Article
Multidisciplinary Sciences
Donato Santovito, Lisa Toto, Velia De Nardis, Pamela Marcantonio, Rossella D'Aloisio, Alessandra Mastropasqua, Domenico De Cesare, Marco Bucci, Camilla Paganelli, Lucia Natarelli, Christian Weber, Agostino Consoli, Rodolfo Mastropasqua, Francesco Cipollone
Summary: DR patients have higher levels of circulating miR-25-3p and miR-320b, and lower levels of miR-495-3p, which are associated with disease severity. These miRNAs could serve as biomarkers for DR and suggest novel molecular targets for improving patient care.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Hua Hu, Meng Zhao, Zhaoyang Li, Hongli Nie, Jia He, Zhuo Chen, Jing Yuan, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Summary: This study explored the differentially expressed miRNAs in type 2 diabetes and their potential cellular functions. It was found that miR-193b-3p expression increased in type 2 diabetes cases while TPI1 expression decreased. miR-193b-3p may affect glucose metabolism by inhibiting insulin receptor and GLUT2 expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Hongli Nie, Hua Hu, Zhaoyang Li, Ruixin Wang, Jia He, Peiwen Li, Weiya Li, Xu Cheng, Jun An, Zefang Zhang, Jiao Bi, Jinqiu Yao, Huan Guo, Xiaomin Zhang, Meian He
Summary: This study found significant associations between several plasma metal levels and diabetes risk, as well as certain plasma miRNAs being related to diabetes risk. MiR-122-5p mediated the relationship between titanium and diabetes risk by 48.0%.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Alessandro Mantovani, Andrea Dalbeni, Denise Peserico, Filippo Cattazzo, Michele Bevilacqua, Gian Luca Salvagno, Giuseppe Lippi, Giovanni Targher, Elisa Danese, Cristiano Fava
Summary: This study reveals marked differences in plasma bile acid profiles between patients with and without T2DM, with higher levels of both primary and secondary bile acids in T2DM patients, as well as specific bile acid species showing significant associations with T2DM status. Further research is needed to elucidate the potential interplay between these differences in plasma bile acid profiles and the pathophysiology of T2DM.
Article
Endocrinology & Metabolism
Wanglong Gou, Liang Yue, Xin-yi Tang, Yan-yan Wu, Xue Cai, Menglei Shuai, Zelei Miao, Yuanqing Fu, Hao Chen, Zengliang Jiang, Jiali Wang, Yunyi Tian, Congmei Xiao, Nan Xiang, Zhen Wu, Yu-ming Chen, Tiannan Guo, Ju-Sheng Zheng
Summary: This study identified proteomic biomarkers for incident T2D among Chinese populations and found seven proteins associated with T2D. The research also indicated a potential synergistic interaction between dietary factors such as red meat intake and these biomarkers in exaggerating the risk of T2D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Alejandro Villasanta-Gonzalez, Juan Francisco Alcala-Diaz, Cristina Vals-Delgado, Antonio Pablo Arenas, Magdalena P. Cardelo, Juan Luis Romero-Cabrera, Fernando Rodriguez-Cantalejo, Javier Delgado-Lista, Maria M. Malagon, Pablo Perez-Martinez, Matthias B. Schulze, Antonio Camargo, Jose Lopez-Miranda
Summary: The study identified a plasma fatty acid profile associated with the development of T2DM, which can be used as a predictive biomarker. Patients with higher FA scores were more likely to develop T2DM and had lower insulin sensitivity and higher hepatic insulin resistance.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Immunology
Anna-Mari Schroderus, Josh Poorbaugh, Samantha McElyea, Stephanie Beasley, Lin Zhang, Kirsti Nanto-Salonen, Reeta Rintamaki, Jussi Pihlajamaki, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Robert J. Benschop, Tuure Kinnunen
Summary: This study aimed to examine plasma IL-21 levels in individuals at different stages of type 1 diabetes progression. The results showed that adults with established type 1 diabetes had higher plasma IL-21 levels compared to healthy controls, but no significant correlation was found with clinical variables. In children, plasma IL-21 levels were almost ten times higher, but no significant differences were detected between different groups.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Hongmei Zhu, Siu-wai Leung
Summary: This study synthesized the evidence from microRNA-type 2 diabetes association studies and microRNA-regulated type 2 diabetes pathway delineation studies to identify and validate statistically and biologically significant microRNAs as type 2 diabetes biomarkers. Sixteen microRNAs were found to meet the criteria for biomarker selection.
Article
Biochemistry & Molecular Biology
Tiago Morais, Alexandre L. Seabra, Barbara G. Patricio, Marta Guimaraes, Mario Nora, Pedro F. Oliveira, Marco G. Alves, Mariana P. Monteiro
Summary: The study revealed that there are differences in VAT metabolic fingerprint between obesity and different glycemic statuses, characterized by higher isoleucine consumption, lower acetate production, and lower pyruvate and pyroglutamate consumption in pre-diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anand Thakarakkattil Narayanan Nair, Agata Wesolowska-Andersen, Caroline Brorsson, Aravind Lathika Rajendrakumar, Simona Hapca, Sushrima Gan, Adem Y. Dawed, Louise A. Donnelly, Rory McCrimmon, Alex S. F. Doney, Colin N. A. Palmer, Viswanathan Mohan, Ranjit M. Anjana, Andrew T. Hattersley, John M. Dennis, Ewan R. Pearson
Summary: An analysis of newly diagnosed diabetes patients reveals the impact of phenotypic variation on disease onset, clinical outcomes, and drug response. The study shows that patients with different phenotypes have varying risks of diabetic complications and respond differently to different drugs. These findings are important for personalized treatment of diabetes.
Article
Medicine, General & Internal
Anders Gummesson, Elias Bjornson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Baeckhed, Jochen M. Schwenk, Per-Anders Jansson, Mathias Uhlen, Goran Bergstrom
Summary: The study found distinct protein patterns in early-stage type 2 diabetes patients, reflecting key metabolic syndrome features. These patterns improved after treatment, indicating that comprehensive protein profiling can be a useful tool in elucidating the biological effects of diabetes treatments.
Article
Multidisciplinary Sciences
Sonu Yadav, Russell Pickford, Robert A. Zammit, J. William O. Ballard
Summary: The dingo's metabolome is significantly different from domestic dog breeds, with notable variations in protein and lipid metabolites. Hybridization between dingoes and domestic dogs may influence carbohydrate metabolism, potentially due to differences in genetic factors such as amylase 2B copy number.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Nawajes Mandal, Frankie Stentz, Peace Chiamaka Asuzu, Ebenezer Nyenwe, Jim Wan, Sam Dagogo-Jack
Summary: This study compares the plasma sphingolipid profiles in Black and White adults with and without family history of type 2 diabetes (T2D). It found that healthy adults with a family history of T2D have higher levels of sphingomyelin and oleic acid-containing sphingolipids in their plasma compared to those without a family history, suggesting a potential link between these sphingolipids and the development of T2D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jing-Wan Qi, Bing Huang, Shuang Wang, Dan Song, Jing Xu, Ying Cui, Bin Guo
Summary: This study investigated the relationship between plasma VD2 and T2DM and found that VD2 levels were similar in patients with and without T2DM. Caution should be exercised in giving VD2 supplementation to patients with T2DM unless other diseases requiring VD2 supplementation are present.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Giuseppina Catanzaro, Federica Conte, Sofia Trocchianesi, Elena Splendiani, Viviana Maria Bimonte, Edoardo Mocini, Tiziana Filardi, Agnese Po, Zein Mersini Besharat, Maria Cristina Gentile, Paola Paci, Susanna Morano, Silvia Migliaccio, Elisabetta Ferretti
Summary: Obesity is a major risk factor for many non-communicable diseases. This study aimed to identify circulating biomarkers for obese patients at higher risk of developing type 2 diabetes (DM2) through the analysis of circulating microRNAs. The results suggest that miR-155-5p could be a potential circulating biomarker for DM2, and its combination with other inflammatory markers in obese patients can predict the risk of developing DM2.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Federico Carlini, Federico Ivaldi, Francesca Gualandi, Ursula Boschert, Diego Centonze, Giuseppe Matarese, Marco Salvetti, Nicole Kerlero de Rosbo, Antonio Uccelli
Summary: The study reveals an important relationship between dCK activity and the effect of cladribine on B and T cells, depending on their activation status. Further research is needed to evaluate whether dCK activity could be a suitable predictive biomarker of lymphocyte response to cladribine in the future.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Silvia Garavelli, Francesco Prattichizzo, Antonio Ceriello, Mario Galgani, Paola de Candia
Summary: Type 1 diabetes is characterized by autoimmune destruction of insulin-secreting beta cells. Recent research suggests that extracellular vesicles (EVs) may serve as biomarkers and therapeutic targets for disease progression and complications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Endocrinology & Metabolism
Francesco Prattichizzo, Paola de Candia, Antonio Nicolucci, Antonio Ceriello
Summary: This meta-analysis aimed to explore the impact of HbA1c values at hospital pre-admission or at-admission on COVID-19 mortality or worsening in patients with diabetes. The results from seven observational studies showed that HbA1c was linearly associated with increased risk of COVID-19 mortality or worsening, especially in patients with poor glycaemic control.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Oncology
Luca Simula, Ylenia Antonucci, Giorgia Scarpelli, Valeria Cancila, Alessandra Colamatteo, Simona Manni, Biagio De Angelis, Concetta Quintarelli, Claudio Procaccini, Giuseppe Matarese, Claudio Tripodo, Silvia Campello
Summary: The PD-1 signaling pathway downregulates T-cell response by inhibiting Drp1 activity, leading to reduced motility and proliferation of tumor-infiltrating T cells. This highlights the potential of targeting Drp1 activity as a valuable strategy to enhance anticancer immune response in future immunotherapy approaches.
MOLECULAR ONCOLOGY
(2022)
Article
Clinical Neurology
Francesca De Vito, Alessandra Musella, Diego Fresegna, Francesca Romana Rizzo, Antonietta Gentile, Mario Stampanoni Bassi, Luana Gilio, Fabio Buttari, Claudio Procaccini, Alessandra Colamatteo, Silvia Bullitta, Livia Guadalupi, Silvia Caioli, Valentina Vanni, Sara Balletta, Krizia Sanna, Antonio Bruno, Ettore Dolcetti, Roberto Furlan, Annamaria Finardi, Valerio Licursi, Jelena Drulovic, Tatjana Pekmezovic, Clorinda Fusco, Sara Bruzzaniti, Eran Hornstein, Antonio Uccelli, Marco Salvetti, Giuseppe Matarese, Diego Centonze, Georgia Mandolesi
Summary: MiR-142-3p is a potential negative prognostic CSF marker of MS, showing positive correlations with clinical progression, IL-1 beta signalling, and synaptic excitability. Treatment with DMF, a disease-modifying therapy, had a superior effect on patients with low levels of miR-142-3p.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Editorial Material
Immunology
Paola de Candia, Giuseppe Matarese
Summary: This study reveals the role of folate-dependent one carbon metabolism enzyme MTHFD2 in CD4(+) T cell polarization and suggests its involvement in suppressing pro-inflammatory T cells while promoting regulatory T cells.
Article
Immunology
Lucia La Sala, Sara Gandini, Antonino Bruno, Raffaele Allevi, Matteo Gallazzi, Pamela Senesi, Maria Teresa Palano, Paola Meregalli, Ermanno Longhi, Carmen Sommese, Livio Luzi, Emilio Trabucchi
Summary: This study assessed the effects of a two-dose regimen of the Pfizer mRNA vaccine on the immune system. The results showed that the vaccine stimulated the increase of B cells and NK cells, but had a limited effect on T cells. These findings raise concerns about the effectiveness of a two-dose vaccination in providing full immune protection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Federica Azzolini, Luana Gilio, Luigi Pavone, Ennio Iezzi, Ettore Dolcetti, Antonio Bruno, Fabio Buttari, Alessandra Musella, Georgia Mandolesi, Livia Guadalupi, Roberto Furlan, Annamaria Finardi, Teresa Micillo, Fortunata Carbone, Giuseppe Matarese, Diego Centonze, Mario Stampanoni Bassi
Summary: The study found that GFAP and sTREM-2 are suitable biomarkers for central inflammation in multiple sclerosis (MS) and are associated with certain inflammatory factors and clinical characteristics. Enhanced CSF expression of GFAP may indicate a higher risk of progression in patients.
Article
Cardiac & Cardiovascular Systems
Lucia La Sala, Elena Tagliabue, Simona Mrakic-Sposta, Anna Chiara Uccellatore, Pamela Senesi, Ileana Terruzzi, Emilio Trabucchi, Luigi Rossi-Bernardi, Livio Luzi
Summary: This study showed that circulating miR-21, ROS, and HNE levels decreased significantly in dysglycemic subjects after habit intervention, along with improvements in metabolic parameters. There was a significant positive interaction between the miR-21 axis and glycemic parameters after habit intervention, with lower miR-21 levels strongly associated with a reduction in glycemic damaging-axis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rosalba La Grotta, Paola de Candia, Fabiola Olivieri, Giulia Matacchione, Angelica Giuliani, Maria Rita Rippo, Elena Tagliabue, Monica Mancino, Francesca Rispoli, Sabina Ferroni, Cesare Celeste Berra, Antonio Ceriello, Francesco Prattichizzo
Summary: This study investigated the effect of SGLT-2 inhibitors on low-grade inflammation (LGI) in patients with type 2 diabetes (T2D) and the underlying mechanism. The results showed that SGLT-2 inhibitors can reduce circulating levels of IL-6, a marker of LGI, and this effect may be mediated by the lowering of uric acid and insulin concentrations. These findings are important for understanding the protective effect of SGLT-2 inhibitors on cardiovascular and renal diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Andrea Sonaglioni, Gian Luigi Nicolosi, Elisabetta Rigamonti, Michele Lombardo, Lucia La Sala
Summary: The pathological remodeling of myocardial tissue is the main cause of heart diseases. Myocardial fibrosis, characterized by the excessive accumulation of extracellular matrix proteins in response to an injury, plays a critical role in disrupting heart functionality. The diagnosis of myocardial fibrosis remains a challenge, with current techniques being invasive or non-specific. Two-dimensional speckle tracking echocardiography (STE) has emerged as a non-invasive imaging modality for tissue characterization, but it has limitations and criticisms. Coupling STE with molecular approaches and studying epigenetic markers and microRNA-based mechanisms may provide insights into tissue characterization and assessment of myocardial fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Claudio Procaccini, Paola de Candia, Claudia Russo, Giusy De Rosa, Maria Teresa Lepore, Alessandra Colamatteo, Giuseppe Matarese
Summary: Nutrition plays a significant role in physiological processes, especially the function of the immune system. Excessive energy intake causes inflammation, while calorie restriction without malnutrition has been shown to delay aging and have anti-inflammatory effects. This review discusses the ability of different calorie restriction-related nutritional strategies to control autoimmune, cardiovascular, and infectious diseases through preclinical studies and human clinical trials, with a focus on immunological aspects. The cellular and molecular mechanisms underlying the beneficial effects of calorie restriction, such as immune cell metabolic rewiring, regulatory T cell expansion, and gut microbiota composition, are also summarized. Despite the need for further studies on feasibility and efficacy in clinical practice, experimental observations suggest that calorie restriction can lower inflammation in various pathologies and thus represents a promising therapeutic strategy for human health control.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Renata Auricchio, Martina Galatola, Donatella Cielo, Roberta Rotondo, Fortunata Carbone, Roberta Mandile, Martina Carpinelli, Serena Vitale, Giuseppe Matarese, Carmen Gianfrani, Riccardo Troncone, Salvatore Auricchio, Luigi Greco
Summary: This study explored the relationship between antibody production in genetically susceptible individuals and systemic inflammation in celiac disease. The early and isolated production of anti-native gliadin-IgA antibodies may be a marker of tolerance to deamidated gliadin and tissue transglutaminase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alessandra Colamatteo, Clorinda Fusco, Teresa Micillo, Thomas D'Hooghe, Paola de Candia, Carlo Alviggi, Salvatore Longobardi, Giuseppe Matarese
Summary: Embryo implantation failure and spontaneous abortions are the main causes of infertility in developed countries. The success rate of medically assisted procreation techniques remains relatively low due to incomplete understanding of the various factors involved in implantation and fetal development. Recent research has highlighted the importance of immunogenic tolerance mechanisms in establishing an anti-inflammatory state conducive to a healthy pregnancy. This review explores the role of the immune system in the endometrial-embryo crosstalk, particularly focusing on Foxp3(+) CD4(+)CD25(+) regulatory T (Treg) cells, and discusses recent therapeutic advances in early immune-mediated pregnancy loss.
TRENDS IN MOLECULAR MEDICINE
(2023)