Induction of colon and cervical cancer cell death by cinnamic acid derivatives is mediated through the inhibition of Histone Deacetylases (HDAC)

The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways

(2016) Igor Hrgovic et al.   BMC CANCER

An overview on the role of dietary phenolics for the treatment of cancers

(2016) Preethi G. Anantharaju et al.   Nutrition Journal

Blocking NF-κB sensitizes non-small cell lung cancer cells to histone deacetylase inhibitor induced extrinsic apoptosis through generation of reactive oxygen species

(2015) Selvaraju Karthik et al.   BIOMEDICINE & PHARMACOTHERAPY

Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents

(2015) Madhusoodanan Mottamal et al.   MOLECULES

Romidepsin induces cell cycle arrest, apoptosis, histone hyperacetylation and reduces matrix metalloproteinases 2 and 9 expression in bortezomib sensitized non-small cell lung cancer cells

(2014) Selvaraju Karthik et al.   BIOMEDICINE & PHARMACOTHERAPY

Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHAin vitroandin vivo

(2014) Lin Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a Tolypocladium sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells

(2014) Lin Du et al.   JOURNAL OF NATURAL PRODUCTS

Cytotoxic Effect of p-Coumaric Acid on Neuroblastoma, N2a Cell via Generation of Reactive Oxygen Species Leading to Dysfunction of Mitochondria Inducing Apoptosis and Autophagy

(2014) S. Shailasree et al.   MOLECULAR NEUROBIOLOGY

Potassium channels in cell cycle and cell proliferation

(2014) D. Urrego et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Role of Dietary Histone Deacetylases (HDACs) Inhibitors in Health and Disease

(2014) Shalome Bassett et al.   Nutrients

The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety

(2014) Martins Ekor   Frontiers in Pharmacology

PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma

(2013) P. G. Richardson et al.   BLOOD

Histone deacetylase (HDAC) inhibitory and antiproliferative activities of phenolic-rich extracts derived from the rhizome of Hydnophytum formicarum Jack.: sinapinic acid acts as HDAC inhibitor

(2013) Thanaset Senawong et al.   BMC Complementary and Alternative Medicine

Randomized Phase II, Double-Blind, Placebo-Controlled Study of Exemestane With or Without Entinostat in Postmenopausal Women With Locally Recurrent or Metastatic Estrogen Receptor-Positive Breast Cancer Progressing on Treatment With a Nonsteroidal Aromatase Inhibitor

(2013) Denise A. Yardley et al.   JOURNAL OF CLINICAL ONCOLOGY

Histone Deacetylases

(2013) Sabnam Parbin et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

(2013) Christopher J. Millard et al.   MOLECULAR CELL

Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression

(2013) M C C Sachweh et al.   Cell Death & Disease

Antioxidant and Antimicrobial Activities of Cinnamic Acid Derivatives

(2012) M. Sova   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer

(2011) K Ted Thurn et al.   Future Oncology

Preclinical studies on histone deacetylase inhibitors as therapeutic reagents for endometrial and ovarian cancers

(2011) Brahma N Singh et al.   Future Oncology

Histone Deacetylase Inhibitors: Emerging Mechanisms of Resistance

(2011) Robert W. Robey et al.   MOLECULAR PHARMACEUTICS

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

(2011) Ying Chen et al.   NATURE NEUROSCIENCE

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

(2010) Jerome C. Bressi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apoptotic Sensitivity of Colon Cancer Cells to Histone Deacetylase Inhibitors Is Mediated by an Sp1/Sp3-Activated Transcriptional Program Involving Immediate-Early Gene Induction

(2010) A. J. Wilson et al.   CANCER RESEARCH

Nonhistone protein acetylation as cancer therapy targets

(2010) Brahma N Singh et al.   Expert Review of Anticancer Therapy

Charting histone modifications and the functional organization of mammalian genomes

(2010) Vicky W. Zhou et al.   NATURE REVIEWS GENETICS

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

(2010) J.- H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies

(2009) Gamze Bora-Tatar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Clinical Studies of Histone Deacetylase Inhibitors

(2009) H. M. Prince et al.   CLINICAL CANCER RESEARCH

Histone Deacetylase Inhibitors

(2009) Xujun Ma et al.   DRUGS

Vorinostat in solid and hematologic malignancies

(2009) David Siegel et al.   Journal of Hematology & Oncology

HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability

(2009) M Krishnan et al.   ONCOGENE

The Cytoplasmic Deacetylase HDAC6 Is Required for Efficient Oncogenic Tumorigenesis

(2008) Y.-S. Lee et al.   CANCER RESEARCH

Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon

(2008) Markus Waldecker et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

HDAC4 Promotes Growth of Colon Cancer Cells via Repression of p21

(2008) Andrew J. Wilson et al.   MOLECULAR BIOLOGY OF THE CELL

PBISe, a novel selenium-containing drug for the treatment of malignant melanoma

(2008) S. V. Madhunapantula et al.   MOLECULAR CANCER THERAPEUTICS

Role of histone deacetylase inhibitor-induced reactive oxygen species and DNA damage in LAQ-824/fludarabine antileukemic interactions

(2008) Roberto R. Rosato et al.   MOLECULAR CANCER THERAPEUTICS