Article
Biotechnology & Applied Microbiology
Huan Gong, Ming Zhang, Yiwen Han, Ying Zhang, Jing Pang, Yanyang Zhao, Beidong Chen, Wei Wu, Ruomei Qi, Tiemei Zhang
Summary: This study investigated the impact of caloric restriction, exercise, and high-fat diet on microRNA expression in the liver. A total of 84 differentially expressed microRNAs were identified across the three lifestyle modifications, with common and distinct functional categories and pathways enriched. This comprehensive comparison provides insights into the molecular effects of lifestyle on health and offers valuable guidance for future research on the role of microRNAs.
Article
Medicine, Research & Experimental
Huan Yang, Zhen Cao, Yang Wang, Jiahui Wang, Jintao Gao, Biao Han, Fangmei Yu, Yixiong Qin, Yong Guo
Summary: This study explored the impact of treadmill training on bone metabolism by detecting differentially expressed miRNAs in mouse bone tissues. The results showed that treadmill training improved the mechanical properties of mouse femur bones and altered the expression profiles of certain miRNAs involved in bone metabolism and osteogenic differentiation. Moreover, similarities in miRNA expression patterns between bone tissue and osteocytes suggest potential roles of these miRNAs in regulating bone metabolism.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Eloisa Sanches Pereira Nascimento, Walter Moreno Campos Nunes, Eduardo Marques Guerra, Marcello Rodrigues da Roza, Suellen Silva-Costa, Wilcelly Machado-Silva, Gleiciane Gontijo Avelar, Otavio de Toledo Nobrega, Rodolfo P. Vieira, Veronica Moreira Amado, Cesar Augusto Melo-Silva
Summary: Combined exercise training can improve exercise capacity in HPS animals and modify the expression of genes related to lung inflammation, but it does not significantly impact respiratory mechanical issues and lung tissue remodeling.
Article
Genetics & Heredity
Julie A. Hicks, Hsiao-Ching Liu
Summary: As chicks transition from embryonic to post-hatching life, their metabolism must quickly switch from deriving energy from the yolk to utilizing feed as the main energy source; hepatically-expressed miRNAs help facilitate this metabolic shift in the chick liver; adipose tissue plays a vital role in the metabolic switch.
Article
Chemistry, Analytical
Britt S. R. Claes, Kasper K. Krestensen, Gargey Yagnik, Andrej Grgic, Christel Kuik, Mark J. Lim, Kenneth J. Rothschild, Michiel Vandenbosch, Ron M. A. Heeren
Summary: A novel technology called MALDIIHC was published, which combined MALDI-MSI and IHC to achieve targeted imaging of biomolecules in tissue. The utility of targeted MALDIIHC and its complementarity with untargeted on-tissue proteomics was explored using breast cancer tissue. MALDI-2 was also investigated and demonstrated to improve MALDI-IHC. The combination of multiplexed MALDI-IHC with image-guided proteomics showed great potential in studying diseases.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Britt S. R. Claes, Kasper K. Krestensen, Gargey Yagnik, Andrej Grgic, Christel Kuik, Mark J. Lim, Kenneth J. Rothschild, Michiel Vandenbosch, Ron M. A. Heeren
Summary: A novel technique called MALDIIHC was published recently, which combines MALDI-MSI and IHC to achieve targeted imaging of biomolecules in tissue. This study explored the utility of targeted MALDIIHC and its complementarity with untargeted spatial proteomics using breast cancer tissue. The combination of multiplexed MALDI-IHC with image-guided proteomics showed great potential for disease investigation. Additionally, the effect of MALDI-2 in improving MALDI-IHC was investigated.
ANALYTICAL CHEMISTRY
(2023)
Article
Immunology
Tao Wang, Xinlei Ba, Xiaonan Zhang, Na Zhang, Guowen Wang, Bin Bai, Tong Li, Jiahui Zhao, Yanjiao Zhao, Yang Yu, Bing Wang
Summary: Protein tyrosine phosphatases play a significant role in regulating signaling pathways in cancer and have clinical relevance. This study provides comprehensive analysis of the regulatory mechanisms and clinical significance of classical PTPs in various types of cancer and highlights their potential as therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Psychology, Multidisciplinary
Jacob W. Pickersgill, Claudia V. Turco, Karishma Ramdeo, Ravjot S. Rehsi, Stevie D. Foglia, Aimee J. Nelson
Summary: Neuroplasticity refers to the brain's ability to adapt structurally and functionally in response to experience, and is associated with learning, memory, and cognitive improvements. Lifestyle factors such as exercise, diet, and sleep influence the brain's propensity for neuroplasticity. This review combines evidence from molecular, systems, and behavioral neuroscience to explain how these lifestyle factors affect neuroplasticity.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Physiology
Christopher G. Vann, Xin Zhang, Alastair Khodabukus, Melissa C. C. Orenduff, Yu-Hsiu Chen, David L. L. Corcoran, George A. A. Truskey, Nenad Bursac, Virginia B. B. Kraus
Summary: Exercise-mimetic contractile activity of human engineered muscle affects the expression of miRs and the number of secreted EVs, providing new insights into the role of exercise in organ-organ interactions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Lisa Wanders, Anouk Gijbels, Esmee A. Bakker, Inez Trouwborst, Kelly M. Jardon, Koen C. M. Manusama, Gabby B. Hul, Edith J. M. Feskens, Lydia A. Afman, Ellen E. Blaak, Maria T. E. Hopman, Gijs H. Goossens, Dick H. J. Thijssen
Summary: The aim of this study is to investigate the associations between the spectrum of physical activity (from sedentary behavior to exercise) and tissue-specific insulin resistance. The study found that physical activity is beneficially associated with whole-body insulin resistance, but the associations vary depending on the primary site of insulin resistance (muscle or liver).
Review
Nutrition & Dietetics
Jinghua Zhang, Zhen-Bo Cao
Summary: Exercise can affect the levels of vitamin D metabolites in circulation. Endurance exercise can increase serum 25(OH)D levels, but has limited effect on serum 1,25(OH)(2)D levels. Exercise may influence 25(OH)D levels in the circulation by regulating the storage of vitamin D metabolites in tissues or their utilization by target tissues. The effects of exercise on 25(OH)D levels may be dependent on factors such as vitamin D nutritional status, exercise type and intensity, and sex. Further research is needed to investigate the effects and mechanisms of exercise on vitamin D metabolites.
Article
Neurosciences
Juliano Ten Kathen Jung, Luiza Souza Marques, Vanessa Angonesi Zborowski, Guilherme Lutz Silva, Cristina Wayne Nogueira, Gilson Zeni
Summary: This study evaluated the role of resistance exercise in an anxiety-depression-like dyad in a model of stress. The results showed that resistance exercise can alleviate anxiety and depressive symptoms in stressed mice, while reducing neuroinflammation.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ahmad H. Alghadir, Sami A. Gabr, Murad Al-Momani, Fidaa Al-Momani
Summary: The study found that cognitive decline was associated with elevated levels of cortisol, pro-inflammatory cytokines, and adiposity markers, while improvements in cognitive function and reductions in cortisol and cytokine levels were observed after a 12-week moderate aerobic exercise program. Physical activity may serve as a non-drug strategy for treating cognitive disorders in older adults.
Article
Cell Biology
Zaccagnini Germana, Greco Simona, Longo Marialucia, Maimone Biagina, Voellenkle Christine, Fuschi Paola, Carrara Matteo, Creo Pasquale, Maselli Davide, Tirone Mario, Mazzone Massimiliano, Gaetano Carlo, Spinetti Gaia, Martelli Fabio
Summary: miR-210 has a context-dependent regulation on the inflammatory response, with overexpression associated with improved angiogenesis and tissue repair. Infiltrating cells with mismatched miR-210 levels lead to a pro-fibrotic phenotype, impairing tissue repair, causing fibrosis, and dysfunctional angiogenesis.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Malik Yousef, Gokhan Goy, Ramkrishna Mitra, Christine M. Eischen, Amhar Jabeer, Burcu Bakir-Gungor
Summary: The study introduces a novel tool called miRcorrNet for integrating and analyzing miRNA and mRNA gene expression profiles. It shows comparable accuracy with other existing tools, includes ranking steps for classification, and accurately prioritizes pan-cancer regulating high-confidence miRNAs. The tool has been evaluated using data from The Cancer Genome Atlas and a completely independent dataset, demonstrating its effectiveness in identifying biologically significant miRNA groups.
Article
Geriatrics & Gerontology
Vandre C. Figueiredo, Randall F. D'Souza, Douglas W. Van Pelt, Marcus M. Lawrence, Nina Zeng, James F. Markworth, Sally D. Poppitt, Benjamin F. Miller, Cameron J. Mitchell, John J. McCarthy, Esther E. Dupont-Versteegden, David Cameron-Smith
Summary: The study found that changes in RNA concentration during muscle disuse and reloading were associated with changes in ribosome biogenesis and degradation, indicating that both processes are important determinants of translational capacity. The pre-clinical data help explain the reduced translational capacity after muscle immobilization in humans and demonstrate that ribosome biogenesis and degradation might be valuable therapeutic targets to maintain muscle mass during disuse.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Nutrition & Dietetics
Nicola A. Gillies, Amber M. Milan, Pamela H. P. Chia, Pankaja Sharma, Sarah M. Mitchell, Nina Zeng, Farha Ramzan, Randall F. D'Souza, Cameron J. Mitchell, Scott O. Knowles, Stephanie Andraos, Anders Sjodin, Karl-Heinz Wagner, Nicole C. Roy, David Cameron-Smith
Summary: This study showed that increasing animal-based protein intake can reduce homocysteine levels in older men. Changes in one-carbon metabolite ratios were observed in subjects with different protein intake levels.
Article
Nutrition & Dietetics
Stephanie Andraos, Beatrix Jones, Clare Wall, Eric Thorstensen, Martin Kussmann, David Cameron-Smith, Katherine Lange, Susan Clifford, Richard Saffery, David Burgner, Melissa Wake, Justin O'Sullivan
Summary: The study reveals that family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults. Concordance in B vitamer levels was found between parent-child pairs, with different generations showing specificity in their vitamer concentrations.
Article
Nutrition & Dietetics
Aahana Shrestha, Linda M. Samuelsson, Pankaja Sharma, Li Day, David Cameron-Smith, Amber M. Milan
Summary: For female dairy avoiders, sheep milk and cow milk showed similar effects on acute digestive comfort and lactose malabsorption. Despite lower lactose content, sheep milk did not increase adverse digestive symptoms after ingestion, indicating its potential tolerability compared to cow milk.
FRONTIERS IN NUTRITION
(2021)
Article
Physiology
Thomas Bjornsen, Mathias Wernbom, Goran Paulsen, James F. Markworth, Sveinung Berntsen, Randall F. D'Souza, David Cameron-Smith, Truls Raastad
Summary: High-frequency BFRRE training simultaneously stresses both fiber types, with type I fibers being most affected. This training results in changes in heat shock protein responses, protein translocation, and glycogen content.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Nicola A. Gillies, Bernhard Franzke, Barbara Wessner, Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Anela Tosevska, Eva-Maria Strasser, Nicole C. Roy, Amber M. Milan, David Cameron-Smith, Karl-Heinz Wagner
Summary: The study found that choline metabolites such as choline, betaine, and dimethylglycine play a central role in the co-regulation of 1C metabolism and cardiometabolic health in older adults. Additionally, changes in some metabolites were associated with improvements in lipid metabolism.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Letter
Nutrition & Dietetics
Vidit V. Satokar, Wayne S. Cutfield, David Cameron-Smith, Benjamin B. Albert
Summary: This manuscript responds to concerns raised by industry-based scientists about the quality and functionality of commercial fish oils, and highlights the importance of independently verifying n-3 PUFA content and oxidation state before using them in clinical trials.
Article
Endocrinology & Metabolism
Caitlin S. Mitchell, Shirmila D. Premaratna, Garth Bennett, Maria Lambrou, Lauren A. Stahl, Markandeya Jois, Elizabeth Barber, Christopher P. Antoniadis, Stephen C. Woods, David Cameron-Smith, Richard S. Weisinger, Denovan P. Begg
Summary: The study demonstrates that ACE inhibition and angiotensin receptor blockade can reduce food intake to produce weight loss, suggesting that the anti-inflammatory effects of ACE inhibition may be independent of weight loss.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Behavioral Sciences
Jia Jiet Lim, Ivana R. Sequeira, Wilson C. Y. Yip, Louise W. Lu, Daniel Barnett, David Cameron-Smith, Sally D. Poppitt
Summary: This study aimed to identify biomarkers of appetite response using a whey protein preload intervention. The results showed that most biomarkers changed in response to the intervention, but did not suppress appetite or energy intake. Glycine had the strongest association with appetite response. The use of multiple biomarkers improved the estimation of appetite response.
Article
Endocrinology & Metabolism
Karen Mei-Ling Tan, Mya-Thway Tint, Narasimhan Kothandaraman, Fabian Yap, Keith M. Godfrey, Yung Seng Lee, Kok Hian Tan, Peter D. Gluckman, Yap-Seng Chong, Mary F. F. Chong, Johan G. Eriksson, David Cameron-Smith
Summary: This study found that higher plasma concentrations of KYN pathway metabolites are associated with obesity and increased risk for metabolic syndrome and fatty liver in prepubertal Asian children.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
Utpal Kumar Prodhan, Amber Marie Milan, Aahana Shrestha, Mark Hedley Vickers, David Cameron-Smith, Matthew Philip Greig Barnett
Summary: This study found that milk protein digestion is largely unaffected by dairy- and lactose-intolerances.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Physiology
Chantal A. A. Pileggi, Christopher P. P. Hedges, Randall F. F. D'Souza, Brenan R. R. Durainayagam, Nina Zeng, Vandre C. C. Figueiredo, Anthony J. R. Hickey, Cameron J. J. Mitchell, David Cameron-Smith
Summary: Mitochondrial dynamics show limited changes in response to inactivity. Restoration of ambulatory activity can reverse the altered gene expression patterns, while resistance training has little effect on gene expression changes.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Brenan Durainayagam, Cameron J. J. Mitchell, Amber M. M. Milan, Marlena C. C. Kruger, Nicole C. C. Roy, Karl Fraser, David Cameron-Smith
Summary: The aim of this study was to examine the dynamic responses of plasma metabolome in overweight females in relation to meal glycaemic load (GL). The results showed that participants with Metabolic Syndrome (MetS) had lower concentrations of certain amino acids and metabolites related to energy metabolism after meals. However, the manipulation of meal GL had minimal impact on the postprandial metabolome, indicating that individual metabolic health has a greater influence.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Physiology
Randall F. D'Souza, Vandre C. Figueiredo, James F. Markworth, Nina Zeng, Christopher P. Hedges, Llion A. Roberts, Truls Raastad, Jeff S. Coombes, Jonathan M. Peake, Cameron J. Mitchell, David Cameron-Smith
Summary: Cold water immersion (CWI) affects muscle adaptations to exercise training by modulating miRNA expression, with attenuated muscle hypertrophy and increased angiogenesis. This study examined the regulatory mechanisms involved in cleavage and nuclear export of mature miRNA, and found that CWI suppressed mRNA expression of DROSHA, EXPORTIN-5, and DICER in skeletal muscle. MiR-133a and miR-126 remained elevated at 24 hours post-exercise only in the CWI trial. However, the gene targets of these miRNA did not differ between trials.
PHYSIOLOGICAL REPORTS
(2023)
Review
Nutrition & Dietetics
N. Gillies, D. Cameron-Smith, S. Pundir, C. R. Wall, A. M. Milan
Summary: This systematic review investigates the dietary adequacy of folate, riboflavin, vitamins B-6 and B-12 in older adults and found that riboflavin inadequacy increases with age, while folate adequacy varies between studies. Limited evidence and inconsistency were reported for vitamins B-6 and B-12. Further research is needed to better understand changes in micronutrient intake with age and improve recommendations for older adults.
BRITISH JOURNAL OF NUTRITION
(2021)