Article
Dentistry, Oral Surgery & Medicine
Xian Jun David Lu, Kelly Yi Ping Liu, Eitan Prisman, Jonn Wu, Yuqi Sarah Zhu, Catherine Poh
Summary: This study assessed the prognostic values of p16 and HPV markers in oropharyngeal squamous cell carcinoma (OpSCC). The results showed that human papillomavirus (HPV) is more prognostic than p16 for OpSCC. HPV-positive patients have better clinical outcomes.
Article
Sport Sciences
Naoki Kikuchi, Takafumi Tajima, Yuki Tamura, Yoshiaki Yamanaka, Kunitaka Menuki, Takanobu Okamoto, Mikako Sakamaki-Sunaga, Akinori Sakai, Kenji Hiranuma, Koichi Nakazato
Summary: This study found an association between the ALDH2 rs671 polymorphism and muscle phenotypes and athletic capacity in the Japanese population. The AA genotype and A allele were associated with reduced muscle strength and poorer athletic performance.
Review
Pharmacology & Pharmacy
Hong Zhang, Liwu Fu
Summary: ALDH2 plays a crucial role in tumorigenesis and progression, with the ALDH2*2 polymorphism associated with tumor development. This study summarizes the essential functions and potential mechanisms of ALDH2 in cancer. Therefore, ALDH2 is considered a potential therapeutic target for cancer treatment.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Biochemistry & Molecular Biology
Aly A. M. Shaalan, Sara H. Mokhtar, Hanadi Talal Ahmedah, Amany Almars, Eman A. Toraih, Afaf T. Ibrahiem, Manal S. Fawzy, Mai A. Salem
Summary: This study identified the potential association of the LINC ROR (rs1942347) variant with the prognosis of colon cancer, suggesting that this variant may impact the clinicopathological features and outcome of the disease.
Article
Multidisciplinary Sciences
Joon Young Hur, Bo Mi Ku, Sehhoon Park, Hyun Ae Jung, Se-Hoon Lee, Myung-Ju Ahn
Summary: This study investigated the prognostic value of FOXP3+ regulatory T cells in oropharyngeal squamous cell carcinoma (OPSCC). The results showed that high Treg cell density was correlated with longer recurrence-free survival (RFS) in patients with locally advanced OPSCC tumors.
Article
Nutrition & Dietetics
Maki Igarashi, Shun Nogawa, Tsuyoshi Hachiya, Kyohei Furukawa, Shoko Takahashi, Huijuan Jia, Kenji Saito, Hisanori Kato
Summary: This study suggests that the rs671 polymorphism modifies the association between dietary behaviors and BMI independently of drinking habits, providing evidence for the potential use of rs671 polymorphism information for precision nutrition with East Asians.
Article
Oncology
Luca Bergamaschi, Giulia Marvaso, Mattia Zaffaroni, Maria Giulia Vincini, Oriana D'Ecclesiis, Stefania Volpe, Annamaria Ferrari, Stefano Filippo Zorzi, Maria Cossu Rocca, Annarita Sabbatini, Giulia Cannillo, Emanuela Zagallo, Anna Starzynska, Mohssen Ansarin, Federica Cattani, Sara Gandini, Roberto Orecchia, Daniela Alterio, Barbara Alicja Jereczek-Fossa
Summary: This study focuses on the impact of sarcopenia on oncological outcomes and toxicity in patients with oropharyngeal carcinoma undergoing radiotherapy. The study found that developing sarcopenia during radiotherapy is associated with worse progression-free survival and overall survival. Prompt nutritional intervention can improve oncological outcomes in these patients.
Article
Surgery
Ho-Jung Shin, Chul-Kyu Roh, Sang-Yong Son, Hur Hoon, Sang-Uk Han
Summary: Low serum total cholesterol is associated with higher postoperative complication rate in gastric cancer patients, and decreasing total cholesterol is linked to poor prognosis. Therefore, preoperative total cholesterol can serve as a predictor for postoperative survival and complications in gastric cancer patients.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guangwen Zhang, Ziliang Xu, Jianyong Zheng, Mian Wang, Jialiang Ren, Xiaocheng Wei, Yi Huan, Jinsong Zhang
Summary: Multi b-value DWI with histogram features can predict the prognosis of LARC patients, and combined with clinicopathologic factors, it can indicate the risk of progression before treatment.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Sweet Ping Ng, Houda Bahig, Amit Jethanandani, Erich M. Sturgis, Faye M. Johnson, Baher Elgohari, G. Brandon Gunn, Renata Ferrarotto, Jack Phan, David I. Rosenthal, Steven J. Frank, Clifton D. Fuller, Adam S. Garden
Summary: The study evaluated the prognostic value of pre-treatment neutrophil-to-lymphocyte ratio (NLR) in patients with oropharyngeal cancer. It found that patients with lower NLR had more favorable overall survival and disease control outcomes, regardless of HPV status.
BRITISH JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Hailun Xie, Lishuang Wei, Guanghui Yuan, Mingxiang Liu, Shuangyi Tang, Jialiang Gan
Summary: The study investigated the relationship between prognostic nutritional index (PNI) and survival in patients with colorectal cancer (CRC) who underwent surgical treatment. Low PNI was associated with high tumor burden, invasive pathological features, and poor host status. Patients with low PNI had a higher incidence of complications and longer hospital stay. PNI was an independent risk factor affecting postoperative complications, progression-free survival (PFS), and overall survival (OS) of CRC patients.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Daisuke Murakami, Kenji Matsuda, Hiromitsu Iwamoto, Yasuyuki Mitani, Yuki Mizumoto, Yuki Nakamura, Ibu Matsuzaki, Ryuta Iwamoto, Yuichi Takahashi, Fumiyoshi Kojima, Shin-Ichi Murata, Hiroki Yamaue
Summary: The interaction between CD155 and TIGIT may play an important role in the immunological mechanism of colorectal cancer. High expression of CD155 and TIGIT is associated with worse prognosis. Evaluation of the combined expression of CD155 and TIGIT may effectively predict the postoperative prognosis of colorectal cancer.
Article
Oncology
Jiajia Zhu, Liang Li, Yuansheng Duan, Yansheng Wu, Xudong Wang
Summary: This study found that pre-treatment serum ALB levels are closely associated with clinicopathological characteristics and prognosis of oropharyngeal cancer patients, serving as a reliable prognostic marker.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medical Laboratory Technology
Timothy Tiutan, Joseph S. Wallins, Samantha Brown, Mithat Gonen, Deborah Korenstein
Summary: This study investigated the utility of procalcitonin (PCT) as a predictor of disease severity and death in cancer patients with COVID-19. The findings showed that elevated PCT levels on admission were associated with a higher risk of progression of COVID-19 and/or mortality. Therefore, initial PCT levels may be associated with prognosis in hospitalized COVID-19 patients with underlying cancer.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Geriatrics & Gerontology
Guo-Tian Ruan, Hai-Lun Xie, Kai-Tao Yuan, Shi-Qi Lin, He-Yang Zhang, Chen-An Liu, Jin-Yu Shi, Yi-Zhong Ge, Meng-Meng Song, Chun-Lei Hu, Xiao-Wei Zhang, Xiao-Yue Liu, Ming Yang, Kun-Hua Wang, Xin Zheng, Yue Chen, Wen Hu, Ming-Hua Cong, Li-Chen Zhu, Li Deng, Han-Ping Shi
Summary: This study investigated the prognostic prediction value of systemic inflammation and performance status in patients with colorectal cancer cachexia. The results showed that the systemic inflammatory markers CRP, LCR, and CAR were stable and consistent with the survival of patients with CRC, both in non-cachexia and cachexia populations. High inflammation and poor performance status indicated a worse prognosis in patients with CRC cachexia, compared with non-cachexia patients. The ECOG-PS may be an independent risk factor for CRC. The combined evaluation of systemic inflammation and ECOG-PS could provide a simple survival prediction for patients with CRC cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Oncology
Naomi Kiyota, Makoto Tahara, Junki Mizusawa, Takeshi Kodaira, Hirofumi Fujii, Tomoko Yamazaki, Hiroki Mitani, Shigemichi Iwae, Yasushi Fujimoto, Yusuke Onozawa, Nobuhiro Hanai, Takenori Ogawa, Hiroki Hara, Nobuya Monden, Eiji Shimura, Shujiro Minami, Takashi Fujii, Kaoru Tanaka, Akihiro Homma, Seiichi Yoshimoto, Nobuhiko Oridate, Koichi Omori, Tsutomu Ueda, Kenji Okami, Ichiro Ota, Kiyoto Shiga, Masashi Sugasawa, Takahiro Asakage, Yuki Saito, Shigeyuki Murono, Yasumasa Nishimura, Kenichi Nakamura, Ryuichi Hayashi
Summary: The study demonstrates that chemoradiotherapy with weekly cisplatin is noninferior to 3-weekly cisplatin in terms of overall survival for patients with postoperative high-risk locally advanced squamous cell carcinoma of the head and neck. Weekly cisplatin also leads to fewer adverse reactions compared to the 3-weekly regimen.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Munechika Tsumura, Seiichiro Makihara, Asami Nishikori, Yuka Gion, Toshiaki Morito, Shotaro Miyamoto, Tomoyuki Naito, Kensuke Uraguchi, Aiko Oka, Tomoyasu Tachibana, Yorihisa Orita, Shin Kariya, Mitsuhiro Okano, Mizuo Ando, Yasuharu Sato
Summary: This study found that HPV infection, young adulthood, diabetes mellitus, and advanced tumor stage may be associated with the recurrence of sinonasal inverted papilloma.
Article
Oncology
Taku Nose, Yohei Funakoshi, Hirotaka Suto, Yoshiaki Nagatani, Yoshinori Imamura, Masanori Toyoda, Naomi Kiyota, Hironobu Minami
Summary: This study investigated the time-dependence of PD-1 occupancy after discontinuation of nivolumab and its relationship with re-challenge efficacy. The results showed that it takes approximately 32.4 to 48.9 weeks to decrease PD-1 occupancy by 50% to 70%. Furthermore, patients with lower PD-1 occupancy at recurrence had better efficacy with re-challenge of nivolumab.
MOLECULAR AND CLINICAL ONCOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Kensuke Uraguchi, Shin Kariya, Mizuo Ando
Summary: This article presents a rare case of labyrinthitis ossificans following acute otitis media. The T2-weighted MRI showed decreased signal intensity in the right inner ear, consistent with the clinical presentation.
CLINICAL CASE REPORTS
(2022)
Article
Oncology
Robert I. Haddad, Kevin Harrington, Makoto Tahara, Robert L. Ferris, Maura Gillison, Jerome Fayette, Amaury Daste, Piotr Koralewski, Bogdan Zurawski, Miren Taberna, Nabil F. Saba, Milena Mak, Andrzej Kawecki, Gustavo Girotto, Miguel Angel Alvarez Avitia, Caroline Even, Joaquin Gabriel Reinoso Toledo, Alexander Guminski, Urs Muller-Richter, Naomi Kiyota, Mustimbo Roberts, Tariq Aziz Khan, Karen Miller-Moslin, Li Wei, Athanassios Argiris
Summary: In patients with recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN), first-line nivolumab plus ipilimumab did not show a significant difference in overall survival compared to the standard treatment. However, there may be some advantages in certain populations, and it has a better safety profile.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Yasunori Fujita, Fumika Kamitani, Masaaki Yamamoto, Hidenori Fukuoka, Yushi Hirota, Nobuharu Nishiyama, Naho Goda, Yuko Okada, Yuiko Inaba, Hiroki Nakajima, Yukako Kurematsu, Keitaro Kanie, Hiroki Shichi, Shin Urai, Masaki Suzuki, Naoki Yamamoto, Hironori Bando, Genzo Iguchi, Hirotaka Suto, Yohei Funakoshi, Naomi Kiyota, Yutaka Takahashi, Wataru Ogawa
Summary: The combination of hypophysitis and type 1 diabetes mellitus (T1DM) caused by immune checkpoint inhibitors (ICIs) is extremely rare, and its clinical features are unclear. This study analyzed the clinical features of three cases and reviewed previously reported cases with combined hypophysitis and T1DM due to ICIs.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Oncology
Kazuma Iwashita, Hikaru Kubota, Riku Nishioka, Yuki Emoto, Daisuki Kawahara, Takeaki Ishihara, Daisuke Miyawaki, Ikuno Nishibuchi, Yasushi Nagata, Ryohei Sasaki
Summary: This study aimed to construct a prognostic survival model for esophageal cancer patients who underwent radical irradiation using skeletal muscle radiomics. The predictive model constructed by machine learning and LASSO algorithm showed good performance in predicting the survival of esophageal cancer patients, with high accuracy, specificity, sensitivity, and area under the concentration-time curve.
ANTICANCER RESEARCH
(2023)
Article
Hematology
Yohei Funakoshi, Kimikazu Yakushijin, Goh Ohji, Takaji Matsutani, Wataru Hojo, Hironori Sakai, Sakuya Matsumoto, Marika Watanabe, Akihito Kitao, Yasuyuki Saito, Shinichiro Kawamoto, Katsuya Yamamoto, Taiji Koyama, Yoshiaki Nagatani, Shiro Kimbara, Yoshinori Imamura, Naomi Kiyota, Mitsuhiro Ito, Hironobu Minami
Summary: The use of tixagevimab/cilgavimab is an important strategy to protect immunocompromised patients with haematological malignancies from COVID-19. However, it can mask the production of anti-spike antibody after vaccination, making it difficult to assess vaccine response. A new quantification method using B-cell receptor (BCR) repertoire assay and the Coronavirus Antibody Database (CoV-AbDab) has been established to assess the response to SARS-CoV-2 vaccination at mRNA level. The fluctuation in matching sequences can be analyzed to evaluate the postvaccine immune response.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Otorhinolaryngology
Sataksi Chatterjee, Naomi Kiyota, Richa Vaish, Atul Sharma, Makoto Tahara, Vanita Noronha, Kumar Prabhash, Anil D'Cruz
Summary: Concurrent chemoradiotherapy with 3-weekly cisplatin has been the standard treatment for locoregionally advanced head and neck cancer. However, concerns about toxicity, compliance, and real-world applicability have led to exploration of weekly cisplatin chemoradiotherapy as an alternative. A literature review comparing the two regimens was conducted, highlighting the noninferiority of the weekly regimen in both adjuvant and definitive settings.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Kazuhiro Kitajima, Junpei Kuyama, Takashi Kawahara, Tsuyoshi Suga, Tomoaki Otani, Shigeyasu Sugawara, Yumiko Kono, Yukihisa Tamaki, Ayumi Seko-Nitta, Yoshinobu Ishiwata, Kimiteru Ito, Akira Toriihara, Shiro Watanabe, Makoto Hosono, Hideaki Miyake, Shingo Yamamoto, Ryohei Sasaki, Mitsuhiro Narita, Koichiro Yamakado
Summary: This retrospective study investigated the efficacy of change in the automated bone scan index (aBSI) as an imaging biomarker for treatment response and survival prediction in mCRPC patients treated with Ra-223. The study analyzed data from 205 Japanese mCRPC patients who received Ra-223 treatment between July 2016 and August 2020. The results showed that changes in aBSI, alkaline phosphatase (ALP), and prostate-specific antigen (PSA) were significant prognostic factors for overall survival in these patients.
Article
Health Care Sciences & Services
Katherine J. Taylor, Cecilie D. Amdal, Kristin Bjordal, Guro L. Astrup, Bente B. Herlofson, Frederic Duprez, Ricardo R. Gama, Alexandre Jacinto, Eva Hammerlid, Melissa Scricciolo, Femke Jansen, Irma M. Verdonck-de Leeuw, Giuseppe Fanetti, Orlando Guntinas-Lichius, Johanna Inhestern, Tatiana Dragan, Alexander Fabian, Andreas Boehm, Ulrike Woehner, Naomi Kiyota, Maximilian Krueger, Pierluigi Bonomo, Monica Pinto, Sandra Nuyts, Joaquim C. Silva, Carmen Stromberger, Francesco Tramacere, Ayman Bushnak, Pietro Perotti, Michaela Plath, Alberto Paderno, Noa Stempler, Maria Kouri, Susanne Singer
Summary: This study investigated the long-term problems of head and neck cancer survivors. The most frequent problems reported were dry mouth, difficulty swallowing/eating, hoarseness/difficulty speaking, and pain in the head and neck. The use of chemo-radiotherapy compared to surgery alone increased the odds of reporting dry mouth and difficulty swallowing/eating, but decreased the odds of hoarseness/difficulty speaking and pain in the head and neck. Patients diagnosed with UICC stage IV had increased odds of reporting hoarseness/difficulty speaking. Laryngeal cancer survivors had lower odds of reporting dry mouth compared to oropharynx cancer survivors, but higher odds of hoarseness/difficulty speaking.
Review
Oncology
Hiroto Ishiki, Yuichiro Kikawa, Mitsumi Terada, Junki Mizusawa, Michitaka Honda, Tsuguo Iwatani, Tomonori Mizutani, Keita Mori, Naoki Nakamura, Tempei Miyaji, Takuhiro Yamaguchi, Masahiko Ando, Kenichi Nakamura, Haruhiko Fukuda, Naomi Kiyota
Summary: Assessing patient-reported outcomes and health-related quality of life in cancer clinical trials has become increasingly important due to the promotion of patient and public involvement in cancer treatment development. The Japan Clinical Oncology Group has seen growing demand for such assessments, but standardized methods for analyzing and interpreting the results are still lacking. To address this issue, the Japan Clinical Oncology Group has reorganized its patient-reported outcome/quality of life research committee and revised its research policy to promote the inclusion of patient-reported outcomes in future trials.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Yoshiaki Nagatani, Naomi Kiyota, Yoshinori Imamura, Taiji Koyama, Yohei Funakoshi, Masato Komatsu, Masanori Teshima, Ken-Ichi Nibu, Kazuko Sakai, Kazuto Nishio, Manami Shimomura, Tetsuya Nakatsura, Daiki Ikarashi, Takayuki Nakayama, Shigehisa Kitano, Hironobu Minami
Meeting Abstract
Oncology
Yoshiaki Nagatani, Naomi Kiyota, Yoshinori Imamura, Taiji Koyama, Yohei Funakoshi, Masato Komatsu, Masanori Teshima, Ken-Ichi Nibu, Kazuko Sakai, Kazuto Nishio, Manami Shimomura, Tetsuya Nakatsura, Daiki Ikarashi, Takayuki Nakayama, Shigehisa Kitano, Hironobu Minami
Article
Materials Science, Biomaterials
Yukiya Kitayama, Takuya Yamada, Kentaro Kiguchi, Aoi Yoshida, Shuhei Hayashi, Hiroaki Akasaka, Kazunori Igarashi, Yuya Nishimura, Yu Matsumoto, Ryohei Sasaki, Eri Takano, Hirobumi Sunayama, Toshifumi Takeuchi
Summary: A novel stealth radiation sensitizer based on Au-embedded molecularly imprinted polymer nanogels (Au MIP-NGs) was developed for low-dose X-ray radiation therapy. It showed good affinity and selectivity towards human serum albumin, and improved the efficiency of pancreatic cancer treatment in mouse models.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)