Article
Oncology
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick
Summary: The study demonstrated that the EBNA1 inhibitor VK-1727 selectively inhibited cell growth in EBV-positive gastric carcinoma and reduced tumor growth in animal models, but not in EBV-negative gastric carcinoma. Short-term treatment tended to activate viral genes, while long-term treatment resulted in significant decrease in viral gene expression.
Article
Biochemistry & Molecular Biology
Masatoshi Ito, Kai Kudo, Hiroshi Higuchi, Hiroko Otsuka, Masayuki Tanaka, Nahoko Fukunishi, Takuma Araki, Masako Takamatsu, Yoko Ino, Yayoi Kimura, Ai Kotani
Summary: The study revealed that EVs derived from EBV-transformed lymphomas contain immunomodulatory proteins and phospholipids associated with TAM formation, which may contribute to the development of lymphomas.
Review
Gastroenterology & Hepatology
Hisashi Iizasa, Andy Visi Kartika, Sintayehu Fekadu, Shunpei Okada, Daichi Onomura, Afifah Fatimah Azzahra Ahmad Wadi, Mosammat Mahmuda Khatun, Thin Myat Moe, Jun Nishikawa, Hironori Yoshiyama
Summary: This article discusses the roles of Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV) infections in the formation of gastric cancer. Previous studies have suggested that H. pylori infection may cooperate with EBV infection to promote gastric cancer development, while others have reported that H. pylori infection accelerates tumorigenesis caused by EBV infection.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Oncology
Miriam Verdu-Bou, Gustavo Tapia, Agueda Hernandez-Rodriguez, Jose-Tomas Navarro
Summary: Epstein-Barr virus (EBV) plays a role in lymphomagenesis, particularly in populations with immunodeficiencies like people living with HIV (PLWH). The presence of EBV in these lymphomas affects their epidemiological, pathological, and clinical characteristics, as well as their prognosis. EBV, along with cooperation with HIV, mediates the pathogenic roles in lymphomas arising in PLWH.
Article
Immunology
Julien Lupo, Raphaele Germi, Remi Lancar, Michele Algarte-Genin, Houria Hendel-Chavez, Yassine Taoufik, Nicolas Mounier, Marialuisa Partisani, Fabrice Bonnet, Marie-Caroline Meyohas, Bruno Marchou, Anastasiia Filippova, Sophie Prevot, Dominique Costagliola, Patrice Morand, Caroline Besson
Summary: In the modern cART era, the EBV DNA load in whole blood and plasma at NHL diagnosis does not serve as prognostic markers for HIV-NHL patients.
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Immunology
Hannes Vietzen, Philipp B. Staber, Sarah M. Berger, Philippe L. Furlano, Laura M. Kuehner, Simone Lubowitzki, Alexander Pichler, Robert Strassl, Jan J. Cornelissen, Elisabeth Puchhammer-Stoeckl
Summary: EBV infection has recurrent reactivations in most adults, but only a minority progress to EBV+ Hodgkin or non-Hodgkin lymphomas. This study found that EBV+ lymphoma patients have significantly higher expression of HLA-E*0103/0103 genotype and impaired NKG2C+ NK cell responses, and blocking NKG2A with monoclonal antibodies can effectively control the growth of EBV+ tumor cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch'ng, K. Mark Parnell, Nicolas M. Reinoso-Vizcaino, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, Micah A. Luftig
Summary: The study found that EBV infection directly induced temporal expression of MCT1 and MCT4 in B lymphocytes, with MCT1 being crucial for early B cell proliferation and MCT4 upregulation leading to acquired resistance to MCT1 antagonism in LCLs. Dual inhibition of MCT1/4 resulted in growth arrest and lactate buildup in LCLs, suggesting a potential therapeutic approach for targeting viral lymphomas associated with EBV and KSHV.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Article
Oncology
Ziyuan Shen, Lingling Hu, Mingkang Yao, Chenlu He, Qinhua Liu, Fei Wang, Weiying Gu, Ying Wang, Manyu Dong, Taigang Zhu, Ting Yin, Fei Li, Yingliang Jin, Shuiping Huang, Hao Zhang, Wei Sang
Summary: A retrospective multicenter study of 454 lymphoma patients found that elevated EBV DNA load can affect the prognosis of NKTL, FL, and DLBCL. The integration of EBER status and EBV DNA can differentiate the prognosis of HL patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Virology
Qiliang Lu, Wen Fu, Guangxiong Ouyang, Qiuran Xu, Dongsheng Huang
Summary: This case highlights the importance of considering EBV infection in young patients with spleen rupture without obvious cause to prevent misdiagnosis and missed diagnosis.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Cell Biology
Arghavan Zebardast, Sadra S. Tehrani, Tayebeh Latifi, Farzin Sadeghi
Summary: EBV-encoded miRNAs play a crucial role in the pathogenesis of EBVaGC, participating in carcinogenesis and the progression of malignancies by regulating gene expression and other activities.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Cong Sun, Xin-chun Chen, Yin-feng Kang, Mu-sheng Zeng
Summary: EBV is a common human herpesvirus associated with infectious mononucleosis, malignancies, and autoimmune diseases. Despite efforts to develop a prophylactic vaccine, there is currently no EBV vaccine in clinical use. Insights from the COVID-19 pandemic and global vaccine development offer opportunities for designing an effective prophylactic EBV vaccine to control worldwide EBV infection and associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Leon D. Kaulen, Evgeniya Denisova, Felix Hinz, Ling Hai, Dennis Friedel, Octavian Henegariu, Dirk C. Hoffmann, Jakob Ito, Alexandros Kourtesakis, Pascal Lehnert, Sofia Doubrovinskaia, Philipp Karschnia, Louisa von Baumgarten, Tobias Kessler, Joachim M. Baehring, Benedikt Brors, Felix Sahm, Wolfgang Wick
Summary: Immunodeficiency-associated primary CNS lymphoma (PCNSL) is a distinct clinicopathological entity with an inferior prognosis. The genetic alterations that characterize EBV-related CNS lymphomagenesis are unclear, making molecular classification and targeted therapies challenging. This study conducted a comprehensive genetic analysis, integrating clinical, pathological, exome, and RNA sequencing data, to gain insights into the pathobiology of EBV+ PCNSL and provide a rationale for exploring targeted therapies.
ACTA NEUROPATHOLOGICA
(2023)
Article
Oncology
Javid Sadri Nahand, Khadijeh Khanaliha, Hamed Mirzaei, Mohsen Moghoofei, Hossein Bannazadeh Baghi, Maryam Esghaei, Ali Reza Khatami, Maryam Fatemipour, Farah Bokharaei-Salim
Summary: The study evaluated the potential role of HPV and EBV coinfection in prostate cancer development. The findings suggest that HPV/EBV coinfection may influence tumor development and progression through modulation of cellular behaviors.
Article
Multidisciplinary Sciences
Ashley N. Coutu, Alberto J. Taurozzi, Meaghan Mackie, Theis Zetner Trolle Jensen, Matthew J. Collins, Judith Sealy
Summary: Using palaeoproteomics and peptide mass fingerprinting, this study identified key specimens of early domesticated fauna from South Africa, successfully distinguishing between sheep and wild bovids and confirming the earliest evidence of domesticated animals in southern Africa. The research highlights the importance of developing regional frameworks for biomolecular species identification using Zooarchaeology by Mass Spectrometry.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Robert Seed, Kenji Kobayashi, Saburo Ito, Naoki Takasaka, Anthony Cormier, Jillian M. Jespersen, Jean Publicover, Suprita Trilok, Alexis J. Combes, Nayvin W. Chew, Jocelyne Chapman, Matthew F. Krummel, Jianlong Lou, James Marks, Yifan Cheng, Jody L. Baron, Stephen L. Nishimura
Summary: The study revealed an association between tumor cell alpha v beta 8 integrin and T-reg enrichment, demonstrating a highly localized mechanism specific to tumors that promotes TGF-beta activation, immunosuppressive T-reg differentiation, and tumor growth.
SCIENCE IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Arjanneke F. van de Merbel, Geertje van der Horst, Maaike H. van der Mark, Selas T. F. Bots, Diana J. M. van den Wollenberg, Corrina M. A. de Ridder, Debra Stuurman, Tilly Aalders, Sigrun Erkens-Schulz, Nadine van Montfoort, Wouter R. Karthaus, Niven Mehra, Minke Smits, Jack A. Schalken, Wytske M. van Weerden, Rob C. Hoeben, Gabri van der Pluijm
Summary: The study evaluated the oncolytic efficacy of the bioselected oncolytic reovirus mutant jin-3 in multiple human prostate cancer models, showing tumor tropism and potent anti-cancer immune responses.
CANCER GENE THERAPY
(2022)
Article
Biology
Tiziana Siciliano, Ingo H. Simons, Alicia-Marie K. Beier, Celina Ebersbach, Cem Aksoy, Robert Seed, Matthias B. Stope, Christian Thomas, Holger H. H. Erb
Summary: Antiandrogen therapy is a primary treatment for metastasized prostate cancer. This study systematically compares the effects of different antiandrogens on cellular backgrounds, showing variations in androgen receptor-mediated gene transcription and cell viability, as well as highlighting the importance of androgen receptor protein stability in antiandrogen efficiency.
Article
Multidisciplinary Sciences
Patrick Leopold Ruther, Immanuel Mirnes Husic, Pernille Bangsgaard, Kristian Murphy Gregersen, Pernille Pantmann, Milena Carvalho, Ricardo Miguel Godinho, Lukas Friedl, Joao Cascalheira, Alberto John Taurozzi, Marie Louise Schjellerup Jorkov, Michael M. Benedetti, Jonathan Haws, Nuno Bicho, Frido Welker, Enrico Cappellini, Jesper Velgaard Olsen
Summary: The authors developed a workflow called Species by Proteome INvestigation (SPIN) for analyzing archaeological bone using liquid chromatography-tandem mass spectrometry, which is capable of identifying over 150 mammalian species with automated sample preparation and faster data acquisition. The SPIN method was successfully validated in both known reference bones and blind tests of Iron-Age material from Scandinavia, demonstrating its reproducibility and high throughput capabilities. This new method has the potential to expand to other biological tissues and taxa in the future.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Luise Orsted Brandt, Alberto J. Taurozzi, Meaghan Mackie, Mikkel-Holger S. Sinding, Filipe Garrett Vieira, Anne Lisbeth Schmidt, Charlotte Rimstad, Matthew J. Collins, Ulla Mannering
Summary: Fur trade was an important aspect of the Viking Age, but its archaeological study has been challenging due to its poor preservation. However, through the analysis of fur samples from Danish Viking-era graves, it was possible to identify the different species used, indicating a highly developed manufacturing and material knowledge. The presence of beaver fur, a non-local species, suggests a luxury commodity limited to the elite, serving as a recognizable symbol of social status.
Article
Humanities, Multidisciplinary
Tuuli M. Kasso, Renee Enevold, Samuel Johns, Guillermo Rangel-Pineros, Alberto J. Taurozzi, Alister Sutherland, Max Ramsoe, Lora V. Angelova, Melanie Roffet-Salque, Matthew J. Collins, Christian Caroe
Summary: Beeswax, previously used in medieval sealing wax, has the potential to be a biomolecular archive for historical information. Analysis of medieval wax seals revealed the presence of pollen and fungal spores, but only a small amount of DNA could be sequenced. This study provides a framework for future research on using wax seals as biological archives and understanding the degradation of cultural heritage objects.
Article
Multidisciplinary Sciences
Willemien de Kock, Meaghan Mackie, Max Ramsoe, Morten E. Allentoft, Annette C. Broderick, Julia C. Haywood, Brendan J. Godley, Robin T. E. Snape, Phil J. Bradshaw, Hermann Genz, Matthew von Tersch, Michael W. Dee, Per J. Palsboll, Michelle Alexander, Alberto J. Taurozzi, Canan Cakirlar
Summary: By combining bioarchaeology with contemporary data, researchers have found that Mediterranean green turtles have been using the same North African seagrass meadows for at least 5,000 years, highlighting the significance of protecting these critical coastal habitats.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Dorothea Mylopotamitaki, Florian S. Harking, Alberto J. Taurozzi, Zandra Fagernas, Ricardo M. Godinho, Geoff M. Smith, Marcel Weiss, Tim Schueler, Shannon P. McPherron, Harald Meller, Joo Cascalheira, Nuno Bicho, Jesper V. Olsen, Jean-Jacques Hublin, Frido Welker
Summary: High-throughput proteomic analysis of archaeological skeletal remains can provide valuable information about past fauna community compositions and species dispersals. However, the extraction of ancient proteins from bone specimens is challenging due to degradation. In this study, six proteomic extraction methods were compared on Late Pleistocene remains with different levels of proteome preservation. The results showed that simple acid-insoluble extraction methods performed better in highly degraded contexts, while for well-preserved specimens, the approach using EDTA demineralization and protease-mix proteolysis yielded the highest number of identified peptides.
SCIENTIFIC REPORTS
(2023)
Article
Ecology
Rachel M. Winter, Willemien de Kock, Meaghan Mackie, Max Ramsoe, Elena Desidera, Matthew Collins, Paolo Guidetti, Samantha Presslee, Marta Munoz Alegre, Tarek Oueslati, Arturo Morales Muniz, Dimitris Michailidis, Youri van den Hurk, Alberto J. Taurozzi, Canan Cakirlar
Summary: Marine historical ecology provides baselines for fisheries management; The groupers play a crucial role in Mediterranean fisheries and have been overfished; Zooarchaeology by Mass Spectrometry (ZooMS) can be used to identify grouper species; 22 novel ZooMS biomarkers for groupers were discovered; Research on an archaeological site revealed the dominance and resilience of Epinephelus aeneus in the Mediterranean for the past 4000 years despite fishing pressures, habitat degradation, and climate changes; Reconstructing catch size also showed that Epinephelus aeneus can grow 30 cm larger than previously documented.
ECOLOGY AND EVOLUTION
(2023)
Article
Archaeology
Theis Zetner Trolle Jensen, Lisa Yeomans, Louise Le Meillour, Pia Wistoft Nielsen, Max Ramsoe, Meaghan Mackie, Pernille Bangsgaard, Moritz Kinzel, Ingolf Thuesen, Matthew J. Collins, Alberto J. Taurozzi
Summary: Poor preservation of collagen in dry and/or arid environments has limited the application of Zooarchaeology by mass spectrometry (ZooMS) analysis in many regions. This study successfully identified petrous bones from the 10,000-year-old site of Shka over bar rat Msaied in Jordan using a new extraction method called Tryps-IN, outperforming traditional workflows. This opens up possibilities for further bioarchaeological research in this significant archaeological region.
JOURNAL OF ARCHAEOLOGICAL SCIENCE-REPORTS
(2023)
Article
Archaeology
Urs Leuzinger, Jehanne Affolter, Claudia Beck, Simone Benguerel, Marcel Cornelissen, Benjamin Dietre, Jean Nicolas Haas, Ferdinand Kleyhons, Werner Kofler, Walter Oberhuber, Hannah Stanger, Pere Gelabert, Regula Gubler, Irka Hajdas, Walter Imhof, Reto Jagher, Roger JeanRichard, Caroline Leuzinger, Christine Puempin, Theis Z. T. Jensen, Alberto J. Taurozzi, Catherine Leuzinger-Piccand, Werner Mueller, Caroline Posch, Werner H. Schoch, Sarah Stadler, Pascal Staub, Timothy Taylor, Shevan Wilkin
Summary: In the summers of 2020 and 2021, an archaeological and palaeoecological team excavated the Flozerbandli site, uncovering Early Mesolithic layers dating from 9746-8294 BC. They found charcoal fragments, stone artifacts, animal bones, and paleoethnobotanical remains, with the notable discovery of a red deer antler fragment dating back to 10,519-10,028 BC, adorned with regular rows of pit marks. Additionally, other Mesolithic sites have been discovered in the Muotathal area.
ARCHAOLOGISCHES KORRESPONDENZBLATT
(2022)
Review
Urology & Nephrology
Arjanneke F. van de Merbel, Geertje van der Horst, Gabri van der Pluijm
Summary: Preclinical knowledge and potential biomarkers for urological cancers have limited translation into clinical practice. Patient-derived tumor models, including 3D culture systems and xenograft models, have improved capacity to mimic the complexity of urological cancers. Opportunities for personalized therapeutic approaches for patients with urological cancers are limited and clinical validation of preclinical data is crucial for translation into treatment decisions.
NATURE REVIEWS UROLOGY
(2021)