Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes

Chondroprotective and anti-inflammatory effects of S-methylisothiourea, an inducible nitric oxide synthase inhibitor in cartilage and synovial explants model of osteoarthritis

(2014) Venkanna Balaganur et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

(2013) Brendan L. Thoms et al.   ARTHRITIS AND RHEUMATISM

Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation

(2013) Hui-ming Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Loss of methylation in CpG sites in the NF-κB enhancer elements of inducible nitric oxide synthase is responsible for gene induction in human articular chondrocytes

(2012) María C. de Andrés et al.   ARTHRITIS AND RHEUMATISM

The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes – Implications for osteoarthritis

(2011) Kei Imagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory Effects of Pentosan Polysulfate Sodium on MAP-Kinase Pathway and NF-^|^kappa;B Nuclear Translocation in Canine Chondrocytes In Vitro

(2011) Takafumi SUNAGA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

HIF-2α - a mediator of osteoarthritis?

(2010) Christopher L Murphy   CELL RESEARCH

Inhibition of Hypoxia-inducible Factor-targeting Prolyl Hydroxylase Domain-containing Protein 2 (PHD2) Enhances Matrix Synthesis by Human Chondrocytes

(2010) Brendan L. Thoms et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

HIF-2α as a possible therapeutic target of osteoarthritis

(2010) T. Saito et al.   OSTEOARTHRITIS AND CARTILAGE

Pentosan polysulfate promotes proliferation and chondrogenic differentiation of adult human bone marrow-derived mesenchymal precursor cells

(2010) Peter Ghosh et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy

(2009) Jolene Bohensky et al.   ARTHRITIS AND RHEUMATISM

OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed?

(2009) M.-P. Hellio Le Graverand-Gastineau   OSTEOARTHRITIS AND CARTILAGE

Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes

(2008) Giuseppe M. Campo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Current concepts in the pathogenesis of osteoarthritis

(2008) S. Krasnokutsky et al.   OSTEOARTHRITIS AND CARTILAGE

Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage

(2008) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE

Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation

(2008) Kelvin S. C. Cheung et al.   RHEUMATOLOGY INTERNATIONAL