Article
Nutrition & Dietetics
Anna Pietrzak, Marcin Banasiuk, Mariusz Szczepanik, Agnieszka Borys-Iwanicka, Tomasz Pytrus, Jaroslaw Walkowiak, Aleksandra Banaszkiewicz
Summary: This study evaluated the effectiveness of oral sodium butyrate as an add-on to standard therapy in children and adolescents with newly diagnosed IBD. The results showed that a 12-week supplementation with sodium butyrate did not show efficacy in these patients.
Article
Gastroenterology & Hepatology
Jeffrey S. Hyams, Michael Brimacombe, Yael Haberman, Thomas Walters, Greg Gibson, Angela Mo, David Mack, Anne Griffiths, Brendan Boyle, Neal LeLeiko, James Markowitz, Joel Rosh, Ashish Patel, Sapana Shah, Robert Baldassano, Marian Pfefferkorn, Cary Sauer, Joelynn Dailey, Suresh Venkateswaran, Subra Kugathasan, Lee A. Denson
Summary: This study developed a model for predicting the risk of colectomy in children newly diagnosed with ulcerative colitis. The findings suggest that a small group of children with severe UC still require colectomy despite current therapies. The gene signature observations provide additional targets for managing patients who do not respond to current medical treatments.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Medicine, General & Internal
Hee Man Kim, Jihoon Kim, Hyunil Kim, Soon Chang Park, Jung Kuk Lee, Dae Ryong Kang, Su Young Kim, Hyun-Soo Kim
Summary: This study aimed to assess the risk of gastric cancer in newly diagnosed UC patients. The results showed that patients with UC had a decreased risk of gastric cancer compared with non-UC individuals in South Korea. Within the UC population, advancing age (>= 60 years) was identified as a significant risk factor for gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Aleksandra Czajkowska, Katarzyna Guzinska-Ustymowicz, Anna Pryczynicz, Dariusz Lebensztejn, Urszula Daniluk
Summary: This study aimed to investigate the relationship between MMP-9 and TIMP-1 and UC phenotypes, disease activity index, and inflammatory markers. The results showed that children with UC had significantly higher levels of these markers in their serum and feces compared to the control group. Additionally, serum MMP-9 correlated with the severity of the disease and other markers, while serum TIMP-1 correlated with disease activity, inflammatory markers, and erythrocyte sedimentation rate. Serum and fecal levels of MMP-9 and TIMP-1 can be useful in distinguishing UC patients and evaluating disease phenotypes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Hana Cipcic Paljetak, Anja Baresic, Marina Panek, Mihaela Peric, Mario Matijasic, Ivana Lojkic, Ana Barisic, Darija Vranesic Bender, Dina Ljubas Kelecic, Marko Brinar, Mirjana Kalauz, Marija Milicevic, Dora Grgic, Niksa Turk, Irena Karas, Silvija Cukovic-Cavka, Zeljko Krznaric, Donatella Verbanac
Summary: This study compares the differences in gut microbiota between newly diagnosed, treatment-naive adult inflammatory bowel disease (IBD) patients (CD and UC) with irritable bowel syndrome (IBS) patients and healthy individuals. The results show that changes in gut microbiota are detectable at the onset of disease and may play a significant role in the development of IBD.
Article
Gastroenterology & Hepatology
Chenthan Krishnakumar, Ashwin N. Ananthakrishnan, Brendan M. Boyle, Anne M. Griffiths, Neal S. LeLeiko, David R. Mack, James F. Markowitz, Joel R. Rosh, Cary G. Sauer, Thomas D. Walters, Erin Bonkowski, Lee A. Denson, Jeffrey S. Hyams, Subra Kugathasan
Summary: This study suggests that longitudinal changes in fecal calprotectin levels may be better predictors of 1-year clinical outcomes in children with newly diagnosed ulcerative colitis than baseline values.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Medicine, General & Internal
Urszula Daniluk, Kamila Kwiatek-Sredzinska, Piotr Jakimiec, Jaroslaw Daniluk, Aleksandra Czajkowska, Dariusz Marek Lebensztejn
Summary: The study revealed that a significant proportion of children with IBD have liver pathology, with the majority of cases being detected after the diagnosis of IBD. Patients with a specified diagnosis of liver pathology were typically younger and had higher ALT activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Hiroaki Kitae, Tomohisa Takagi, Yuji Naito, Ryo Inoue, Yuka Azuma, Takashi Torii, Katsura Mizushima, Toshifumi Doi, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Takeshi Ishikawa, Hideyuki Konishi, Yoshito Itoh
Summary: This study analyzed the fecal microbiota of patients with quiescent ulcerative colitis (qUC) to identify the relapse-associated microbiota. The study found significant differences in the fecal microbiota between healthy controls and qUC patients, and differences in microbial community variation between sustained remission and relapsed patients. The study also identified three genera associated with relapse and found that different clusters based on these genera had different subsequent clinical courses and activated different metabolic pathways.
Article
Biochemistry & Molecular Biology
Mengfan Luo, Qiaoyue Yuan, Mingzhen Liu, Xingye Song, Yingjie Xu, Tao Zhang, Xiaoqun Zeng, Zhen Wu, Daodong Pan, Yuxing Guo
Summary: This study aimed to develop a novel astaxanthin nanoparticle using gum arabic (GA) and whey protein powder enriched with milk fat globule membranes (MFGM-WPI) as carriers and investigated its effect and alleviation mechanism on colitis in mice. Results showed that MFGM-GA-astaxanthin effectively improved bioaccessibility of astaxanthin, reduced oxidative stress, alleviated colitis symptoms, repaired intestinal barrier function, and restored abnormalities of gut flora. This study provides a promising therapeutic approach for colon diseases using astaxanthin nanoparticles.
Article
Gastroenterology & Hepatology
Laila Aldars-Garcia, Ruben Gil-Redondo, Nieves Embade, Sabino Riestra, Montserrat Rivero, Ana Gutierrez, Iago Rodriguez-Lago, Luis Fernandez-Salazar, Daniel Ceballos, Jose Manuel Benitez, Mariam Aguas, Iria Baston-Rey, Fernando Bermejo, Maria Jose Casanova, Rufo Lorente, Yolanda Ber, Daniel Ginard, Maria Esteve, Ruth de Francisco, Maria Jose Garcia, Ruben Frances, Ainhoa Rodriguez Pescador, Benito Velayos, Elena Guerra del Rio, Sandra Marin Pedrosa, Alejandro Minguez Sabater, Manuel Barreiro-de Acosta, Alicia Algaba, Cristina Verdejo Gil, Olga Rivas, Vanesa Royo, Montserrat Aceituno, Ana Garre, Montserrat Baldan-Martin, Cristina Ramirez, Ancor Sanz-Garcia, Juan J. Lozano, Julia Sidorova, Oscar Millet, David Bernardo, Javier P. Gisbert, Maria Chaparro
Summary: This study investigates the metabolic differences in different subgroups of newly diagnosed treatment-naive IBD patients. The results indicate alterations in energy and amino acid metabolism in IBD patients, with an increased demand for ketone bodies. The differences in metabolites are more pronounced in Crohn's disease patients compared to ulcerative colitis patients, and in serum compared to urine. Cluster analysis identifies three distinct patient profiles with significant differences in clinical, anthropometric, and metabolomic variables.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Jin Young Yoon, Jae Myung Cha, Chang Kyun Lee, Young Sook Park, Kyu Chan Huh, Jeong Eun Shin, You Sun Kim, Chang Soo Eun, Soon Man Yoon, Jae Hee Cheon, Young Soo Park, Byong Duk Ye, YoungJa Lee, Youngdoe Kim, Hyo Jong Kim
Summary: This study investigated the early clinical course of moderate-to-severe UC patients and found that Korean patients may have more favorable outcomes than Western patients in the short term. Factors influencing medication use were disease severity, extent, and endoscopic severity at baseline. Long-term outcomes of these patients require further investigation.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Nutrition & Dietetics
Bridgette Wilson, Oezge Eyice, Ioannis Koumoutsos, Miranda C. Lomer, Peter M. Irving, James O. Lindsay, Kevin Whelan
Summary: Prebiotics may not reduce clinical scores or inflammation in patients with active ulcerative colitis, but can normalize stools. The increase in proportions of Bifidobacterium and Christensenellaceae only occurred in patients with less active diseases, suggesting that the prebiotic effect may depend on disease activity.
Article
Medicine, Research & Experimental
Wei Zhou, Hua Zhang, Lihua Huang, Chuankai Sun, Yuhan Yue, Xiaolei Cao, Hongling Jia, Chunyue Wang, Yunfei Gao
Summary: This study investigated the preventive effects of DSF+Cu2+ on ulcerative colitis in mice and found that DSF and Cu2+ could significantly reverse the symptoms of colitis and inhibit inflammation by multiple mechanisms, including macrophage activation and intestinal barrier protection. The treatment also improved the gut microbiota, highlighting its potential for UC therapy.
Article
Biochemistry & Molecular Biology
Yiren Yang, Yuwei Zhang, Jiangping Song, Yaqian Li, Liuyang Zhou, Hongtao Xu, Kaizhang Wu, Jie Gao, Mouming Zhao, Yang Zheng
Summary: This study found that polysaccharides from bergamot (BP) can alleviate colitis symptoms by regulating gut microbiota and metabolism. The results showed that BP can promote the proliferation of beneficial bacteria, increase the levels of short-chain fatty acids and L-phenylalanine, and reduce inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Zewen Mei, Xingxi Huang, Heng Zhang, Danyi Cheng, Xin Xu, Mingyue Fang, Jutuan Hu, Yangyang Liu, Yunxiang Liang, Yuxia Mei
Summary: Chitin derivatives have a therapeutic effect in ulcerative colitis mice model by relieving inflammation symptoms, protecting the colon, and increasing the abundance of gut microbiota and concentrations of short-chain fatty acids.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Gunnar Steineck, Heike Schmidt, Eleftheria Alevronta, Fei Sjoberg, Cecilia Magdalena Bull, Dirk Vordermark
SEMINARS IN RADIATION ONCOLOGY
(2016)
Article
Multidisciplinary Sciences
Lena K. Nyberg, Saair Quaderi, Gustav Emilsson, Nahid Karami, Erik Lagerstedt, Vilhelm Muller, Charleston Noble, Susanna Hammarberg, Adam N. Nilsson, Fei Sjoberg, Joachim Fritzsche, Erik Kristiansson, Linus Sandegren, Tobias Ambjornsson, Fredrik Westerlund
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Eleftheria Alevronta, Viktor Skokic, Ulrica Wilderang, Gail Dunberger, Fei Sjoberg, Cecilia Bull, Karin Bergmark, Rebecka Jornsten, Gunnar Steineck
Article
Biochemical Research Methods
Fei Sjoberg, Forough Nowrouzian, Ignacio Rangel, Charles Hannoun, Edward MooreA, Ingegerd Adlerberth, Agnes E. Wold
JOURNAL OF MICROBIOLOGICAL METHODS
(2013)
Article
Pediatrics
Bill Hesselmar, Fei Sjoberg, Robert Saalman, Nils Aberg, Ingegerd Adlerberth, Agnes E. Wold
Article
Multidisciplinary Sciences
Gunnar Steineck, Viktor Skokic, Fei Sjoberg, Cecilia Bull, Eleftheria Alevronta, Gail Dunberger, Karin Bergmark, Ulrica Wilderang, Jung Hun Oh, Joseph O. Deasy, Rebecka Jornsten
Article
Microbiology
Maria Bankvall, Fei Sjoberg, Gita Gale, Agnes Wold, Mats Jontell, Sofia Ostman
JOURNAL OF ORAL MICROBIOLOGY
(2014)
Article
Microbiology
Ignacio Rangel, John Peter Ganda Mall, Roger Willen, Fei Sjoberg, Elisabeth Hultgren-Hornquist
FEMS MICROBIOLOGY ECOLOGY
(2016)