Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Aleena Mir, Amit Kumar, Javed Alam, Ufana Riaz
Summary: Composite hydrogels with conducting polymers were synthesized and studied for drug release. The release kinetics showed prolonged and sustained release at different pH values.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Oya Irmak Sahin, Kubra Uzuner, Ayse Neslihan Dundar, Mahmud Ekrem Parlak, Latife Betul Gul, Adnan Fatih Dagdelen, Furkan Turker Saricaoglu, Senay Simsek
Summary: Food gels are attractive for their biocompatibility, eco-friendly characteristics, and wide range of medical and food applications. This study examined the use of phycocyanin and honey embedded in a gel-type delivery system composed of alginate and gelatin. The results showed that higher alginate concentration increased the release of phenolic content, and the gel structure protected the phenolic content during digestion and enhanced their bio-accessibility. The study suggests that a combination of 1.5 g/100 mL alginate with gelatin can improve the functionality and bio-accessibility of functional ingredients without affecting sensory properties.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Jiawei Huang, Linhong Chen, Ming Huang, Mingxian Liu
Summary: The application of nanotechnology in agrochemicals release can effectively reduce fertilizer usage and improve utilization. Urea was successfully intercalated into halloysite by solid-phase milling, and the maximum loading was 14.99 ± 1.33 wt%. Urea-Hal-sodium alginate hydrogel beads were fabricated by crosslinking, which showed good water retention and slow release properties. The release time of urea in the hydrogel was 60 times longer compared to pure urea. The hydrogel has a promising future in slow-release fertilizers for modern agriculture.
APPLIED CLAY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Wing-Fu Lai, Obireddy Sreekanth Reddy, Lucy Law, Haicui Wu, Wing-Tak Wong
Summary: In this study, a crosslinked blended hydrogel was generated using gelatine and chitosan with clusteroluminogenic properties, which not only exhibited intrinsic antibacterial properties and high tunability in delivery performance but also had a self-indicating capacity for quality control during hydrogel preparation. The release profiles of the agent-loaded gels followed the Higuchi model well, with the non-Fickian mechanism being the major mechanism of the release process. Our gels have high efficiency in agent loading and have great potential in bioactive agent delivery and related biomedical applications.
Article
Biochemistry & Molecular Biology
Loredana Elena Nita, Aurica P. Chiriac, Alina Ghilan, Alina Gabriela Rusu, Daniela Pamfil, Irina Rosca, Liliana Mititelu-Tartau
Summary: In this study, enhanced antibacterial activity was achieved by loading norfloxacin into improved hydrogels and forming a complex with cyclodextrin. The release profile of norfloxacin was successfully modulated with the use of cyclodextrin, demonstrating controlled-release properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Anna Tverdokhlebova, Ilya Sterin, Costel C. Darie, Evgeny Katz, Oleh Smutok
Summary: This study investigated the electrochemically controlled release of proteins in a Ca2+-cross-linked alginate hydrogel deposited on an electrode surface. By applying different electrical potentials, the pH of the hydrogel could be modified, resulting in the shrinkage or swelling of the hydrogel film. The release of proteins was inhibited or activated depending on the pH changes. The release inhibition was effective with the application of +0.6 V, while the release activation was influenced by the protein size and charge. Cyclic application of oxidative and reductive potentials allowed for the repetitive change between inhibition and activation states. The alginate hydrogel film shrinking-swelling and protein release process were studied using a confocal fluorescent microscope.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Seung Hun Park, Richard S. Kim, Wesley R. Stiles, Minjoo Jo, Lingxue Zeng, Sunghoon Rho, Yoonji Baek, Jonghan Kim, Moon Suk Kim, Homan Kang, Hak Soo Choi
Summary: Deferoxamine (DFO) is an FDA-approved iron-chelating agent with good therapeutic efficacy, but its short blood half-life poses challenges for patients who require frequent administrations. By integrating crosslinked hyaluronic acid and Pluronic F127 into an injectable hydrogel formulation, a prolonged release of DFO nanochelators is achieved, significantly extending the half-life and demonstrating potential for the treatment of iron overload disorders.
Review
Biochemistry & Molecular Biology
Marianne Leveque, Mourad Bekhouche, Jean-Christophe Farges, Audrey Aussel, Kadiatou Sy, Raphael Richert, Maxime Ducret
Summary: The success of regenerative endodontic procedures relies on various parameters including the nature of biomolecules or chemical compounds, hydrogel concentration, solubility of bioactive molecules, and apex size. The lack of knowledge regarding these parameters hinders the prediction of clinical outcomes and suggests the need for further research and development of mathematical models to predict the bioactivity of endodontic hydrogel.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Aiman Karim, Abdur Rehman, Jianguo Feng, Asia Noreen, Elham Assadpour, Mohammad Saeed Kharazmi, Zhang Lianfu, Seid Mahdi Jafari
Summary: Alginate-based nanocarriers have great potential in the delivery of bioactive compounds. Calcium alginate and sodium alginate, as the most promising wall materials, are non-toxic, relatively cheap, simple to produce, and biocompatible and biodegradable. The review discusses different alginate-based nanocarriers and their entrapment of bioactives, as well as their bioavailability in the gastric environment. Alginate-based nanocarriers can be used as emulsifiers/encapsulants for various bioactives, including vitamins, minerals, peptides, essential oils, and carotenoids. The combination of alginate-based nanocarriers with other polysaccharides/emulsifiers is recognized as the most effective approach for the protection, delivery, and sustained release of bioactives.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: Polymer nanofibers have high surface area for efficient transport, while hydrogels combine flexibility and customizable transport properties. Combining nanofibers with hydrogels advances biomedical applications, especially in sustained drug delivery. Nanofiber hydrogels can maintain drug release rates for days to months and are crucial for 3D or 4D printable systems.
Article
Chemistry, Applied
Sonita A. P. Siboro, Daru S. B. Anugrah, Kalyan Ramesh, Sang-Hyug Park, Hyeung-Rak Kim, Kwon Taek Lim
Summary: The study demonstrates that the drug release behavior of alginate hydrogels is significantly influenced by the proportion of crosslinkers and porosity. Porous hydrogels lead to faster drug release, while non-porous hydrogels result in slow release. Furthermore, porous alginate hydrogels can sustainably release doxorubicin for up to 35 days.
CARBOHYDRATE POLYMERS
(2021)
Article
Biotechnology & Applied Microbiology
Jiaxin Li, Weichang Li, Mengjie Kong, Zongtai Li, Tao Yang, Qinmei Wang, Wei Teng
Summary: A bi-layered scaffold for guided bone regeneration (GBR) composed of a fiber barrier layer and a self-healing hydrogel repair layer has been successfully fabricated. This system can provide an osteogenic microenvironment, maintain the stability of the osteogenic space, and regulate the release of bioactive substances. The study shows that the hybrid scaffold has good biocompatibility, cell barrier function, and can enhance bone regeneration activity.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Juping Ma, Penghui Wang, Chuanfei Tang, Huiyun Liao, Wenjie Zhang, Rong Yang, Tianqi Shi, Xiaoyan Tan, Bo Chi
Summary: Endoscopic submucosal dissection (ESD) is an effective method for treating early gastrointestinal cancers. In this study, a dynamic injectable hydrogel with shear-thinning properties was developed for ESD surgery. The hydrogel demonstrated self-healing abilities and antioxidant activity, and resulted in higher submucosal elevation heights compared to commercial ESD solutions. These findings suggest that the hydrogel has the potential to assist in ESD surgery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Sajjad Haider, Hafiz Abdul Mannan, Javed Hussain, Anarwul Hasan
Summary: Biopolymer-based composite hydrogels have shown great potential for tissue regeneration and antitumor applications, with excellent drug release properties and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Priscilla A. Williams, Kevin T. Campbell, Eduardo A. Silva
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Engineering, Biomedical
Kevin T. Campbell, Roberta S. Stilhano, Eduardo A. Silva
Article
Engineering, Biomedical
Dustin J. Hadley, Eduardo A. Silva
ANNALS OF BIOMEDICAL ENGINEERING
(2019)
Review
Biochemistry & Molecular Biology
Fabio S. M. Yamaguchi, Shahin Shams, Eduardo A. Silva, Roberta S. Stilhano
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Engineering, Biomedical
A. L. Torres, S. J. Bidarra, D. P. Vasconcelos, J. N. Barbosa, E. A. Silva, D. S. Nascimento, C. C. Barrias
Article
Materials Science, Biomaterials
Kevin T. Campbell, Kajetan Wysoczynski, Dustin J. Hadley, Eduardo A. Silva
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2020)
Article
Dentistry, Oral Surgery & Medicine
Sands R. Warren, Catia S. Verbeke, Kazuhisa Ouhara, Eduardo A. Silva, Susan Hsiong, Toshihisa Kawai, David Mooney
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Multidisciplinary Sciences
Jai Woong Seo, Elizabeth S. Ingham, Lisa Mahakian, Spencer Tumbale, Bo Wu, Sadaf Aghevlian, Shahin Shams, Mo Baikoghli, Poorva Jain, Xiaozhe Ding, Nick Goeden, Tatyana Dobreva, Nicholas C. Flytzanis, Michael Chavez, Kratika Singhal, Ryan Leib, Michelle L. James, David J. Segal, R. Holland Cheng, Eduardo A. Silva, Viviana Gradinaru, Katherine W. Ferrara
NATURE COMMUNICATIONS
(2020)
Review
Engineering, Biomedical
Kevin T. Campbell, Eduardo A. Silva
ADVANCED HEALTHCARE MATERIALS
(2020)
Review
Biochemistry & Molecular Biology
Roberta Sessa Stilhano, Angelica Jardim Costa, Michelle Sayuri Nishino, Shahin Shams, Cynthia Silva Bartolomeo, Ana Cristina Breithaupt-Faloppa, Eduardo Alexandre Silva, Ana Lopez Ramirez, Carla Maximo Prado, Rodrigo Portes Ureshino
Article
Cell & Tissue Engineering
Tomas Gonzalez-Fernandez, Alejandro J. Tenorio, Kevin T. Campbell, Eduardo A. Silva, J. Kent Leach
Summary: This study evaluated four commonly used alginate-based bioinks for 3D bioprinting of bone tissues, highlighting the importance of bioink properties in modulating cell behavior and the biofabrication of clinically relevant bone tissues. The study found that the physical properties of bioinks significantly affected the biological performance of encapsulated mesenchymal stromal cells and their osteogenic potential. Additionally, the study identified alginate-CaCl2 as the most effective bioink for promoting osteogenic differentiation and partial mineralization of cell-laden bone constructs.
TISSUE ENGINEERING PART A
(2021)
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Review
Nutrition & Dietetics
Maria Luiza G. A. Seixas, Lucas Pari Mitre, Shahin Shams, Gabriel Barbugian Lanzuolo, Cynthia Silva Bartolomeo, Eduardo A. Silva, Carla Maximo Prado, Rodrigo Ureshino, Roberta Sessa Stilhano
Summary: COVID-19's impact on the respiratory system has been extensively studied, but the evidence for its effects on skeletal muscle is not strong enough to effectively treat and prevent muscle impairment. Studies have shown that COVID-19 is associated with skeletal muscle damage, including conditions like sarcopenia and myalgia. Understanding the interaction between COVID-19 and skeletal muscle, as well as exploring new cell culture techniques, is crucial for improving treatment plans for infected patients.
FRONTIERS IN NUTRITION
(2022)
Review
Chemistry, Multidisciplinary
Maryam Rahmati, Eduardo A. Silva, Janne E. Reseland, Catherine A. Heyward, Havard J. Haugen
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Materials Science, Biomaterials
Justin L. Madrigal, Shahin Shams, Roberta S. Stilhano, Eduardo A. Silva
BIOMATERIALS SCIENCE
(2019)