Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways

Cichoric acid regulates the hepatic glucose homeostasis via AMPK pathway and activates the antioxidant response in high glucose-induced hepatocyte injury

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Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA

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Increased circulating resistin is associated with insulin resistance, oxidative stress and platelet activation in type 2 diabetes mellitus

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NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) and cytochrome P450 oxidoreductase (CYP450OR) differentially regulate menadione-mediated alterations in redox status, survival and metabolism in pancreatic β-cells

(2016) Joshua P. Gray et al.   TOXICOLOGY LETTERS

Enhancement of Bioavailability and Pharmacodynamic Effects of Thymoquinone Via Nanostructured Lipid Carrier (NLC) Formulation

(2015) Mohammed Elmowafy et al.   AAPS PHARMSCITECH

Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells

(2015) Di Zhu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model

(2014) Khalid M. Alkharfy et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

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SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential

(2013) Munehiro Kitada et al.   Diabetes & Metabolism Journal

Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats

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Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

The level of menadione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: Role of NADH and consequences for insulin secretion

(2011) Emma Heart et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AMPK and SIRT1: a long-standing partnership?

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NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

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Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling

(2010) Stacey B. Dula et al.   CELL CALCIUM

An Increase in the Circulating Concentration of Monocyte Chemoattractant Protein-1 Elicits Systemic Insulin Resistance Irrespective of Adipose Tissue Inflammation in Mice

(2010) Sanshiro Tateya et al.   ENDOCRINOLOGY

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

(2009) Takeshi Yoshizaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

Association Between Plasma Monocyte Chemoattractant Protein-1 Concentration and Cardiovascular Disease Mortality in Middle-Aged Diabetic and Nondiabetic Individuals

(2009) L. Piemonti et al.   DIABETES CARE

Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin–nicotinamide induced diabetic rats

(2009) Leelavinothan Pari et al.   LIFE SCIENCES

Dyslipidemia in type 2 diabetes mellitus

(2009) Arshag D Mooradian   Nature Reviews Endocrinology

In vitro toxicological properties of thymoquinone

(2008) M. Khader et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

(2008) Deborah M. Muoio et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY