Article
Multidisciplinary Sciences
Haiou Xia, Xiaoxiao Zhu, Chunxiang Zhu
Summary: The study found that TNF-α is positively correlated with prenatal fatigue and can serve as an independent biomarker for prenatal fatigue. Lowering pro-inflammatory cytokines may be an effective method to reduce prenatal fatigue and enhance maternal and child health.
Review
Biochemistry & Molecular Biology
Ferenc Sipos, Gyorgyi Muzes
Summary: Inflammatory processes and cancer stem cells (CSCs) play important roles in tumorigenesis. CSCs are associated with cancer properties such as metastasis, treatment resistance, and disease recurrence. This review explores the reciprocal interplay between CSCs and immune cells in the tumor microenvironment, highlighting how CSCs influence leukocyte reprogramming and promote pro-tumor immune cells. The study also emphasizes the potential of immune cells in eliminating CSCs, while addressing the immune evasion mechanisms in CSCs and their clinical implications.
Article
Biochemistry & Molecular Biology
Lyudmila Bel'skaya, Alexandra Loginova, Elena A. Sarf
Summary: The aim of this study was to compare the salivary cytokine profile of breast cancer patients with the clinicopathological characteristics of the tumor. The results showed that the content of cytokines in saliva correlated well with the stage and differentiation of breast cancer. Additionally, the study revealed the correlation between certain salivary cytokines and the molecular subtype and hormonal receptor status of breast cancer.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Oncology
Aileen M. Garcia-Vargas, Yarelis M. Roque-Reyes, Desiree M. Arroyo-Villegas, Daniel Santiago-Negron, Maria M. Sanchez-Vazquez, Alejandro Rivera-Torres, Andrea C. Reyes-Melendez, Valerie Cardona-Berdecia, Miosotis Garcia-Maldonado, Olga M. Viquez, Magaly Martinez-Ferrer
Summary: Prostate cancer is a common cancer in men and the role of BAT1 gene in prostate cancer has been studied. Down-regulation of BAT1 gene may increase cell migration and invasion and affect the expression of inflammatory cytokines and cell adhesion and migration-related genes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Psychiatry
Yiyue Yang, Kaiqi Gu, Changyang Meng, Jia Li, Qiao Lu, Xiaobo Zhou, Deping Yan, Dongxiao Li, Changzhen Pei, Yue Lu, Shenglan Ran, Jing Li
Summary: There is a relationship between sleep and inflammatory factors, and the quality of sleep in MDD patients is associated with specific inflammatory factors. Poor sleep quality is negatively correlated with IL-2 and IL-8 levels, and positively correlated with IL-6, IL-10, CRP, TNF-alpha, CXCL-1, CXCL-2, and IFN-gamma levels.
PSYCHIATRY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hannah M. Fisher, Joseph G. Winger, Shannon N. Miller, Arianna N. Wright, Jennifer C. Plumb Vilardaga, Catherine Majestic, Sarah A. Kelleher, Tamara J. Somers
Summary: The study found that higher levels of emotional support were significantly associated with lower levels of fatigue, pain interference, and depressive symptoms. More instrumental support was linked to more depressive symptoms, but not fatigue or pain interference. Higher levels of fatigue and pain interference were significantly related to higher levels of depressive symptoms.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Biochemistry & Molecular Biology
Grzegorz Chmielewski, Michal S. Majewski, Jakub Kuna, Mateusz Mikiewicz, Magdalena Krajewska-Wlodarczyk
Summary: Fatigue is a common symptom in various rheumatic diseases, affecting patients' quality of life and exacerbating disability. Its nature involves multiple factors, including physiological, psychological, and social aspects. Despite its significance, fatigue is often underestimated in clinical practice. Comprehensive assessment of the subjective components of fatigue is crucial for effective management of this symptom in inflammatory joint diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ivan K. Domingo, Asna Latif, Amit P. Bhavsar
Summary: Cisplatin, a widely used chemotherapeutic drug, is effective against various solid cancers but limited by its adverse drug reactions. The most common reactions include nephrotoxicity, peripheral neuropathy, and ototoxicity. Previous studies focused on oxidative stress as the cause of these toxicities, but recent evidence suggests that inflammation may be the main driving force. This review summarizes the common and distinct inflammation characteristics among different adverse reactions, as well as current treatments targeting pro-inflammatory signaling pathways to improve the use of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Jimoh Olatunji Abubakar, Daramola Olajumoke Temidayo, Okin-Aminu Hafsat Ololade, Ojo Olayinka Abosede
Summary: Thermal stress is the main stressor affecting rabbit productivity in the tropics. This study examined the effects of three tropical herbs (mistletoe, Moringa, and Phyllanthus) on the immune response, oxidative status, adipokines, and growth of rabbits during heat stress. The results showed that the rabbits supplemented with Phyllanthus and mistletoe had better performance. The herbal supplements suppressed pro-inflammatory cytokines, boosted immune response, improved antioxidant activity, and promoted growth in rabbits under thermal discomfort.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Review
Biochemistry & Molecular Biology
Ferenc Zador, Samia Joca, Gabor Nagy-Grocz, Szabolcs Dvoracsko, Edina Szucs, Csaba Tomboly, Sandor Benyhe, Laszlo Vecsei
Summary: Substance use/abuse is a major cause of depression, potentially leading to inflammatory reactions triggering depressive symptoms, and increased pro-inflammatory cytokines may affect tryptophan metabolism, resulting in reduced serotonin levels, and subsequently inducing depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Robert J. Pawlik, Liubov Petrakova, Lisa Brotte, Harald Engler, Sven Benson, Sigrid Elsenbruch
Summary: This study investigated the relationship between pro-inflammatory cytokines and visceral sensitivity in healthy individuals, finding that systemic cytokine levels do not contribute significantly to interindividual variability in visceroception.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rafael Cardoso Maciel Costa Silva, Luis Tan, Danielle Aparecida Rodrigues, Elisa Beatriz Prestes, Caroline Pereira Gomes, Andreza Moreira Gama, Pedro Lagerblad de Oliveira, Claudia Neto Paiva, Benedicte Manoury, Marcelo Torres Bozza
Summary: The study indicates that chloroquine may be used as a supportive therapy to control heme-induced deleterious inflammation in different hemolytic diseases by inhibiting inflammatory effects induced by heme.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jiebo Zhu, Min Joung Lee, Jong Hun An, Eungseok Oh, Woosuk Chung, Jun Young Heo
Summary: Microglial activation is correlated with the unfolded protein response (UPRmt) in mitochondria, which acts as a protective mechanism during neuroinflammation and may be a potential therapeutic target for reducing inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
R. Norman, R. Viney, N. K. Aaronson, J. E. Brazier, D. Cella, D. S. J. Costa, P. M. Fayers, G. Kemmler, S. Peacock, A. S. Pickard, D. Rowen, D. J. Street, G. Velikova, T. A. Young, M. T. King
QUALITY OF LIFE RESEARCH
(2016)
Article
Urology & Nephrology
Athene Lane, Chris Metcalfe, Grace J. Young, Tim J. Peters, Jane Blazeby, Kerry N. L. Avery, Daniel Dedman, Liz Down, Malcolm D. Mason, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan
Article
Oncology
M. D. Mason, R. Moore, G. Jones, G. Lewis, J. L. Donovan, D. E. Neal, F. C. Hamdy, J. A. Lane, J. N. Staffurth
Article
Health Care Sciences & Services
Johannes M. Giesinger, Jacobien M. Kieffer, Peter M. Fayers, Mogens Groenvold, Morten Aa. Petersen, Neil W. Scott, Mirjam A. G. Sprangers, Galina Velikova, Neil K. Aaronson
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2016)
Article
Health Care Sciences & Services
Skye T. Dong, Daniel S. J. Costa, Phyllis N. Butow, Melanie R. Lovell, Meera Agar, Galina Velikova, Paulos Teckle, Allison Tong, Niall C. Tebbutt, Stephen J. Clarke, Kim van der Hoek, Madeleine T. King, Peter M. Fayers
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2016)
Editorial Material
Ophthalmology
T. Fayers, G. K. Loh, M. F. Cordeiro, V. Lee, R. Jain, P. M. Fayers
Article
Health Care Sciences & Services
Sally J. Wheelwright, Jane B. Hopkinson, Anne-Sophie Darlington, Deborah F. Fitzsimmons, Peter Fayers, Trude R. Balstad, Anne Bredart, Eva Hammerlid, Stein Kaasa, Ourania Nicolatou-Galitis, Monica Pinto, Heike Schmidt, Tora S. Solheim, Florian Strasser, Iwona M. Tomaszewska, Colin D. Johnson
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2017)
Article
Health Care Sciences & Services
Mogens Groenvold, Morten Aagaard Petersen, Anette Damkier, Mette Asbjoern Neergaard, Jan Bjoern Nielsen, Lise Pedersen, Per Sjogren, Annette Sand Stromgren, Tove Bahn Vejlgaard, Christian Gluud, Jane Lindschou, Peter Fayers, Irene J. Higginson, Anna Thit Johnsen
PALLIATIVE MEDICINE
(2017)
Article
Economics
Madeleine T. King, Rosalie Viney, A. Simon Pickard, Donna Rowen, Neil K. Aaronson, John E. Brazier, David Cella, Daniel S. J. Costa, Peter M. Fayers, Georg Kemmler, Helen McTaggart-Cowen, Rebecca Mercieca-Bebber, Stuart Peacock, Deborah J. Street, Tracey A. Young, Richard Norman
Correction
Health Care Sciences & Services
R. Norman, R. Viney, N. K. Aaronson, J. E. Brazier, D. Cella, D. S. J. Costa, P. M. Fayers, G. Kemmler, S. Peacock, A. S. Pickard, D. Rowen, D. J. Street, G. Velikova, T. A. Young, M. T. King
QUALITY OF LIFE RESEARCH
(2017)
Article
Geriatrics & Gerontology
Ola Magne Vagnildhaug, David Blum, Andrew Wilcock, Peter Fayers, Florian Strasser, Vickie E. Baracos, Marianne J. Hjermstad, Stein Kaasa, Barry Laird, Tora S. Solheim
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Geriatrics & Gerontology
Tora S. Solheim, Barry J. A. Laird, Trude Rakel Balstad, Guro B. Stene, Asta Bye, Neil Johns, Caroline H. Pettersen, Marie Fallon, Peter Fayers, Kenneth Fearon, Stein Kaasa
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Oncology
Morten Aa Petersen, Neil K. Aaronson, Juan Arraras, Wei-Chu Chie, Thierry Conroy, Anna Costantini, Linda Dirven, Peter Fayers, Eva-Maria Gamper, Johannes M. Giesinger, Esther J. J. Habets, Eva Hammerlid, Jorunn Helbostad, Marianne J. Hjermstad, Bernhard Holzner, Colin Johnson, Georg Kemmler, Madeleine T. King, Stein Kaasa, Jon H. Loge, Jaap C. Reijneveld, Susanne Singer, Martin J. B. Taphoorn, Lise H. Thamsborg, Krzysztof A. Tomaszewski, Galina Velikova, Irma M. Verdonck-de Leeuw, Teresa Young, Mogens Groenvold
EUROPEAN JOURNAL OF CANCER
(2018)