Article
Multidisciplinary Sciences
Sebastian Stannard, Ann Berrington, Nisreen A. Alwan
Summary: This study examines the impact of parental separation on adult hypertension and finds that women are more susceptible to its effects than men. Family socioeconomic status and cognitive and behavioral development indicators play a partial mediating role in childhood, while adult factors such as health behaviors, family socioeconomic status, body mass index, and mental wellbeing also influence the relationship between childhood predictors and adult hypertension.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Michael E. Roettger, Brian Houle, Jake Najman, Tara R. McGee
Summary: This study provides evidence that parental imprisonment, especially in early childhood, is associated with increased BMI, blood pressure, sedentary hours, and waist circumference in females in early adulthood, implying that parental imprisonment is a risk factor for cardiometabolic health issues in later life among females.
SSM-POPULATION HEALTH
(2022)
Article
Endocrinology & Metabolism
Camila Paixao dos Santos, Antonio Viana do Nascimento-Filho, Amanda Aparecida Araujo, Danielle da Silva Dias, Deiwet Ribeiro Silva, Nathalia Bernardes, Tania Plens Shecaira, Maria Claudia Irigoyen, Katia De Angelis
Summary: The excessive consumption of fructose by parents is associated with early autonomic, cardiovascular, and metabolic derangement in their offspring. The offspring of fructose parents have lower birth weight, increased blood triglyceride levels, and insulin resistance. They also show higher mean arterial pressure and impaired baroreflex sensitivity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Humanities, Multidisciplinary
Rajesh Kumar Rai, S. Subramanian, Sebastian Vollmer
Summary: This study examined the relationship between various parental characteristics and the health outcomes of children, including anthropometric failure, anaemia, and mortality. The findings indicated that the age and education level of parents, as well as maternal height, were associated with these health outcomes. Specifically, children of fathers aged 30-39 were less likely to experience anthropometric failure and anaemia, while the survival of children with fathers below 18 at marriage was at risk. Parental education was found to have a protective association with anthropometric failure, anaemia, and under-five mortality. Additionally, increasing maternal height was linked to lower odds of anthropometric failure and under-five mortality. Moreover, maternal tobacco use was associated with an increase in under-five mortality, and children with diabetic fathers had a higher risk of under-five mortality.
HUMANITIES & SOCIAL SCIENCES COMMUNICATIONS
(2022)
Article
Pediatrics
Rui Deng, Ke Lou, Siliang Zhou, Xingxiu Li, Bin Dong, Jun Ma, Jie Hu
Summary: This study found that parental reproductive age is associated with the risk of elevated blood pressure in offspring, and this association is influenced by offspring lifestyle. A U-shaped relationship between maternal age and risk of elevated blood pressure was observed, while risk of elevated blood pressure decreased with increasing paternal age. The significant associations between maternal/paternal age and risk of elevated blood pressure were only observed in offspring with worse lifestyle behaviors, not in those with healthier lifestyle.
FRONTIERS IN PEDIATRICS
(2023)
Article
Environmental Sciences
Kun Pan, Shuo Jiang, Xihao Du, Xuejiao Zeng, Jia Zhang, Liying Song, Lei Lei, Ji Zhou, Haidong Kan, Qinghua Sun, Yuquan Xie, Chen Dong, Jinzhuo Zhao
Summary: The study found that parental exposure to PM2.5 can lead to elevated blood pressure in offspring, affecting the expression of related proteins in the vasculature and kidneys, and potentially mediating through Th17- and Treg-related immune microenvironment.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Victoria R. Franks, Rose Thorogood, Patricia Brekke
Summary: Across the animal kingdom, little is known about the development of social environments, particularly in wild populations. This study examines how associations among young animals form and are influenced by environmental or genetic conditions established by parents. The results suggest that the natal environment created by parents, rather than genetic condition, establishes the foundation for social associations in offspring.
Article
Peripheral Vascular Disease
Baojian Xue, Yang Yu, Terry G. Beltz, Fang Guo, Shun-Guang Wei, Alan Kim Johnson
Summary: Voluntary exercise can protect male offspring against maternal gestational hypertension-induced hypertensive response sensitization and reduce enhanced brain reactivity and centrally driven sympathetic activity.
Article
Psychiatry
Ye Liu, Yu Liu, Yuzhu Lu, Jiangping Li, Shulan He
Summary: This study investigated the intergenerational association of parental famine exposure with depression and cognition in the offspring using data from the Chinese Family Panel Studies database. The results showed significant negative correlations between parental famine exposure during different life stages and offspring depression and cognitive function, indicating varying degrees of negative impact on offspring.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Valeriya Chekanova, Julien Vaucher, Pedro Marques-Vidal
Summary: This study aimed to assess the association between genetic markers and hypertension control. Two surveys conducted in Lausanne, Switzerland revealed poor control of hypertension, with older age consistently associated with worse control. However, no associations were found between genetic risk scores or individual SNPs and hypertension control.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Kevin M. Yasmin, Kevin M. O'Shaughnessy
Summary: Genome-wide scans have provided clues to the genetic components of hypertension. This study used an extreme discordant sib pair strategy to analyze markers from two loci of interest and found correlations between certain markers and blood pressure. These findings are important for understanding the genetic mechanisms of hypertension.
Article
Biochemistry & Molecular Biology
Emily A. Willoughby, Matt McGue, William G. Iacono, Aldo Rustichini, James J. Lee
Summary: The study found that dizygotic twins with higher polygenic scores for educational attainment are more likely to achieve higher education within families. Additionally, parental genotype also influences offspring outcomes independently of the offspring's own genotype, contributing to variance in offspring years of education. Control for parental IQ or socioeconomic status can mitigate or eliminate the effect of parental genotype on offspring education.
MOLECULAR PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Allison M. Harrison, Manoranjan S. D'Souza, Sarah L. Seeley, Sophocles Chrissobolis
Summary: The study shows that prenatal methamphetamine exposure adversely affects endothelial function in a sex-dependent manner in adult rat offspring. However, there was no significant impact on blood pressure. This suggests that adult males with a history of prenatal methamphetamine exposure may be at greater risk of developing cardiovascular disease due to endothelial dysfunction.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Siyi Jin, Ting Wang, Chen Wenying, Yuxuan Wu, Shuiping Huang, Ping Zeng
Summary: This study found a genetic correlation between fetal-specific birthweight and blood pressure and identified several shared genes related to both factors. Additionally, a causal relationship was found between maternal-specific birthweight and offspring blood pressure. These findings provide important insights into the mechanisms and early prevention of high blood pressure.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Ecology
Ulrika Candolin, Sara Goncalves, Pankaj Pant
Summary: Parental care can affect offspring survival, with male sticklebacks investing more care when receiving more eggs. In disturbed environments, this optimal balance may be distorted, leading to maladaptive parental behavior that reduces offspring survival.
Article
Nutrition & Dietetics
Giulia Coletta, Josephine S. Jakubowski, Stuart M. Phillips, Stephanie Atkinson, Alexandra Papaioannou, Janet M. Pritchard
Summary: Sarcopenia is prevalent among total joint replacement (TJR) patients and non-TJR community participants, with lower protein intake being common in both groups. The study found that low appendicular lean soft-tissue mass (ALSTMBMI) was more common in TJR patients according to less conservative cut-points, while weakness was not a major issue. Moreover, higher daily protein intake was associated with better grip strength and ALSTMBMI. These findings suggest that a dietary intervention to increase protein intake may improve the surgical outcomes of TJR patients.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Medicine, General & Internal
Sandi M. Azab, Meera Shanmuganathan, Russell J. de Souza, Zachary Kroezen, Dipika Desai, Natalie C. Williams, Katherine M. Morrison, Stephanie A. Atkinson, Koon K. Teo, Meghan B. Azad, Elinor Simons, Theo J. Moraes, Piush J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Philip Britz-McKibbin, Sonia S. Anand
Summary: Childhood obesity is associated with cardiometabolic disease. Metabolomics research found that serum metabolites are associated with early childhood overweight and adiposity. The relationship between metabolism and obesity is influenced by sex.
Article
Developmental Biology
Neda Mortaji, John Krzeczkowski, Stephanie Atkinson, Bahar Amani, Louis A. A. Schmidt, Ryan Van Lieshout
Summary: This study found that a maternal nutrition and exercise intervention during pregnancy can improve infant emotion regulation. Infants in the intervention group had higher heart rate variability and better temperament compared to the control group. These findings suggest that pregnancy nutrition and exercise interventions may have a positive impact on infant emotion regulation.
DEVELOPMENTAL PSYCHOBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jacqueline Halton, Jinui Ma, Paul Babyn, Mary Ann C. Matzinger, Sue Kaste, Maya V. Scharke, Conrad Fernandez, Paivi Miettunen, Josephine Ho, Nathalie Alos, Sharon Abish, Ronald Barr, Elizabeth B. Cairney, David M. Dix, Ronald Grant, Sara Israels, Victor Lewis, Beverly Wilson, Stephanie Atkinson, David Cabral, Elizabeth Cummings, Celia Rodd, Robert Stein, Anne Marie L. Sbrocchi, Jacob Jaremko, Khaldoun Koujok, Nazih Shenouda, Frank Rauch, Kerry M. Siminoski, Leanne Ward, Canadian STOPP Consortium
Summary: Osteonecrosis is a common complication in children with acute lymphoblastic leukemia after therapy. A study evaluated the prevalence of osteonecrotic lesions in 86 children using multisite magnetic resonance imaging and found that 35% of the children had ON. Clinical factors such as bone mineral density changes were also considered in the analysis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Claire N. Tugault-Lafleur, Olivia De-Jongh Gonzalez, Janice Macdonald, Jennifer Bradbury, Tom Warshawski, Geoff D. C. Ball, Katherine Morrison, Josephine Ho, Jill Hamilton, Annick Buchholz, Louise Masse
Summary: The study aimed to test the efficacy of the Aim2Be app with support from a live coach in reducing weight outcomes and improving lifestyle behaviors among adolescents with overweight and obesity. The results showed no significant differences in weight outcomes and health behaviors between the intervention and control groups at 3 months. However, among waitlist control participants, there were declines in weight outcomes and some health behaviors after receiving access to the app, and adolescents who used Aim2Be with live coaching reported more time being active outside of school compared to those without coaching.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Nutrition & Dietetics
Meera Shanmuganathan, Meghan Bogert, Zachary Kroezen, Philip Britz-McKibbin, Stephanie A. Atkinson
Summary: This study explores the intake of choline and carnitine during pregnancy and their effects on choline and carnitine metabolites. The findings showed that despite inadequate choline intake, serum-free choline levels were elevated in late pregnancy and enriched in cord blood compared with maternal serum. However, serum carnitine levels declined in late pregnancy. The higher cord:maternal concentrations in choline and carnitine metabolites suggest active uptake in late pregnancy, reflecting the importance of these circulating metabolites in fetal development.
JOURNAL OF NUTRITION
(2023)
Correction
Multidisciplinary Sciences
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
NATURE COMMUNICATIONS
(2023)
Article
Obstetrics & Gynecology
Rose A. Schmidt, Tina W. Wey, Kelly D. Harding, Isabel Fortier, Stephanie Atkinson, Suzanne Tough, Nicole Letourneau, Julia A. Knight, William D. Fraser, Alan Bocking
Summary: This study analyzed the sociodemographic characteristics associated with alcohol consumption during pregnancy and its impact on fetal development and birth outcomes by pooling data from multiple Canadian cohort studies. The results showed that alcohol use during pregnancy was related to drinking prior to pregnancy, smoking during pregnancy, and white ethnicity, while higher income level was associated with drinking during pregnancy. However, neither alcohol use during pregnancy nor binge drinking during pregnancy was significantly associated with preterm delivery or low birth weight for gestational age in the sample studied. Therefore, future pregnancy and birth cohorts should include questions related to alcohol consumption before and during pregnancy to support data reusability and collaborative research.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Endocrinology & Metabolism
Katherine M. Morrison, Elizabeth Gunn, Stephanie Schwindt, Linda Hu, Mark Tarnopolsky
Summary: The study aimed to evaluate how dropping out of a paediatric weight management program (PWM) affects health indicators over a 2-year period. An observational study followed children and youth with obesity in a family-based behavior modification PWM and measured their health indicators at four research visits over 2 years, independent of clinic visits. The results showed that lower attrition rate correlated with larger declines in BMI z-score and body fat, while improvements in health-related quality of life (HRQoL) were similar for all attrition groups. Children who attended at least one treatment visit reported improved HRQoL up to 2 years, regardless of their duration in the clinic. However, those who visited the clinic after 1 year showed greater declines in body fat and BMI z-score at 2 years. The study concludes that reducing attrition can enhance anthropometric health outcomes during PWM.
Article
Nutrition & Dietetics
Kendra Dempsey, Michelle F. Mottola, Stephanie A. Atkinson
Summary: This study aimed to assess the maternal diet quality and create an algorithm to evaluate adherence to an intervention of high protein/dairy nutrition and walking exercise during pregnancy. The results showed that the intervention group significantly improved their diet scores and adherence scores, but adherence decreased in the late pregnancy primarily due to lower step counts.
CURRENT DEVELOPMENTS IN NUTRITION
(2023)
Article
Chemistry, Medicinal
L. McKerracher, T. Moffat, M. E. Barker, B. Murray-Davis, K. M. Kennedy, C. J. Bellissimo, E. Yeo, D. Hotoft, L. Zalot, V. Parlette, S. A. Atkinson, D. M. Sloboda
Summary: This study used survey data from 341 pregnant Canadians and found that higher-income and higher-educated pregnant women were more likely to use probiotics, regardless of their pregnancy health indicators. These findings suggest that socio-economic factors may play a significant role in the use of probiotics during pregnancy.
Article
Endocrinology & Metabolism
Fahd Alshammri, Hannah Geddie, Noor Sawalha, Gloria Kim, Karen Mcassey, Katherine M. Morrison
Summary: This study evaluated the adherence to lipid screening guidelines in a pediatric diabetes program and found that dyslipidemia is highly prevalent in pediatric diabetes patients, associated with obesity but also present in non-obese patients.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Rehabilitation
Madison L. Giles, Geoff D. C. Ball, Revi Bonder, Annick Buchholz, Jan Willem Gorter, Katherine M. Morrison, Arnaldo Perez, Meaghan Walker, Amy C. Mcpherson
Summary: This study aimed to explore the understanding of bodyweight, health and weight management among children with spina bifida (SB) and their parents, and identify appropriate services and supports for managing their health and weight. Using interpretive description and qualitative analysis, data were collected through individual interviews with children with SB (aged 10-18) and their parents attending Canadian SB clinics. The findings revealed that both children and parents had a weight-centric approach to health, viewing weight as under individual control, primarily through diet. Trusting relationships between healthcare providers, children and families were important in discussing weight.
DISABILITY AND REHABILITATION
(2023)
Article
Public, Environmental & Occupational Health
Neda Mortaji, John Krzeczkowski, Stephanie Atkinson, Bahar Amani, Louis A. Schmidt, Ryan J. Van Lieshout
Summary: This study evaluated the impact of a pregnancy nutrition+exercise intervention on fetal neurodevelopment and found that infants of mothers in the intervention group had higher scores in expressive language and general adaptive behavior at 12 months. However, there were no significant differences in cognitive, receptive language, motor, and socioemotional functioning between groups. Further research is needed to determine the clinical utility of nutrition+exercise interventions for optimizing infant neurodevelopment.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Gastroenterology & Hepatology
Katherine M. Kennedy, Andreas Plagemann, Julia Sommer, Marie Hofmann, Wolfgang Henrich, Jon F. R. Barrett, Michael G. Surette, Stephanie Atkinson, Thorsten Braun, Deborah M. Sloboda
Summary: Maternal adaptations to pregnancy are affected by high pre-pregnancy BMI (pBMI) and excess gestational weight gain (GWG). This study suggests that the gut microbiome may play a role in these adaptations and that previous pregnancies can have persistent impacts on maternal adaptations. It also highlights the influence of parity on the effect of maternal GWG on infant gut microbiome.
