Article
Immunology
Lydia M. Roberts, Tara D. Wehrly, Ian Leighton, Patrick Hanley, Jamie Lovaglio, Brian J. Smith, Catharine M. Bosio
Summary: Pulmonary infections trigger tissue-resident and circulating T cell responses, which are crucial for vaccine development. The relative contribution of tissue-resident and circulating T cells in Francisella tularensis infection is not fully understood, hindering the design of effective vaccines. This study elucidates the role of circulating T cells in host defense using a parabiotic mouse model.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Kevin D. Mlynek, Curtis R. Cline, Sergei S. Biryukov, Ronald G. Toothman, Beth A. Bachert, Christopher P. Klimko, Jennifer L. Shoe, Melissa Hunter, Zander M. Hedrick, Jennifer L. Dankmeyer, Sherry Mou, David P. Fetterer, Ju Qiu, Eric D. Lee, Christopher K. Cote, Qingmei Jia, Marcus A. Horwitz, Joel A. Bozue
Summary: The study found that the potential tularemia vaccine candidate rLVS Delta capB/iglABC can provide robust protection against different strains of Francisella tularensis. In animal experiments, rats vaccinated with rLVS showed high levels of protection against various F. tularensis strains.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Immunology
Jaejo Kim, Seung-Heon Lee, Ha-Hyun Kim, Jong-Hyeon Park, Choi-Kyu Park
Summary: Three commercial vaccines are used for routine vaccination in domestic livestock farms in Korea to control foot-and-mouth disease (FMD). Cross-inoculation of pigs with these vaccines does not hinder the immune response against the primary vaccine strains and enhances cross-reactivity against heterologous vaccine antigens. This suggests that cross-inoculation of FMD vaccines can be used as a strategy to overcome the limitation of the antigenic spectrum induced by the original regimen.
Article
Microbiology
Ondraya M. Frick, Virginia A. Livingston, Chris A. Whitehouse, Sarah L. Norris, Derron A. Alves, Paul R. Facemire, Douglas S. Reed, Aysegul Nalca
Summary: The study showed that cynomolgus macaques infected with aerosolized F. tularensis exhibited similar symptoms and disease progression as seen in humans, indicating that these macaques are a reliable animal model for testing medical countermeasures against aerosolized F. tularensis.
Article
Multidisciplinary Sciences
Imene Ammam, Camille D. Brunet, Nouria Boukenaoui-Ferrouk, Julien Peyroux, Sylvie Berthier, Jean Boutonnat, Karim Rahal, Idir Bitam, Max Maurin
Summary: This study demonstrates the existence of tularemia in wild lagomorphs in Algeria, highlighting the need for investigations into the presence of this disease among the human population of the country.
SCIENTIFIC REPORTS
(2022)
Article
Medical Laboratory Technology
Francisco Raposo, Giuseppe Lippi
Summary: This study examined the antibody response in individuals who received an overdose of the BNT162b2 vaccine, finding that despite the overdosage, the vaccine was able to elicit a significant antibody response. The findings suggest that the prime-dose of the vaccine is sufficient to trigger an effective antibody response.
CLINICA CHIMICA ACTA
(2021)
Article
Immunology
Nathella Pavan Kumar, V. V. Banurekha, Girish C. P. Kumar, Arul Nancy, C. Padmapriyadarsini, A. Stella Mary, K. R. Uma Devi, Manoj Murhekar, Subash Babu
Summary: Covaxin vaccination induces enhanced cytokine and chemokine responses as early as month 1, following prime-boost vaccination, indicating robust activation of innate and adaptive immune responses in vaccine recipients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Lydia M. Roberts, Ian Leighton, Benjamin Schwarz, Tara D. Wehrly, Tyler J. Evans, Catharine M. Bosio
Summary: The metabolite itaconate plays a critical role in modulating inflammatory responses among macrophages infected with intracellular pathogens. This study investigates its effect on T cell responses using Francisella tularensis as a model. It reveals that itaconate deficient mice have prolonged primary infection but are more resistant to secondary infection, suggesting the importance of metabolic perturbations in antigen presenting cells on vaccine-elicited immune responses.
CELLULAR IMMUNOLOGY
(2022)
Article
Cell Biology
Ramiro A. Ramirez-Valdez, Faezzah Baharom, Ahad Khalilnezhad, Sloane C. Fussell, Dalton J. Hermans, Alexander M. Schrager, Kennedy K. S. Tobin, Geoffrey M. Lynn, Shabnam Khalilnezhad, Florent Ginhoux, Benoit J. Van den Eynde, Carol Sze Ki Leung, Andrew S. Ishizuka, Robert A. Seder
Summary: A heterologous prime-boost vaccination strategy using a self-assembling peptide nanoparticle TLR-7/8 agonist vaccine and a chimp adenovirus vaccine is found to enhance CD8 T cells and induce tumor regression. Intravenous administration of the chimp adenovirus has higher CD8 T cell responses compared to intramuscular administration. This strategy represents a translatable paradigm for enhancing anti-tumor immunity in humans.
Article
Immunology
Augusto Varese, Bianca Mazzitelli, Fernando Erra Diaz, Maria Victoria Kjolhede, Diego Ojeda, Alejandra Vellicce, Penelope Arto, Carla Cicero, Maria Pascowski, Laura Figueras, Barbara Broese, Rosa Davila, Rocio Zarlenga, Federico Rivelli, Camila Verruno, Valeria Silenzi, Ivana Beltran, Andrea Gamarnik, Ana Ceballos, Carlos Zala, Adelina Badolati, Jorge Geffner
Summary: In vaccinated healthcare workers, breakthrough infection with the Omicron variant of SARS-CoV-2 induces a strong neutralizing antibody response.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Noopur Bhatnagar, Ki-Hye Kim, Jeeva Subbiah, Sakinah Muhammad-Worsham, Bo Ryoung Park, Rong Liu, Phillip Grovenstein, Bao-Zhong Wang, Sang-Moo Kang
Summary: The study suggests that heterologous prime-boost influenza vaccination strategy is more effective in inducing broader protective immunity compared to repeated vaccination with the same antigen, by increasing strain-specific hemagglutination inhibition titers and high levels of IgG antibodies.
Article
Immunology
Seyedeh-Raheleh Niavarani, Guillaume St-Cyr, Lauren Daniel, Christine Lawson, Hugo Giguere, Almohanad A. Alkayyal, Lee-Hwa Tai
Summary: Triple negative breast cancer (TNBC) is a highly aggressive and difficult to treat subtype of breast cancer. Current treatment methods such as surgery, chemotherapy, and hormone/Her2 targeted therapies are not effective for TNBC patients. However, immunotherapies show promise in TNBC due to the high number of immune cells in the tumor. This preclinical study proposes a novel vaccination strategy using an oncolytic virus-infected cell vaccine to target TNBC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lindsay C. Dahora, Marije K. Verheul, Katherine L. Williams, Celina Jin, Lisa Stockdale, Guy Cavet, Eldar Giladi, Jennifer Hill, Dongkyoon Kim, Yvonne Leung, Benjamin G. Bobay, Leonard D. Spicer, Sheetal Sawant, Sjoerd Rijpkema, S. Moses Dennison, S. Munir Alam, Andrew J. Pollard, Georgia D. Tomaras
Summary: Recent advances in vaccine development for Salmonella Typhi infections have resulted in the licensing of new vaccines that use the Vi polysaccharide (Vi PS) conjugated to a carrier protein. Antibodies elicited by these vaccines play a key role in protecting against typhoid fever. A study on human antibody response to Vi-TT vaccine prime followed by Vi-PS boost revealed convergent B cell responses, heterogeneous avidity, and Fc effector functions mediated by Vi-specific antibodies. Further research on epitope targeting and Fc functions will improve the design of high-efficacy Vi vaccines for diverse populations.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Nadine Stetter, Wiebke Hartmann, Marie-Luise Brunn, Stephanie Stanelle-Bertram, Guelsah Gabriel, Minka Breloer
Summary: Helminth infections can impair vaccine efficacy by modulating the immune response, and drug-induced deworming may not fully restore antibody responses and protection. Combining deworming with an improved vaccination regimen can enhance protection against infection in previously helminth-infected individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Tzu-Chuan Ho, Yi-Ming Arthur Chen, Hung-Pin Chan, Chin-Chuan Chang, Kuo-Pin Chuang, Che-Hsin Lee, Cheng-Hui Yuan, Yu-Chang Tyan, Ming-Hui Yang
Summary: The current findings suggest that heterologous vaccination with ChAdOx1-S and mRNA vaccines can enhance immune responses against SARS-CoV-2, although some recipients may experience a slight decrease in immune responses. Larger scale studies encompassing diverse populations are needed to further assess the effectiveness of this vaccine strategy.
Article
Virology
Aaron W. Walters, Michael R. Kujawa, Joseph R. Albe, Douglas S. Reed, William B. Klimstra, Amy L. Hartman
Article
Microbiology
Arthur S. Kim, S. Kyle Austin, Christina L. Gardner, Adam Zuiani, Douglas S. Reed, Derek W. Trobaugh, Chengqun Sun, Katherine Basore, Lauren E. Williamson, James E. Crowe, Mark K. Slifka, Daved H. Fremont, William B. Klimstra, Michael S. Diamond
NATURE MICROBIOLOGY
(2019)
Article
Microbiology
Derek W. Trobaugh, Chengqun Sun, Matthew D. Dunn, Douglas S. Reed, William B. Klimstra
Article
Immunology
Katherine J. O'Malley, Jennifer D. Bowling, Eileen M. Barry, Karsten R. O. Hazlett, Douglas S. Reed
INFECTION AND IMMUNITY
(2019)
Article
Biotechnology & Applied Microbiology
Jennifer D. Bowling, Katherine J. O'Malley, William B. Klimstra, Amy L. Hartman, Douglas S. Reed
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Microbiology
Joseph R. Albe, Devin A. Boyles, Aaron W. Walters, Michael R. Kujawa, Cynthia M. McMillen, Douglas S. Reed, Amy L. Hartman
Article
Public, Environmental & Occupational Health
Gregory Brett Moreau, Stacey L. Burgess, Jeffrey M. Sturek, Alexandra N. Donlan, William A. Petri, Barbara J. Mann
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2020)
Article
Multidisciplinary Sciences
Henry Ma, Jeneveve D. Lundy, Emily L. Cottle, Katherine J. O'Malley, Anita M. Trichel, William B. Klimstra, Amy L. Hartman, Douglas S. Reed, Tobias Teichert
Review
Multidisciplinary Sciences
Cesar Munoz-Fontela, William E. Dowling, Simon G. P. Funnell, Pierre-S. Gsell, A. Ximena Riveros-Balta, Randy A. Albrecht, Hanne Andersen, Ralph S. Baric, Miles W. Carroll, Marco Cavaleri, Chuan Qin, Ian Crozier, Kai Dallmeier, Leon de Waal, Emmie de Wit, Leen Delang, Erik Dohm, W. Paul Duprex, Darryl Falzarano, Courtney L. Finch, Matthew B. Frieman, Barney S. Graham, Lisa E. Gralinski, Kate Guilfoyle, Bart L. Haagmans, Geraldine A. Hamilton, Amy L. Hartman, Sander Herfst, Suzanne J. F. Kaptein, William B. Klimstra, Ivana Knezevic, Philip R. Krause, Jens H. Kuhn, Roger Le Grand, Mark G. Lewis, Wen-Chun Liu, Pauline Maisonnasse, Anita K. McElroy, Vincent Munster, Nadia Oreshkova, Angela L. Rasmussen, Joana Rocha-Pereira, Barry Rockx, Estefania Rodriguez, Thomas F. Rogers, Francisco J. Salguero, Michael Schotsaert, Koert J. Stittelaar, Hendrik Jan Thibaut, Chien-Te Tseng, Julia Vergara-Alert, Martin Beer, Trevor Brasel, Jasper F. W. Chan, Adolfo Garcia-Sastre, Johan Neyts, Stanley Perlman, Douglas S. Reed, Juergen A. Richt, Chad J. Roy, Joaquim Segales, Seshadri S. Vasan, Ana Maria Henao-Restrepo, Dan H. Barouch
Article
Biotechnology & Applied Microbiology
Devin A. Boyles, Madeline M. Schwarz, Joseph R. Albe, Cynthia M. McMillen, Katherine J. O'Malley, Douglas S. Reed, Amy L. Hartman
Summary: Rift Valley fever virus (RVFV) causes sporadic disease in Africa and the Saudi Arabian peninsula, with infection through mosquito bite or mucosal exposure during handling of infected livestock. Disease presents as self-limiting fever, but in rare cases can lead to hepatitis, encephalitis, and ocular disease. Recent studies reveal that RVFV can enter the brain through the olfactory pathway, causing neurological disease.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Microbiology
Ondraya M. Frick, Virginia A. Livingston, Chris A. Whitehouse, Sarah L. Norris, Derron A. Alves, Paul R. Facemire, Douglas S. Reed, Aysegul Nalca
Summary: The study showed that cynomolgus macaques infected with aerosolized F. tularensis exhibited similar symptoms and disease progression as seen in humans, indicating that these macaques are a reliable animal model for testing medical countermeasures against aerosolized F. tularensis.
Article
Microbiology
Julie A. Lovchik, Douglas S. Reed, Julie A. Hutt, Fangfang Xia, Rick L. Stevens, Thero Modise, Eileen M. Barry, Terry H. Wu
Summary: The study revealed variations in virulence and genetic differences among different SCHU S4 strains, with NR-643 and FTS-635 showing lower virulence compared to other strains. Therefore, it is recommended that NR-643/FTS-635 be clearly designated as a separate SCHU S4 substrain and no longer used in studies evaluating potential vaccines and therapeutics.
Article
Immunology
Mayuresh M. Abhyankar, Barbara J. Mann, Jeffrey M. Sturek, Savannah Brovero, G. Brett Moreau, Anjali Sengar, Crystal M. Richardson, Sayeh Agah, Anna Pomes, Peter M. Kasson, Mark A. Tomai, Christopher B. Fox, William A. Petri
Summary: This vaccine formulation induced strong systemic neutralizing antibodies in mice, providing complete protection against a lethal challenge and lung injury, as well as virus clearance from the lungs. Additionally, the adjuvanted vaccine elicited systemic and local anti-Spike IgA, which could be a key feature for a COVID-19 vaccine.
Article
Microbiology
Lauren E. Shoudy, Prachi Namjoshi, Gabriela Giordano, Sudeep Kumar, Jennifer D. Bowling, Carl Gelhaus, Eileen M. Barry, Allan J. Hazlett, Brian A. Hazlett, Kristine L. Cooper, Phillip R. Pittman, Douglas S. Reed, Karsten R. O. Hazlett
Summary: This study identified correlates of protection (COPs) for vaccines against Francisella tularensis through a rabbit model, establishing a reliable marker for vaccine efficacy against high-dose challenges. This finding holds significant promise for guiding future vaccine trials in higher animals.
Article
Immunology
Aimee L. Cunningham, Barbara J. Mann, Aiping Qin, Araceli E. Santiago, Christen Grassel, Michael Lipsky, Stefanie N. Vogel, Eileen M. Barry