Article
Endocrinology & Metabolism
Tommi Valikangas, Niina Lietzen, Maria K. Jaakkola, Lars Krogvold, Morten C. Eike, Henna Kallionpaa, Soile Tuomela, Clayton Mathews, Ivan C. Gerling, Sami Oikarinen, Heikki Hyoty, Knut Dahl-Jorgensen, Laura L. Elo, Riitta Lahesmaa
Summary: This study analyzed the whole-pancreas gene expression of recently diagnosed type 1 diabetes (T1D) patients and found that the expression of core acinar cell genes was higher in the patients compared to non-diabetic controls. Upregulation of immune and inflammation related genes was observed in the pancreatic islets of T1D patients, while downregulation of regenerating gene family (REG) genes was observed in the exocrine acinar cell dominated whole-pancreas samples. The study highlights the importance of studying both exocrine and endocrine compartments of the pancreas to better understand the molecular mechanisms of T1D.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Laura Soldovieri, Gianfranco Di Giuseppe, Gea Ciccarelli, Giuseppe Quero, Francesca Cinti, Michela Brunetti, Enrico C. Nista, Antonio Gasbarrini, Sergio Alfieri, Alfredo Pontecorvi, Andrea Giaccari, Teresa Mezza
Summary: In the past few decades, various approaches have been explored to restore sufficient β-cell mass in diabetic patients. Stem cells are an attractive source of new β-cells, while inducing endogenous regeneration is also an alternative option. This review summarizes the latest evidence on physiological and pathological conditions associated with pancreatic regeneration and proliferation, as well as the signaling cascade mediating cell growth.
MOLECULAR METABOLISM
(2023)
Article
Psychiatry
Mario Simjanoski, Karen Jansen, Thaise Campos Mondin, Fernanda Pedrotti Moreira, Igor Soares Vieira, Ricardo Azevedo da Silva, Luciano Dias de Mattos Souza, Benicio N. Frey, Taiane de Azevedo Cardoso, Flavio Kapczinski
Summary: The study aimed to assess the differences in subjective cognitive dysfunction between major depressive disorder (MDD) and recently diagnosed Bipolar Disorder (BD) across euthymia and mood episodes. Results showed higher subjective cognitive dysfunction in individuals recently diagnosed with BD compared to those with MDD during euthymia.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Igor Soares Vieira, Nathalia Tessele Barreto, Fernanda Pedrotti Moreira, Thaise Campos Mondin, Mario Simjanoski, Taiane de Azevedo Cardoso, Flavio Kapczinski, Karen Jansen, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva
Summary: The study revealed differences in sleep efficiency and disturbances between euthymic BD and MDD, highlighting the importance of regular sleep assessments for individuals recently diagnosed with BD. These differences can provide valuable insights for prognosis, treatment, and the presence of subsyndromal symptoms in the absence of a mood episode.
PSYCHIATRY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Nicoletta Dozio, Rita Indirli, Gian Maria Giamporcaro, Laura Frosio, Alessandra Mandelli, Andrea Laurenzi, Andrea Mario Bolla, Angela Stabilini, Andrea Valle, Massimo Locatelli, Giulia Martina Cavestro, Marina Scavini, Manuela Battaglia, Emanuele Bosi
Summary: The study aimed to investigate pancreatic exocrine function in patients with type 1 diabetes (T1D) using non-invasive tests. Results showed that impaired exocrine pancreatic function, marked by low fecal elastase-1, serum pancreatic amylase, and lipase levels, is associated with reduced nutritional indexes in T1D patients.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Medicine, General & Internal
Zheng Yang, Shengqi Li, Huaying Liu, Qisheng Su, Xiaohong Li, Yulin Qiu, Wuning Mo
Summary: This study identified differentially expressed genes in diabetes of the exocrine pancreas, with HLA-DRA being suggested as a potential marker gene. The immune system and infection-related pathways were found to be enriched in DEP.
Article
Health Care Sciences & Services
Felippe O. Marcondes, David Cheng, Margarita Alegria, Jennifer S. Haas
Summary: This study assessed racial/ethnic differences in the receipt of guideline-directed diabetes care for complication prevention by individuals recently diagnosed with diabetes. Hispanics recently diagnosed with diabetes were found to be less likely to receive some indicators of guideline-directed care for the prevention of complications, with lack of insurance and SES potentially explaining these differences. Future work should consider policy change and providers' behaviors linked to racial/ethnic disparities in diabetes care.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Psychology, Clinical
Carrie Tully, Christine H. Wang, Manuela Sinisterra, Lauren Clary, Marisa E. Hilliard, Maureen Monaghan, Jichuan Wang, Randi Streisand
Summary: A study evaluated the diabetes-specific functioning among parents of young children newly diagnosed with Type 1 diabetes. The findings suggest that parents' emotional functioning and family protective factors are associated with their diabetes-specific functioning, and child-illness factors are related to both parents' diabetes-specific and emotional functioning.
Article
Endocrinology & Metabolism
Aleksander L. Hansen, Reimar W. Thomsen, Charlotte Brons, Helene M. L. Svane, Rasmus T. Jensen, Mette K. Andersen, Torben Hansen, Jens S. Nielsen, Peter Vestergaard, Kurt Hojlund, Niels Jessen, Michael H. Olsen, Henrik T. Sorensen, Allan A. Vaag
Summary: Low birthweight is associated with earlier onset of type 2 diabetes and lower BMI and waist circumference. Individuals with low birthweight have more comorbidities and require more medication for glucose-lowering and hypertension control.
Article
Medicine, General & Internal
Mary M. Wicks, Elizabeth L. M. Barr, Louise Maple-Brown
Summary: Pancreatitis and diabetes are prevalent among Aboriginal and non-Aboriginal people in Central Australia. Alcohol is the most common cause of pancreatitis among Aboriginal people, while biliary causes are more common among non-Aboriginal people. Post-pancreatitis diabetes mellitus (PPDM) diagnosis testing is insufficient.
INTERNAL MEDICINE JOURNAL
(2023)
Article
Endocrinology & Metabolism
Anna Giovenzana, Federica Vecchio, Federica Cugnata, Alessandro Nonis, Alessandra Mandelli, Angela Stabilini, Benedetta Allegra Mazzi, Maurizio De Pellegrin, Andrea Laurenzi, Riccardo Bonfanti, Manuela Battaglia, Emanuele Bosi, Alessandra Petrelli
Summary: Exocrine pancreas dysfunction precedes the onset of type 1 diabetes in adult at-risk individuals and may be unrelated to fasting C-peptide levels. High-risk HLA genotypes negatively affected P-amylase levels in autoantibody negative adult individuals.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Ruth S. Weinstock, Bruce W. Bode, Satish K. Garg, David C. Klonoff, Caroline El Sanadi, W. Blair Geho, Douglas B. Muchmore, Marc S. Penn
Summary: The aim of this study was to investigate whether an increased bolus: basal insulin ratio with liver-targeted bolus insulin would increase bolus insulin usage and decrease hypoglycaemic events. The results showed that liver-targeted bolus insulin safely decreased hypoglycaemic events and symptoms without compromising glucose control.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Dan Ouchi, Maria Giner-Soriano, Carles Vilaplana-Carnerero, Ramon Monfa, Ferran Torres, Rosa Morros
Summary: The aim of this study was to analyze the initial and subsequent treatments prescribed to newly diagnosed type 2 diabetes mellitus patients. The majority of patients started treatment with a single metformin medication, while a smaller percentage began with combination therapy. Metformin was the most commonly used first and third-line therapy, while metformin with DPP4i or sulfonylurea combination therapy was more prevalent as second-line therapy.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Teresa Rodriguez-Calvo, Lars Krogvold, Natalie Amirian, Knut Dahl-Jorgensen, Matthias von Herrath
Summary: In type 1 diabetes patients, CD8(+) T cells infiltrate the pancreas with high frequency, reactive against specific epitope derived from preproinsulin signal peptide. The study also showed the heterogeneity of islet distribution and CD8(+) T-cell infiltration, contributing to limited existing knowledge of T-cell reactivity in the pancreas of donors with recent-onset T1D. Antigen-specific therapies directed toward preproinsulin could have high clinical impact.
Article
Endocrinology & Metabolism
Guoqing Li, Jinfang Sun, Jun Zhang, Yingqi Lv, Dechen Liu, Xiangyun Zhu, Liang Qi, Zhiwei Chen, Zheng Ye, Xianghui Su, Ling Li
Summary: This study identified biomarkers and potential molecular mechanisms of diabetes of the exocrine pancreas (DEP) through gene expression analysis and bioinformatics methods. The identified genes were involved in macrophage activation and Toll-like receptor signaling pathway, which play important roles in the pathogenesis of DEP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Microbiology
Anello Marcello Poma, Sarah Salehi Hammerstad, Angelo Genoni, Alessio Basolo, Knut Dahl-Jorgensen, Antonio Toniolo
Summary: Autoimmune thyroid disorders such as Hashimoto's thyroiditis and Graves' disease are thought to potentially have origins in enterovirus infections of thyroid cells. Research has shown that persistent enterovirus infection in thyroid tissue from AITD patients can suppress interferon and cytokine pathways while upregulating genes associated with immune responses. These findings suggest a potential benefit in targeting viral infections and inflammation in the early stages of AITD.
Article
Endocrinology & Metabolism
Sami Oikarinen, Lars Krogvold, Bjorn Edwin, Trond Buanes, Olle Korsgren, Jutta E. Laiho, Maarit Oikarinen, Johnny Ludvigsson, Oskar Skog, Mahesh Anagandula, Gun Frisk, Heikki Hyoty, Knut Dahl-Jorgensen
Summary: The Diabetes Virus Detection (DiViD) study collected pancreatic tissue, purified pancreatic islets, duodenal mucosa, serum, PBMCs, and stools from six adult patients with newly diagnosed type 1 diabetes. The study found enterovirus (EV) RNA in various tissues of these patients, indicating a potential persistent virus in the pancreatic islets of some patients.
Article
Psychology, Clinical
Line Wisting, Severina Haugvik, Anne Louise Wennersberg, Trine Wiig Hage, Eric Stice, Marion P. Olmsted, Ata Ghaderi, Cathrine Brunborg, Torild Skrivarhaug, Knut Dahl-Jorgensen, Oyvind Ro
Summary: The study indicates that the virtual Diabetes Body Project is feasible and shows meaningful reductions in primary and secondary outcomes, suggesting it is a promising intervention that warrants further evaluation through a randomized controlled trial.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2021)
Article
Ophthalmology
Nina C. B. B. Veiby, Aida Simeunovic, Martin Heier, Cathrine Brunborg, Naila Saddique, Morten C. Moe, Knut Dahl-Jorgensen, Goran Petrovski, Hanna D. Margeirsdottir
Summary: The study aimed to investigate the role of retinal vessel density, central retinal vessel diameter, and retinal oxygen saturation in the development of non-proliferative diabetic retinopathy. Results showed that age and AV-O2 saturation difference were significantly associated with NPDR.
ACTA OPHTHALMOLOGICA
(2022)
Article
Medicine, Research & Experimental
David B. Dunger, Sylvaine F. A. Bruggraber, Adrian P. Mander, M. Loredana Marcovecchio, Timothy Tree, Piotr Jaroslaw Chmura, Mikael Knip, Anke M. Schulte, Chantal Mathieu
Summary: The INNODIA consortium has established an infrastructure to evaluate clinical data and identify biomarkers for future clinical trials in newly diagnosed type 1 diabetes. They have developed a master protocol to improve phase 2 studies, including standardized assessment, collection of mechanistic data, and evaluation of combination therapies.
Article
Immunology
Laura Nigi, Noemi Brusco, Giuseppina E. Grieco, Daniela Fignani, Giada Licata, Caterina Formichi, Elena Aiello, Lorella Marselli, Piero Marchetti, Lars Krogvold, Knut Dahl Jorgensen, Guido Sebastiani, Francesco Dotta
Summary: The interaction between genetic and environmental factors determines the development of type 1 diabetes. Some viruses can infect and damage pancreatic beta cells, and MDA5 may play a role in the response of pancreatic islets to viral infections. In T1D donors, MDA5 expression is increased and may characterize dedifferentiated or newly forming islet cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Tommi Valikangas, Niina Lietzen, Maria K. Jaakkola, Lars Krogvold, Morten C. Eike, Henna Kallionpaa, Soile Tuomela, Clayton Mathews, Ivan C. Gerling, Sami Oikarinen, Heikki Hyoty, Knut Dahl-Jorgensen, Laura L. Elo, Riitta Lahesmaa
Summary: This study analyzed the whole-pancreas gene expression of recently diagnosed type 1 diabetes (T1D) patients and found that the expression of core acinar cell genes was higher in the patients compared to non-diabetic controls. Upregulation of immune and inflammation related genes was observed in the pancreatic islets of T1D patients, while downregulation of regenerating gene family (REG) genes was observed in the exocrine acinar cell dominated whole-pancreas samples. The study highlights the importance of studying both exocrine and endocrine compartments of the pancreas to better understand the molecular mechanisms of T1D.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lars Krogvold, Angelo Genoni, Anna Puggioni, Daniela Campani, Sarah J. Richardson, Christine S. Flaxman, Bjorn Edwin, Trond Buanes, Knut Dahl-Jorgensen, Antonio Toniolo
Summary: This study has found the presence of enterovirus genomes in the pancreas of type 1 diabetes patients, suggesting a potential link between enterovirus infection and the development of type 1 diabetes.
Article
Endocrinology & Metabolism
Lars Krogvold, Pia Leete, Ida M. Mynarek, Mark A. Russell, Ivan C. Gerling, Nataliya I. Lenchik, Clayton Mathews, Sarah J. Richardson, Noel G. Morgan, Knut Dahl-Jorgensen
Summary: The study reveals that newly diagnosed type 1 diabetes patients have enhanced gene expressions related to cellular stress and increased immunological activity in their islet cells compared to controls. Additionally, increased viral response proteins were observed in beta-cells of newly diagnosed type 1 diabetes patients, providing evidence for the hypothesis that enteroviral infection of islet beta-cells contributes to the pathogenesis of type 1 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Hasim Tekin, Knud Josefsen, Lars Krogvold, Knut Dahl-Jorgensen, Ivan Gerling, Flemming Pociot, Karsten Buschard
Summary: The incidence of type 1 diabetes in children under 18 years of age increases after COVID-19 infection. Decreased expression of PDE12 is associated with T1D development, while rare PDE12 SNPs may increase the risk of T1D.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Knud Josefsen, Lars Krogvold, Ivan C. Gerling, Flemming Pociot, Knut Dahl-Jorgensen, Karsten Buschard
Summary: This study suggests that dormant beta cells in type 1 diabetes (T1D) exhibit secretion defects, fetal dedifferentiation, and desynchronization. Combining with previous evidence, it is proposed to treat individuals with ongoing T1D development prophylactically with type 2 diabetes (T2D) medicine and anti-inflammatory compounds to reactivate dormant beta cells and prevent autoimmune destruction. Further investigation into T2D mechanisms during T1D development is needed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Gronroos, Tommi Valikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Seren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo
Summary: This study aimed to identify transcriptional changes associated with disease progression in patients with recent-onset type 1 diabetes. They found that genes and pathways related to innate immunity were downregulated during the first year after diagnosis. Associations between gene expression changes and ZnT8A autoantibody positivity were also observed. Additionally, changes in the expression of 16 genes were found to predict the decline in C-peptide at 24 months, and increased B cell levels and decreased neutrophil levels were associated with rapid progression, consistent with previous reports.
Article
Endocrinology & Metabolism
Therese Weider, Angelo Genoni, Francesco Broccolo, Trond H. Paulsen, Knut Dahl-Jorgensen, Antonio Toniolo, Sara Salehi Hammerstad
Summary: This study found a high prevalence of common viruses in thyroid tissue, with enteroviruses, human herpesvirus 6, and parvovirus B19 being the most common. The significance of these detected viruses as causal agents, possible cofactors, or bystanders remains to be determined.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Louise Granlund, Anders Hedin, Miriam Wahlhuetter, Peter Seiron, Olle Korsgren, Oskar Skog, Marcus Lundberg
Summary: This study showed that acinar nuclei density is preserved and no acinar atrophy is found in type 1 diabetes. The expression of digestive enzymes is evenly distributed, with occasional amylase-negative regions in formalin-fixed tissues. Transcriptional alterations in type 1 diabetes in the acinar tissue, independent of the distance from islets, were also identified. The enrichment of gene sets Myc Targets V2 and Estrogen Response Early may be linked to the increased incidence of pancreatic cancer in type 1 diabetes.
BMJ OPEN DIABETES RESEARCH & CARE
(2021)
Article
Psychology, Clinical
Line Wisting, Astrid Ro, Torild Skrivarhaug, Knut Dahl-Jorgensen, Oyvind Ro
Summary: This study found that among females with type 1 diabetes, illness perception personal control and coping strategy seeking emotional social support explained 23.2% of the variance in hemoglobin A1c, while among males, personal control remained significant and explained 13.9% of the variance. The associations between psychological aspects and hemoglobin A1c suggest that addressing these aspects clinically may help improve metabolic control and reduce the risk of complications.
JOURNAL OF HEALTH PSYCHOLOGY
(2021)
