Article
Biochemistry & Molecular Biology
Kayla M. Scott, D. Joshua Cohen, Barbara D. Boyan, Zvi Schwartz
Summary: The study reveals that IL-1β and TNF-α induce cartilage destruction and progression of osteoarthritis, which can be prevented by miR-122. Conversely, miR-451 exacerbates these effects. Furthermore, the WNT/β-catenin signaling pathway also influences the actions of IL-1β and TNF-α.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Salvatore Cuzzocrea, Roberta Fusco, Rosalba Siracusa, Rosanna Di Paola
Summary: Resveratrol administration can alleviate behavioral changes, inflammation, and oxidative stress induced by low back pain (LBP). It regulates the WNT/beta-catenin pathway and related gene expressions, which reduces LBP symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yongjun Hu, Hongwei Pan, Jianqiang Peng, Jin He, Mingxiang Tang, Sulan Yan, Jingjing Rong, Junshan Li, Zhaofen Zheng, Haijun Wang, Yanfu Liu, Xin Zhong
Summary: The study showed that RES attenuates cell necroptosis induced by myocardial hypoxia/reoxygenation injury by inhibiting the TNF-α/RIP1/RIP3/MLKL signaling pathway, leading to increased cell viability and decreased necroptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Elena Della Morte, Stefania Niada, Chiara Giannasi, Luigi Zagra, Anna Teresa Brini
Summary: This study found that TNF-α can rapidly induce a decrease in Cx43 expression in articular chondrocytes, mainly through the proteasomal pathway. The proteasome inhibitor MG132 and the synthetic factor TGF-β 1 can reverse this decrease. These results suggest a potentially important role of Cx43 perturbation in joint inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eloi Franco-Trepat, Ana Alonso-Perez, Maria Guillan-Fresco, Miriam Lopez-Fagundez, Andres Pazos-Perez, Antia Crespo-Golmar, Susana Belen Bravo, Veronica Lopez-Lopez, Alberto Jorge-Mora, Jose P. Ceron-Carrasco, Ana Lois Iglesias, Rodolfo Gomez
Summary: Osteoarthritis is a progressive rheumatic disease characterized by joint inflammation and degradation. The compound beta boswellic acid (BBA) has shown potential in reducing cartilage loss by inhibiting TLR4 and IL1R signaling in OA joint cells. This study presents solid evidence of BBA's therapeutic properties, suggesting its potential as a treatment for OA after further clinical evaluations.
Article
Orthopedics
Zhu Guo, Chensheng Qiu, Christina Mecca, Yang Zhang, Jiang Bian, Yan Wang, Xiaolin Wu, Tianrui Wang, Weiliang Su, Xianglin Li, Wei Zhang, Bohua Chen, Hongfei Xiang
Summary: Elevated LT alpha is closely associated with IVDD and may induce apoptosis of NP cells and reduce important extracellular matrix proteins, leading to adverse effects on IVDD progression.Optimal conditions for LT alpha treatment to induce NP cell degeneration have been determin
BMC MUSCULOSKELETAL DISORDERS
(2021)
Review
Cell & Tissue Engineering
Ning Wang, Yangfan Lu, Benjamin B. B. Rothrauff, Aojie Zheng, Alexander Lamb, Youzhen Yan, Katelyn E. E. Lipa, Guanghua Lei, Hang Lin
Summary: In the synovial joint, mechanical force plays a crucial role in influencing chondrocyte behavior. This is achieved through mechanotransduction pathways that convert mechanical signals into biochemical cues, leading to changes in chondrocyte phenotype and extracellular matrix composition/structure. Recent studies have revealed the involvement of estrogen receptor alpha (ER alpha) in mediating the chondrocyte response to mechanical loading, highlighting its important role in mechanotransduction. This review summarizes the current understanding of mechanotransduction pathways in chondrocytes, explores the specific roles of ER alpha, and proposes future research directions to further elucidate its involvement in biomechanical cues.
Article
Orthopedics
Zhimin Wu, Ying Wang, Guoqiang Yan, Chengai Wu
Summary: Eugenol has been shown to have anti-inflammatory, antioxidant, and antiapoptotic effects in multiple systems and organs of the human body. This study demonstrates its therapeutic potential for osteoarthritis (OA) by protecting cartilage and subchondral bone, inhibiting inflammatory molecules, and blocking IL-1β-induced signaling pathways.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Haijun Zhao, Weijie Zhu, Wude Mao, Chengkai Shen
Summary: The study demonstrates that PRP can protect chondrocytes from doxorubicin-induced damage, inhibiting apoptosis and inflammation, and improving cartilage destruction. This research provides a new theoretical basis for the clinical treatment of osteoarthritis caused by doxorubicin.
MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Shahanshah Khan, Youn-Tae Kwak, Lan Peng, Shuiqing Hu, Brandi L. Cantarel, Cheryl M. Lewis, Yunpeng Gao, Ram S. Mani, Thirumala-Devi Kanneganti, Hasan Zaki
Summary: NLRP12 serves as a negative regulator of the Wnt/β-catenin pathway, suppressing the development and invasion of colorectal tumors. It downregulates activation of β-catenin in intestinal epithelial cells. The study identifies an interaction between NLRP12 and STK38, revealing that NLRP12 inhibits the phosphorylation of GSK3β, leading to degradation of β-catenin.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Neurosciences
Wei Li, Dengping Liu, Jiaqi Xu, Jun Zha, Chen Wang, Jianzhong An, Zhanli Xie, Shigang Qiao
Summary: This study found that activated astrocytes secrete TNF-alpha, which induces platelet invasion and accumulation in the cerebral cortex during cerebral ischemia/reperfusion (I/R) injury. TNF-alpha expression enhances platelet reactivity through the RIP1/RIP3/AKT pathway. Additionally, the administration of anti-TNF-alpha antibodies alleviates ischemic damage. These findings provide novel insights into the pathological role of platelets activated by astrocyte-derived TNF-alpha in cerebral I/R injury.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Junyoung Park, Hyunju Choi, Fukushi Abekura, Hak-Seong Lim, Jong-Hwan Im, Woong-Suk Yang, Cher-Won Hwang, Young-Chae Chang, Young-Choon Lee, Nam Gyu Park, Cheorl-Ho Kim
Summary: Flavonoids and phenolic acids are the most important phenolic compounds in oats, with wide-ranging biological responses such as antioxidative and anti-inflammatory properties. Avenanthramide C, a component of oats, has been found to be highly antioxidant and anti-inflammatory, but its role in anti-atherosclerosis activity needs further investigation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
Panida Kongjam, Noel Pabalan, Phuntila Tharabenjasin, Hamdi Jarjanazi, Wanna Chaijaroenkul, Kesara Na-Bangchang
Summary: This meta-analysis suggests that TNF-alpha -308G >A gene polymorphism may affect the risk of P. falciparum severe malaria, particularly in individuals of Asian descent.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Integrative & Complementary Medicine
Lei Liu, Bin Liu, Liang Li, Xiangdong Zhou, Qi Li
Summary: This study investigates the therapeutic effects of resveratrol on pulmonary fibrosis and the underlying mechanism. The results show that resveratrol can improve collagen deposition, reduce inflammation, and treat pulmonary fibrosis by regulating the TGF-beta/Smad/ERK signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Tingling Zou, Lan Ma, Lili Gu, Shuhua Xi, Kaiqiang Zhang, Xiaoying Guo
Summary: This study found that excessive consumption of fluoride leads to dental fluorosis, inhibiting ameloblast differentiation and matrix degradation through the regulation of clock genes, PPAR gamma, and Wnt/beta-catenin signaling pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Oncology
Mohsen Karami Fath, Ali Azargoonjahromi, Nafiseh Jafari, Maryam Mehdi, Fatemeh Alavi, Mona Daraei, Niloufar Mohammadkhani, Anna-Lena Mueller, Aranka Brockmueller, Mehdi Shakibaei, Zahra Payandeh
Summary: Melanoma, the most aggressive form of skin cancer, can be treated through various approaches such as surgery, chemotherapy, and immunotherapy. However, the development of resistance mechanisms has reduced the efficiency of these strategies. Therapeutic monoclonal antibodies and cancer vaccines have shown promise in improving melanoma treatment outcomes. Additionally, the use of extracellular vesicles (EVs) as a novel molecular structure has potential in melanoma therapy.
Article
Genetics & Heredity
Mangala Hegde, Uzini Devi Daimary, Aviral Kumar, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mehdi Shakibaei, Ajaikumar B. Kunnumakkara
Summary: This study analyzed gene expression data to identify potential predictive markers for breast cancer metastasis and validated their expression regulation, clinicopathological factors, and DNA methylation patterns in breast cancer patients.
Article
Biochemistry & Molecular Biology
Anna-Lena Mueller, Aranka Brockmueller, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: The study revealed that Calebin A can alleviate tendonitis inflammation by inhibiting the adhesion between T-lymphocytes and tenocytes and modulating NF-kappa B/Scleraxis signaling, indicating its potential as a preventive and therapeutic agent for tendonitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aranka Brockmueller, Parviz Shayan, Mehdi Shakibaei
Summary: This study found that resveratrol can exert its suppressive actions on tumor microenvironment (TME)-induced tumorigenesis in colorectal cancer (CRC) cells through the beta 1-integrin receptor. Resveratrol altered the distribution pattern and expression of beta 1-integrin on the surface of CRC cells in TME, leading to decreased cell proliferation and viability, and increased apoptosis. Inhibition of beta 1-integrin or interruption of downstream signaling pathway attenuated the anti-tumor effects of resveratrol. The results highlight the important role of beta 1-integrins as signal carriers for resveratrol in CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Devivasha Bordoloi, Choudhary Harsha, Ganesan Padmavathi, Kishore Banik, Bethsebie Lalduhsaki Sailo, Nand Kishor Roy, Sosmitha Girisa, Krishan Kumar Thakur, Amrita Devi Khwairakpam, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Mehdi Shakibaei, Ajaikumar B. Kunnumakkara
Summary: Lung cancer is a major cause of cancer-related deaths in men and one of the deadliest cancers in women. This study identifies the protein TIPE3 as a biomarker for lung cancer, showing significant upregulation in lung cancer tissues. Knockout of TIPE3 is found to reduce the proliferation, survival, and migration of lung cancer cells, and arrests the G2 phase of the cell cycle through inactivation of multiple signaling pathways. The study also reveals the positive regulation of TIPE3 in tobacco-induced lung cancer.
Review
Nutrition & Dietetics
Anna-Lena Mueller, Aranka Brockmueller, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: Tendinitis is a common tendon disease caused by mechanical overuse, injuries, drug abuse, and lifestyle factors. Nuclear factor kappa B is an important pro-inflammatory transcription factor that regulates genes involved in inflammation, degradation, and cell death. Plant-derived nutraceuticals can target multiple signaling pathways and suppress inflammation in tendinitis.
Article
Genetics & Heredity
Mangala Hegde, Uzini Devi Daimary, Sandra Jose, Anjana Sajeev, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mehdi Shakibaei, Ajaikumar B. Kunnumakkara
Summary: Regulation of calcium levels is crucial for cell signaling and homeostasis, and has implications in diseases like cancer. This study investigates the involvement of SOC proteins in head and neck squamous cell cancer, and their correlation with genes involved in mitochondrial dynamics.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Anna-Lena Mueller, Aranka Brockmueller, Niusha Fahimi, Tahere Ghotbi, Sara Hashemi, Sadaf Sadri, Negar Khorshidi, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: CRC, with its high incidence of distant metastases and drug resistance, requires novel therapeutic strategies. Bacteriotherapy, utilizing microorganisms linked to CRC pathogenesis, offers a promising and low side-effect treatment option. Various mechanisms and techniques associated with bacteriotherapy have been successful in targeting CRC tumors.
Article
Pharmacology & Pharmacy
Lukas Dehe, Shaaban A. Mousa, Mohammed Shaqura, Mehdi Shakibaei, Michael Schaefer, Sascha Treskatsch
Summary: This study examined the effects of chronic volume overload on myocardial opioid receptors and the inflammatory response in the failing heart. The results showed that opioid receptor blockade by naltrexone improved left ventricular function and reduced inflammatory cytokine expression. This suggests that antagonism of the myocardial opioid system can improve cardiac function and modulate the inflammatory response.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Biomaterials
Kiana Yousefipour, Hamid-Reza Rahimi, Mojtaba Shakibaei, Mehdi Ranjbar, Atefeh Ameri, Mahboubeh Adeli-Sardou
Summary: This study synthesized Mg / Ca-LDH nanostructures using a microwave-assisted reverse micelle method and characterized their properties. The cellular toxicity of the synthesized nano-LDH was evaluated, and it was found that the C sample had the lowest toxicity among the preparations. These findings suggest that Mg / Ca-LDH nanostructures have the potential to be used as drug carrier materials.
Review
Biochemistry & Molecular Biology
Aranka Brockmueller, Negin Mahmoudi, Amir Kian Movaeni, Anna-Lena Mueller, Abdol-Mohammad Kajbafzadeh, Mehdi Shakibaei, Masoumeh Majidi Zolbin
Summary: Neurodegenerative diseases are a group of neurological disorders caused by various destructive illnesses, affecting neurons in the central nervous system and resulting in impaired brain functions. The combination of stem cells and natural products offers a new perspective for the treatment of these diseases.
NEUROCHEMICAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Amir Reza Moravejolahkami, Mehdi Shakibaei, Andrea Mary Fairley, Manoj Sharma
Summary: Dysbiosis in the gut has been linked to T1DM, and this review analyzed the effects of probiotics, prebiotics, and synbiotics on T1DM patients. After evaluating 258 entries, five trials were included, showing that probiotic supplementation decreased fasting blood glucose but had no significant effect on HbA1c, C-peptide, and insulin requirements. Probiotics may serve as a complementary therapeutic strategy for T1DM, but more trials are needed.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Aranka Brockmueller, Sosmitha Girisa, Ajaikumar B. B. Kunnumakkara, Mehdi Shakibaei
Summary: Resveratrol can enhance the sensitivity of colorectal cancer cells to 5-FU by regulating the beta 1-integrin/HIF-1α signaling axis, leading to suppression of cancer cell growth and invasion, inhibition of inflammation and cancer stem cell production. These findings highlight the potential application of resveratrol in the treatment of colorectal cancer by overcoming chemoresistance to 5-FU.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Aranka Brockmueller, Samson Mathews Samuel, Alena Mazurakova, Dietrich Busselberg, Peter Kubatka, Mehdi Shakibaei
Summary: Colorectal cancer (CRC) is a major global malignant disease often resistant to chemotherapy drugs. Two polyphenolic turmeric ingredients, calebin A and curcumin, show anti-inflammatory and anticancer effects, including the ability to sensitize CRC cells to chemotherapy drugs. They modulate inflammation, proliferation, cell cycle, cancer stem cells, and apoptotic signaling to convert chemoresistant CRC cells into non-chemoresistant cells. Further studies and clinical trials are needed to test their effectiveness in overcoming cancer chemoresistance.
Review
Oncology
Aranka Brockmueller, Anjana Sajeev, Lenka Koklesova, Samson Mathews Samuel, Peter Kubatka, Dietrich Busselberg, Ajaikumar B. Kunnumakkara, Mehdi Shakibaei
Summary: Despite medical treatment successes, colorectal cancer (CRC) remains a leading cause of cancer deaths worldwide. Chemotherapy can lead to side effects and drug resistance, highlighting the need for natural compounds that can sensitize cancer cells to overcome resistance. Resveratrol, a natural polyphenolic compound, has been shown to enhance the effectiveness of chemotherapy by modulating multiple pathways in CRC cells.
CANCER AND METASTASIS REVIEWS
(2023)
