Article
Cell Biology
Meimei Yang, Jing He, Sixuan Xia, Yudong Wang, Jun Xiong, Cong Liao, Nan Li, Sanfu Qu, Chao Shen
Summary: Human cancer cell lines play a crucial role in cancer research, but it is important to ensure the authenticity of these cell lines. A study has found that the MGC-803 cell line, previously believed to be derived from gastric adenocarcinoma, is actually similar to the HeLa cell line and contains genetic material from human papilloma virus 18. Further analysis revealed that MGC-803 is a hybrid cell line derived from HeLa and cells from a different patient with Asian genetic ancestry.
Article
Biochemistry & Molecular Biology
Maria Baleva, Ivan Chicherin, Uliana Piunova, Viktor Zgoda, Maxim Patrushev, Sergey Levitskii, Piotr Kamenski
Summary: Protein biosynthesis in mitochondria is closely linked to the assembly of inner membrane complexes and must be coordinated with cytosolic translation. The molecular mechanisms underlying mitochondrial translation regulation are not well understood. This study reveals that PTCD2 functions as a translational regulator of another mitochondrially encoded subunit of cytochrome c oxidase, COIII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Information Systems
Anqing Zheng, He Zhao, Zhunchen Luo, Chong Feng, Xiaopeng Liu, Yuming Ye
Summary: This study focuses on utilizing citation information in scientific literature to extract relations between online resources and scientific terms, aiming to improve online scientific resource profiling. Experimental results show that our framework outperforms other methods by around 5% in scientific information extraction tasks, indicating a promising step towards utilizing citation information to enhance online scientific resource profiling.
INFORMATION PROCESSING & MANAGEMENT
(2021)
Article
Humanities, Multidisciplinary
Noemia de Morais Santos, Paolo Francesco Cottone, Carla Antloga, Alexander Hochdorn, Ariana Morais Carvalho, Mariana Andrade Barbosa
Summary: This study explores how gender conceptions impact women's entrepreneurship, particularly in Latin languages. The findings suggest that female terms are often ignored in discussions about entrepreneurship, highlighting the need to incorporate the voices of women in literature on entrepreneurship in Brazil.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2022)
Article
Biology
Wout S. Lamers, Kevin Boyack, Vincent Lariviere, Cassidy R. Sugimoto, Nees Jan van Eck, Ludo Waltman, Dakota Murray
Summary: Disagreement is crucial for scientific progress, but the level of disagreement varies across different fields, with social sciences and humanities having the highest level and mathematics and computer science having the lowest. Analysis of individual articles reveals significant episodes of disagreement in science and highlights the influence of methodological artifacts.
Article
Biotechnology & Applied Microbiology
Jose Escandell, Filipa Moura, Sofia B. Carvalho, Ricardo J. S. Silva, Ricardo Correia, Antonio Roldao, Patricia Gomes-Alves, Paula M. Alves
Summary: The majority of rAAVs for clinical use are produced using the HEK293 cell line, but this platform has manufacturing bottlenecks such as low product quality and high cost. The HeLa-based stable cell line rAAV production system offers a scalable alternative, but has barriers due to time and complexity. This study developed a more streamlined and efficient process using the HeLaS3-based cell line, achieving high yield and purity of rAAV2.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Feng Chen, Hong-Mei Wang, Ling-Qi Kong, Qin-Hua Chen, Li-Na Ke, He-Liu Dai, Xiao-Hua Zeng
Summary: Heterocyclic compounds, such as pyrrolidone, have been widely used and studied in various fields. In this study, a new fluorine-containing rhopaladins' analog called RPDPD was synthesized and evaluated for its anti-tumor activity in vitro. The results showed that RPDPD inhibited the proliferation of HeLa cells and induced apoptosis, possibly through the inhibition of E6 and E7 mRNA expressions and the modulation of the TIMP3/MMP3 signaling pathway.
FRONTIERS IN CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Ana Rocio Rivera-Martinez, Itzen Aguiniga-Sanchez, Jorge Cadena-Iniguez, Isabel Soto-Cruz, Alberto Monroy-Garcia, Guadalupe Gomez-Garcia, Edgar Ledesma-Martinez, Benny Weiss-Steider, Edelmiro Santiago-Osorio
Summary: The wild species Sechium chinantlense (SCH) has been found to have antitumor properties, inhibiting proliferation in cervical cancer cells without harming normal cells.
Article
Biochemistry & Molecular Biology
Anna Julia Elias, Lajos Balogh, Tomas Branyik, Erzsebet Mak, Eva Csajbokne Csobod, Marta Veresne Balint, Csilla Benedek
Summary: The study aimed to investigate the antitumorigenic potential of a xanthohumol-enriched beer. The results showed that adding xanthohumol to beer did not have a protective effect on tumor growth or enhance plasma antioxidant capacity. However, it had a less harmful effect on the liver compared to an ethanolic solution.
Article
Polymer Science
Nevin Cankaya, Bahar Vurgun, Serap Yalcin
Summary: In this study, poly(N-cyclohexylacrylamide) polymer/organoclay-based nanocomposites were successfully synthesized and characterized by in situ polymerization. A positive correlation between clay ratio and thermal stability was observed, and in vitro studies have shown potential cytotoxic properties. Further research is needed to validate the potential of these nanocomposites as drug delivery systems through in vivo studies.
Article
Nanoscience & Nanotechnology
Xiongwei Liu, Kuizhong Shan, Xiaxia Shao, Xianqing Shi, Yun He, Zhen Liu, Joe Antony Jacob, Lichun Deng
Summary: The biomimetic approach of synthesizing silver nanoparticles using Rhizophora apiculata leaf extract showed dose-dependent cytotoxic effects on HEK-293 and HeLa cells, being three times more toxic to HEK-293 cells compared to HeLa cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biology
Filipe Michels Bianchi, Leonardo Tresoldi Goncalves
Summary: Journals often advise non-native English speaking authors to have their manuscripts proofread by a native English speaker, but they do not show the same concern for specimen identification in biological research. The lack of transparency in taxonomic procedures violates the basic scientific principle of reproducibility, and there is a need for continuous search for practical alternatives to improve and verify taxonomic identifications.
Article
Chemistry, Multidisciplinary
Prathama S. Mainkar, Ambica Vankamamidi, Srivari Chandrasekhar
Summary: In the past, twinning in research publications was serendipitous, but it has become more frequent nowadays. This may be attributed to researchers' desire to publish on popular topics, base research programs on popular keywords, and funding agencies preferentially supporting certain areas of research.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Oncology
Fang Cao, Hao Sun, Zhenli Yang, Yanhua Bai, Xiao Hu, Yuhong Hou, Xiaocui Bian, Yuqin Liu
Summary: The STR profiles of MGc80-3 and HeLa cells overlap partially, suggesting potential contamination in the MGc80-3 cell line. Various methods, including STR profiling, SNP genotyping, PCR, HPV-18 screening, karyotyping, xenograft examination, tissue-specific gene expression analysis, and RNA sequencing were used to determine the nature of MGc80-3. The results indicate that MGc80-3 is a somatic hybrid with HeLa cells, showing characteristics of both gastric cancer cell lines and HeLa cells.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Chemistry, Inorganic & Nuclear
Meltem Goksel, Mahmut Durmus, Zekeriya Biyiklioglu
Summary: Novel compounds including silicon(iv) phthalocyanine derivatives were synthesized, characterized and their photophysicochemical properties were studied. The effects of quaternization on these phthalocyanines were determined, and the cytotoxicity of water soluble silicon phthalocyanines against cancer cell lines was demonstrated through photodynamic therapy activities.
DALTON TRANSACTIONS
(2021)
Article
Oncology
Wytske M. Hepkema, Serge P. J. M. Horbach, Joyce M. Hoek, Willem Halffman
Summary: Biomedical researchers commonly use biological models and resources, but issues such as misidentified cell lines, antibody problems, and reliability of animal models can affect study results. Journal guidelines can improve reporting quality, but their effectiveness may vary depending on factors like implementation conditions and community support.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Environmental Studies
Serge P. J. M. Horbach, Joeri K. Tijdink, Lex M. Bouter
Summary: This article calls on research funding organizations to experiment with integrating partial randomization into their grant allocation processes and assess its feasibility, potential implications, and perceptions. Traditional models of grant allocation based on peer review have shown shortcomings, while partial randomization holds the potential for being more fair, efficient, and diverse.
SCIENCE AND PUBLIC POLICY
(2022)
Article
Information Science & Library Science
Serge P. J. M. Horbach, Freek J. W. Oude Maatman, Willem Halffman, Wytske M. Hepkema
Summary: Citation practices are important in scientific reporting, but the development of automated citation recommendation tools should be approached with caution. These tools may encourage questionable citing practices, such as perfunctory citation and affirmation biases. Lack of transparency in the tools' underlying algorithms also poses problems. It is necessary to understand and evaluate the consequences of citation recommendation tools before implementation or broad distribution.
RESEARCH EVALUATION
(2022)
Article
Medical Ethics
Mohammad Hosseini, Enric Senabre Hidalgo, Serge P. J. M. Horbach, Stephan Guttinger, Bart Penders
Summary: Although adherence to Mertonian values of science can cause friction with the normative structures and practices of Open Science, new normative structures need to consider the aspirations and outcomes of Open Science practices. The intersection of Open Science practices with Mertonian values becomes complicated when interests of different groups collide. Acknowledging and exploring these tensions can inform researchers' behavior and improve their interactions with other normative structures.
ACCOUNTABILITY IN RESEARCH-ETHICS INTEGRITY AND POLICY
(2022)
Article
Biochemistry & Molecular Biology
Serge P. J. M. Horbach, Lex M. Bouter, George Gaskell, Maura Hiney, Panagiotis Kavouras, Niels Mejlgaard, Nick Allum, Noemie Aubert Bonn, Anna-Kathrine Bendtsen, Costas A. Charitidis, Nik Claesen, Kris Dierickx, Anna Domaradzka, Andrea Reyes Elizondo, Nicole Foger, Wolfgang Kaltenbrunner, Teodora Konach, Krishma Labib, Ana Marusic, Daniel Pizzolato, Tine Ravn, Rea Roje, Mads P. Sorensen, Borana Taraj, Giuseppe A. Veltri, Joeri K. Tijdink
Summary: Research integrity is a key concern for stakeholders in science, and research funders play a crucial role in fostering it. To promote research integrity, we recommend that funders develop and implement a Research Integrity Promotion Plan (RIPP).
Article
Computer Science, Interdisciplinary Applications
Serge P. J. M. Horbach, Jesper W. Schneider, Maxime Sainte-Marie
Summary: There has been a gender gap in academia, particularly in staff positions and career progression. This study focuses on gender differences in funding applications and investigates whether writing styles contribute to the skewed funding patterns. The findings suggest that writing styles are unlikely to be a significant factor in explaining the funding disparities.
JOURNAL OF INFORMETRICS
(2022)
Review
Multidisciplinary Sciences
Serge P. J. M. Horbach, Joeri K. Tijdink, Lex Bouter
Summary: Transparency is becoming the norm in the global research enterprise. This article summarizes ongoing efforts to increase transparency in science and funding, and proposes the adoption of open applications. Open applications could lead to more diverse collaboration, recognition of research ideas, fairer procedures for grant allocation, and increased trust in the funding process.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Environmental Studies
Serge P. J. M. Horbach, Mads P. Sorensen, Nick Allum, Abigail-Kate Reid
Summary: This paper examines the researchers' 'local context' in the successful implementation of research integrity policies using the International Research Integrity Survey. The survey results show that academics identify more strongly with their transnational epistemic communities than with their immediate working surroundings. The theoretical understanding of academics' 'local context' is proposed based on the concept of cosmopolitanism and solidarity.
SCIENCE AND PUBLIC POLICY
(2023)
Article
History & Philosophy Of Science
Sander Turnhout, Willem Halffman
Summary: Wildlife field guide books provide information for identifying species and expressing their features. This article explores how these identification tools and characteristics evolve over time in response to wider community concerns. Using Dutch field guides for dragonflies as an example, the article discusses the impact of ethics, recreational value, observational tools, biodiversity monitoring, and conservation goals on species identification. The article highlights the importance of transdisciplinary cooperation and suggests potential applications to other observational practices and communities.
SOCIAL STUDIES OF SCIENCE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Tony Ross-Hellauer, Lex M. Bouter, Serge P. J. M. Horbach
Summary: Open Peer Review is gaining attention and use, but there is a need for additional evidence to responsibly promote it. In this article, we propose a preliminary research agenda and issue a call to action.
Article
Computer Science, Information Systems
Jing Wang, Willem Halffman, Yuehong Helen Zhang
Summary: Journal lists in China categorize, compare, and assess research and scholarly publications, reflecting the distinctive values, quality criteria, and ranking principles of the Chinese research policy and publishing system. These lists reflect changes in research policy, such as a shift away from output-dominated evaluation, specific concerns about research misconduct, and balancing national research needs against international standards, resulting in distinctly Chinese quality criteria. However, contrasting concerns and inaccuracies lead to contradictions and limitations in journal lists as policy tools.
JOURNAL OF THE ASSOCIATION FOR INFORMATION SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Studies
Jing Wang, Willem Halffman, Serge P. J. M. Horbach
Summary: This study investigates the reception of journal lists among Chinese scientists and finds that researchers consider institutional evaluation regimes, epistemic cultures, and the influence of the commercial publishing industry when selecting publication outlets.
SCIENCE AND PUBLIC POLICY
(2023)
Correction
Ethics
Mohammad Hosseini, Serge P. J. M. Horbach
RESEARCH INTEGRITY AND PEER REVIEW
(2023)
Review
Ethics
Mohammad Hosseini, Serge P. J. M. Horbach
Summary: The emergence of large language models (LLMs) like OpenAI's ChatGPT has sparked discussions in academia. Using LLMs in writing tasks, including peer review, can improve productivity. However, there are no guidelines on how to use LLMs in review tasks. Research suggests that LLMs have the potential to alter the roles of peer reviewers and editors, improving the quality of peer review but raising concerns about biases, confidentiality, and reproducibility.
RESEARCH INTEGRITY AND PEER REVIEW
(2023)