Article
Biochemistry & Molecular Biology
Young-Kyung Lee, Hangy Lee, Yun Na Kim, Jun Kang, Eun Ju Jeong, Jung-Rae Rho
Summary: Five sesquiterpene lactones belonging to the eudesmanolide class were isolated from the halophyte Sonchus brachyotus DC. The structures were determined using spectroscopic methods. Compound 1, 5 alpha,6 beta H-eudesma-3,11(13)-dien-12,6 alpha-olide, exhibited potent anti-inflammatory effects on LPS-activated RAW264.7 macrophages by suppressing the expression of iNOS and COS-2 and inhibiting the production of TNF-alpha, IL-6, and IL-10. Compound 1 also regulated the Nrf2/HO-1 pathway.
Article
Agronomy
Trizah K. Milugo, David P. Tchouassi, Reginald A. Kavishe, Rhoel R. Dinglasan, Baldwyn Torto
Summary: Extracts from the invasive weed Parthenium hysterophorus have larvicidal activity, with ethylene glycol derivative and 2 alpha-azidocoronopilin showing higher efficacy than parthenin. Structural modifications of parthenin with hydroxyl groups enhance its larvicidal effects, suggesting potential for lead chemical development in larval source management.
PEST MANAGEMENT SCIENCE
(2021)
Article
Plant Sciences
Moola M. Nyambe, Edet F. Archibong, Mamello Sekhoacha, Kazhila C. Chinsembu
Summary: Gonorrhea is a common sexually transmitted infection caused by Neisseria gonorrhoeae, which has developed resistance to first-line antimicrobial treatments. This study validates the use of Pechuel-loeschea leubnitziae, a medicinal plant, for the treatment of gonorrhea and identifies xerantholide as the active ingredient with anti-gonorrheal activity.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Hyo Moon Cho, Eun Jin Park, Yeon Joo Park, Jorge Ponce-Zea, Van Hieu Mai, Thi Phuong Doan, Byeol Ryu, Young Won Chin, Won Keun Oh
Summary: Two undescribed sesquiterpene lactone-proaporphine hybrid skeletons, two undescribed sesquiterpenes, and four known compounds were isolated from the aerial part of Magnolia grandiflora L. The structures of isolated compounds were determined using various methods. These compounds were investigated for their anti-inflammatory activity.
Article
Biochemistry & Molecular Biology
Ruben L. Rodriguez-Exposito, Nathalia Nocchi, Maria Reyes-Batlle, Ines Sifaoui, Blanca Suarez-Gomez, Ana R. Diaz-Marrero, Maria L. Souto, Jose E. Pinero, Jose J. Fernandez, Jacob Lorenzo-Morales
Summary: Studies have shown that certain sesquiterpene lactones isolated from the indigenous zoanthid Palythoa aff. clavata collected at the coast of Lanzarote, Canay Islands exhibit anti-amoebic effects, with 4-epi-arbusculin A and isobadgerin showing promising activity and low cytotoxicity. The mode of action of compounds 2 and 11 on Acanthamoeba castellanii Neff involves induction of PDC mechanisms.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Ting Cheng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur
Summary: This study identified miR-4284 as a key regulator of mitochondrial basal proton leak and oxidative DNA damage in TNBC cells and tumors. This finding is significant for understanding the progression and treatment of TNBC.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Christian Bailly
Summary: The dried flower buds of Daphne genkwa Sieb. et Zucc. have long been used in traditional Chinese medicine to treat inflammatory diseases. Various diterpenoids, including the yuanhuacin (YC) series and analogues, have been isolated from Genkwa Flos. These compounds have shown potential as anticancer agents, with YC being particularly effective against lung and breast cancers. Although protein kinase C has been identified as a key factor in YC's activity, the exact molecular targets of these compounds remain unclear. The pharmacological activity of each compound and the properties of Genkwa Flos extracts are discussed, along with the potential toxic effects associated with their use.
Article
Multidisciplinary Sciences
Layla Molina, David E. Williams, Raymond J. Andersen, Roy M. Golsteyn
Summary: The investigation found a new sesquiterpene lactone named hymenoratin from the plant Hymenoxys richardsonii in the prairie ecological zone of Canada, exhibiting anti-mitotic activity against cancer cells and causing prolonged mitotic arrest. Treatment with hymenoratin led to high levels of cyclin B and dephosphorylated Cdk1 in cells, indicating potential as a novel anti-cancer compound in the sesquiterpene lactone chemical family.
Article
Chemistry, Applied
Amira Mohamed, Marwa H. A. Hassan, Ahmed M. Gouda, Sameh AbouZid, Dalia El Amir
Summary: Five sesquiterpene lactones were isolated from Ambrosia maritima L., among which hymenin showed the highest cytotoxic activity against various cancer cell lines. Hymenin also exhibited high selectivity to COX-1 and significant inhibition of NO. The structure-activity relationship study revealed the importance of alpha-methylene-gamma-lactone moiety and the presence of an OH group at C-1 in enhancing the cytotoxic activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Sihyun Baek, Joseph Christian Utomo, Ji Young Lee, Kunal Dalal, Yeo Joon Yoon, Dae-Kyun Ro
Summary: This study focuses on using multiplex CRISPR-Cas9 technology to build complex metabolic pathways in Saccharomyces cerevisiae. By identifying and characterizing intergenic loci adjacent to highly expressed genes, the researchers successfully constructed synthetic metabolic pathways.
METABOLIC ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Tahir Mehmood, Chatchai Muanprasat
Summary: This review discusses the anti-cancer activities of deoxyelephantopin and isodeoxyelephantopin, major compounds found in Elephantopus scaber and Elephantopus carolinianus. These compounds target multiple signaling pathways deregulated in cancers, disrupting several processes involved in cancer progression. The future research directions for these compounds in anti-cancer drug development are also discussed.
Article
Biochemistry & Molecular Biology
Su-Jin Hong, Ok-Kyoung Kwon, Daseul Hwang, Su Hyun Goo, Doo-Young Kim, Min Ha Kim, Soo-Young Kim, Hyun-Jae Jang, Sei-Ryang Oh
Summary: The bioactive components of Canavalia lineata (Thunb.) DC pods were investigated, and several compounds were identified. Among them, the isoflavonoid derivative cajanin (7) showed the strongest anti-inflammatory activity, highlighting its potential as a candidate for treating inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Xiao-yan Zhi, Li-li Song, Jing Liang, Si-qi Wei, Yang Li, Yuan Zhang, Xiao-juan Hao, Hui Cao, Chun Yang
Summary: In this study, a series of Michael-type amino derivatives were prepared from xanthatin, showing promising inhibition activity against spores of F. solani and significant antifungal effect on C. mandshurica. The amino derivatives of xanthatin could be considered as potential lead structures for the development of environmentally friendly fungicidal candidates.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Applied
Muneera S. M. Al-Saleem, Lamya H. Al-Wahaibi, Ali A. El-Gamal, Shaza M. Al-Massarani, Nasir A. Siddiqui, Omer A. Basudan, Mounir M. Salem-Bekhit, Maged S. Abdel-Kader, Reem A. El-Gamal, Wael M. Abdel-Mageed
Summary: A new sesquiterpene lactone, along with twenty-one known compounds, were identified from the aerial parts of Centaurothamnus maximus. The isolated compounds showed promising antibacterial and antifungal activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Maryam Fattahian, Mustafa Ghanadian, Behzad Zolfaghari, Sara Abdeyazdan, Sedigheh Saberi, Fazila Zulfiqar, Ikhlas A. Khan, Zulfiqar Ali
Summary: Two new eudesmane-type sesquiterpene lactones and an unprecedented elemane-type sesquiterpene lactone were isolated from Seriphidium khorassanicum. They showed dose- and time-dependent activity against Leishmania major amastigotes, with one compound exhibiting the strongest activity and highest selectivity index.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
R. Villagomez, M. Quiroz, A. Tito, O. Sterner, G. R. Almanza
CHEMISTRY OF NATURAL COMPOUNDS
(2015)
Article
Chemistry, Multidisciplinary
Sudhirkumar Shinde, Zahra El-Schich, Atena Malakpour, Wei Wan, Nishtman Dizeyi, Reza Mohammadi, Knut Rurack, Anette Gjorloff Wingren, Borje Sellergren
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2015)
Article
Chemistry, Multidisciplinary
Zhen Li, Henrik Persson, Karl Adolfsson, Laura Abariute, Magnus T. Borgstrom, Dan Hessman, Kalle Astrom, Stina Oredsson, Christelle N. Prinz
Article
Plant Sciences
Eliana M. Maldonado, Daniel Svensson, Stina M. Oredsson, Olov Sterner
PHYTOCHEMISTRY LETTERS
(2014)
Article
Multidisciplinary Sciences
Rodrigo Villagomez, Rajni Hatti-Kaul, Olov Sterner, Giovanna Almanza, Javier A. Linares-Pasten
Article
Endocrinology & Metabolism
Kateryna Pierzynowska, Stina Oredsson, Stefan Pierzynowski
JOURNAL OF DIABETES RESEARCH
(2020)
Article
Multidisciplinary Sciences
Andrea Salm, Sandhya R. Krishnan, Marta Collu, Ombeline Danton, Matthias Hamburger, Marco Leonti, Giovanna Almanza, Jurg Gertsch
Summary: This study conducted a cross-sectional ethnopharmacological field study in Bolivia, discovering potential antichagasic botanical drugs and identifying hydroxyanthraquinone as a potential lead scaffold for anti-Trypanosoma cruzi drugs. The research suggests that phylogenetic hotspots in the plant kingdom may be a valuable resource for drug discovery based on ethnopharmacological hypotheses.
Article
Biotechnology & Applied Microbiology
Kateryna Pierzynowska, Sofia Thomasson, Stina Oredsson
Summary: The article describes a study on the effects of α-amylase on human neuroblastoma cells. The research shows that α-amylase can inhibit cell proliferation and directly impact glucose uptake, suggesting its potential as an anticancer agent for neuroblastoma treatment.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Toxicology
Atena Malakpour-Permlid, Stina Oredsson
Summary: The translation describes the importance of two-dimensional (2D) culturing for cancer drug development, but highlights the limitations due to not mimicking the in vivo three-dimensional (3D) tumor microenvironment. The development of a 3D culture model using electrospun fibres made of biocompatible polycaprolactone (PCL) is explained, along with the observation of lower toxicity of anti-cancer compounds in 3D cultures compared to 2D, suggesting the potential use of a cost-efficient 96-well assay for pre-clinical screening.
TOXICOLOGY REPORTS
(2021)
Article
Integrative & Complementary Medicine
Wendy Soria Sotillo, Santiago Tarqui, Xiaoli Huang, Giovanna Almanza, Stina Oredsson
Summary: The methoxyflavone sideritoflavone showed high toxicity in all cell lines, inhibiting both CSC and non-CSC sub-populations equally. Treatment with sideritoflavone resulted in cell cycle arrest and DNA double strand breaks, as well as activation of specific signal transduction pathways. Additionally, cell movement was decreased by sideritoflavone treatment.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Integrative & Complementary Medicine
Nigatu Tuasha, Daniel Seifu, Endalamaw Gadisa, Beyene Petros, Stina Oredsson
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)