Article
Biochemistry & Molecular Biology
Sofia Persson, Kumari A. Ubhayasekera, Jonas Bergquist, Sahruh Turkmen, Inger Sundstroem Poromaa, Evangelia Elenis
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women, and hyperandrogenism can cause psychological morbidity and impaired quality of life. This study aimed to investigate whether hyperandrogenism persists into midlife and its impact on quality of life.
Article
Biochemistry & Molecular Biology
Yanling Wu, Belen Chanclon, Peter Micallef, Elisabet Stener-Victorin, Ingrid Wernstedt Asterholm, Anna Benrick
Summary: The study demonstrates that elevated levels of adiponectin in utero can improve insulin sensitivity, reduce body weight and fat mass gain in adult offspring, and protect against PNA-induced visceral adiposity in the offspring.
Article
Obstetrics & Gynecology
Sofia Persson, Evangelia Elenis, Sahruh Turkmen, Michael S. Kramer, Eu-Leong Yong, Inger Sundstrom Poromaa
Summary: This study found that polycystic ovary syndrome is an independent risk factor for type 2 diabetes, regardless of BMI adjustment. Women with the hyperandrogenic PCOS phenotype face a higher risk of type 2 diabetes than those with the normoandrogenic PCOS phenotype.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Alexandra L. Cara, Laura L. Burger, Bethany G. Beekly, Susan J. Allen, Emily L. Henson, Richard J. Auchus, Martin G. Myers, Suzanne M. Moenter, Carol F. Elias
Summary: Androgens are steroid hormones important for sexual differentiation and reproductive function. Excess androgens, however, can lead to polycystic ovary syndrome, causing fertility problems. They can also disrupt energy homeostasis and metabolic function. In this study, the researchers found that a certain population of leptin receptor neurons, which are critical for energy regulation and reproductive function, are directly affected by androgens. The study suggests that the effects of hyperandrogenism on sexual maturation and reproductive function in females are controlled by distinct neural circuits.
Article
Biochemistry & Molecular Biology
Akari Kusamoto, Miyuki Harada, Jerilee M. K. Azhary, Chisato Kunitomi, Emi Nose, Hiroshi Koike, Zixin Xu, Yoko Urata, Tetsuaki Kaku, Nozomi Takahashi, Osamu Wada-Hiraike, Yasushi Hirota, Kaori Koga, Tomoyuki Fujii, Yutaka Osuga
Summary: It has been found that prenatal androgen exposure may cause gut microbial dysbiosis early in life, which is associated with the development of PCOS later on. Offspring with prenatal androgen exposure showed reproductive and metabolic phenotypic abnormalities, with differences in gut microbiome composition already apparent at 4 weeks of age.
Article
Multidisciplinary Sciences
Manuel Luque-Ramirez, Andres E. Ortiz-Flores, Lia Nattero-Chavez, M. Angeles Martinez-Garcia, Maria Insenser, Francisco Alvarez-Blasco, Elena Fernandez-Duran, Alejandra Quintero-Tobar, Sara de Lope Quinones, Hector F. Escobar-Morreale
Summary: Normoferritinemic women with functional hyperandrogenism may experience mild iron overload. Iron excess, hyperandrogenism, and cardioautonomic dysfunction contribute to blood pressure abnormalities in these patients. Scheduled bloodletting to decrease iron stores did not override the blood pressure abnormalities caused by the use of combined oral contraceptives in women with functional hyperandrogenism.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Regine Stutz, Christopher Meyer, Elisabeth Kaiser, Sybelle Goedicke-Fritz, Harry W. Schroeder, Robert Bals, Christoph Haertel, Tobias Rogosch, Sebastian Kerzel, Michael Zemlin
Summary: The scarcity of N-nucleotides may contribute to an inability to mount a robust allergic immune response in neonates. In a murine model of allergic airway inflammation, the expression of fetal-like antigen receptors was associated with a reduced ability to develop asthma phenotype, emphasizing the importance of somatically-generated antigen-receptor repertoire diversity in type one allergic immune responses.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Zhen Zhang, Qianyun Liu, Ying Sun, Jiali Li, Jiejie Liu, Ruangang Pan, Liu Cao, Xianying Chen, Yingjian Li, Yuzhen Zhang, Ke Xu, Deyin Guo, Li Zhou, Ke Lan, Yu Chen
Summary: The study suggests that the N7-MTase of coronaviruses can serve as an ideal target for designing live attenuated vaccines, as demonstrated by recombinant viruses lacking the N7-MTase gene that induce long-term immune responses and provide full protection.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Obstetrics & Gynecology
Shari Mackens, Panagiotis Drakopoulos, Margot Fauve Moeykens, Linde Mostinckx, Liese Boudry, Ingrid Segers, Herman Tournaye, Christophe Blockeel, Michel De Vos
Summary: This study aimed to investigate whether there are differences in cumulative live birth rates (CLBR) between different phenotypes of polycystic ovary syndrome (PCOS) after a freeze-all strategy is used to prevent OHSS. The results showed that the CLBR in women with PCOS was around 70% regardless of phenotype when a freeze-all strategy was used.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Biochemistry & Molecular Biology
Renata Silverio, Robson Barth, Andrea S. Heimann, Patricia Reckziegel, Gustavo J. dos Santos, Silvana Y. Romero-Zerbo, Francisco J. Bermudez-Silva, Alex Rafacho, Emer S. Ferro
Summary: Oral administration of Pep19 can alleviate high-fat diet-induced obesity and have positive effects on metabolic traits, morphology, and behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Jianqiong Zhu, Hongzhen Li, Wulin Aerbajinai, Chutima Kumkhaek, Mehdi Pirooznia, Ankit Saxena, Pradeep Dagur, Kyung Chin, Griffin P. Rodgers
Summary: This study investigated the role of KLF1-GATA1 fusion proteins in hemoglobin expression and phenotypic correction of SCD. The results showed that KLF1-GATA1 fusion proteins enhanced the expression of δ-globin and HbA2, reducing hypoxia-related sickling in erythroid cells. Furthermore, transplantation of SCD mouse hematopoietic stem cells expressing KLF1-GATA1 fusion proteins improved anemia severity, reduced sickling of red blood cells, and restored organ function in SCD mice, suggesting the potential of KLF1-GATA1 fusion constructs as a new gene therapy approach for hemoglobinopathies.
Article
Multidisciplinary Sciences
Geraldine Vitry, Rebecca Finch, Gavin Mcstay, Afshin Behesti, Sebastien Dejean, Tricia Larose, Virginia Wotring, Willian Abraham da Silveira
Summary: In this study, the transcriptome response of liver and quadriceps from mice during spaceflight on NASA RR1 mission was compared, revealing that lipid metabolism was the most affected biological process in these two organs.
Article
Biochemistry & Molecular Biology
Kanako Nakayama, Hiroe Tetsu, Taku Nishijo, Takuo Yuki, Masaaki Miyazawa
Summary: Allergic contact dermatitis (ACD) and atopic dermatitis (AD) are common inflammatory diseases. This study investigated the commonality of findings across haptens and mechanisms focused on dendritic cells (DCs) in AD. The results revealed that attenuated contact hypersensitivity (CHS) responses in AD may be hapten-independent and the tolerogenic phenotype of hapten-bearing DCs can contribute to reduced T-cell proliferation and CHS responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Jie Li, Qi He, Lingwei Wang, Dandan Chen, Chen Qiu, Peng Xu, Yongzhen Lu, Yuwei Zeng, Rongchang Chen
Summary: The study demonstrated that targeting SET with shRNA effectively suppressed the expression of SET, promoted apoptosis of ASMCs, and participated in the development of chronic asthma through modulation of ASMCs phenotype markers and calcium channel-related proteins.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Vappu Nieminen-Pihala, Petri Rummukainen, Fan Wang, Kati Tarkkonen, Kaisa K. Ivaska, Riku Kiviranta
Summary: Ebfs are transcription factors that regulate the differentiation of multiple cell types of mesenchymal origin, including osteoblasts. Deletion of Ebf1 or Ebf2 has different effects on bone formation and bone mass. Targeted deletion of Ebf2 in limb bud mesenchyme cells has mild effects on bone phenotype, while deletion of both Ebf1 and Ebf2 in mesenchymal lineage cells leads to significant increase in bone volume. This phenotype is gender-dependent to some extent and is affected by age. Ebfs likely play important roles in regulating bone homeostasis.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Reproductive Biology
Nannan Kang, Huizhi Shan, Junxia Wang, Jie Mei, Yue Jiang, Jidong Zhou, Chenyang Huang, Hui Zhang, Mei Zhang, Xin Zhen, Guijun Yan, Haixiang Sun
Summary: CAPN7 negatively regulates decidualization of human endometrial stromal cells by hydrolyzing AKT1 and promoting its phosphorylation. Increased expression of CAPN7 in endometriosis suggests that dysregulation of CAPN7 may be a potential cause of endometriosis.
BIOLOGY OF REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Jiao Tian, Nannan Kang, Junxia Wang, Haixiang Sun, Guijun Yan, Chenyang Huang, Jie Mei
Summary: This study identified differentially expressed genes (DEGs) in the endometrium of patients with adenomyosis after GnRHa treatment, indicating significant changes in immune system-associated signal transduction. The highly expressed chemokine (C-C motif) ligand 21 (CCL21) in the eutopic endometrium after GnRHa treatment may be involved in improving endometrial receptivity in adenomyosis.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mei Zhang, Xinyu Cai, Jingyu Liu, Jidong Zhou, Qingqing Shi, Yue Jiang, Nannan Kang, Xin Zhen, Min Wu, Panpan Qiu, Guijun Yan, Haixiang Sun, Dong Li
Summary: Decidualization is crucial for successful pregnancy, and abnormal decidualization is a major cause of recurrent implantation failure. This study found that the lncRNA lncSAMD11-1:1 is significantly decreased in the endometrium of patients with recurrent implantation failure. Overexpression of lncSAMD11-1:1 promotes decidualization and embryo implantation, improving decidualization in patients with recurrent implantation failure.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Andrology
Qiuling Yue, Lina Yu, Wenwen Liu, Jidong Zhou, Xuechun Hu, Yixun Liu, Xue Zhou, Limin Wu, Bo Xu, Xianhong Tong, Xiaohua Jiang, Guijun Yan, Shun Bai
Summary: Through studying the Homez mutant mice, it was found that the Homez gene does not play a crucial role in spermatogenesis and male fertility, but it does regulate the transcription of certain Zhx genes. This finding could prevent unnecessary duplicative work by other research groups.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Materials Science, Ceramics
Meng Miao, Zhipeng Wang, Zhiming Guo, Guijun Yan, Jinfeng Xing
Summary: Researchers have developed a precursor ink for a lattice-matched methylammonium lead iodide solid sol of lead sulfide quantum dots (PbS-QDs/MAPbI3 solid sol) through ligand exchange. They then fabricated a high-performance uncooled photoconductive near-infrared sensor based on this solid sol using a simple dip coating method. This sensor exhibits outstanding overall performance in sensing near-infrared light with high external quantum efficiency, responsivity, detectivity, speed, linearity, and response retention rate.
CERAMICS INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Xinyu Cai, Yue Jiang, Zhiwen Cao, Mei Zhang, Na Kong, Lina Yu, Yedong Tang, Shuangbo Kong, Wenbo Deng, Haibin Wang, Jianxin Sun, Lijun Ding, Ruiwei Jiang, Haixiang Sun, Guijun Yan
Summary: The expression of Mammalian sterile 20 (STE20)-like kinase 1 (Mst1) in the endometrium was decreased in women with recurrent implantation failure (RIF), but its activation promoted trophoblast-uterine epithelium adhesion. Nur77 facilitated trophoblast-uterine epithelium adhesion through the Mst1 signaling pathway and regulated embryo implantation by modulating integrin signaling. This study provides a new approach for assessing endometrial receptivity and treating implantation failure.
Article
Plant Sciences
Rudra Bhattarai, Hui Liu, Kadambot H. M. Siddique, Guijun Yan
Summary: This study compared two NIL pairs with the most contrasting performance in metribuzin treatment and different genetic backgrounds using RNA sequence analysis, identifying nine candidate genes underlying Qsns.uwa.4 A.2 responsible for metribuzin resistance. Quantitative RT-qPCR further validated the candidate genes, with TraesCS4A03G1099000 (nitrate excretion transporter), TraesCS4A03G1181300 (aspartyl protease), and TraesCS4A03G0741300 (glycine-rich proteins) identified as key factors for metribuzin resistance.
Article
Genetics & Heredity
Hui Zhang, Zhilong Wang, Quan Zhou, Zhiwen Cao, Yue Jiang, Manlin Xu, Jingyu Liu, Jidong Zhou, Guijun Yan, Haixiang Sun
Summary: This study found that the expression of INHBB is significantly reduced in women with recurrent implantation failure. The INHBB-ADCY1-mediated cAMP signaling pathway regulates decidualization in these patients.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Environmental Sciences
Yajie Guan, Manlin Xu, Zhe Zhang, Chuanming Liu, Jidong Zhou, Fei Lin, Junshun Fang, Yang Zhang, Qiuling Yue, Xin Zhen, Guijun Yan, Haixiang Sun, Wenwen Liu
Summary: Circadian disturbance, caused by factors like shift employment and nighttime light pollution, is common in modern culture. This study investigated the effects of maternal circadian disruption before pregnancy on the reproductive health of offspring in mice. It was found that the female offspring exposed to constant light showed obesity, abnormal lipid metabolism, earlier puberty onset, impaired ovarian function, and downregulated expression of various genes involved in circadian rhythm and ovarian function. This study also identified altered immune responses as a potential mechanism for the damage to ovarian function.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Tanushree Halder, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Identifying quantitative trait loci (QTL) for different root traits in bread wheat can help breeders develop climate-resilient and high-yielding wheat varieties. This study detected 14 QTL for eight root traits on nine wheat chromosomes and validated two QTL for shallow root depth and high root dry mass in independent populations. The identified QTL and candidate genes are valuable resources for future root trait improvement in wheat.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Endocrinology & Metabolism
Qingqing Shi, Chenyang Huang, Jingyu Liu, Yifan Li, Na Kong, Jie Mei, Xiaoyue Shen, Yanxin Sun, Feifei Lu, Haixiang Sun, Guijun Yan
Summary: Investigated the effects of hormone replacement therapy (HRT) alone or in combination with tamoxifen on patients with thin endometrium in frozen-thawed embryo transfer (FET) cycles. Found that while tamoxifen can significantly increase endometrial thickness, it may not improve the pregnancy outcomes of patients with thin endometrium.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Agronomy
Guannan Liu, Dongcheng Liu, Aimin Zhang, Hui Liu, Md Sultan Mia, Daniel Mullan, Guijun Yan
Summary: This study identified a novel SNP and developed a highly efficient KASP marker for drought tolerance in wheat. The findings have significant implications for research on drought tolerance in wheat.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Agronomy
Guannan Liu, Daniel Mullan, Aimin Zhang, Hui Liu, Dongcheng Liu, Guijun Yan
Summary: Common wheat is an important crop, but markers and genes related to pre-harvest sprouting (PHS) resistance in white-grained wheat are limited. In this study, KASP markers and functional genes related to PHS resistance on wheat chromosome 3AL were identified using near isogenic lines and the 90K SNP chip. These markers and genes are valuable for high-throughput evaluation, marker-assisted selection, and understanding the genetic pathways controlling PHS.
Article
Materials Science, Multidisciplinary
Qiang Zhang, Minghui Jiang, Guijun Yan, Yaqing Feng, Bao Zhang
Summary: In this study, stable CsPbBr3 quantum dots were successfully synthesized by introducing fluorinated aromatic ammonium bromide, leading to significantly improved photoluminescence quantum yield. The use of short ligand chains also improved carrier transport, resulting in a significant increase in the luminance of CsPbBr3 quantum dot light-emitting diodes.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
