Article
Immunology
Kiersten Scott, Thien Trong Phan, Nabila Boukelmoune, Cobi J. Heijnen, Robert Dantzer
Summary: Chronic restraint stress affects the behavior of mice, specifically their voluntary wheel running but not working for food. This indicates a dissociation between energy demanding and energy procuring activities, possibly due to adaptive response to mitochondrial dysfunction caused by chronic restraint stress.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Behavioral Sciences
Tong Zhang, Naoya Nishitani, Kazuhei Niitani, Ryoma Nishida, Yusaku Futami, Satoshi Deyama, Katsuyuki Kaneda
Summary: This study investigated changes in neuronal activity in brain regions associated with motivation in mice during different intensities of rotation on running wheels. The results suggest that subareas of the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) may play a critical role in the motivational effects of running wheel rotations.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Endocrinology & Metabolism
Chloe Tezenas du Montcel, Jingxian Cao, Julia Mattioni, Heloise Hamelin, Nicolas Lebrun, Nicolas Ramoz, Philip Gorwood, Virginie Tolle, Odile Viltart
Summary: In eating disorders, particularly anorexia nervosa (AN), patients exhibit intense physical activity which is inappropriate regarding food restriction and chronic undernutrition, and exacerbates weight loss and energy deprivation. Rodent models of food restriction exhibit increased running wheel activity in the food anticipation period, also known as Food Anticipatory Activity (FAA). We hypothesize that the drive for physical activity in chronic food restriction is triggered by metabolic factors but also relies on motivational aspects that we aim to decipher in this study.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Annika Reuser, Kristin Wenzel, Stephan B. Felix, Marcus Doerr, Martin Bahls, Stephanie Koenemann
Summary: This article introduces a method that combines radiotelemetry system and running wheels to determine spontaneous cage activity and voluntary exercise levels of individual animals in group-housed rodents. A software tool is developed for fast and reliable data analysis. This method can be used to study the benefits of physical activity and the impact of therapeutic interventions on animal behavior.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
Isabella M. Fuentes, Brittni M. Jones, Aaron D. Brake, Angela N. Pierce, Olivia C. Eller, Rachel M. Supple, Douglas E. Wright, Julie A. Christianson
Summary: Studies suggest that voluntary exercise can alleviate the negative impact of a history of early life stress exposure on patients with chronic pain and mood disorders, with evidence showing that voluntary wheel running may improve outcomes related to urologic chronic pelvic pain syndrome.
Article
Immunology
Kiersten S. Scott, Brandon Chelette, Chinenye Chidomere, A. Phillip West, Robert Dantzer
Summary: Cisplatin decreases energy-consuming activities but not energy-procuring activities unless they require a choice between options differing in their cost-benefit ratio. The physical dimension of fatigue is more likely to develop in cisplatin-treated individuals than the motivational dimension of fatigue.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Meina Zhu, Deepa Kamath Kasaragod, Kazuya Kikutani, Kei Taguchi, Hidenori Aizawa
Summary: The WRAQ system is an independent solution for monitoring mouse wheel-running activity, capable of recording activity data for at least 30 days and providing real-time monitoring and online reporting of circadian time. It effectively detects changes in wheel-running activity, offering a cost-effective solution for research findings.
Article
Chemistry, Medicinal
Swati Sahoo, Prashant S. Kharkar, Niteshkumar U. Sahu, S. Brijesh
Summary: The anxiolytic activity of Psidium guajava L. leaf ethanolic extract was investigated, showing significant effects on neurotransmitter levels in the brain, particularly monoamines, GABA, and glutamate. In silico studies suggested potential interaction of PLE components with GABA(A) and 5-HT(1A) receptors as a mechanism for its anxiolytic effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Laura Niiranen, Ville Stenback, Mikko Tulppo, Karl-Heinz Herzig, Kari A. Makela
Summary: Exercise has been proven to improve cognitive function, and studies on both humans and animals have shown this. Laboratory mice are often used as a model to study the effects of exercise, and running wheels provide a voluntary and stress-free form of exercise for mice. This study aimed to analyze the relationship between the cognitive state of a mouse and its wheel-running behavior. The results showed that high-runner mice exhibited enhanced learning capabilities and ate more compared to the other groups. Interestingly, individual mice had different reactions when introduced to running wheels, suggesting the importance of considering individual differences in voluntary endurance exercise studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Brian S. Wolff, Hannah R. Allen, Li Rebekah Feng, Leorey N. Saligan
Summary: Recent clinical studies have suggested that a common polymorphism of the BDNF gene may be related to the severity of fatigue following cancer treatment. In this study, transgenic mice homozygous for the Val66Met BDNF gene were used to investigate the effect of the polymorphism on fatigue-like behavior. The results showed that the Val66Met mice lost more weight during the baseline wheel-running period and exhibited a less severe fatigue-like phenotype during the first week after chemotherapy treatment.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Elias Elias, Ariel Y. Zhang, Abigail G. White, Matthew J. Pyle, Melissa T. Manners
Summary: In addition to physical health benefits, exercise has positive effects on mental health and can reduce symptoms of mental illness. It can also promote psychological development. The study on mice shows that exercise can counteract the negative effects of chronic stress on behavior, and it is effective for both males and females. The effects of exercise on chronic stress-induced behaviors are influenced by sex-specific factors.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Article
Biochemistry & Molecular Biology
Carmen Ferrer-Perez, Marina D. Reguilon, Jose Minarro, Marta Rodriguez-Arias
Summary: This study evaluates the impact of physical activity on the rewarding effects of cocaine induced by social stress and the neuroinflammatory response. The results indicate that continuous access to running wheels enhances cocaine place preference, while intermittent access has a protective effect. Furthermore, wheel running increases sensitivity to cocaine by promoting inflammation.
Article
Behavioral Sciences
Katherine M. Contreras, Martial Caillaud, Bradley Neddenriep, Deniz Bagdas, Jane L. Roberts, Esad Ulker, Alyssa B. White, Raneem Aboulhosn, Wisam Toma, Tala Khalefa, Ahd Adel, Jared A. Mann, M. Imad Damaj
Summary: Treatment with CFA reduced the distance traveled in C57BL/6J mice but not in DBA/2J mice; paclitaxel induced CIPN in mice, with only female C57BL/6J mice showing a decrease in distance traveled following treatment;amp; CCI surgery resulted in a gradual decrease in mechanical sensitivity and distance traveled in mice. Comparing these chronic pain models in different mouse strains may help to understand the genetic differences underlying pain perception and its impact on behavior.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Cell Biology
Felix Atmanspacher, Rolf Schreckenberg, Annemarie Wolf, Ivica Grgic, Klaus-Dieter Schlueter
Summary: Physical activity and aldosterone pharmacological treatment may have additive effects on renal protection in hypertensive rats, although exercise stresses kidneys and needs to be cautious.
Article
Clinical Neurology
Imane Hurel, Carolina Muguruza, Bastien Redon, Giovanni Marsicano, Francis Chaouloff
Summary: This study investigated the effects of THC on mouse wheel-running preference, performance, running motivation, and seeking behavior. The results showed that THC was ineffective in influencing running motivation, preference, and seeking behavior through CB1 receptor stimulation. Further research is needed to explore the impact of cannabis on exercise motivation.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)