The Dkk3 gene encodes a vital intracellular regulator of cell proliferation

An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

(2014) Eli J. Fine et al.   NUCLEIC ACIDS RESEARCH

A systems-wide screen identifies substrates of the SCF TrCP ubiquitin ligase

(2014) T. Y. Low et al.   Science Signaling

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline

(2013) Désirée R.M. Seib et al.   Cell Stem Cell

Epigenetic silencing of the WNT antagonist Dickkopf 3 disrupts normal Wnt/β-catenin signalling and apoptosis regulation in breast cancer cells

(2013) Tingxiu Xiang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanisms and function of substrate recruitment by F-box proteins

(2013) Jeffrey R. Skaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Using defined finger–finger interfaces as units of assembly for constructing zinc-finger nucleases

(2013) Cong Zhu et al.   NUCLEIC ACIDS RESEARCH

A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities

(2012) Rani Najdi et al.   DIFFERENTIATION

An optimized two-finger archive for ZFN-mediated gene targeting

(2012) Ankit Gupta et al.   NATURE METHODS

Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos

(2011) Steffen Biechele et al.   DEVELOPMENTAL BIOLOGY

Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling

(2011) Ilkka Pietilä et al.   DEVELOPMENTAL BIOLOGY

Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6

(2011) Victoria E. Ahn et al.   DEVELOPMENTAL CELL

Genome-wide characterization of transcriptional start sites in humans by integrative transcriptome analysis

(2011) R. Yamashita et al.   GENOME RESEARCH

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

(2011) Fuqiang Chen et al.   NATURE METHODS

Crystal structures of the extracellular domain of LRP6 and its complex with DKK1

(2011) Zhihong Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dickkopf3 overexpression inhibits pancreatic cancer cell growthin vitro

(2011) Yu-Mei Gu   WORLD JOURNAL OF GASTROENTEROLOGY

Generation of Axin1 conditional mutant mice

(2010) Rong Xie et al.   GENESIS

Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis

(2009) I. V. Chia et al.   GENETICS

βTrCP- and Rsk1/2-Mediated Degradation of BimEL Inhibits Apoptosis

(2009) Elinor Dehan et al.   MOLECULAR CELL

Dkk1 and Wnt3 interact to control head morphogenesis in the mouse

(2008) S. L. Lewis et al.   DEVELOPMENT

Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCFFWD1/β-TrCP-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1

(2008) Makio Hayakawa et al.   GENES TO CELLS

Dkk3, downregulated in cervical cancer, functions as a negative regulator of β-catenin

(2008) Eun-Ju Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

(2008) Risto Kerkela et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

(2008) Xiangdong Meng et al.   NATURE BIOTECHNOLOGY

The functional consequences of alternative promoter use in mammalian genomes

(2008) Ramana V. Davuluri et al.   TRENDS IN GENETICS

Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing

(2007) Edgar A. Otto et al.   HUMAN MUTATION