Article
Biochemistry & Molecular Biology
Alexander Yemelin, Annamaria Brauchler, Stefan Jacob, Andrew J. Foster, Julian Laufer, Larissa Heck, Luis Antelo, Karsten Andresen, Eckhard Thines
Summary: Diseases caused by dimorphic phytopathogenic and systemic dimorphic fungi have increased in prevalence. Understanding the morphogenic transition to the virulent state may provide novel means of controlling these fungi. This study identified two novel factors involved in the transition to the pathogenic state and gained insight into their role using transcriptome analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Chen Wang, Andrew W. Milgate, Peter S. Solomon, Megan C. McDonald
Summary: This study identified a gene within a Class II transposon that affects the virulence of Zymoseptoria tritici, adding complexity to the genetic mechanisms of infection by this important pathogen.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Agronomy
Steven Kildea, Pierre Hellin, Thies M. Heick, Stephen Byrne, Fiona Hutton
Summary: This study reveals a wide range of sensitivity to mefentrifluconazole in European Z. tritici populations. The Irish population showed the lowest sensitivity to the tested azoles. Further analysis of the Irish population in 2021 demonstrated that sensitivity differences were associated with the frequencies of key resistance mechanisms. Reductions in the efficacy of mefentrifluconazole were observed towards strains with the lowest sensitivity under glasshouse conditions.
PEST MANAGEMENT SCIENCE
(2023)
Article
Genetics & Heredity
Carolina Sardinha Francisco, Bruce A. McDonald, Javier Palma-Guerrero
Summary: Fungal wheat pathogen Zymoseptoria tritici undergoes morphological transitions in response to temperature changes, and the regulatory mechanisms involve the genes ZtMsr1 and ZtYvh1. The formation of different morphotypes is a survival strategy in response to intracellular osmotic stress.
FUNGAL GENETICS AND BIOLOGY
(2023)
Article
Plant Sciences
Adam Kuzdralinski, Justyna Lesniowska-Nowak, Michal Nowak, Magdalena Kawecka, Anna Kot, Karolina Rozaniecka, Agnieszka Ostrowska, Marta Muszynska, Adam Wasko, Hubert Szczerba
Summary: New primer sets were developed for species-specific identification of Zymoseptoria tritici in wheat leaf samples, showing high specificity and sensitivity in both in silico validation and in vitro tests on common wheat samples with visual symptoms of Septoria tritici blotch conducted in Poland.
Article
Microbiology
Minely Ceron-Bustamante, Francesco Tini, Giovanni Beccari, Paolo Benincasa, Lorenzo Covarelli
Summary: The wheat pathogen Zymoseptoria tritici responds to light by modulating its gene expression, and different light wavelengths have specific effects on its growth and host colonization. Blue light reduces colony growth, while dark and red light promote fungal development. White light stimulates host colonization, while red light represses it. This study demonstrates the importance of light in the interaction between Z. tritici and wheat.
Article
Plant Sciences
Karolina Lavrukaite, Thies M. Heick, Jurate Ramanauskiene, Rita Armoniene, Antanas Ronis
Summary: Zymoseptoria tritici is a major cause of yield loss in winter wheat worldwide due to its ability to cause septoria leaf blotch. Fungicides are commonly used by farmers to protect their crops, but the effectiveness of these measures is decreasing rapidly as the pathogen develops resistance through natural mutation mechanisms. This study conducted sensitivity tests, mutation detection, and field experiments in Lithuania to assess the current situation of fungicide resistance. The findings reveal an increase in resistance mutations and provide important information on the status of fungicide resistance in the Lithuanian Z. tritici population.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Fateme Ghiasi Noei, Mojtaba Imami, Fardad Didaran, Mohammad Amin Ghanbari, Elham Zamani, Amin Ebrahimi, Sasan Aliniaeifard, Mohsen Farzaneh, Mohammad Javan-Nikkhah, Angela Feechan, Amir Mirzadi Gohari
Summary: This study investigates the biochemical and physiological changes in wheat during gene-for-gene interaction with the fungal pathogen Zymoseptoria tritici. It reveals the immune response triggered by the recognition of AvrStb6 by the resistance gene Stb6 and analyzes plant responses to pathogen infection, including transient stomatal closure and maintenance of photosynthesis. The findings demonstrate the coordination of antioxidant enzyme expression and activity to counteract oxidative stress in the Stb6-AvrStb6 interaction.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agronomy
Holger Klink, Joseph-Alexander Verreet, Mario Hasler, Tim Birr
Summary: Research suggests that the sensitivity of Z. tritici towards older triazole fungicides has been decreasing over the years, while the new isopropanol triazole mefentrifluconazole has shown consistent efficacy in inhibiting the fungal growth of Z. tritici.
Article
Agronomy
Remi Platel, Melodie Sawicki, Qassim Esmaeel, Beatrice Randoux, Pauline Trapet, Mohammed El Guilli, Noureddine Chtaina, Segolene Arnauld, Alexandre Bricout, Alice Rochex, Natacha Bourdon, Patrice Halama, Cedric Jacquard, Essaid Ait Barka, Philippe Reignault, Maryline Magnin-Robert, Ali Siah
Summary: This study isolated two strains of Bacillus velezensis with antimicrobial activity against Zymoseptoria tritici, a pathogen causing the highly significant disease Septoria tritici blotch on wheat crops. The strains were found to produce different types of cyclic lipopeptides, with one strain showing stronger antifungal activity due to the synthesis of putative bacillomycin D. This research provides new potential for the biocontrol of Z. tritici.
Article
Plant Sciences
Remi Platel, Anca Lucau-Danila, Raymonde Baltenweck, Alessandra Maia-Grondard, Pauline Trapet, Maryline Magnin-Robert, Beatrice Randoux, Morgane Duret, Patrice Halama, Jean-Louis Hilbert, Francois Coutte, Philippe Jacques, Philippe Hugueney, Philippe Reignault, Ali Siah
Summary: The lipopeptide mycosubtilin from Bacillus subtilis can protect wheat against Zymoseptoria tritici through direct and indirect modes of action. It primes the expression of defense-related genes and promotes the accumulation of flavonoids in wheat during the early stages of infection. Abscisic acid (ABA) biosynthesis and ABA-associated signaling pathways are also regulated, suggesting a role of this phytohormone in the indirect activity of mycosubtilin. This study provides new insights into induced immunity in wheat and the potential use of mycosubtilin as a biocontrol compound against Z. tritici.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agronomy
Eoghan Curran, James I. I. Burke, Angela Feechan
Summary: Zymoseptoria tritici is a globally important fungal pathogen causing a foliar disease in wheat. Co-infection of multiple strains of this fungus is known to be common in the field, yet its impact on disease severity and plant defense remains unclear.
Article
Agronomy
Tim Birr, Mario Hasler, Joseph-Alexander Verreet, Holger Klink
Summary: The study found that the sensitivity of wheat septoria tritici blotch to specific fungicides has changed over different time periods, with sensitivity remaining stable or decreasing for most fungicides except for a slight increase in sensitivity for one. Over the past 21 years, complete resistance of Z. tritici to quinone outside inhibitors has developed, and resistance to two other fungicides has gradually increased, posing a major challenge for future wheat cultivation.
Article
Biotechnology & Applied Microbiology
Na Wang, Jin Gao, Yang Liu, Rui Shi, Songlin Chen
Summary: This study reveals the key regulatory factors associated with female-biased sexual size dimorphism in Chinese tongue sole through GWAS and DAP-seq, identifies the relevant SNP and genes, and explores the regulatory network of zbed1 in this species.
Article
Plant Sciences
Sepideh Hatami Rad, Leila Ebrahimi, Daniel Croll
Summary: Managing pathogen damage in wheat production is crucial. This study analyzed the evolution of the AvrStb6 effector in Iranian isolates of Z. tritici. It found a high genetic diversity and global diversity patterns of AvrStb6, highlighting its importance for Z. tritici virulence.
Article
Chemistry, Organic
Ulrich Kauhl, Lars Andernach, Stefan Weck, Louis P. Sandjo, Stefan Jacob, Eckhard Thines, Till Opatz
JOURNAL OF ORGANIC CHEMISTRY
(2016)
Article
Agriculture, Multidisciplinary
Stefan Jacob, Alexander Yemelin, Stefan Bohnert, Karsten Andresen, Eckhard Thines
JOURNAL OF PLANT DISEASES AND PROTECTION
(2017)
Article
Microbiology
S. Matheis, A. Yemelin, D. Scheps, K. Andresen, S. Jacob, E. Thines, A. J. Foster
MICROBIOLOGICAL RESEARCH
(2017)
Article
Microbiology
Stefan Jacob, Thomas Groetsch, Andrew J. Foster, Anja Schueffler, Patrick H. Rieger, Louis P. Sandjo, Johannes C. Liermann, Till Opatz, Eckhard Thines
Review
Mycology
Stefan Jacob, Eckhard Thines
MYCOLOGICAL PROGRESS
(2017)
Article
Agronomy
Stefan Bohnert, Hendrik Neumann, Eckhard Thines, Stefan Jacob
PEST MANAGEMENT SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Stefan Bohnert, Larissa Heck, Christoph Gruber, Hendrik Neumann, Ute Distler, Stefan Tenzer, Alexander Yemelin, Eckhard Thines, Stefan Jacob
MOLECULAR MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Stefan Bohnert, Luis Antelo, Christiane Gruenewald, Alexander Yemelin, Karsten Andresen, Stefan Jacob
Article
Biotechnology & Applied Microbiology
A. Linkies, S. Jacob, P. Zink, M. Maschemer, W. Maier, E. Koch
Summary: The study compares and characterizes six different Chaetomium species as biocontrol agents, identifying Chaetomium aureum and Chaetomium cochliodes as promising candidates for biocontrol due to their activity against the plant pathogen Phytophthora infestans. This systematic study provides valuable insights into the potential use of Chaetomium species as biocontrol agents.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Microbiology
Sri Buehring, Alexander Yemelin, Thomas Michna, Stefan Tenzer, Stefan Jacob
Summary: This study identified structural variations and amplified putative isoforms in the mRNA of the MoYPD1 gene in the rice blast fungus at the cDNA level, suggesting that alternative splicing contributes to increased signal diversity in signal transduction. Furthermore, mutant strains overexpressing these isoforms confirmed that alternative splicing is a valid molecular mechanism to enhance signal diversity in eukaryotic multistep phosphorelay systems.
Article
Microbiology
Katharina Bersching, Stefan Jacob
Summary: This study identified the importance of the group III two-component hybrid histidine kinase MoHik1p in sensing external osmotic stress and mediating the fungicidal activity of phenylpyrrole fludioxonil. A mutant strain with a modified HisKA signaling domain revealed the crucial role of H736 in the action of fludioxonil, but not in sensing sorbitol stress. This provides evidence of the different molecular mechanisms involved in the action of fludioxonil and the perception of osmotic stress.
Article
Biochemistry & Molecular Biology
Alexander Yemelin, Annamaria Brauchler, Stefan Jacob, Andrew J. Foster, Julian Laufer, Larissa Heck, Luis Antelo, Karsten Andresen, Eckhard Thines
Summary: Diseases caused by dimorphic phytopathogenic and systemic dimorphic fungi have increased in prevalence. Understanding the morphogenic transition to the virulent state may provide novel means of controlling these fungi. This study identified two novel factors involved in the transition to the pathogenic state and gained insight into their role using transcriptome analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Microbiology
Stefan Jacob, Sebastian Bormann, Michael Becker, Luis Antelo, Dirk Holtmann, Eckhard Thines
Summary: The filamentous fungus Magnaporthe oryzae shows potential as an alternative platform for the production of industrially important enzymes. By successfully expressing unspecific peroxygenase from Agrocybe aegerita in M. oryzae, the possibility of establishing M. oryzae as a broadly applicable alternative expression system has been demonstrated. This fungus is easy to handle, fast-growing, and offers similarities to human biology in posttranslational modifications.
Article
Microbiology
Katharina Bersching, Thomas Michna, Stefan Tenzer, Stefan Jacob
Summary: The dynamic interplay of signaling networks in cellular processes is characterized by reversible protein phosphorylation. Quantitative phospho-peptidomics has become a powerful platform for comprehensively analyzing the phosphorylation profile of living organisms. However, the presence of missing values in experimental procedures remains a major problem, reducing confidence in subsequent bioinformatic processing. By using data independent acquisition (DIA) in a filamentous fungus model organism, we were able to increase data completeness while maintaining data quality, providing a refined methodology for investigating signaling processes in filamentous fungi.