4.6 Article

Psychosocial stress and central adiposity: A Brazilian study with a representative sample of the public health system users

期刊

PLOS ONE
卷 13, 期 7, 页码 -

出版社

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0197699

关键词

-

资金

  1. Foundation for Research and Innovation Support of the State of Espirito Santo - FAPES [SUS - PPSUS 10/2013, 74713515/2016, PPSUS 05/2015, 65883616/2014]

向作者/读者索取更多资源

Objective To assess the association between indicators of psychosocial stress and central adiposity in adult users of the Unified Health System (SUS) from Southeast of Brazil. Methods This cross-sectional study was conducted with 384 adults (20 to 59 years old) from the city of Alegre, Southeastern Brazil. The simple random sample represented the population using the public health system of the municipality. The prevalence of obesity was based on the Body Mass Index, and central adiposity (dependent variable) was measured by waist circumference in centimeters. The independent variables were the following indicators of psychosocial stress: food and nutrition insecurity (yes/no), serum cortisol (mu g/dL), symptoms suggestive of depression using the Beck Depression Inventory-II > 17 (yes/no), and altered blood pressure > 130/85 mmHg (yes/no). Univariate linear regression was performed between central adiposity and each stress indicator, and later the models were adjusted for socioeconomic, health, and lifestyle variables. All analyses were made separately by rural and urban location. Results The prevalence of weight excess, by the classification of the Body Mass Index > 25.0 kg/ m2, was 68.3% and, by waist circumference, 71.5% of individuals presented an increased risk for metabolic complications related to central adiposity. Mean waist circumference scores for the rural and urban population were 89.3 +/- 12.7 cm and 92.9 +/- 14.7 cm, respectively (p = 0.012). Indicators of stress that were associated with central adiposity were: cortisol in the rural population (beta = -0.60; 95% CI = -1.09;-0.11) and altered blood pres- Competing interests: The authors have declared sure in the urban population (beta = 6.66; 95% CI = 2.14;11.18). This occurred both in the raw analysis and in the models adjusted for confounding factors. Conclusion Central adiposity was inversely associated with cortisol in the rural population and directly associated with higher arterial blood pressure in the urban population, suggesting a local influence on how individuals react to stress.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Behavioral Sciences

Food and nutritional insecurity is associated with depressive symptoms mediated by NR3C1 gene promoter 1F methylation

Aline Ribeiro Borcoi, Suzanny Oliveira Mendes, Ivana Alece Arantes Moreno, Joaquim Gasparini dos Santos, Flavia Vitorino Freitas, Julia Assis Pinheiro, Mayara Mota de Oliveira, Wagner Miranda Barbosa, Juliana Kruger Arpini, Anderson Barros Archanjo, Andre Willian Hollais, Cinthia Vidal Monteiro da Silva Couto, Camila Vieira Chagas David, Barbara Risse Quaioto, Bruna Pereira Sorroche, Iuri Drumond Louro, Lidia Maria Rebolho Batista Arantes, Adriana Madeira Alvares-da-Silva

Summary: This study aimed to investigate the relationship between socioeconomic stressors, epigenetic changes in the NR3C1-1F gene, and depressive symptoms, suggesting that FNiS may lead to depressive symptoms and that NR3C1-1F DNA methylation can act as a mediator in this relationship.

STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS (2021)

Article Multidisciplinary Sciences

Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation

Julia de Assis Pinheiro, Flavia Vitorino Freitas, Aline Ribeiro Borcoi, Suzanny Oliveira Mendes, Catarine Lima Conti, Juliana Krueger Arpini, Tamires dos Santos Vieira, Rafael Assis de Souza, Dirceu Pereira dos Santos, Wagner Miranda Barbosa, Anderson Barros Archanjo, Mayara Mota de Oliveira, Joaquim Gasparini dos Santos, Bruna Pereira Sorroche, Jose Claudio Casali-da-Rocha, Leonardo Oliveira Trivilin, Elizeu Batista Borloti, Iuri Drumond Louro, Lidia Maria Rebolho Batista Arantes, Adriana Madeira Alvares-da-Silva

Summary: NR3C1 gene methylation is associated with trauma and mental issues, and its regulation under environmental effects is complex. Alcohol consumption, overweight, and high cortisol levels are related to NR3C1 demethylation, while depression is related to its methylation.

SCIENTIFIC REPORTS (2021)

Article Multidisciplinary Sciences

Chlorine, chromium, proteins of oxidative stress and DNA repair pathways are related to prognosis in oral cancer

Aricia Leone Evangelista Monteiro de Assis, Anderson Barros Archanjo, Raul C. Maranhao, Suzanny O. Mendes, Rafael P. de Souza, Rafael de Cicco, Mayara M. de Oliveira, Aline R. Borcoi, Lucas de L. Maia, Fabio D. Nunes, Marcelo dos Santos, Leonardo O. Trivilin, Christiano J. G. Pinheiro, Adriana M. Alvares-da-Silva, Breno Valentim Nogueira

Summary: Comparing chemical and histopathological data with clinical progression in OSCC patients reveals potential biomarkers for tumor aggressiveness and prognosis. Enzymes related to oxidative stress and DNA repair play a crucial role in tumor growth and relapse, while trace elements may serve as disease prognosis markers. Targeting these factors could lead to novel therapeutic strategies for managing OSCC.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Virtual screening and in vitro assays of novel hits as promising DPP-4 inhibitors

Simone Queiroz Pantaleao, Eric Allison Philot, Heberth de Paula, Mirela Ines de Sairre, Angelica Nakagawa Lima, Loren Monielly Pires, Raquel Alves dos Santos, Ana Ligia Scott, Kathia Maria Honorio

Summary: This study aimed to find new inhibitors of the DPP-4 enzyme for the treatment of diabetes through virtual screening. By analyzing the physicochemical properties, molecular interactions, and biological assays of compounds, a potential DPP-4 inhibitor was discovered.

BIOCHIMIE (2022)

Article Medicine, Research & Experimental

Lifestyle and NR3C1 exon 1F gene methylation is associated with changes in glucose levels and insulin resistance

Marcele Lorentz Mattos de Souza, Aline Ribeiro Borcoi, Bruna Aparecida Borges Dutra, Tamires dos Santos Vieira, Suzanny Oliveira Mendes, Ivana Alece Arantes Moreno, Barbara Risse Quaioto, Amanda Sgrancio Olinda, Ester Ribeiro Cunha, Flavia Vitorino Freitas, Julia Assis Pinheiro, Joaquim Gasparini dos Santos, Bruna Pereira Sorroche, Lidia Maria Rebolho Batista Arantes, Carmem Luiza Sartorio, Adriana Madeira Alvares da Silva

Summary: This study investigated the relationship between glucose and insulin levels and NR3C1 gene methylation in adults. The results showed that age and NR3C1 gene methylation were directly related to glucose levels and insulin resistance, while not being overweight and obese, and not smoking were indirectly related to glucose levels and insulin resistance. The findings suggest that habits and lifestyle may influence the regulation of the NR3C1 gene.

LIFE SCIENCES (2022)

Article Agriculture, Multidisciplinary

Synthesis and Phytotoxic Evaluation of Isatin Derivatives Supported by 3D-QSAR Study

Pedro Alves Bezerra Morais, Karolinni B. Britto, Evandro Messias, Peterson de Andrade, Elias Werner, Adilson Vidal Costa, Valdemar Lacerda Jr, Christiano Jorge Gomes Pinheiro, Heberth de Paula, Warley de Souza Borges

Summary: To address the issues of weed infestation and herbicide resistance, the authors synthesized eight isatin derivatives using Click Chemistry. These derivatives were evaluated for their phytotoxic activity against two model plants, Lactuca sativa and Allium cepa. Six derivatives showed similar activity to the positive control trifluralin, with compound 8 being more active than trifluralin in L. sativa. ALS crystallographic structure analysis revealed the inhibitory activity of compounds 11 and 17 against A. cepa.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

Article Neurosciences

Methylation of BDNF gene in association with episodic memory in women

Ivana Alece Arantes Moreno, Daniela Rodrigues de Oliveira, Aline Ribeiro Borcoi, Luciana Fungaro Rissatti, Flavia Vitorino Freitas, Lidia Maria Rebolho Batista Arantes, Suzanny Oliveira Mendes, Tamires dos Santos Vieira, Barbara Risse Quaioto, Paola Cerbino Doblas, Amanda Sgrancio Olinda, Ester Ribeiro Cunha, Joaquim Gasparini dos Santos, Julia Assis Pinheiro, Bruna Pereira Sorroche, Adriana Madeira Alvares da Silva

Summary: This study aimed to explore the association between DNAm levels in BDNF promoter IV and verbal learning and memory performance in healthy women. A cross-sectional study was conducted with 53 individuals, and episodic memory was assessed using the Rey Auditory Verbal Learning Test (RAVLT). The results showed that DNAm at CpG site 5 was significantly associated with learning capacity, with a 0.068 reduction in verbal learning performance for every 1% increase in DNAm at CpG site 5.

FRONTIERS IN NEUROSCIENCE (2023)

Article Medicine, General & Internal

PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: A cross-sectional study

Mayara Mota de Oliveira, Gabriela Tonini Peterle, Cinthia Vidal Monteiro da Silva Couto, Lucas de Lima Maia, Andre Kuhl, Joaquim Gasparini dos Santos, Raquel Ajub Moyses, Leonardo Oliveira Trivilin, Aline Ribeiro Borcoi, Anderson Barros Archanjo, Aricia Leone Evangelista Monteiro de Assis, Fabio Daumas Nunes, Marcelo dos Santos, Adriana Madeira Alvares da Silva

Summary: The study revealed a significant association between positive PAI-1 expression in mononuclear inflammatory cell infiltrate and lymph node status as well as cytoplasmic expression of VEGFA in OSCC. Multivariate analysis demonstrated weak PAI-1 expression as an independent marker for lymph node metastases, with approximately 8-fold increased risk compared to strong expression.

ANNALS OF MEDICINE AND SURGERY (2021)

Article Parasitology

Occurrence of Meloidogyne arenaria in black pepper (Piper nigrum L.) in the extreme south of the State of Bahia, Brazil

R. A. De Souza, F. R. Alves, C. M. G. De Oliveira, J. M. O. Rosa, J. De Assis Pinheiro, G. P. De Aguiar, W. B. Moraes

Summary: Samples of black pepper root from the southern region of Bahia, Brazil, were characterized biochemically and morphologically to identify the presence of galls, using three criteria. This study resulted in the first report of the pathosystem involving Meloidogyne arenaria in the State.

HELMINTHOLOGIA (2021)

暂无数据