Article
Endocrinology & Metabolism
Junwei Zhang, Mingze Du, Zhen Li, Wenxia Liu, Bingnan Ren, Yuchao Zhang, Yichun Guan
Summary: The clinical outcomes of dydrogesterone (DYG) and medroxyprogesterone (MPA) in the progestin-primed ovarian stimulation (PPOS) protocol for patients with poor ovarian response (POR) were found to be similar, indicating that both combinations can be useful options for PPOS protocols.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Hyun Joo Lee, Hye Kyung Noh, Jong Kil Joo
Summary: The aim of this study was to evaluate whether the POSEIDON criteria can predict the prognosis of COS. The study found that ovarian reserve seems to outweigh patients' age when predicting the ART outcomes of low-responder infertile women. However, when there are no differences in ovarian reserve, younger women with low AMH have a higher probability of pregnancy than their AMH-matched older counterparts.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Judith-Marie Mifsud, Livia Pellegrini, Mauro Cozzolino
Summary: Ovarian endometriosis affects fertility, but oocyte cryopreservation offers the opportunity to preserve fertility and achieve a live birth for patients diagnosed with this condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
J. Bruno-Gaston, J. Jung, T. Kumar, P. Zarutskie, W. Gibbons, S. Devaraj
Summary: This study evaluated the diagnostic performance of high-sensitivity picoAMH ELISA in predicting ovarian response and ovarian hyperstimulation syndrome. The results demonstrated that picoAMH is a valuable tool for predicting ovarian response and outperformed AFC in predicting OHSS.
CLINICAL BIOCHEMISTRY
(2021)
Article
Obstetrics & Gynecology
Marcelle I. Cedars
Summary: This month's Views and Reviews focuses on individuals with low ovarian reserve and limited response to stimulation, providing insights into patient characterization and alternative management strategies.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Quoc Huy Hoang, Hung Sy Ho, Huong Thuy Do, Tien Viet Nguyen, Hong Phuong Nguyen, Minh Tam Le
Summary: The study demonstrated that applying TTG in infertile women with POR may improve outcomes of IVF, but extending the application of TTG to 6 weeks did not significantly improve the response to ovarian stimulation or pregnancy outcomes compared to 4 weeks of pretreatment.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2021)
Article
Medicine, General & Internal
Junyu Zhai, Shang Li, Yinci Zhu, Yun Sun, Zi-Jiang Chen, Yanzhi Du
Summary: Serum SHBG concentration is positively correlated with ovarian response in non-PCOS patients, but not in PCOS patients.
FRONTIERS IN MEDICINE
(2021)
Review
Endocrinology & Metabolism
Rong-Rong Wang, Meng-Hua Su, Li-Ying Liu, Yuan-Yuan Lai, Xiao-Li Guo, Di Gan, Xiao-Yan Zheng, Han Yang, Si-Yi Yu, Fan-Rong Liang, Wei Wei, Ying Zhong, Jie Yang
Summary: This study aimed to determine the effect of acupuncture in treating poor ovarian response (POR). Seven randomized controlled trials were included for analysis, which revealed that acupuncture combined with assisted therapy can significantly improve implantation rate, number of oocytes retrieved, endometrial thickness, antral follicle count, reduce follicle-stimulating hormone levels, and improve estradiol levels. However, no statistical variation was observed in improving clinical pregnancy rate and other related outcomes. The effectiveness of acupuncture in improving the pregnancy outcome of POR patients remains doubtful, and more randomized controlled trials are needed for future meta-analyses to confirm its efficacy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Haixia Song, Qin Qin, Caixia Yuan, Hong Li, Fang Zhang, Lingling Fan
Summary: The study used LC-MS to analyze the serum metabolomic profile in women with POR, identifying potential biological markers and significant differences in the nicotinate and nicotinamide metabolism pathway, hinting at new insights for prediction and therapy of POR. Further investigation into the functional associations of these metabolites is warranted.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Jihyun Kim, Hoyoung Lee, Tae-Young Choi, Joong Il Kim, Byoung-Kab Kang, Myeong Soo Lee, Jong Kil Joo, Kyu Sup Lee, Sooseong You
Summary: The study showed that network-optimized acupuncture followed by IVF treatment significantly increased the number of retrieved mature oocytes in women with poor ovarian response, especially in those aged over 37 years and undergoing multiple controlled ovarian hyperstimulation cycles. The negative correlation between the number of retrieved mature oocytes and consecutive controlled ovarian hyperstimulation cycles was not observed in the acupuncture + IVF group, suggesting that acupuncture may be considered as a beneficial treatment option for women facing poor ovarian response and advanced maternal age or multiple IVF cycles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Diane M. Tober, Kevin Richter, Dougie Zubizarreta, Said Daneshmand
Summary: This study aimed to evaluate self-reported survey data from US oocyte donors on their experiences with ovarian hyperstimulation syndrome (OHSS) and investigate possible correlations between OHSS severity and number of oocytes retrieved, trigger type, and prior OHSS history. An 85-question retrospective survey was conducted online, and the results showed that donors who received GnRH agonist triggers reported milder OHSS compared to those who received hCG or dual triggers. Among donors undergoing multiple retrieval cycles, the severity of OHSS in the second cycle was strongly associated with the severity in the first cycle.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Endocrinology & Metabolism
Philippe R. Koninckx, Rodrigo Fernandes, Anastasia Ussia, Larissa Schindler, Arnaud Wattiez, Shaima Al-Suwaidi, Bedayah Amro, Basma Al-Maamari, Zeinab Hakim, Muna Tahlak
Summary: Understanding the pathophysiology of endometriosis is changing the approach to diagnosis and treatment, with factors such as aromatase activity and progesterone resistance being key. Diagnosis is primarily through laparoscopy guided by clinical experience, and medical therapy after surgery may be necessary to prevent new lesions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chia Lin Chang
Summary: The decline in fertility in aging women, especially those with poor ovarian response (POR) or primary ovarian insufficiency (POI), is a major concern. Researchers have explored alternative approaches, including adjunct interventions and mechanical procedures, to improve fertility outcomes. However, the molecular mechanisms underlying fertility decline in aging women are not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Athanasios Papathanasiou, Nausheen Mawal
Summary: The research found that the risk of POR during repeat IVF is approximately 11.5% and is mainly associated with oocyte yield and ovarian reserve levels during the initial treatment, with women with low ovarian reserve having the highest risk of POR.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Shai E. Elizur, Adva Aizer, Michal Yonish, Tal Shavit, Raoul Orvieto, Roy Mashiach, Shlomo B. Cohen, Elad Berkowitz
Summary: This retrospective cohort study aimed to evaluate the outcome of fertility-preservation treatments in women with endometrioma, particularly those with endometrioma larger than 4 cm. The results showed that women who underwent surgery for endometrioma before fertility-preservation treatment had a significant reduction in the number of MII oocytes. However, among those who did not undergo surgery, the size of endometrioma did not affect the outcomes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Multidisciplinary Sciences
Mathilde Bourdon, Pietro Santulli, Chloe Maignien, Vanessa Gayet, Khaled Pocate-Cheriet, Louis Marcellin, Charles Chapron
Article
Multidisciplinary Sciences
Mathilde Bourdon, Pietro Santulli, Chloe Maignien, Khaled Pocate-Cheriet, Asim Alwohaibi, Louis Marcellin, Sarah Blais, Charles Chapron
Article
Developmental Biology
M. Bourdon, P. Santulli, L. Doridot, M. Jeljeli, C. Chene, S. Chouzenoux, C. Nicco, L. Marcellin, C. Chapron, F. Batteux
Summary: The study showed that aberrant expression of immune cell markers, particularly increased inflammatory cell markers and decreased B cell markers, was observed during the development of adenomyosis. Additionally, activation of Notch1 signaling was associated with abnormal expression of immune and EMT markers in the early stages of adenomyosis development.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Pietro Santulli, Mathilde Bourdon, Sonia Koutchinsky, Chloe Maignien, Louis Marcellin, Lorraine Maitrot-Mantelet, Khaled Pocate Cheriet, Catherine Patrat, Charles Chapron
Summary: In women with endometriosis undergoing fertility preservation, factors such as previous surgery for ovarian endometriosis, age, and total dose of gonadotrophin used significantly affect the oocyte yield after ovarian stimulation. Additionally, anti-Mullerian hormone levels and gravidity are positively correlated with an increase in the number of retrieved oocytes after the first stimulation cycle.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Mathilde Bourdon, Benjamine Pham, Louis Marcellin, Corinne Bordonne, Anne Elodie Millischer, Chloe Maignien, Pietro Santulli, Charles Chapron
Summary: This study found that women with radiologically diagnosed adenomyosis who also had endometriosis had a significantly higher risk of miscarriage. The risk was even higher for those with deep infiltrating endometriosis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Chloe Maignien, Mathilde Bourdon, Louis Marcellin, Christelle Laguillier-Morizot, Didier Borderie, Ahmed Chargui, Catherine Patrat, Genevieve Plu-Bureau, Charles Chapron, Pietro Santulli
Summary: This study aimed to investigate whether the serum progesterone concentration on the day of vitrified-warmed embryo transfer would affect the live birth rate. The study found that a low serum progesterone concentration was associated with lower live birth rate and higher early miscarriage rate.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Chloe Maignien, Mathilde Bourdon, Juan Pablo Scarano-Pereira, Alessandro Martinino, Meryam Cheloufi, Louis Marcellin, Charles Chapron, Pietro Santulli
Summary: This study compared the cumulative live birth rates in endometriosis patients undergoing assisted reproductive technology after laparoscopic salpingectomy and hysteroscopic proximal tubal occlusion. The results showed that in the management of hydrosalpinx, both treatments had similar cumulative live birth rates.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
M. Bourdon, P. Santulli, C. Bordonne, A. E. Millisher, L. Maitrot-Mantelet, C. Maignien, L. Marcellin, L. Melka, C. Chapron
Summary: This study observed the impact of adenomyosis on the live birth rate in women with endometriosis undergoing ART treatment. The results showed that the presence of adenomyosis, especially T2 high-signal intensity spots within the myometrium, had a negative impact on the live birth rate in women undergoing ART.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Mathilde Bourdon, Yaniv Dahan, Chloe Maignien, Catherine Patrat, Corinne Bordonne, Louis Marcellin, Charles Chapron, Pietro Santulli
Summary: This study investigated whether endometrioma size affects the number of oocytes retrieved during IVF/ICSI in women with endometriosis-related infertility. The results showed no significant difference in the number of retrieved oocytes according to endometrioma size. Factors such as age, smoking habit, FSH concentration, and previous surgery for ovarian endometriosis were found to impact the number of oocytes retrieved.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
C. Maignien, M. Bourdon, L. Marcellin, J. Guibourdenche, A. Chargui, C. Patrat, G. Plu-Bureau, C. Chapron, P. Santulli
Summary: BMI, parity, and non-European geographic origin are factors associated with low serum progesterone levels on the day of frozen embryo transfer in hormone replacement therapy (HRT) cycles. This study highlights the importance of identifying these factors to predict which patients would benefit from tailored progesterone supplementation.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Mathilde Bourdon, Asim Alwohaibi, Chloe Maignien, Louis Marcellin, Ahmed Chargui, Khaled Pocate Cheriet, Catherine Patrat, Charles Chapron, Pietro Santulli
Summary: This study aimed to provide information on the chances for motherhood in patients undergoing Assisted Reproductive Technology (ART) by describing freeze-all outcomes according to different indications. The results showed a significant difference in cumulative live birth rate (cLBR) using the freeze-all approach between the main indications of ovarian hyperstimulation syndrome (OHSS) risk and endometriosis. These findings are crucial for guiding patient decision-making and improving the success rate of ART.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
M. Bourdon, V Antoine, U. Combes, L. Maitrot-Mantelet, L. Marcellin, C. Maignien, C. Chapron, P. Santulli
Summary: The study found no association between endometriosis and a history of childhood and/or adolescent sexual abuse, but there was a link between severe pelvic pain and sexual abuse.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Chloe Maignien, Rami El Hachem, Mathilde Bourdon, Louis Marcellin, Celine Chalas, Catherine Patrat, Inaki Gonzalez-Foruria, Charles Chapron, Pietro Santulli
Summary: This study aimed to investigate the reproductive outcomes and prognostic factors of live birth rates in patients with endometriosis referred to oocyte donation after multiple IVF failures. The study found that oocyte donation is a viable option for addressing infertility and recurrent IVF failures in patients with endometriosis.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Pietro Santulli, Christophe Blockeel, Mathilde Bourdon, Giovanni Coticchio, Alison Campbell, Michel De Vos, Kirsten Tryde Macklon, Anja Pinborg, Juan A. Garcia-Velasco
Summary: While there is extensive research on fertility preservation in women with malignant diseases, there is limited research on the role of fertility preservation in non-malignant conditions. This includes various benign gynaecological conditions that may affect reproductive potential. Currently, there is insufficient data to develop guidelines for clinical practice in fertility preservation for women with benign gynaecological conditions.
HUMAN REPRODUCTION OPEN
(2023)