Article
Biochemistry & Molecular Biology
Jingqian Su, Siyuan Chen, Jianbin Xiao, Zhihua Feng, Shan Hu, Qiaofen Su, Qi Chen, Duo Chen
Summary: This study explores the therapeutic potential of aloe-emodin (AE) in the treatment of CLP-induced sepsis, demonstrating its ability to mitigate systemic inflammation and regulate the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Pratsanee Hiengrach, Wimonrat Panpetch, Ariya Chindamporn, Asada Leelahavanichkul
Summary: Macrophage depletion exacerbates sepsis by promoting bacterial dysbiosis and gut leakage.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Andrew S. Wagner, Stephen W. Lumsdaine, Mikayla M. Mangrum, Todd B. Reynolds
Summary: To effectively induce disease, Candida albicans masks immunogenic β(1,3)-glucan epitopes within its cell wall under a layer of mannosylated glycoproteins. Treatment with the antifungal drug caspofungin enhances the exposure (unmasking) of β(1,3)-glucan, making the fungal cells more visible to the host immune system and attenuating disease progression. Our study reveals a correlation between increased chitin synthesis and β(1,3)-glucan unmasking in response to caspofungin, suggesting that altered chitin synthesis drives increased unmasking during drug exposure.
Article
Immunology
Bin Zhang, Feng Zheng, Anpeng Liu, Zhen Li, Fei Zheng, Qiangsheng Liu, Liu Yang, Kai Chen, Yanlin Wang, Zongze Zhang, Qianwen He, Jia Zhan
Summary: Activation of CB2 receptors plays a protective role in sepsis by inhibiting pyroptosis and reducing the release of inflammatory mediators. The protective effect depends on the presence of endogenous CB2 receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tania Lima, Stefan B. Gunnarsson, Elisabete Coelho, Dmitry Evtuguin, Alexandra Correia, Manuel A. Coimbra, Tommy Cedervall, Manuel Vilanova
Summary: This study developed a method using nanoparticles to modulate the deleterious inflammatory response caused by fungal infection. The results showed that β-Glc-PS nanoparticles can reduce the inflammatory response caused by C. albicans cells and decrease the production of reactive oxygen species. This provides a theoretical basis for the development of targeted therapy for fungal infections.
Article
Immunology
Wanwei Sun, Heping Wang, Huijun Hu, Xiaojian Ma, Huazhi Zhang, Jianwen Chen, Yanyun Du, Ruirui He, Zhihui Cui, Qianwen Peng, Chenhui Wang
Summary: This study demonstrates that EPHB2 acts as a coreceptor for Dectin-1 ligand recognition and plays an essential role in antifungal immunity by phosphorylating Syk.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Raquel Pires Nakama, Aparecida Donizette Malvezi, Maria Isabel Lovo-Martins, Lucas Felipe dos Santos, Ana Paula Canizares Cardoso, Gustavo Scacco, Andressa Mendes Dionisio de Freitas, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
Summary: The study found that metabolic syndrome can improve survival rates in septic mice, prevent damage to hematological and cardiovascular functions, and reduce the typical feature of increased nitric oxide in sepsis.
Article
Biochemistry & Molecular Biology
Pratsanee Hiengrach, Peerapat Visitchanakun, Pakteema Tongchairawewat, Ponphisudti Tangsirisatian, Thitiphat Jungteerapanich, Patcharee Ritprajak, Dhammika Leshan Wannigama, Pattarin Tangtanatakul, Asada Leelahavanichkul
Summary: BAM15 shows potential as an adjuvant therapy against sepsis hyperinflammation by attenuating multiple aspects of septic conditions, such as survival, organ damage, apoptosis, and brain injury, as well as regulating mitochondrial functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Peng
Summary: Our study reveals the important role of the HPC-PFC pathway in improving cognitive dysfunction in a mouse model of CLP sepsis and provides a novel pathogenetic mechanism for SAE.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Aliaa Anter, Al-Shaimaa F. Ahmed, Asmaa S. A. Hammad, Waleed Hassan Almalki, Sara Mohamed Naguib Abdel Hafez, AlShaimaa W. Kasem, Mohamed A. El-Moselhy, Mohammad W. Alrabia, Ahmed R. N. Ibrahim, Mahmoud El-Daly
Summary: The study aimed to evaluate the effect of menthol against sepsis-induced mortality, acute lung injury (ALI), and acute kidney injury (AKI). Menthol improved survival after sepsis and alleviated the development of ALI and AKI. Additionally, menthol also suppressed inflammation and apoptosis markers, showing its protective role in experimental sepsis.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Antonio Serrano, Miguel A. Basante-Bedoya, Martine Bassilana, Robert A. Arkowitz
Summary: Ergosterol, an essential component of the fungal plasma membrane, plays a critical role in the cell cycle of Candida albicans. The dynamics of ergosterol and its response to drug treatment were investigated using the D4H reporter. The study showed that highly polarized ergosterol is not necessary for budding or filamentous growth in this opportunistic pathogen.
Article
Biochemistry & Molecular Biology
Donghwan Park, MyungJa Ro, A-Jin Lee, Dong-Wook Kwak, Yunro Chung, Jae-Hong Kim
Summary: The study found that BLT2, a receptor for leukotriene B-4 with low affinity, plays a role in sepsis, a systemic inflammatory response syndrome caused by infection. Levels of BLT2 ligands and synthesizing enzymes for LTB4 and 12(S)-HETE were significantly increased in lung and liver tissues in a septic mouse model. Blocking BLT2 suppressed the production of sepsis-associated cytokines and alleviated lung inflammation in the sepsis group, suggesting that BLT2 may be a potential therapeutic target for sepsis patients.
MOLECULES AND CELLS
(2021)
Article
Physiology
Jose Maria Moreno-Navarrete, Ferran Comas, Vincent de Jager, Jose Manuel Fernandez-Real, Hjalmar R. Bouma
Summary: The study found that sepsis reduces the expression of adipogenesis-related genes in white adipose tissue while promoting inflammation in adipose tissue. In contrast, sepsis increases inflammation in brown adipose tissue without affecting the expression of thermogenic genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Summary: Neutrophil extracellular traps (NETs) can contribute to host inflammatory tissue damage during sepsis. This study investigated a novel therapeutic agent, neonatal NET-Inhibitory Factor (nNIF), and found that nNIF inhibited NET formation and improved survival in a mouse model of sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Fateme Abedini, Shahla Roudbar Mohammadi, Mostafa Dahmardehei, Marjan Ajami, Maryam Salimi, Halala Khalandi, Monireh Mohsenzadegan, Farhad Seif, Bahador Nikoueian Shirvan, Sanaz Yaalimadad, Maryam Roudbary, Celia F. Rodrigues
Summary: Beta-glucan ointment has efficacy in burn wound healing and has a significant impact on IL-4 levels.
Article
Critical Care Medicine
Wimonrat Panpetch, Naraporn Somboonna, Dewi Embong Bulan, Jiraphorn Issara-Amphorn, Navaporn Worasilchai, Malcolm Finkelman, Ariya Chindamporn, Tanapat Palaga, Somying Tumwasorn, Asada Leelahavanichkul
Article
Biodiversity Conservation
Suppakarn Jandang, Dewi E. Bulan, Suchana Chavanich, Voranop Viyakarn, Kornrawee Aiemsomboon, Naraporn Somboonna
Summary: This study reported the occurrence of coral disease in a coral hatchery in Thailand. The disease was commonly found on corals aged two to five years old during the months of November to December. Analysis showed that the dominant bacteria genus in the diseased corals was Vibrio spp. This disease occurrence in the coral hatchery may have significant effects on the health and survival of juvenile corals before transplantation to natural reefs for restoration.
Article
Environmental Sciences
Dewi Embong Bulan, Alisa Wilantho, Patcharaporn Krainara, Voranop Viyakarn, Suchana Chavanich, Narapom Somboonna
FRONTIERS IN MARINE SCIENCE
(2018)
Article
Environmental Sciences
Dewi Embong Bulan, Alisa Wilantho, Sissades Tongsima, Voranop Viyakarn, Suchana Chavanich, Narapom Somboonna
FRONTIERS IN MARINE SCIENCE
(2018)