Article
Gastroenterology & Hepatology
Quazim A. Alayo, Edward Loftus Jr, Andres Yarur, David Alvarado, Matthew A. Ciorba, Lisa de las Fuentes, Parakkal Deepak
Summary: Population-based studies have shown that patients with inflammatory bowel disease (IBD) have an increased risk of acute arterial events (AAEs). This study aimed to assess the risk of incident AAEs and premature AAEs in participants with IBD in the UK Biobank (UKB) and found that IBD patients had a higher risk of AAEs and premature AAEs compared to non-IBD controls.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Timothy R. Card, Eran Zittan, Geoffrey C. Nguyen, Matthew J. Grainge
Summary: The study aimed to assess the cardiovascular risk in patients with inflammatory bowel diseases, finding no overall excess of vascular events in the IBD group, but an increased risk of myocardial infarction with more active disease. This suggests the potential for anti-inflammatory therapies to reduce cardiovascular risk in IBD patients.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Biology
Alina Ecaterina Jucan, Otilia Gavrilescu, Mihaela Dranga, Iolanda Valentina Popa, Bogdan Mircea Mihai, Cristina Cijevschi Prelipcean, Catalina Mihai
Summary: New research suggests a possible link between inflammatory bowel disease (IBD) and an increased risk of ischemic heart disease (IHD). The disruption of the intestinal mucosal barrier in IBD may lead to the translocation of endotoxins into the bloodstream, triggering a pro-inflammatory response that can contribute to endothelial dysfunction, atherosclerosis, and acute cardiovascular events. It is crucial to monitor and manage cardiovascular risk factors in IBD patients, and optimize therapy during active flares. Further studies, biomarkers, and scoring systems are needed for optimal management of IHD risk in IBD patients.
Article
Gastroenterology & Hepatology
Pablo A. Olivera, Stephane Zuily, Paulo G. Kotze, Veronique Regnault, Sameer Al Awadhi, Peter Bossuyt, Richard B. Gearry, Subrata Ghosh, Taku Kobayashi, Patrick Lacolley, Edouard Louis, Fernando Magro, Siew C. Ng, Alfredo Papa, Tim Raine, Fabio Teixeira, David T. Rubin, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of venous and arterial thrombotic events. This Evidence-Based Guideline provides 19 recommendations for clinical practice, including the use of thromboprophylaxis during hospitalization and aiming for deep remission to reduce risk. Therapies for IBD may modulate this risk, and antitumour necrosis factor agents could potentially reduce the risk of thrombotic events.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Medicine, Research & Experimental
Lu-guang Li, Xin Ma
Summary: Ischemic cerebrovascular disease (ICVD) is a major cause of mortality and disability worldwide and is often caused by atherosclerosis. ICVD is easily complicated by lower-extremity peripheral arterial disease (PAD) and the management of coexistent PAD in ICVD patients is often neglected. Duplex ultrasound is a preferred method for early screening and evaluation of PAD in ICVD patients. New antithrombotic strategies are expected to further reduce the incidence of stroke in ICVD patients with PAD.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Bing Chen, Lauren V. Collen, Craig Mowat, Kim L. Isaacs, Siddharth Singh, Sunanda V. Kane, Francis A. Farraye, Scott Snapper, Hani Jneid, Carl J. Lavie, Chayakrit Krittanawong
Summary: This article reviews the association between chronic inflammatory bowel disease and atherosclerotic cardiovascular diseases, heart failure, and atrial fibrillation. The mechanisms underlying this association may involve shared risk factors and pathophysiology. A multidisciplinary team is needed for optimal care.
AMERICAN JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Ana Maria Pello Lazaro, Luis M. Blanco-Colio, Juan Antonio Franco Pelaez, Jose Tunon
Summary: Inflammation plays a significant role in atherogenesis and plaque complications, with certain drugs showing anti-inflammatory effects. Inflammatory biomarkers can predict cardiovascular events. Some anti-inflammatory drugs have been successful in reducing the incidence of cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Mi Jung Kwon, Hyo Geun Choi, Yoo Hwan Kim, Joo-Hee Kim, Hyun Taek Rim, Heui Seung Lee, Jae Keun Oh, In Bok Chang, Joon Ho Song, Ji Hee Kim
Summary: A longitudinal follow-up study in Korea found a significant association between migraine and the development of stroke and ischemic heart disease, even after adjusting for cardiovascular risk factors.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Immunology
Xiaoqian Sun, Yanqin Li, Qiong Deng, Yueyao Hu, Jianteng Dong, Wei Wang, Yong Wang, Chun Li
Summary: Macrophages undergo metabolic reprogramming, which influences their inflammatory function. In ischemic heart disease, the polarization and metabolic shifts of macrophages can affect the balance of inflammatory effects and determine disease progression and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Antoni Stadnicki, Izabela Stadnicka
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of thromboembolism (TE), particularly in venous TE (VTE). The risk of arterial TE (ATE) is less significant but the heightened risk of cardiovascular diseases must be addressed in IBD patients. The mechanisms underlying arterial and venous thrombosis in IBD are similar and may be triggered by impaired intestinal barrier and bacterial components.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Immunology
Jianli Zhou, Qiao Zhang, Yuzhen Zhao, Yuchen Song, Yanan Leng, Moxian Chen, Shaoming Zhou, Zhaoxia Wang
Summary: Inflammatory bowel disease (IBD) is a group of chronic diseases including Crohn's disease and ulcerative colitis, which have a global impact on both children and adults. The burden of IBD is increasing worldwide, and the costs associated with it are high. The pathogenesis of IBD is still unclear, but is believed to be related to environmental factors, gut microbiota, immune imbalance, and genetic susceptibility. This article reviews the research progress on alternative splicing events, splicing factors, and splicing mutations associated with IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Elsa A. van Wassenaer, Renee R. van der Klift, Mira S. Staphorst, Johanna H. van der Lee, Marc A. Benninga, Bart G. P. Koot
Summary: Children with inflammatory bowel disease (IBD) reported low discomfort after undergoing monitoring tests such as ultrasound (US), magnetic resonance entrography (MRE), and gastro-intestinal (GI)-endoscopy. Among these tests, GI-endoscopy was rated as most discomfortable, while US was preferred as a monitoring tool among non-invasive options.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Anand Kumar, Vinayak Shenoy, Megan C. Buckley, Laura Durbin, James Mackey, Anjali Mone, Arun Swaminath
Summary: This study found that endoscopic disease activity is a factor affecting the quality of bowel preparation in patients with IBD, while biologic therapy helps reduce the incidence of suboptimal bowel preparation.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Tiberiu A. Pana, Mohamed O. Mohamed, Allan B. Clark, Eoin Fahy, Mamas A. Mamas, Phyok. Myint
Summary: This study examined the impact of atrial fibrillation and heart failure on the prognosis of patients with acute ischemic stroke, as well as the effects of revascularization therapies on their outcomes. The results indicated that both atrial fibrillation and heart failure were associated with increased in-hospital mortality, with a greater impact seen in patients with both conditions. Additionally, it was found that revascularization therapies significantly improved outcomes in these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Gorm Roager Madsen, Kristina Bertl, Nikolaos Pandis, Andreas Stavropoulos, Johan Burisch
Summary: In this questionnaire-based study, periodontitis was found to be significantly associated with increased IBD disease activity in the last 12 months, as well as increased IBD disability.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Lucile Dheyriat, Daniel Ward, Laurent Beaugerie, Tine Jess, Julien Kirchgesner
Summary: Patients with inflammatory bowel disease (IBD) are at increased risk of acute arterial events. The use of anti-tumor necrosis factor (anti-TNF) agents has a protective effect against the first occurrence of acute arterial events. In this study, the effect of anti-TNF and thiopurines on the risk of recurrent acute arterial events in IBD patients with a previous history of such events was assessed.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Lucas Guillo, Benoit Flachaire, Jerome Avouac, Catherine Dong, Maria Nachury, Guillaume Bouguen, Anthony Buisson, Ludovic Caillo, Mathurin Fumery, Cyrielle Gilletta, Xavier Hebuterne, Pierre Lafforgue, David Laharie, Emmanuel Mahe, Hubert Marotte, Stephane Nancey, Sebastien Ottaviani, Jean-Hugues Salmon, Guillaume Savoye, Melanie Serrero, Mathieu Uzzan, Manuelle Viguier, Christophe Richez, Laurent Peyrin-Biroulet, Philipe Seksik, Thao Pham
Summary: In a French multicenter cohort study, the effectiveness and safety of combination therapies (COMBIO) were assessed in patients with refractory/overlapping immune-mediated inflammatory diseases (IMIDs).
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Aurelien Amiot, Jean-Francois Rahier, Filip Baert, Stephane Nahon, Ailsa Hart, Nikos Viazis, Livia Biancone, Eugeni Domenech, Catherine Reenears, Laurent Peyrin-Biroulet, Laurent Beaugerie, Johan Burisch
Summary: This study reports on the impact of the COVID-19 outbreak in patients with inflammatory bowel disease (IBD). The results show that the risk of COVID-19 and severe COVID-19 is not increased in IBD patients compared to the general population. There is also no negative impact of IBD-related medication on the risk of COVID-19 or severe COVID-19. Additionally, the COVID-19 outbreak led to a decrease in endoscopic and imaging procedures, but did not affect clinical activity and treatment.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Jean-Francois Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamas Molnar, Mark Lowenberg, Jonas Halfvarson, Edyta Zagorowicz, Helene Rousseau, Cedric Baumann, Filip Baert, Laurent Beaugerie
Summary: The I-CARE study aims to evaluate the benefit-risk ratio of current therapies in IBD patients. It collected data from 10,206 patients and observed the treatment risks of anti-tumor necrosis factor and other biologic therapies, particularly the risks of cancer/lymphoma and serious infections. The results showed that different treatment regimens had varying effects on patients, and further research is needed to assess specific risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Camille Danne, Chloe Michaudel, Jurate Skerniskyte, Julien Planchais, Aurelie Magniez, Allison Agus, Marie-Laure Michel, Bruno Lamas, Gregory Da Costa, Madeleine Spatz, Cyriane Oeuvray, Chloe Galbert, Maxime Poirier, Yazhou Wang, Alexia Lapiere, Nathalie Rolhion, Tatiana Ledent, Cedric Pionneau, Solenne Chardonnet, Floriant Bellvert, Edern Cahoreau, Amandine Rocher, Rafael Rose Arguello, Carole Peyssonnaux, Sabine Louis, Mathias L. Richard, Philippe Langella, Jamel El-Benna, Benoit Marteyn, Harry Sokol
Summary: Inflammatory bowel disease (IBD) is caused by a combination of genetic predisposition, gut microbiota dysbiosis, and environmental factors. Caspase recruitment domain 9 (Card9) is an IBD susceptibility gene that has been shown to protect against intestinal inflammation and fungal infection. However, the specific cell types and mechanisms involved in the CARD9 protective role against inflammation are still unknown.
Article
Gastroenterology & Hepatology
Chloe Michaudel, Camille Danne, Allison Agus, Aurelie Magniez, Anne Aucouturier, Madeleine Spatz, Antoine Lefevre, Julien Kirchgesner, Nathalie Rolhion, Yazhou Wang, Aonghus Lavelle, Chloe Galbert, Gregory Da Costa, Maxime Poirier, Alexia Lapiere, Julien Planchais, Petr Nadvornik, Peter Illes, Cyriane Oeuvray, Laura Creusot, Marie-Laure Michel, Nicolas Benech, Anne Bourrier, Isabelle Nion-Larmurier, Cecilia Landman, Mathias L. Richard, Patrick Emond, Philippe Seksik, Laurent Beaugerie, Rafael Rose Arguello, David Moulin, Sridhar Mani, Zdenek Dvorak, Luis G. Bermudez-Humaran, Philippe Langella, Harry Sokol
Summary: This study identified a new mechanism linking tryptophan metabolism to intestinal inflammation and inflammatory bowel diseases (IBDs). Bringing back xanthurenic acid (XANA) and kynurenic acid (KYNA) has protective effects involving Aryl hydrocarbon Receptor (AhR) activation and the rewiring of cellular energy metabolism in intestinal epithelial cells and CD4(+) T cells. Manipulating the endogenous metabolic pathway with aminoadipate aminotransferase (AADAT) may provide new therapeutic strategies for correcting tryptophan metabolism alterations in IBD.
Article
Multidisciplinary Sciences
Katherine M. Kennedy, Marcus C. de Goffau, Maria Elisa Perez-Munoz, Marie-Claire Arrieta, Fredrik Backhed, Peer Bork, Thorsten Braun, Frederic D. Bushman, Joel Dore, Willem M. de Vos, Ashlee M. Earl, Jonathan A. Eisen, Michal A. Elovitz, Stephanie C. Ganal-Vonarburg, Michael G. Ganzle, Wendy S. Garrett, Lindsay J. Hall, Mathias W. Hornef, Curtis Huttenhower, Liza Konnikova, Sarah Lebeer, Andrew J. Macpherson, Ruth C. Massey, Alice Carolyn McHardy, Omry Koren, Trevor D. Lawley, Ruth E. Ley, Liam O'Mahony, Paul W. O'Toole, Eric G. Pamer, Julian Parkhill, Jeroen Raes, Thomas Rattei, Anne Salonen, Eran Segal, Nicola Segata, Fergus Shanahan, Deborah M. Sloboda, Gordon C. S. Smith, Harry Sokol, Tim D. Spector, Michael G. Surette, Gerald W. Tannock, Alan W. Walker, Moran Yassour, Jens Walter
Summary: The colonization of microbial communities in the human fetus and the prenatal intrauterine environment is still controversial. Recent studies analyzing microbial populations in human fetuses indicate that the detected signals might be due to contamination during sample collection or DNA sequencing processes. The presence of live and replicating microbial populations in healthy fetal tissues contradicts fundamental concepts in immunology and clinical microbiology. This has significant implications for our understanding of human immune development and highlights the challenges in studying microbial communities in low-biomass environments.
Article
Substance Abuse
Tetsuya Kouno, Suling Zeng, Yanhan Wang, Yi Duan, Sonja Lang, Bei Gao, Phillipp Hartmann, Noemi Cabre, Cristina Llorente, Chloe Galbert, Patrick Emond, Harry Sokol, Michael James, Chun Cheih Chao, Jian-Rong Gao, Mylene Perreault, David L. Hava, Bernd Schnabl
Summary: This study demonstrates that engineering gut bacteria to produce tryptophan metabolites can alleviate liver disease caused by alcohol through Ahr activation in intestinal immune cells.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Letter
Gastroenterology & Hepatology
Julien Kirchgesner, Magali Svrcek
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Thomas Wolf, Ayanna Lewis, Laurent Beaugerie, Magali Svrcek, Julien Kirchgesner, St Antoine IBD Network
Summary: In patients with inflammatory bowel disease, post-inflammatory polyps do not increase the risk of colorectal neoplasia after controlling for histologic activity.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Adeline Dolly, Sarah A. Potgens, Morgane M. Thibaut, Audrey M. Neyrinck, Gabriela S. de Castro, Chloe Galbert, Camille Lefevre, Elisabeth Wyart, Silvio P. Gomes, Daniela C. Goncalves, Nicolas Lanthier, Pamela Baldin, Joshua R. Huot, Andrea Bonetto, Marilia Seelaender, Nathalie M. Delzenne, Harry Sokol, Laure B. Bindels
Summary: This study explores the potential role of the aryl hydrocarbon receptor (AHR) in cancer cachexia and finds that impaired AHR signaling contributes to hepatic inflammatory and metabolic disorders, exacerbating cachectic features. These findings provide innovative therapeutic strategies for cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Immunology
Leslie Landemaine, Gregory Da Costa, Elsa Fissier, Carine Francis, Stanislas Morand, Jonathan Verbeke, Marie-Laure Michel, Romain Briandet, Harry Sokol, Audrey Gueniche, Dominique Bernard, Jean-Marc Chatel, Luc Aguilar, Philippe Langella, Cecile Clavaud, Mathias L. Richard
Summary: This study demonstrates that Staphylococcus epidermidis strains originating from healthy skin and atopic skin have different effects. Strains from atopic skin alter the structure of a 3D reconstructed skin model, while strains from healthy skin do not. The metabolites produced by strains from healthy skin can activate the aryl hydrocarbon receptor pathway, while strains from atopic skin cannot.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Madeleine Spatz, Gregory Da Costa, Rebecka Ventin-Holmberg, Julien Planchais, Chloe Michaudel, Yazhou Wang, Camille Danne, Alexia Lapiere, Marie-Laure Michel, Kaija-Leena Kolho, Philippe Langella, Harry Sokol, Mathias L. Richard
Summary: This study investigated the effects of antibiotic treatment on the fungal microbiota in the gut. It was found that amoxicillin-clavulanic acid treatment led to a decrease in the overall fungal population in mouse feces and a remodeling of the fungal community. Certain bacterial strains were shown to inhibit fungal growth. This study provides new insights into the interactions between fungi and bacteria in the gut and may offer new strategies for modulating gut microbiota equilibrium.
Review
Microbiology
Nicolas Benech, Harry Sokol
CURRENT OPINION IN MICROBIOLOGY
(2023)