Article
Behavioral Sciences
Shihao Huang, Ewa Galaj, Jinfeng Wang, Yi Guo, Shuang Wang, Mengxu Shi, Xueyong Yin, Keyao Liu, Yixiao Luo, Li Meng, Haishui Shi
Summary: The study shows that artesunate has antioxidant, anti-inflammatory, and immunomodulatory effects, and can prevent oxidative damage and depression-like symptoms. This suggests that artesunate may have prophylactic and therapeutic potential in the treatment of depression.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Nikolaos Vlachos, Marios Lampros, Spyridon Voulgaris, George A. Alexiou
Summary: Cancer is a leading cause of death worldwide, and developing new chemotherapy drugs is time-consuming and costly, making drug repurposing a faster and more cost-effective alternative. Antipsychotic drugs, which have anti-cancer properties, have gained increasing interest for their potential role in cancer treatment.
Review
Biochemistry & Molecular Biology
Izabela Rumienczyk, Maria Kulecka, Malgorzata Statkiewicz, Jerzy Ostrowski, Michal Mikula
Summary: Despite no approved treatment for sepsis, preclinical studies have shown the potential of oncology drugs in improving sepsis. Further testing of standard and oncology drug combinations holds promise for better clinical outcomes in sepsis.
Article
Medicine, General & Internal
Giulio Antonelli, Mariacristina Parravano, Lucilla Barbano, Eliana Costanzo, Matteo Bertelli, Maria Chiara Medori, Vincenzo Parisi, Lucia Ziccardi
Summary: PRPH2 gene mutations are frequently found in inherited retinal dystrophies (IRD) and cause a wide range of clinical phenotypes. In this study, 28 subjects with IRD carrying pathogenic PRPH2 mutations were analyzed. The results showed that these patients presented with reduced visual acuity and abnormal dark adaptation in their 40s. Various imaging methods, such as fundus autofluorescence and optical coherence tomography angiography, were found to be effective in the early recognition and detection of this dystrophy.
Article
Nutrition & Dietetics
Ilaria Piano, Mattia Di Paolo, Francesca Corsi, Eugenia Piragine, Silvia Bisti, Claudia Gargini, Stefano Di Marco
Summary: Research has shown that retinal diseases can be caused by a variety of factors, with treatments still needing improvement, especially in the case of gene therapy. Current studies are mostly focused on animal models, with challenges in progressing to human clinical trials. By studying the treatment outcomes in different animal models, the effectiveness of each therapy can be better evaluated.
Review
Medicine, General & Internal
Alessandro Arrigo, Emanuela Aragona, Francesco Bandello
Summary: Diabetic retinopathy is a common complication of diabetes that can cause visual impairment. Anti-VEGF therapies have significantly improved the management of proliferative diabetic retinopathy. The role of anti-VEGF as a substitute for laser treatment or as a combination therapy is still debated. Overall, anti-VEGF treatments are considered the first-line choice for diabetic retinopathy management.
ANNALS OF MEDICINE
(2022)
Review
Oncology
Christina Pfab, Luisa Schnobrich, Samir Eldnasoury, Andre Gessner, Nahed El-Najjar
Summary: Despite advancements in cancer treatment, therapeutic resistance remains a major challenge. Drug repurposing offers a promising strategy to address this challenge by quickly identifying new therapeutic options. Clinical trials are evaluating the anti-cancer activities of antimicrobial agents and their mechanisms of action against various cancers.
Article
Biochemical Research Methods
Sisir Nandi, Mohit Kumar, Mridula Saxena, Anil Kumar Saxena
Summary: The novel coronavirus disease (COVID-19) is a global threat without specific chemotherapeutics, scientists have discovered 13 compounds with good binding affinity through in-silico molecular docking for inhibition of the COVID-19 protease target.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Pharmacology & Pharmacy
Jiang-Hui Wang, Fan-Li Lin, Jinying Chen, Linxin Zhu, Yu-Fan Chuang, Leilei Tu, Chenkai Ma, Damien Ling, Alex W. Hewitt, Ching-Li Tseng, Manisha H. Shah, Bang V. Bui, Peter van Wijngaarden, Gregory J. Dusting, Peng-Yuan Wang, Guei-Sheung Liu
Summary: TAK1 plays a regulatory role in inflammatory stimuli-induced endothelial activation and angiogenesis. Inhibition of TAK1 by 5Z-7-oxozeaenol attenuates aberrant retinal angiogenesis in a rat model of oxygen-induced retinopathy. These findings suggest that targeting TAK1 may have therapeutic potential for the treatment of retinal neovascular pathologies.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Oncology
Brenda F. M. Castro, Jason C. Steel, Christopher J. Layton
Summary: Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are leading causes of blindness and vision loss worldwide. Current treatments for these diseases have limitations, and there is a need for alternative long-lasting options. Adeno-associated virus (AAV) has shown promise for ocular gene delivery, with studies exploring different strategies and pathways to optimize treatment. AAV-mediated gene delivery has shown promising results in preclinical and clinical trials for AMD and DR.
Review
Oncology
Derek B. Oien, Christopher L. Pathoulas, Upasana Ray, Prabhu Thirusangu, Eleftheria Kalogera, Viji Shridhar
Summary: Quinacrine, originally an antimalarial drug, has been rediscovered as an anticancer agent due to its multiple mechanisms including inhibition of cancer cell growth and DNA repair processes. Its potential in treating aggressive tumors such as high grade serous ovarian cancer has been highlighted in recent studies.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Ophthalmology
Yimei Liu, Meiling Feng, Jingjing Cai, Shifeng Li, Xufeng Dai, Ge Shan, Shengzhou Wu
Summary: Intravitreal injection of bortezomib significantly reduced choroidal neovascularization (CNV) by inhibiting angiogenesis and leakage in a dose-dependent manner. The injection also decreased the levels of VEGF-A, MCP-1, and PDGF-D while inhibiting VEGFR-2 and PDGFRB pathways in the choroid/retinal pigment epithelium (RPE) tissue. Additionally, bortezomib injections hindered the recruitment of mural cells or macrophages to injured spots and had a negative impact on electroretinogram responses.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Usama Ramadan Abdelmohsen, Soad A. L. Bayoumi, Nesma M. Mohamed, Yaser A. Mostafa, Che J. Ngwa, Gabriele Pradel, Salwa F. Farag
Summary: Malaria is a dangerous parasitic disease, and new antimalarial drugs are urgently needed. Natural products, particularly phenylpropanoids, have shown potential as antimalarial agents. In this study, in silico analysis and in vitro assays were conducted to assess the antimalarial activity of naturally-occurring phenylpropanoids.
Article
Chemistry, Multidisciplinary
Pitchayathida Mee-udorn, Kochakorn Phiwkaow, Ruchanok Tinikul, Kamonpan Sanachai, Somchart Maenpuen, Thanyada Rungrotmongkol
Summary: This study used molecular docking to screen FDA-approved drugs and identified a new potential inhibitor of Plasmodium falciparum serine hydroxymethyltransferase (PfSHMT). Inhibition assays and molecular dynamics simulations confirmed the inhibitory effect and binding affinity of the compound, suggesting it as a rational approach for novel antimalarial drug design.
Review
Chemistry, Medicinal
Abraham Hang, Samuel Feldman, Aana Amin, Jorge A. Rivas Ochoa, Susanna Park
Summary: Vascular endothelial growth factors (VEGFs) are important in mediating complications associated with common retinal disorders and drugs that inhibit VEGF have been developed to minimize vision loss. These drugs are injected into the vitreous cavity in a clinic setting.
Article
Immunology
Divine C. Nwafor, Sreeparna Chakraborty, Allison L. Brichacek, Sujung Jun, Catheryne A. Gambill, Wei Wang, Elizabeth B. Engler-Chiurazzi, Duaa Dakhlallah, Anthony B. Pinkerton, Jose Luis Milian, Stanley A. Benkovic, Candice M. Brown
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Chemistry, Medicinal
Satyamaheshwar Peddibhotla, Paul M. Hershberger, R. Jason Kirby, Eliot Sugarman, Patrick R. Maloney, E. Hampton Sessions, Daniela Divlianska, Camilo J. Morfa, David Terry, Anthony B. Pinkerton, Layton H. Smith, Siobhan Malany
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Medicinal
Anthony B. Pinkerton, E. Hampton Sessions, Paul Hershberger, Patrick R. Maloney, Satyamaheshwar Peddibhotla, Meghan Hopf, Eduard Sergienko, Chen-Ting Ma, Layton H. Smith, Michael R. Jackson, Jun Tanaka, Takashi Tsuji, Mayuko Akiu, Steven E. Cohen, Tsuyoshi Nakamura, Stephen J. Gardell
Summary: NAD(+) is a crucial cellular factor with roles in various biological processes, low levels of which are associated with diseases. Activating NAMPT is a novel strategy to increase NAD(+) levels, and a newly discovered compound shows more potent activation.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Engineering, Electrical & Electronic
Ahmad Abdalrazik, Ahmed Gomaa, Ahmed A. Kishk
Summary: A hexaband, quad-circular-polarization slotted patch antenna has been proposed for various applications, with optimized design and feeding method to achieve high efficiency and low cost. The antenna supports quad-band CP operation and offers a wide range of potential applications.
IEEE ANTENNAS AND WIRELESS PROPAGATION LETTERS
(2021)
Article
Computer Science, Information Systems
Ahmed Gomaa, Tsubasa Minematsu, Moataz M. Abdelwahab, Mohammed Abo-Zahhad, Rin-ichiro Taniguchi
Summary: This paper proposes an efficient real-time approach for the detection and counting of moving vehicles based on YOLOv2 and features point motion analysis. By synchronously detecting and tracking vehicle features, accurate counting results are achieved. Experimental results show that the proposed method outperforms existing strategies and improves computational efficiency.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Oncology
Heng Lu, Ahmed Gomaa, Lihong Wang-Bishop, Farah Ballout, Tianling Hu, Oliver McDonald, Mary Kay Washington, Alan S. Livingstone, Timothy C. Wang, Dunfa Peng, Wael El-Rifai, Zheng Chen
Summary: Esophageal adenocarcinoma cells exploit the unfolded protein response for survival, with Aurora kinase A hijacking the pro-survival unfolded protein response in promoting cancer cell survival under stressful conditions. Targeting Aurora kinase A can reverse prosurvival unfolded protein response mechanisms and reduce cancer cell survival, offering a promising treatment approach for esophageal adenocarcinoma patients.
Article
Computer Science, Information Systems
Ahmad Abdalrazik, Ahmed Gomaa, Ahmed A. Kishk
Summary: This paper proposes a quadruple band stacked oval patch antenna that supports L1/L2/L5 GNSS bands and the 2.3 GHz WiMAX band. By etching sunlight-shaped slots into the patches, the antenna is able to fine-tune the phase shifts between different modes versions, resulting in enhanced axial-ratio beamwidth. Despite its simple structure and feeding mechanism, the proposed antenna achieves wider axial-ratio beamwidths compared to previous works.
Article
Geosciences, Multidisciplinary
Abdelhamid Elbshbeshi, Ahmed Gomaa, Abdelmonem Mohamed, Amal Othman, Hosni Ghazala
Summary: The Abu Simbel area in Egypt contains important temples, and the use of microtremor measurement has allowed for evaluation of the dynamic properties and vulnerability of the temples and surrounding region. The seismic vulnerability index was found to be consistent with the amplification factor, indicating the potential for earthquake disasters.
JOURNAL OF AFRICAN EARTH SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Brian E. Krumm, Jeffrey F. DiBerto, Reid H. J. Olsen, Hye Jin Kang, Samuel T. Slocum, Shicheng Zhang, Ryan T. Strachan, Xi-Ping Huang, Lauren M. Slosky, Anthony B. Pinkerton, Lawrence S. Barak, Marc G. Caron, Terry Kenakin, Jonathan F. Fay, Bryan L. Roth
Summary: The NTSR1 receptor is a GPCR found in the brain and peripheral tissues that binds with the endogenous peptide ligand NTS. Recent studies have shown that biasing NTSR1 towards beta-arrestin signaling can attenuate the effects of psychostimulants and drugs of abuse. This study provides cryoEM structures of NTSR1 complexes with Gq and GoA, and discusses the allosteric modulation of NTSR1 by the small-molecule SBI-553.
Article
Humanities, Multidisciplinary
AbdElhamid Elbshbeshi, Ahmed Gomaa, Abdelmonem Mohamed, Amal Othman, Ismael M. Ibraheem, Hosni Ghazala
Summary: It is becoming increasingly popular to use 3-D modeling and digital documentation in the preservation and restoration of heritage sites. This study focuses on developing a digital documentation process for Abu Simbel Temple in Egypt using laser scanning technology. The result is a 3-D digital model that includes various data and a virtual tour, which can help raise heritage awareness, promote tourism, and aid in future restoration efforts.
Meeting Abstract
Gastroenterology & Hepatology
Ahmed R. Gomaa, Zheng Chen, Mohammed Soutto, Shoumin Zhu, Nadeem S. Bhat, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Heng Lu, Ahmed R. Gomaa, Lihong Bishop, Longlong Cao, Wael El-Rifai, Dunfa Peng, Zheng Chen
Meeting Abstract
Gastroenterology & Hepatology
Zheng Chen, Ahmed R. Gomaa, Lihong Bishop, Longlong Cao, Mohammed Soutto, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Ahmed R. Gomaa, Zheng Chen, Mohammed Soutto, Nadeem S. Bhat, Shoumin Zhu, Wael El-Rifai