely to receive chemotherapy, have higher rates of mortality, emergency department visits, hospitalization, and intensive care unit admission, and have lower overall survival.
JCO ONCOLOGY PRACTICE
(2022)
Letter
Hematology
Narendranath Epperla, Qiuhong Zhao, Sayan Mullick Chowdhury, Lauren Shea, Tamara K. Moyo, Nishitha Reddy, Julia Sheets, David M. Weiner, Praveen Ramakrishnan Geethakumari, Malathi Kandarpa, Ximena Jordan Bruno, Colin Thomas, Michael C. Churnetski, Andrew Hsu, Luke Zurbriggen, Xiao-Wei Cherie Tan, Kathryn Lindsey, Joseph Maakaron, Paolo F. Caimi, Pallawi Torka, Celeste Bello, Sabarish Ayyappan, Timothy S. Oh, Reem Karmali, Seo-Hyun Kim, Anna Kress, Shalin Kothari, Yazeed Sawalha, Beth Christian, Kevin A. David, Irl Brian Greenwell, Murali Janakiram, Vaishalee P. Kenkre, Adam J. Olszewski, Jonathon B. Cohen, Neil Palmisiano, Elvira Umyarova, Ryan A. Wilcox, Farrukh T. Awan, Juan Pablo Alderuccio, Stefan K. Barta, Natalie S. Grover, Nilanjan Ghosh, Nancy L. Bartlett, Alex F. Herrera, Geoffrey Shouse
Editorial Material
Ethics
Aleksandra E. E. Olszewski, Lori Mendelsohn, Erin Talati Paquette
AMERICAN JOURNAL OF BIOETHICS
(2023)
Meeting Abstract
Hematology
Narendranath Epperla, Rui Li, Pallawi Torka, Lauren Shea, Reem Karmali, Andrea Anampa-Guzman, Timothy Seijung Oh, Kathryn Lindsey, Irl Brian Greenwell, Sayan Mullick Chowdhury, Kaitlin Annunzio, Beth Christian, Geoffrey Shouse, Alex F. Herrera, Nancy L. Bartlett, Natalie S. Grover, Adam J. Olszewski
Article
Hematology
Diana O. Treaba, Dennis M. Bonal, Anna Chorzalska, Mireia Castillo-Martin, Alissa Oakes, Makayla Pardo, Max Petersen, Christoph Schorl, Kelsey Hopkins, Dean Melcher, Ting C. Zhao, Olin Liang, Eui-Young So, John Reagan, Adam J. Olszewski, James Butera, Douglas C. Anthony, Peter Rintels, Peter Quesenberry, Patrycja M. Dubielecka
Summary: This study evaluated the impact of anthracycline- and cytarabine-based induction chemotherapy on the bone marrow microenvironment in acute myeloid leukemia (AML). Using RNA-seq and histological analysis, the researchers found distinct osteogenic and mesenchymal transcriptome profiles in responders and non-responders to chemotherapy. These findings provide valuable insights into the specific treatment response of AML and may inform optimized therapeutic strategies.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Editorial Material
Hematology
Adam J. Olszewski
Summary: In this study, whole-genome sequencing was used to analyze 230 cases of pediatric and adult Burkitt lymphomas, aiming to discover genomic subgroups of this rare disease. The researchers employed a consensus clustering algorithm based on somatic mutations, copy number alterations, and structural variants. The classification of Burkitt lymphoma subgroups was improved by comparing and adding 295 DLBCL genomes to the analysis, due to the imperfect diagnostic criteria.
Article
Geriatrics & Gerontology
Mengyang Di, Tamra Keeney, Emmanuelle Belanger, Scott F. Huntington, Adam J. Olszewski, Orestis A. Panagiotou
Summary: This study aimed to characterize the prevalence of functional and cognitive impairments, and associations between impairments and treatment among older patients with diffuse large B cell lymphoma (DLBCL) receiving nursing home (NH) care. The study found that NH patients had high rates of functional and cognitive impairments, low rates of chemoimmunotherapy, and poor overall survival. This provides the basis for further research on novel treatment strategies, alternative treatment strategies, and patient preferences in optimizing clinical care and outcomes in this high-risk population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Oncology
Ari Pelcovits, Peter Barth, John L. Reagan, Adam J. Olszewski, Vallerie Rosati, Roxanne Wood, Ashlee Sturtevant, Eric S. Winer
Summary: This study evaluated the safety and efficacy of an all-oral regimen of ixazomib, cyclophosphamide, and dexamethasone in newly diagnosed multiple myeloma patients. The overall response rate was 58.3% and there were no severe peripheral neuropathy cases. However, 50% of patients experienced grade 3 or greater dermatologic toxicity. Limited enrollment prevented further evaluation of this regimen in newly diagnosed multiple myeloma patients.
Letter
Hematology
Faheem Farooq, Justin S. Brandt, Elyce Cardonick, Evgeniya Polushkina, Julie Vose, Sairah Ahmed, Praveen Ramakrishnan Geethakumari, Adam J. Olszewski, Hesham Yasin, Umar Farooq, Nada Hamad, Yong Lin, Charlotte Maggen, Robert Fruscio, Mina Mhallem Gziri, Karina Dahl Steffensen, Frederic Amant, Andrew M. Evens
Review
Oncology
Ari Pelcovits, Thomas A. Ollila, Adam J. Olszewski
Summary: Cutaneous T-Cell Lymphoma (CTCL) is a complex disease that requires a specialized approach to management. Localized disease can often be treated with topical therapy, while more extensive involvement requires systemic therapies. Recent advancements in immune-based treatments offer potential for longer periods of response with less toxicity.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Hematology
Adam J. Olszewski, Tycel J. Phillips, Marc S. Hoffmann, Philippe Armand, Tae Min Kim, Dok Hyun Yoon, Amitkumar Mehta, Richard Greil, Jason Westin, Izidore S. Lossos, Javier L. Munoz, Jason Sit, Michael C. Wei, Annie Yang, Vivian Chen, Enkhtsetseg Purev, Donald L. Yee, Ulrich Jaeger
Summary: The study demonstrates promising activity and a manageable safety profile for Mosunetuzumab-CHOP in previously untreated DLBCL patients, suggesting its potential as a first-line combination regimen for DLBCL.
Article
Oncology
Andre L. De Souza, Anthony E. Mega, John Douglass, Adam J. Olszewski, Ece D. Gamsiz Uzun, Alper Uzun, Charissa Chou, Fenghai Duan, Jinyu Wang, Amin Ali, Dragan J. Golijanin, Sheldon L. Holder, Galina G. Lagos, Howard Safran, Wafik S. El-Deiry, Benedito A. Carneiro
Summary: Despite new therapies, advanced urothelial carcinoma still has a poor prognosis. FGFR2 and FGFR3 mutations, PD-L1 expression, tumor mutational burden, and microsatellite instability are predictive biomarkers. Novel biomarkers can improve treatment sequencing and outcomes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lihua E. Budde, Adam J. Olszewski, Sarit Assouline, Izidore S. Lossos, Catherine Diefenbach, Manali Kamdar, Nilanjan Ghosh, Dipenkumar Modi, Waleed Sabry, Seema Naik, Amitkumar Mehta, Shazia K. Nakhoda, Stephen D. Smith, Kathleen Dorritie, Ting Jia, Song Pham, Ling-Yuh Huw, Jing Jing, Hao Wu, Wahib S. Ead, Iris To, Connie Lee Batlevi, Michael C. Wei, Julio C. Chavez
Summary: In an ongoing phase 1/2 trial, the combination of mosunetuzumab and polatuzumab vedotin showed a promising overall response rate of 59.2% for second-line treatment in patients with transplant-ineligible or CAR-T-cell-ineligible relapsed or refractory large B cell lymphoma.
Meeting Abstract
Hematology
Kaitlin Annunzio, Natalie S. Grover, Rui Li, Daniel Jones, Walter Hanel, Beth Christian, Adam J. Olszewski, Narendranath Epperla
Article
Oncology
Vijaya R. Bhatt, Christopher Wichman, Thuy T. Koll, Alfred L. Fisher, Tanya M. Wildes, Ann Berger, James O. Armitage, Sarah A. Holstein, Lori J. Maness, Krishna Gundabolu
Summary: A study on older adults with AML receiving chemotherapy showed significant comorbidity burden and functional impairments at baseline, but cognitive and physical function improvements or stability, as well as improved depression scores, were observed in a high proportion of patients at three months post-treatment, indicating success of treatment.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Correction
Oncology
Darren J. Walsh, Laura J. Sahm, Michelle O'Driscoll, Bronagh Bolger, Hitam Ameen, Michelle Hannan, Caitriona Goggin, Anne M. Horgan
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Article
Oncology
Eva Futtrup Maksten, Lasse Hjort Jakobsen, Boris Modrau, Hilde Jensvoll, Kristian Hay Kragholm, Judit Meszaros Jorgensen, Michael Roost Clausen, Robert Schou Pedersen, Andriette Dessau-Arp, Thomas Stauffer Larsen, Christian Bjorn Poulsen, Anne Ortved Gang, Peter Brown, Tarec C. El-Galaly, Marianne Tang Severinsen
Summary: The risk of developing dementia is not increased after lymphoma treatment among patients.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)
Review
Oncology
P. A. L. Nelleke Seghers, Marije E. Hamaker, Shane O'Hanlon, Johanneke E. A. Portielje, Hans Wildiers, Pierre Soubeyran, Annemarie Coolbrandt, Siri Rostoft
Summary: This study identified a core set of symptoms to monitor in older patients with multimorbidity treated for cancer. These symptoms include those related to cancer, treatment side effects, functional decline, and destabilization of comorbidities. The results provide a basis for guiding symptom monitoring during cancer treatment.
JOURNAL OF GERIATRIC ONCOLOGY
(2024)