Article
Biochemistry & Molecular Biology
Tie Sun, Jing Tang, Yi-Cong Pan, Chen-Yu Yu, Biao Li, Li-Juan Zhang, Hui-Ye Shu, Qian-Min Ge, Yi Shao
Summary: The study revealed that the concentration of neuron-specific enolase (NSE) is a risk factor for intraocular metastasis (IOM) in patients with renal cell carcinoma.
BIOSCIENCE REPORTS
(2021)
Article
Pediatrics
Hui-Zhi Huang, Xiao-Feng Hu, Xiao-Hong Wen, Li-Qi Yang
Summary: This study aimed to investigate the predictive value of serum NSE, aEEG, and MRI for the neurological outcomes in neonates with HIE. The results showed that increased serum NSE levels, abnormal MRI findings, and abnormal aEEG were associated with worse neurodevelopment outcomes. The combination of these three indicators improved the predictive ability for long-term neurobehavioral prognosis.
Article
Clinical Neurology
Giulio Disanto, Michele Villa, Aleksandra Maleska Maceski, Chiara Prosperetti, Claudio Gobbi, Jens Kuhle, Tiziano Cassina, Pamela Agazzi
Summary: Serum neurofilament light (sNfL) is a promising marker for predicting the outcome of cardiac arrest. The study found that sNfL levels were similar between survivors and non-survivors upon admission, but significant differences were observed after 24 hours. sNfL concentrations showed high predictive value for death, especially when early samples were unavailable or prognosis remained uncertain.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Dongwook Lee, Yongil Cho, Yujin Ko, Nam Hun Heo, Hyung Goo Kang, Sangsoo Han
Summary: The initial serum NSE level in near-hanging patients is found to be an independent predictor of poor neurological outcome, especially in cases of cardiac arrest.
Article
Clinical Neurology
Aurelie Hanin, Sophie Demeret, Jerome Alexandre Denis, Vi-Huong Nguyen-Michel, Benjamin Rohaut, Clemence Marois, Francoise Imbert-Bismut, Dominique Bonnefont-Rousselot, Pierre Levy, Vincent Navarro, Virginie Lambrecq
Summary: The study discussed the relationship between neuron-specific enolase (NSE) and S100-beta (S100B) levels with EEG activity to evaluate seizure risk in patients with acute brain injury. It was found that NSE levels were positively correlated with EEG scores, and higher NSE levels were associated with an increased risk of seizure recurrence.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medical Laboratory Technology
Xiao-Min Liu, Xiao-Hua Liu, Min-Jie Mao, Yi-Jun Liu, Jun-Ye Wang, Shu-Qin Dai
Summary: This study aimed to establish a solution integrated with laboratory information system to clear the bias from hemolysis on serum NSE test. The results showed that the agreement between individual correction equation and NSE assay was satisfactory, indicating the effectiveness of the automated processing algorithm in correcting positive bias from specimen hemolysis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Critical Care Medicine
Emilie Lissner Ostlund, Helena Levin, Niklas Nielsen, Attila Frigyesi, Anna Lybeck
Summary: This study aimed to investigate the predictive ability of NSE levels at different time points after ROSC for long-term neurological prognosis, and to validate previously suggested NSE cut-offs. The results of the local validation study showed that the NSE cut-off values generated were higher than those suggested by previous publications.
Article
Urology & Nephrology
Tibor Szarvas, Anita Csizmarik, Tamas Fazekas, Andras Huttl, Peter Nyirady, Boris Hadaschik, Viktor Gruenwald, Lukas Puellen, Zsolt Juranyi, Zsuzsa Kocsis, Shahrokh F. Shariat, Sabina Sevcenco, Agnieszka Maj-Hes, Gero Kramer
Summary: The study assessed chromogranin A (CGA) and neuron-specific enolase (NSE) levels and changes in different stages of prostate cancer. Results showed higher levels of CGA and NSE in castration-resistant patients compared to hormone-naive patients, with high baseline CGA levels associated with poor survival. Serum CGA levels could assist in tailoring and monitoring therapy for advanced prostate cancer.
Article
Immunology
Changyang Zhong, Ding Lin, Yuan Liu, Chunli Wu
Summary: The study found that serum NSE levels were significantly higher in patients with post-herpetic neuralgia compared to healthy volunteers, with higher levels seen in the severe PHN group. There was a positive correlation between NSE levels and short-term prognosis in patients with PHN after treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Ceren Karaman, Omer Saltuk Bolukbasi, Bahar Bankoglu Yola, Onur Karaman, Necip Atar, Mehmet Lutfi Yola
Summary: In this study, an electrochemical NSE immunosensor based on AuNPs@MoS2/rGO electrode platform and CoFe2O4@Ag nanocomposite as the signal amplification was developed, which can be successfully utilized in the early diagnosis for lung cancer.
ANALYTICA CHIMICA ACTA
(2022)
Article
Medicine, General & Internal
Robert Ryczek, Przemyslaw J. Kwasiborski, Agnieszka Rzeszotarska, Jolanta Dymus, Agata Galas, Anna Kazmierczak-Dziuk, Anna M. Karasek, Marta Mielniczuk, Malgorzata Buksinska-Lisik, Jolanta Korsak, Pawel Krzesinski
Summary: Measurements of NSE and S100B at admission can accurately identify patients with poor clinical outcomes after OHCA with 100% specificity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Dong Ah Lee, Kyung Ran Jun, Hyung Chan Kim, Bong Soo Park, Kang Min Park
Summary: This study evaluated the role of serum NSE levels in patients with transient global amnesia (TGA) and found that a third of patients had elevated NSE levels, which may be associated with cognitive impairment.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Hong-Bo Huang, Jun-Ling Huang, Xiao-Ting Xu, Kun-Bo Huang, Yi-Jian Lin, Jie-Bin Lin, Xi-Bin Zhuang
Summary: Serum NSE concentration may serve as a promising biomarker for the diagnosis and staging of silicosis. The study found significant differences in serum NSE concentration between silicosis patients and the control group, as well as among patients at different stages of silicosis.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Clinical Neurology
Jaimala Kishore, Fouzia Shaikh, Adnan Mustafa Zubairi, Sana Mirza, Montaser N. Alqutub, Abdulrahman M. AlMubarak, Tariq Abduljabbar, Fahim Vohra
Summary: The study evaluated levels of neuron-specific enolase in primary and secondary burning mouth syndrome patients, finding a significant increase in neuron-specific enolase levels in primary burning mouth syndrome patients, indicating a possible neuropathic mechanism. Among secondary burning mouth syndrome patients, individuals with diabetes showed a significant increase in neuron-specific enolase levels.
Article
Medicine, General & Internal
Jinmin Li, Xiangyang Liu, Mo Chen, Jiachen Wang, Xinning Wang
Summary: In this study, serum CA125, NSE, and 24-hour urine VMA levels were found to be useful in assessing the condition and predicting the treatment effect for children with neuroblastoma.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Marie Johne, Kerstin Roemermann, Philip Hampel, Bjoern Gailus, Wiebke Theilmann, Tommi Ala-Kurikka, Kai Kaila, Wolfgang Loescher
Summary: The study evaluated the effect of bumetanide as an adjunct to phenobarbital on neonatal seizures, showing that bumetanide does not increase the efficacy of phenobarbital in a model of birth asphyxia.
Article
Clinical Neurology
Tommi Ala-Kurikka, Alexey Pospelov, Milla Summanen, Aleksander Alafuzoff, Samu Kurki, Juha Voipio, Kai Kaila
Summary: A rat model of birth asphyxia was developed to mimic clinical cases, showing that seizures are triggered after exposure to hypoxia, rather than during the insult.
Review
Neurosciences
Mari A. Virtanen, Pavel Uvarov, Martina Mavrovic, Jean Christophe Poncer, Kai Kaila
Summary: KCC2 is a multifunctional molecule that can regulate the strength and polarity of GABAergic currents and cytoskeletal dynamics. Its various splice variants play roles in controlling early network events and the formation and plasticity of cortical dendritic spines. The versatility of KCC2 actions is evident in mature neurons during plasticity, disease, and aging, making it one of the most important molecules shaping the overall neuronal phenotype.
TRENDS IN NEUROSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Enni Bertling, Peter Blaesse, Patricia Seja, Elena Kremneva, Gergana Gateva, Mari A. Virtanen, Milla Summanen, Inkeri Spoljaric, Pavel Uvarov, Michael Blaesse, Ville O. Paavilainen, Laszlo Vutskits, Kai Kaila, Pirta Hotulainen, Eva Ruusuvuori
Summary: Intracellular pH is regulated by carbonic anhydrase isoforms CA2 and CA7 in neurons. CA7 interacts with actin, affecting cell morphology, while unique amino acids in CA7 promote actin interaction and influence spine density in neurons.
Review
Clinical Neurology
Wolfgang Loescher, Kai Kaila
Summary: This response corrects the inaccurate descriptions of the model and data in a recent study on the pharmacology of neonatal seizures in a novel rat model of birth asphyxia by Ben-Ari and Delpire. The authors also address the implications of bumetanide actions on neurons in other brain disorders due to its poor brain penetration and wide cellular expression patterns of the target protein NKCC1.
Article
Orthopedics
Milla Summanen, Liisa Ukkola-Vuoti, Samu Kurki, Samuli Tuominen, Rami Madanat
Summary: This study utilized electronic medical records from Finnish occupational healthcare to identify the burden of hip and knee osteoarthritis. Results showed that OA patients had more comorbidities, healthcare contacts, sick leave days, and analgesic prescriptions compared to an age- and gender-matched control cohort without OA.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Krisztina Toth, Nikolett Lenart, Peter Berki, Rebeka Fekete, Eszter Szabadits, Balazs Posfai, Csaba Cserep, Ahmad Alatshan, Szilvia Benko, Daniel Kiss, Christian A. Huebner, Attila Gulyas, Kai Kaila, Zsuzsanna Koernyei, Adam Denes
Summary: The NKCC1 ion transporter has an important role in microglia, the main inflammatory cells of the brain, by regulating cellular morphology, volume changes, and inflammatory responses. Microglial NKCC1 deficiency leads to exaggerated inflammation and worsened neurological outcomes.
Editorial Material
Clinical Neurology
Kai Kaila, Wolfgang Loescher
Summary: This article responds to Kevin Staley's critique of our research, explaining that our study was conducted on an asphyxia model, not just hypercarbia; clinically relevant doses of bumetanide lead to significantly lower concentrations in the brain than what is needed for any direct effect on neuronal functions; furthermore, bumetanide's molecular target in the brain has vital functions that make specifically targeting the depolarizing and excitatory actions of gamma-aminobutyric acid in neonatal seizures difficult.
Article
Neurosciences
Wolfgang Loescher, Kai Kaila
Summary: Current NKCC1 inhibitors like bumetanide have limited penetration into the CNS, leading to the need for further research to develop brain-permeant compounds that are selective for NKCC1. Another challenge is to understand the effects of these drugs on different NKCC1-expressing cellular targets within and outside the brain parenchyma.
Article
Neurosciences
Samu N. Kurki, Pavel Uvarov, Alexey S. Pospelov, Kalevi Trontti, Antje K. Huebner, Rakenduvadhana Srinivasan, Masahiko Watanabe, Iiris Hovatta, Christian A. Huebner, Kai Kaila, Mari A. Virtanen
Summary: The widely expressed Na-K-2Cl cotransporter NKCC1 has been hindered in its understanding of its roles in brain functions and disorders due to lack of reliable data on its developmental and (sub)cellular expression patterns. This study provides a well-controlled analysis of NKCC1 protein expression in different cell types of the mouse brain and reveals its high levels in oligodendrocytes, differential expression in neurons, microglia, astrocytes, developing pericytes, and progenitor cells of the dentate gyrus, and the presence of NKCC1 splice variants. These findings contribute to our understanding of NKCC1 functions in the brain and have implications for the development of neuron-targeting NKCC1-blockers.
Article
Neurosciences
Robert J. Hatch, Geza Berecki, Nikola Jancovski, Melody Li, Ben Rollo, Paymaan Jafar-Nejad, Frank Rigo, Kai Kaila, Christopher A. Reid, Steven Petrou
Summary: Brain pH plays a critical role in determining neuronal activity, with alkalosis increasing excitability and acidosis reducing it. This study investigates the molecular mechanisms behind the seizure protection observed when brain pH shifts through the inhalation of carbogen. The findings suggest that acidification reduces excitability in excitatory neurons but has no effect on inhibitory neurons, providing insight into the basis of seizure suppression caused by carbogen-mediated acidification.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Milla Summanen, Mikko Kosunen, Ville Kainu, Anniina Cansel, Severi Niskanen, Lalli Nurmi, Riikka-Leena Leskelae, Outi Isomeri
Summary: Since March 2020, healthcare systems worldwide have faced the burden of COVID-19 as a global pandemic. Vaccinations and preventive measures have reduced the burden, but severe cases leading to hospitalizations and deaths still affect certain high-risk groups. This retrospective observational study analyzed national registry data in Finland from January 2021 to June 2022 to identify the highest risk groups for severe COVID-19 infections. The results indicate that despite a decrease in hospitalizations and deaths, a significant proportion of patients, especially those aged 60 and above, still require hospitalization and experience longer stays.
Article
Clinical Neurology
James Fasham, Antje K. Huebner, Lutz Liebmann, Reham Khalaf-Nazzal, Reza Maroofian, Nderim Kryeziu, Saskia B. Wortmann, Joseph S. Leslie, Nishanka Ubeyratna, Grazia M. S. Mancini, Marjon van Slegtenhorst, Martina Wilke, Tobias B. Haack, Hanan E. Shamseldin, Joseph G. Gleeson, Mohamed Almuhaizea, Imad Dweikat, Bassam Abu-Libdeh, Muhannad Daana, Maha S. Zaki, Matthew N. Wakeling, Lucy McGavin, Peter D. Turnpenny, Fowzan S. Alkuraya, Henry Houlden, Peter Schlattmann, Kai Kaila, Andrew H. Crosby, Emma L. Baple, Christian A. Huebner
Summary: A novel neurodevelopmental disorder associated with biallelic pathogenic variants in SLC4A10 has been identified, which exhibits learning difficulties, seizures, and characteristic brain imaging features. Dysfunction of GABAergic transmission may contribute to the disorder.
Article
Immunology
Samu N. Kurki, Tommi Ala-Kurikka, Arto Lipponen, Alexey S. Pospelov, Taisia Rolova, Jari Koistinaho, Juha Voipio, Kai Kaila
Summary: Systemic inflammation induces both protective and pro-inflammatory responses in the brain, leading to disrupted cognition. The mechanisms underlying the peripheral-central inflammatory signaling are not fully understood.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Cell Biology
Samu N. Kurki, Rakenduvadhana Srinivasan, Jens Laine, Mari A. Virtanen, Tommi Ala-Kurikka, Juha Voipio, Kai Kaila
Summary: Acute neuroinflammation leads to hyperexcitability in dentate gyrus (DG) neurons, caused by disruption of neuronal chloride regulation and loss of GABAergic inhibition, resulting in cognitive impairment.